Gene: TSPAN2

10100
NET3|TSN2|TSPAN-2
tetraspanin 2
protein-coding
1p13.2
Ensembl:ENSG00000134198 MIM:613133 Vega:OTTHUMG00000011878 UniprotKB:O60636
NC_000001.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.201e-1 (AD)  5.061e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17479252chr1:115079239 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11102878chr1:115048377 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DKK20.752
GPC30.745
OR51E10.735
OGN0.735
JPH20.716
CDC20B0.706
ESM10.706
GATA60.703
SLC22A20.702
TRABD2B0.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLIN4-0.345
SLC7A10-0.337
GRIN2C-0.332
RLBP1-0.327
GPR37L1-0.322
SALL3-0.316
CNTFR-0.313
GPR143-0.307
RFX2-0.304
PLIN5-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TSPAN2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSPAN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSPAN2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of TSPAN2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TSPAN2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TSPAN2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TSPAN2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of TSPAN2 mRNA19654921
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TSPAN2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TSPAN2 mRNA22228805|2719552
D004958EstradiolEstradiol affects the expression of TSPAN2 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of TSPAN2 mRNA20170705
C006780bisphenol Abisphenol A results in decreased expression of TSPAN2 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of TSPAN2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TSPAN2 mRNA25979313
D003471CuprizoneCuprizone results in decreased expression of TSPAN2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of TSPAN2 mRNA27989131
D000069439DasatinibDasatinib results in increased expression of TSPAN2 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TSPAN2 mRNA23640034
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TSPAN2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TSPAN2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TSPAN2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TSPAN2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TSPAN2 mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of TSPAN2 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TSPAN2 mRNA24535843
D000431EthanolEthanol results in decreased expression of TSPAN2 mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TSPAN2 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TSPAN2 mRNA17557909
C039281furanfuran results in increased expression of TSPAN2 mRNA27387713
D017313FenretinideFenretinide results in increased expression of TSPAN2 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TSPAN2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TSPAN2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TSPAN2 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TSPAN2 mRNA26644586
D007854LeadLead affects the expression of TSPAN2 mRNA28903495
D007854LeadLead results in increased expression of TSPAN2 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TSPAN2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TSPAN2 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of TSPAN2 mRNA22714537
D000073878Palm OilPalm Oil results in increased expression of TSPAN2 mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TSPAN2 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in decreased expression of TSPAN2 mRNA23892564
D011441PropylthiouracilPropylthiouracil results in decreased expression of TSPAN2 mRNA24780913
C116926rofecoxibrofecoxib results in decreased expression of TSPAN2 mRNA17070997
C009277sodium arsenatesodium arsenate results in increased expression of TSPAN2 mRNA21795629
D053260SootSoot results in decreased expression of TSPAN2 mRNA26551751
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of TSPAN2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TSPAN2 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TSPAN2 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to TSPAN2 promoter]19654925
C009495titanium dioxidetitanium dioxide results in decreased expression of TSPAN2 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of TSPAN2 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TSPAN2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TSPAN2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of TSPAN2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of TSPAN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TSPAN2 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of TSPAN2 mRNA23665938
C029297vinylidene chloridevinylidene chloride results in decreased expression of TSPAN2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25814554  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-IEA-  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007420brain development-IEA-  
GO:0014002astrocyte development-IEA-  
GO:0014005microglia development-IEA-  
GO:0042552myelination-IEA-  
GO:0048709oligodendrocyte differentiation-IEA-  
GO:0061564axon development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS9714763  
GO:0043209myelin sheath-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal