Gene: SGK2

10110
H-SGK2|dJ138B7.2
SGK2, serine/threonine kinase 2
protein-coding
20q13.12
Ensembl:ENSG00000101049 MIM:607589 Vega:OTTHUMG00000033054 UniprotKB:Q9HBY8
NG_029448.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.443e-1 (AD)  2.021e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRIM590.919
NIPAL40.919
SH3TC20.916
COL4A50.909
TMEM1440.908
LDB30.908
FOLH10.905
MOG0.902
DNAH170.896
ST180.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.392
PRTN3-0.386
GPR153-0.38
WTIP-0.376
LTK-0.362
CALB2-0.359
CHRNA2-0.354
PAX2-0.349
PCDH8-0.345
SLC29A4-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of SGK2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SGK2 mRNA"21354444|2890350
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SGK2 mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of SGK2 mRNA"20406850
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of SGK2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SGK2 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGK2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SGK2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of SGK2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SGK2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SGK2 mRNA21641981
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SGK2 mRNA16483693
D000667AmpicillinAmpicillin results in decreased expression of SGK2 mRNA21632981
D001151ArsenicArsenic affects the methylation of SGK2 gene25304211
D000069059Atorvastatin Calcium[Atorvastatin Calcium co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA24204015
D001464BariumBarium inhibits the reaction [SGK2 protein results in increased transport of Potassium]12590200
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of SGK2 mRNA19737606
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SGK2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGK2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SGK2 mRNA19770486|2719552
C006780bisphenol Abisphenol A results in decreased expression of SGK2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide affects the expression of SGK2 mRNA23410634
D002104CadmiumCadmium results in decreased expression of SGK2 mRNA24084258
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SGK2 mRNA28472532
D002994ClofibrateClofibrate results in increased expression of SGK2 mRNA23811191
C480342clothianidinclothianidin results in decreased expression of SGK2 mRNA29044138
D019327Copper SulfateCopper Sulfate results in increased expression of SGK2 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of SGK2 mRNA18579281
D003471CuprizoneCuprizone results in decreased expression of SGK2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of SGK2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SGK2 mRNA27989131
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of SGK2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SGK2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SGK2 mRNA27392435
D004008DiclofenacDiclofenac results in decreased expression of SGK2 mRNA26934552
C000944dicrotophosdicrotophos results in increased expression of SGK2 mRNA28302478
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of SGK2 mRNA18164116
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SGK2 mRNA17942748
D011345FenofibrateFenofibrate results in increased expression of SGK2 mRNA25572481
C065180fluvastatin[fluvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA24204015
D005947GlucoseSGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]24204015
D005978GlutathioneGlutathione deficiency results in increased expression of SGK2 mRNA20621112
C412815GW 4064GW 4064 results in increased expression of SGK2 mRNA26655953
D017313FenretinideFenretinide results in increased expression of SGK2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SGK2 mRNA23410634
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGK2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SGK2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of SGK2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SGK2 mRNA26752646
C410337K 7174K 7174 results in decreased expression of SGK2 mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SGK2 mRNA"24972896
C002950methylformamidemethylformamide analog results in increased expression of SGK2 mRNA17040096
C002950methylformamidemethylformamide results in increased expression of SGK2 mRNA17040096
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SGK2 mRNA23103053
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SGK2 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SGK2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SGK2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SGK2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SGK2 mRNA"25554681
D009532NickelNickel results in decreased expression of SGK2 mRNA24768652|2558310
C025256nonylphenolnonylphenol results in decreased expression of SGK2 mRNA22982499
D010100OxygenOxygen deficiency results in increased expression of SGK2 mRNA26516004
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SGK2 mRNA23602845
D010634PhenobarbitalPhenobarbital results in increased expression of SGK2 mRNA19084549
C006253pirinixic acidpirinixic acid results in increased expression of SGK2 mRNA17426115|1830175
D011188PotassiumBarium inhibits the reaction [SGK2 protein results in increased transport of Potassium]12590200
D011188PotassiumOuabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]12590200
D011188PotassiumSGK2 protein results in increased transport of Potassium12590200
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SGK2 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of SGK2 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of SGK2 mRNA24780913
D015125OxyquinolineOxyquinoline results in decreased expression of SGK2 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of SGK2 mRNA20436886
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA21127053|2420401
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of SGK2 protein24204015
D012293RifampinRifampin promotes the reaction [NR1I2 protein binds to SGK2 promoter]24204015
D012293RifampinRifampin results in increased expression of SGK2 mRNA24204015
D012293RifampinSGK2 mutant form affects the reaction [Rifampin affects the expression of G6PC mRNA]24204015
D012293RifampinSGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of G6PC mRNA]24204015
D012293RifampinSGK2 mutant form inhibits the reaction [[Rifampin co-treated with NR1I2 protein] results in increased expression of PCK1 mRNA]24204015
C089730rosiglitazonerosiglitazone results in increased expression of SGK2 mRNA21515302
D012715Sesame OilSesame Oil results in increased expression of SGK2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog affects the expression of SGK2 mRNA25895662
D019821SimvastatinSGK2 mutant form inhibits the reaction [[Simvastatin co-treated with NR1I2 protein] results in increased secretion of Glucose]24204015
D019821Simvastatin[Simvastatin co-treated with NR1I2 protein] results in increased expression of SGK2 mRNA24204015
D019821SimvastatinSimvastatin promotes the reaction [NR1I2 protein binds to SGK2 promoter]24204015
D053260SootSoot results in increased expression of SGK2 mRNA26551751
D013311StreptozocinStreptozocin results in increased expression of SGK2 mRNA16116964
D010042OuabainOuabain inhibits the reaction [SGK2 protein results in increased transport of Potassium]12590200
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA"18579281
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SGK2 mRNA25172293
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SGK2 mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of SGK2 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SGK2 mRNA25613284
D014303TrinitrotolueneTrinitrotoluene affects the expression of SGK2 mRNA21346803
C057693troglitazonetroglitazone results in increased expression of SGK2 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of SGK2 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of SGK2 mRNA21515302
D014520UrethaneUrethane results in decreased expression of SGK2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SGK2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of SGK2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid results in increased expression of SGK2 mRNA29154799
D014640VancomycinVancomycin results in increased expression of SGK2 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of SGK2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of SGK2 mRNA23410634

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0015459potassium channel regulator activity-IBA21873635  
GO:0015459potassium channel regulator activity-IDA12397388  
GO:0017080sodium channel regulator activity-NAS12632189  
GO:0017080sodium channel regulator activity-TAS16460280  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-TAS20919962  
GO:0006468protein phosphorylation-NAS12397388  
GO:0006979response to oxidative stress-TAS10548550  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0032411positive regulation of transporter activity-TAS16460280  
GO:0034220ion transmembrane transport-TAS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-TAS10548550  
GO:0042127regulation of cell proliferation-TAS20919962  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23681825Heme-related gene expression signatures of meat intakes in lung cancer tissues. (2014 Jul)Lam TKMol Carcinog