Gene: ADAM8

101
CD156|CD156a|MS2
ADAM metallopeptidase domain 8
protein-coding
10q26.3
Ensembl:ENSG00000151651 MIM:602267 Vega:OTTHUMG00000019309 UniprotKB:P78325
NC_000010.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.990e-1 (AD)  2.345e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRABD0.735
SLC26A60.703
MTMR110.702
COLGALT10.696
LRCH40.696
HDAC70.696
CASP20.69
RFX10.688
FAM193B0.685
ABCD40.685

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIO2-0.324
KCNJ16-0.313
OR4F29-0.281
ACBD7-0.276
OR4F5-0.275
CNBD2-0.273
ABCD2-0.269
TRDN-0.266
ZNF98-0.264
LYPD6-0.263

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of ADAM8 mRNA"25710175
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ADAM8 mRNA"20713471
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ADAM8 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of ADAM8 mRNA25088246
C0065932-anthramine2-anthramine results in increased expression of ADAM8 mRNA23038007
D000082AcetaminophenAcetaminophen affects the expression of ADAM8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADAM8 mRNA22545673|2363061
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ADAM8 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ADAM8 mRNA24449571
D001280AtrazineAtrazine results in decreased expression of ADAM8 mRNA27413107
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAM8 mRNA25908611|2719552
C006780bisphenol Abisphenol A results in decreased expression of ADAM8 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of ADAM8 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of ADAM8 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ADAM8 mRNA15003993
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ADAM8 mRNA18560533
D019256Cadmium ChlorideTNF affects the reaction [Cadmium Chloride results in increased expression of ADAM8 mRNA]18560533
D002235CarbofuranCarbofuran results in increased expression of ADAM8 mRNA20211217
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP1A2 mRNA]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP1A2 protein]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of GPT protein]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA mRNA]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of VEGFA mRNA]24646716
D002251Carbon TetrachlorideADAM8 protein affects the reaction [Carbon Tetrachloride results in increased expression of VEGFA protein]24646716
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAM8 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAM8 protein24646716
D002509CephaloridineCephaloridine results in decreased expression of ADAM8 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of ADAM8 mRNA19549813
D002945CisplatinCisplatin results in increased expression of ADAM8 mRNA22023808
D002117CalcitriolCalcitriol results in decreased expression of ADAM8 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of ADAM8 mRNA"22485181
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of ADAM8 mRNA"27840820
D004237DiuronDiuron results in increased expression of ADAM8 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of ADAM8 mRNA20211217
D004726EndosulfanEndosulfan results in increased expression of ADAM8 mRNA26615145
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADAM8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM8 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of ADAM8 mRNA19167457
D005947GlucoseGlucose results in increased expression of ADAM8 mRNA17178593
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM8 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of ADAM8 mRNA20211217
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ADAM8 mRNA12057914
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ADAM8 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAM8 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of ADAM8 mRNA24449571
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ADAM8 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADAM8 mRNA23103053
C523799MRK 003ADAM8 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADAM8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAM8 mRNA"25554681
D009532NickelNickel results in increased expression of ADAM8 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of ADAM8 mRNA16166746
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ADAM8 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADAM8 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ADAM8 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADAM8 mRNA"25510870
D010672PhenytoinPhenytoin results in decreased expression of ADAM8 mRNA14741686
D011374ProgesteroneProgesterone results in decreased expression of ADAM8 mRNA22238285
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ADAM8 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in increased expression of ADAM8 mRNA22300531|2535159
D012834SilverSilver affects the expression of ADAM8 mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of ADAM8 mRNA22561333|2599309
D053260SootSoot results in increased expression of ADAM8 mRNA22461453|2655175
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ADAM8 mRNA26378955
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ADAM8 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA16979875
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of ADAM8 mRNA19945525
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM8 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ADAM8 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of ADAM8 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ADAM8 mRNA27760801
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of ADAM8 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ADAM8 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ADAM8 mRNA18087596
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADAM8 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ADAM8 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of ADAM8 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of ADAM8 mRNA23724009
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ADAM8 mRNA29024780
D014635Valproic AcidValproic Acid results in increased methylation of ADAM8 gene29154799
C025643vinclozolinvinclozolin affects the expression of ADAM8 mRNA19015723
D002762CholecalciferolCholecalciferol results in decreased expression of ADAM8 mRNA16508948
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ADAM8 mRNA27935865
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ADAM8 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-IEA-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI12777399  15574124  17548643  
GO:0008237metallopeptidase activity-IDA12777399  15220135  17548643  
GO:0008270zinc ion binding-TAS18397961  
GO:0043621protein self-association-TAS12777399  
GO:0050839cell adhesion molecule binding-IPI12777399  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-ISS-  
GO:0001525angiogenesis-ISS-  
GO:0002523leukocyte migration involved in inflammatory response-ISS-  
GO:0002675positive regulation of acute inflammatory response-ISS-  
GO:0006508proteolysis-IEA-  
GO:0006954inflammatory response-IDA17548643  
GO:0010954positive regulation of protein processing-NAS17548643  
GO:0022407regulation of cell-cell adhesion-IDA17548643  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0033089positive regulation of T cell differentiation in thymus-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0043406positive regulation of MAP kinase activity-ISS-  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0045089positive regulation of innate immune response-ISS-  
GO:0045780positive regulation of bone resorption-ISS-  
GO:0045785positive regulation of cell adhesion-ISS-  
GO:0048247lymphocyte chemotaxis-ISS-  
GO:0050714positive regulation of protein secretion-IC17548643  
GO:0051044positive regulation of membrane protein ectodomain proteolysis-IDA15220135  17548643  
GO:0051092positive regulation of NF-kappaB transcription factor activity-ISS-  
GO:0051897positive regulation of protein kinase B signaling-ISS-  
GO:0070245positive regulation of thymocyte apoptotic process-ISS-  
GO:0071456cellular response to hypoxia-IDA18566576  
GO:0098609cell-cell adhesion-IEA-  
GO:2000309positive regulation of tumor necrosis factor (ligand) superfamily member 11 production-ISS-  
GO:2000391positive regulation of neutrophil extravasation-IDA17548643  
GO:2000415positive regulation of fibronectin-dependent thymocyte migration-ISS-  
GO:2000418positive regulation of eosinophil migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002102podosome-IDA15220135  
GO:0005737cytoplasm-IDA18397961  
GO:0005886plasma membrane-IDA17548643  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA18397961  
GO:0009986cell surface-IDA17548643  
GO:0032010phagolysosome-IDA17548643  
GO:0032127dense core granule membrane-IDA17548643  
GO:0035579specific granule membrane-TAS-  
GO:0042581specific granule-IDA17548643  
GO:0070820tertiary granule-IDA17548643  
GO:0070821tertiary granule membrane-TAS-  
GO:0071065alpha9-beta1 integrin-vascular cell adhesion molecule-1 complexcolocalizes_withIDA15220135  
GO:0071133alpha9-beta1 integrin-ADAM8 complex-ISS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17124430Elevated soluble ADAM8 in bronchoalveolar lavage fluid in patients with eosinophilic pneumonia. (2007)Matsuno OInt Arch Allergy Immunol
19625177Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry. (2010 Jan)Matsuno ORespir Med
21640993Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts. (2011 Sep)Raitoharju EAtherosclerosis