Gene: ENAM

10117
ADAI|AI1C|AIH2
enamelin
protein-coding
4q13.3
Ensembl:ENSG00000132464 MIM:606585 Vega:OTTHUMG00000129914 UniprotKB:Q9NRM1
NG_013024.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.914e-1 (AD)  2.341e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRTAP15-10.842
OR4C50.83
INSL40.83
OR5H150.825
OR4A150.825
OR4C120.823
KRTAP6-20.823
CDY2A0.823
OR5T20.823
OR5M10.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.366
SLC25A48-0.312
BGLAP-0.3
HPSE2-0.298
KCNJ10-0.297
RLBP1-0.288
GPR37L1-0.284
CDH20-0.278
TMEM221-0.277
PSD2-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A affects the expression of ENAM27352425
C006780bisphenol Abisphenol A results in increased expression of ENAM mRNA23764278|2725713
C006780bisphenol Abisphenol A results in increased expression of ENAM protein23764278|2725713
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ENAM promoter22457795
C029892cupric chloridecupric chloride affects the expression of ENAM mRNA17211630
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ENAM exon15649948|1765220
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of ENAM intron15649948
D005473FluoxetineFluoxetine results in decreased expression of ENAM mRNA21083617
D019833GenisteinGenistein affects the expression of ENAM27352425
D012701SerotoninSerotonin results in decreased expression of ENAM mRNA21083617
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ENAM mRNA"24972896
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of ENAM mRNA]22749964
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENAM mRNA22749964
C011559tributyltinTetrachlorodibenzodioxin promotes the reaction [tributyltin results in decreased expression of ENAM mRNA]22749964
C011559tributyltintributyltin results in decreased expression of ENAM mRNA22749964
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of ENAM gene27618143
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ENAM gene25560391
C025643vinclozolinvinclozolin affects the expression of ENAM27352425

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25789606  
GO:0030345structural constituent of tooth enamel-IBA21873635  
GO:0030345structural constituent of tooth enamel-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0022604regulation of cell morphogenesis-IEA-  
GO:0031214biomineral tissue development-IEA-  
GO:0036305ameloblast differentiation-IBA21873635  
GO:0036305ameloblast differentiation-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0070175positive regulation of enamel mineralization-IBA21873635  
GO:0070175positive regulation of enamel mineralization-IEA-  
GO:0097186amelogenesis-IBA21873635  
GO:0097186amelogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28266114Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases. (2017 Mar)Chapple ILJ Clin Periodontol