Gene info: ID 10105

Gene: PPIF

GENE ID: 10105

Synonyms: CYP3|CyP-M|Cyp-D|CypD

Description: peptidylprolyl isomerase F

Gene type: protein-coding

Location: 10q22.3

dbXrefs: Ensembl:ENSG00000108179 MIM:604486 Vega:OTTHUMG00000018562 UniprotKB:P30405

RefSeq: NC_000010.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.516e-1 (AD) 3.468e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg19939077	chr10:81108060	PPIF		2.240e-11	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MRPS18B	0.905
TUFM	0.9
ACAA1	0.9
GRHPR	0.899
EIF3I	0.898
MPDU1	0.897
EMC7	0.891
TALDO1	0.886
PUF60	0.885
RAB7A	0.884

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.767
OR4F29	-0.733
MTRNR2L6	-0.297
P2RY14	-0.279
MTRNR2L9	-0.276
KRT73	-0.262
DPPA4	-0.253
OR6C74	-0.249
MTRNR2L10	-0.249
IFNG	-0.246

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of PPIF mRNA"	20453058
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PPIF mRNA"	19114083
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PPIF mRNA"	19167446
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPIF mRNA]	12710931
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPIF mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPIF mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PPIF mRNA	25704631
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in increased expression of PPIF mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PPIF mRNA	27153756
D015766	Albendazole	[Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA	16861626
C103505	AM 251	AM 251 results in decreased expression of PPIF mRNA	16500647
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PPIF mRNA	16483693
C006632	arsenic trioxide	arsenic trioxide results in increased oxidation of PPIF protein	26975474
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of PPIF mRNA"	25351596
D001310	Auranofin	Auranofin results in increased oxidation of PPIF protein	26975474
D001310	Auranofin	Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]	26975474
D001310	Auranofin	Auranofin results in increased oxidation of PPIF protein	26975474
D001310	Auranofin	Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]	26975474
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PPIF mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PPIF mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PPIF mRNA	14625279
D001564	Benzo(a)pyrene	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of PPIF mRNA]	14625279
D004958	Estradiol	Estradiol results in increased expression of PPIF mRNA	19167446
C006780	bisphenol A	bisphenol A affects the expression of PPIF mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PPIF mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of PPIF mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in increased expression of PPIF mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of PPIF mRNA	21120746\|2117241
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PPIF mRNA	18804290
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PPIF mRNA	16239168
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PPIF gene	20938992
D009249	NADP	Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]	26975474
D009249	NADP	[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein	26975474
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PPIF mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PPIF mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of PPIF mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of PPIF mRNA	19167446
D003474	Curcumin	Curcumin results in increased expression of PPIF mRNA	17198877
D016572	Cyclosporine	Cyclosporine results in decreased expression of PPIF mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased activity of PPIF protein	22236255
D016572	Cyclosporine	Cyclosporine inhibits the reaction [SLC25A3 protein binds to PPIF protein]	18667415
D016572	Cyclosporine	Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]	26975474
D016572	Cyclosporine	Cyclosporine results in decreased activity of PPIF protein	26975474
D016572	Cyclosporine	Cyclosporine results in decreased activity of PPIF protein	16331251
D013759	Dronabinol	Dronabinol results in decreased expression of PPIF mRNA	18454173
D003958	Diamide	Diamide results in increased oxidation of PPIF protein	26975474
D003958	Diamide	Diamide results in increased oxidation of PPIF protein	26975474
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PPIF mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PPIF mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of PPIF mRNA	19561079
D004008	Diclofenac	PPIF results in increased susceptibility to Diclofenac	20668000
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased oxidation of PPIF protein	26975474
D004178	Diquat	Diquat results in increased expression of PPIF mRNA	21172416
D004317	Doxorubicin	Doxorubicin results in decreased expression of PPIF mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in increased expression of PPIF protein	26678157
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in increased expression of PPIF mRNA]	21233418
D004967	Estrogens	Estrogens results in increased expression of PPIF mRNA	21233418
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PPIF mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPIF mRNA	17942748
D005485	Flutamide	Flutamide results in increased expression of PPIF mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PPIF gene	20938992
C106014	gedunin	gedunin results in decreased expression of PPIF mRNA	17010675
D019833	Genistein	Genistein results in increased expression of PPIF mRNA	17341692
D017313	Fenretinide	Fenretinide results in increased expression of PPIF mRNA	16671099
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PPIF mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased oxidation of PPIF protein	26975474
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased oxidation of PPIF protein	26975474
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PPIF mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in decreased expression of PPIF mRNA	20003209
D007559	Ivermectin	[Ivermectin co-treated with Albendazole] results in decreased expression of PPIF mRNA	16861626
D007608	Kainic Acid	PPIF results in increased susceptibility to Kainic Acid	21378209
D064704	Levofloxacin	Levofloxacin results in decreased expression of PPIF mRNA	24136188
D008558	Melphalan	Melphalan results in increased expression of PPIF mRNA	22363485
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PPIF gene	20938992
D008727	Methotrexate	Methotrexate affects the expression of PPIF mRNA	18502557
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PPIF mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPIF mRNA]	12710931
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PPIF mRNA"	25554681
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of PPIF mRNA	17616710
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of PPIF mRNA	18593933
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of PPIF mRNA	23892564
C046012	pentanal	pentanal results in increased expression of PPIF mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PPIF protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of PPIF mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of PPIF mRNA	21318169
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of PPIF mRNA]	21318169
C027373	potassium chromate(VI)	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of PPIF mRNA]	14625279
D011192	Potassium Dichromate	[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of PPIF mRNA]	14625279
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of PPIF mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of PPIF mRNA	23012394
D011374	Progesterone	Progesterone results in decreased expression of PPIF mRNA	18037150
D011374	Progesterone	Progesterone results in increased expression of PPIF mRNA	20726854
D017378	Quinolinic Acid	PPIF results in increased susceptibility to Quinolinic Acid	21378209
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of PPIF mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of PPIF mRNA	19167446
C059514	resveratrol	resveratrol results in decreased expression of PPIF protein	25505154
D015474	Isotretinoin	Isotretinoin results in decreased expression of PPIF mRNA	20436886
C078903	seocalcitol	seocalcitol results in decreased expression of PPIF mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PPIF mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PPIF mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in increased expression of PPIF mRNA	28595984
D053260	Soot	Soot results in increased expression of PPIF mRNA	26551751
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PPIF mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PPIF mRNA	21570461\|2468072
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PPIF mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PPIF mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PPIF mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PPIF mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of PPIF mRNA	23411599
D014212	Tretinoin	Tretinoin results in decreased expression of PPIF mRNA	23724009
C012589	trichostatin A	trichostatin A results in increased expression of PPIF mRNA	24935251
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PPIF mRNA	19042947
C050414	tripterine	tripterine results in decreased expression of PPIF mRNA	17010675
D014520	Urethane	Urethane results in decreased expression of PPIF mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPIF mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PPIF mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PPIF mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of PPIF mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PPIF gene	25560391
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PPIF mRNA	20044591
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of PPIF mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IBA	21873635
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IDA	20676357
GO:0005515	protein binding	-	IPI	22726440 25416956 26387735
GO:0016018	cyclosporin A binding	-	IBA	21873635
GO:0016018	cyclosporin A binding	-	IDA	20676357
GO:0051082	unfolded protein binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000413	protein peptidyl-prolyl isomerization	-	IDA	20676357
GO:0002931	response to ischemia	-	IBA	21873635
GO:0002931	response to ischemia	-	ISS	-
GO:0006457	protein folding	-	IEA	-
GO:0006979	response to oxidative stress	-	IBA	21873635
GO:0008637	apoptotic mitochondrial changes	-	IBA	21873635
GO:0008637	apoptotic mitochondrial changes	-	IEA	-
GO:0010849	regulation of proton-transporting ATPase activity, rotational mechanism	-	IBA	21873635
GO:0010849	regulation of proton-transporting ATPase activity, rotational mechanism	-	ISS	-
GO:0010939	regulation of necrotic cell death	-	IBA	21873635
GO:0010939	regulation of necrotic cell death	-	IEA	-
GO:0032780	negative regulation of ATPase activity	-	IBA	21873635
GO:0032780	negative regulation of ATPase activity	-	ISS	-
GO:0043066	negative regulation of apoptotic process	-	IDA	19228691
GO:0046902	regulation of mitochondrial membrane permeability	-	IMP	26387735
GO:0046902	regulation of mitochondrial membrane permeability	-	ISS	-
GO:0070266	necroptotic process	-	IBA	21873635
GO:0070266	necroptotic process	-	IEA	-
GO:0070301	cellular response to hydrogen peroxide	-	IBA	21873635
GO:0070301	cellular response to hydrogen peroxide	-	IMP	22726440
GO:0071243	cellular response to arsenic-containing substance	-	IBA	21873635
GO:0071243	cellular response to arsenic-containing substance	-	ISS	-
GO:0071277	cellular response to calcium ion	-	IBA	21873635
GO:0071277	cellular response to calcium ion	-	ISS	-
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IBA	21873635
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	ISS	-
GO:0090201	negative regulation of release of cytochrome c from mitochondria	-	IBA	21873635
GO:0090201	negative regulation of release of cytochrome c from mitochondria	-	IDA	19228691
GO:0090324	negative regulation of oxidative phosphorylation	-	IBA	21873635
GO:0090324	negative regulation of oxidative phosphorylation	-	ISS	-
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	-	IBA	21873635
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	-	IMP	22726440
GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	-	IBA	21873635
GO:1902686	mitochondrial outer membrane permeabilization involved in programmed cell death	-	IMP	26387735
GO:2000276	negative regulation of oxidative phosphorylation uncoupler activity	-	ISS	-
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	-	IBA	21873635
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	-	IMP	19228691

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	-
GO:0005753	mitochondrial proton-transporting ATP synthase complex	COLOCALIZES_WITH	IBA	21873635
GO:0005753	mitochondrial proton-transporting ATP synthase complex	colocalizes_with	ISS	-
GO:0005757	mitochondrial permeability transition pore complex	-	IBA	21873635
GO:0005757	mitochondrial permeability transition pore complex	-	IDA	26387735
GO:0005759	mitochondrial matrix	-	IBA	21873635
GO:0016020	membrane	-	TAS	1744118

KEGG ID	KEGG Term
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29326313	DNA Methylation and Age-Independent Cardiovascular Risk, an Epigenome-Wide Approach: The REGICOR Study (REgistre GIroni del COR). (2018 Mar)	Fernandez-Sanles A	Arterioscler Thromb Vasc Biol