Gene: CDH12

1010
CDHB
cadherin 12
protein-coding
5p14.3
Ensembl:ENSG00000154162 MIM:600562 Vega:OTTHUMG00000090591 UniprotKB:P55289
NC_000005.10
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.358e-1 (AD)  6.036e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs16894341chr5:22344141 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs17839323chr5:21842327 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK50.921
DGKI0.911
CAMK40.909
CDH80.908
LRRTM30.907
CACNA1E0.905
DGKB0.904
NPY5R0.904
LNX10.898
GABRB30.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.603
ROM1-0.568
HEY2-0.568
RNF135-0.567
MYL3-0.566
WWTR1-0.564
CNN2-0.563
YES1-0.563
EMP3-0.559
CSAG1-0.558

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDH12 mRNA"19167446
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDH12 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDH12 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDH12 gene27153756
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of CDH12 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDH12 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CDH12 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of CDH12 mRNA20106945
C017160cypermethrincypermethrin results in increased expression of CDH12 mRNA22528246
D004041Dietary FatsDietary Fats results in increased expression of CDH12 mRNA25016146
C118739entinostatentinostat results in decreased expression of CDH12 mRNA27188386
C071834glycidamideglycidamide results in decreased expression of CDH12 mRNA17822822
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CDH12 protein22344225
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of CDH12 mRNA20971185
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CDH12 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CDH12 mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of CDH12 gene28589171
C017947sodium arsenitesodium arsenite deficiency promotes the reaction [sodium arsenite results in decreased expression of CDH12 mRNA]28336213
C017947sodium arsenitesodium arsenite results in decreased expression of CDH12 mRNA28336213
C017947sodium arsenitesodium arsenite results in decreased methylation of CDH12 gene28336213
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDH12 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDH12 mRNA21570461
D014212TretinoinTretinoin results in increased expression of CDH12 mRNA21934132
D014635Valproic AcidValproic Acid results in decreased expression of CDH12 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in decreased expression of CDH12 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CDH12 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IEA-  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IBA21873635  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007275multicellular organism development-IBA21873635  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-IBA21873635  
GO:0034332adherens junction organization-IBA21873635  
GO:0034332adherens junction organization-TAS-  
GO:0044331cell-cell adhesion mediated by cadherin-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0016342catenin complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-418990Adherens junctions interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal