Gene: FRY

10129
13CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1
FRY microtubule binding protein
protein-coding
13q13.1
Ensembl:ENSG00000073910 MIM:614818 Vega:OTTHUMG00000016696 UniprotKB:Q5TBA9
NC_000013.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.699e-1 (AD)  8.817e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs456053chr13:32061626 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYCBP20.955
SLC35B40.943
NBEA0.943
SYNJ10.941
HEATR5B0.94
DGKI0.939
RASAL20.938
PIK3CB0.937
ADAM220.937
BHLHB90.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.477
MYL3-0.475
ROM1-0.467
HEY2-0.461
S100A1-0.452
TMEM176A-0.45
COPZ2-0.443
S100A16-0.435
CSAG1-0.434
TMEM102-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRY mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of FRY mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of FRY mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FRY protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FRY mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FRY mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FRY mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of FRY mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of FRY mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FRY mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FRY mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of FRY mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FRY mRNA"19150397
D004958EstradiolEstradiol affects the expression of FRY mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of FRY mRNA29275510
C006780bisphenol Abisphenol A affects the expression of FRY mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of FRY mRNA]27082013
C006780bisphenol Abisphenol A affects the expression of FRY mRNA25181051
D000069286BortezomibBortezomib results in increased expression of FRY mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of FRY mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of FRY mRNA17484886
D004390ChlorpyrifosChlorpyrifos affects the expression of FRY mRNA26775027
C018021cobaltous chloridecobaltous chloride results in decreased expression of FRY mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of FRY mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of FRY mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of FRY mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of FRY mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of FRY mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of FRY mRNA23640034
D003703DemecolcineDemecolcine results in decreased expression of FRY mRNA23649840
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of FRY mRNA25380136
D004237DiuronDiuron results in increased expression of FRY mRNA21551480
C118739entinostatentinostat results in decreased expression of FRY mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of FRY mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FRY mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of FRY mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of FRY mRNA23649840
C039281furanfuran results in increased expression of FRY mRNA27387713
D017313FenretinideFenretinide results in decreased expression of FRY mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of FRY mRNA20003209
C008261lead acetatelead acetate results in increased expression of FRY mRNA21829687
C029433lead tetraacetateFRY intron SNP results in decreased susceptibility to lead tetraacetate28732062
D008558MelphalanMelphalan results in decreased expression of FRY mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FRY mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FRY mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRY mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FRY mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FRY mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FRY mRNA"25554681
D009532NickelNickel results in decreased expression of FRY mRNA24768652
C029938nickel sulfatenickel sulfate results in decreased expression of FRY mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of FRY mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of FRY mRNA25729387
D052638Particulate MatterParticulate Matter results in decreased expression of FRY mRNA23085030
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FRY mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of FRY mRNA20813756
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of FRY mRNA]27082013
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FRY mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FRY mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of FRY mRNA20864642
C005556propionaldehydepropionaldehyde results in decreased expression of FRY mRNA26079696
D015125OxyquinolineOxyquinoline results in increased expression of FRY mRNA21632981
C541923sandostatinLARsandostatinLAR results in increased expression of FRY mRNA17210224
D053260SootSoot results in increased expression of FRY mRNA26551751
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of FRY mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FRY mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FRY mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of FRY mRNA25729387
D019772TopotecanTopotecan results in decreased expression of FRY mRNA25729387
D014212TretinoinTretinoin results in decreased expression of FRY mRNA21934132
D014212TretinoinTretinoin results in increased expression of FRY mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FRY mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FRY mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of FRY mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of FRY mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FRY mRNA24935251|2800136
D014750VincristineVincristine results in decreased expression of FRY mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of FRY mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRY mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FRY mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004857enzyme inhibitor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000902cell morphogenesis-IBA21873635  
GO:0031175neuron projection development-IBA21873635  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:1904428negative regulation of tubulin deacetylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000922spindle pole-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005938cell cortex-IBA21873635  
GO:0030427site of polarized growth-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal