Gene: CDH11

1009
CAD11|CDHOB|ESWS|OB|OSF-4
cadherin 11
protein-coding
16q21
Ensembl:ENSG00000140937 MIM:600023 Vega:OTTHUMG00000137494 UniprotKB:P55287
NG_029491.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.664e-1 (AD)  2.449e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCAF130.761
CALU0.759
POFUT10.752
DLC10.751
ASCC30.746
FNDC3A0.744
PRRC10.743
SUCO0.739
ADAM100.735
ZNF8000.735

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.501
OR4F29-0.461
NKX6-3-0.218
SCRT2-0.2
PVALB-0.198
SHISA8-0.198
AP1M2-0.198
BHLHA9-0.197
EIF4E1B-0.191
PRTN3-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of CDH11 mRNA"19095052
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CDH11 mRNA"20406850
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in decreased expression of CDH11 protein"18025290
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDH11 mRNA22129741
C016601afimoxifeneafimoxifene results in decreased expression of CDH11 mRNA19901195
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDH11 gene27153756
D000537Aluminum OxideAluminum Oxide results in increased expression of CDH11 mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDH11 mRNA16483693
D001151ArsenicArsenic results in decreased expression of CDH11 mRNA19654921
C015001arsenitearsenite results in decreased expression of CDH11 mRNA23974009
C547126AZM551248AZM551248 results in increased expression of CDH11 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH11 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDH11 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDH11 mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDH11 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CDH11 mRNA19619570
D004958EstradiolEstradiol results in increased expression of CDH11 mRNA22411564
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in increased expression of CDH11 mRNA]22411564
C006780bisphenol Abisphenol A results in increased expression of CDH11 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of CDH11 promoter27312807
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH11 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of CDH11 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDH11 mRNA12419474
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA]"20230807
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CDH11 mRNA23650126
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CDH11 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of CDH11 mRNA23125180
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDH11 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of CDH11 mRNA15467011
D003474CurcuminCurcumin results in decreased expression of CDH11 protein18025290
D003561CytarabineCytarabine results in decreased expression of CDH11 mRNA21198554
C014347decitabinedecitabine results in decreased expression of CDH11 mRNA18025290
C014347decitabinedecitabine results in decreased expression of CDH11 protein18025290
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CDH11 mRNA21266533
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH11 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CDH11 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of CDH11 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of CDH11 mRNA18042831
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of CDH11 promoter23359474
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CDH11 mRNA22677342
C014476diethyl maleatediethyl maleate results in decreased expression of CDH11 mRNA21161181
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH11 mRNA18164116
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDH11 mRNA22129741
D004221DisulfiramDisulfiram results in decreased expression of CDH11 mRNA20530235
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CDH11 mRNA24690739
D004237DiuronDiuron results in decreased expression of CDH11 mRNA25152437
C118739entinostatentinostat results in decreased expression of CDH11 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDH11 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CDH11 mRNA17351261
C039281furanfuran results in increased expression of CDH11 mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of CDH11 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDH11 mRNA12419474
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CDH11 mRNA22129741
D007545IsoproterenolIsoproterenol results in increased expression of CDH11 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDH11 mRNA24796395|2596192
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDH11 mRNA26644586
D007649KetamineKetamine results in decreased expression of CDH11 mRNA20080153
D007854LeadLead affects the expression of CDH11 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of CDH11 mRNA11578147
D018021Lithium ChlorideCTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]19274078
D018021Lithium Chloride[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 mRNA19274078
D018021Lithium Chloride[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein19274078
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDH11 mRNA26272509|2800136
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDH11 mRNA26011545
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA]"20230807
D015735MifepristoneMifepristone results in increased expression of CDH11 mRNA17584828
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CDH11 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDH11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDH11 mRNA"25554681
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CDH11 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA]"20230807
D010047Ovalbumin[Particulate Matter co-treated with Ovalbumin] results in increased expression of CDH11 mRNA19176365
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDH11 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CDH11 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of CDH11 mRNA19682730
D000073878Palm OilPalm Oil results in increased expression of CDH11 mRNA18042831
D052638Particulate Matter[Particulate Matter co-treated with Ovalbumin] results in increased expression of CDH11 mRNA19176365
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CDH11 mRNA19095052
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CDH11 mRNA21061450
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of CDH11 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of CDH11 protein23718831
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDH11 mRNA23608068
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in increased expression of CDH11 mRNA]22411564
D011748PyrogallolPyrogallol results in increased expression of CDH11 mRNA20362636
D011748PyrogallolSilymarin inhibits the reaction [Pyrogallol results in increased expression of CDH11 mRNA]20362636
D011794QuercetinQuercetin results in increased expression of CDH11 mRNA15309432
C502851quinocetonequinocetone results in increased expression of CDH11 mRNA27046791
D012643SeleniumSelenium results in decreased expression of CDH11 mRNA19244175
D012838SilymarinSilymarin inhibits the reaction [Pyrogallol results in increased expression of CDH11 mRNA]20362636
C017947sodium arsenitesodium arsenite affects the methylation of CDH11 gene28589171
D013629TamoxifenTamoxifen results in increased expression of CDH11 mRNA26908177
D013629TamoxifenTamoxifen affects the expression of CDH11 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDH11 mRNA16443690|1849575
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CDH11 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDH11 mRNA19619570|1990119
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CDH11 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDH11 mRNA24035824
D013893ThiramThiram results in decreased expression of CDH11 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of CDH11 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDH11 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CDH11 mRNA25729387
D014212TretinoinTretinoin results in increased expression of CDH11 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of CDH11 mRNA21934132
D014212TretinoinTretinoin results in increased expression of CDH11 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of CDH11 mRNA20488242
C012589trichostatin Atrichostatin A results in decreased expression of CDH11 mRNA18025290|2627250
C012589trichostatin Atrichostatin A results in decreased expression of CDH11 protein18025290
C012589trichostatin Atrichostatin A results in increased expression of CDH11 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of CDH11 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of CDH11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CDH11 mRNA19101580|2438349
D014640VancomycinVancomycin results in decreased expression of CDH11 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of CDH11 mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0001501skeletal system development-TAS8163513  
GO:0001503ossification-NAS8163513  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-TAS8163513  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0021957corticospinal tract morphogenesis-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0034332adherens junction organization-TAS-  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17409975Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and lifetime never-smokers. (2006 Nov)Lam DCJ Thorac Oncol