Gene: TRAP1

10131
HSP 75|HSP75|HSP90L|TRAP-1
TNF receptor associated protein 1
protein-coding
16p13.3
Ensembl:ENSG00000126602 MIM:606219 Vega:OTTHUMG00000129427 UniprotKB:Q12931
NG_033088.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.770e-1 (AD)  3.422e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCF30.95
C16orf580.949
TCF250.949
UQCRC20.947
PRPF190.946
USP50.944
IDH3B0.943
CRMP10.942
MDH20.942
PPP5C0.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.669
OR4F29-0.618
MTRNR2L6-0.412
MTRNR2L9-0.393
MTRNR2L10-0.39
RAI14-0.337
CXCR2-0.332
CSAG1-0.331
VNN3-0.326
PPBP-0.324

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of TRAP1 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TRAP1 mRNA"22546086
D000082AcetaminophenAcetaminophen results in decreased expression of TRAP1 mRNA22230336|2570463
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of TRAP1 protein26597043
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of TRAP1 mRNA16631469
C006632arsenic trioxidearsenic trioxide results in increased expression of TRAP1 mRNA22521957
D001280AtrazineAtrazine results in increased expression of TRAP1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAP1 protein25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of TRAP1 protein]25628927
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAP1 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRAP1 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRAP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of TRAP1 mRNA25181051
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein26930160
C013418bromfenacoumbromfenacoum results in increased expression of TRAP1 protein28903499
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of TRAP1 protein23736079
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TRAP1 protein21699967
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of TRAP1 promoter22457795
C054133casticincasticin results in increased expression of TRAP1 mRNA27862857
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAP1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of TRAP1 mRNA22300585
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRAP1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of TRAP1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of TRAP1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of TRAP1 mRNA21163907
D003676DeferoxamineDeferoxamine results in decreased expression of TRAP1 mRNA16927372
D003676DeferoxamineDeferoxamine results in decreased expression of TRAP1 protein16927372
D003676DeferoxamineTRAP1 protein inhibits the reaction [Deferoxamine results in increased expression of SOD2 protein]16927372
D003676DeferoxamineTRAP1 protein inhibits the reaction [Deferoxamine results in increased abundance of Reactive Oxygen Species]16927372
D003676DeferoxamineTRAP1 protein inhibits the reaction [Deferoxamine results in increased expression of CAV1 protein]16927372
D013759DronabinolDronabinol results in decreased expression of TRAP1 mRNA18454173
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRAP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRAP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TRAP1 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased degradation of TRAP1 protein17853063
D002945CisplatinCisplatin results in increased expression of TRAP1 mRNA16061661
D002945Cisplatindiethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]17853063
D002945CisplatinTRAP1 protein inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]17853063
D002945CisplatinTRAP1 protein results in decreased susceptibility to Cisplatin17853063
C000944dicrotophosdicrotophos results in increased expression of TRAP1 mRNA28302478
C014476diethyl maleatediethyl maleate inhibits the reaction [Cisplatin results in decreased expression of TRAP1 protein]17853063
C014476diethyl maleateTRAP1 protein results in decreased susceptibility to diethyl maleate17853063
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TRAP1 mRNA17602206
D004298DopamineTRAP1 protein inhibits the reaction [SNCA protein affects the abundance of Dopamine]22319455
D004317DoxorubicinDoxorubicin results in increased expression of TRAP1 mRNA17680992
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TRAP1 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAP1 mRNA17942748
D015025ZearalenoneZearalenone results in increased expression of TRAP1 protein25058043
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of TRAP1 mRNA]15016801
D005485FlutamideFlutamide results in increased expression of TRAP1 protein17311803
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAP1 mRNA20938992
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of TRAP1 protein26930160
D005632FructoseFructose results in decreased expression of TRAP1 protein26930160
D005897GlafenineGlafenine results in decreased expression of TRAP1 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of TRAP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of TRAP1 protein21366594
D006861Hydrogen PeroxidePINK1 protein affects the reaction [Hydrogen Peroxide results in increased expression of TRAP1 protein]21366594
D006861Hydrogen PeroxideTRAP1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]21366594
D006861Hydrogen PeroxideTRAP1 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]21366594
D006861Hydrogen PeroxideTRAP1 protein affects the susceptibility to Hydrogen Peroxide21366594
D006861Hydrogen PeroxideTRAP1 protein results in decreased susceptibility to Hydrogen Peroxide17853063
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of TRAP1 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRAP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of TRAP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRAP1 mRNA28628672
D008095Lithocholic AcidLithocholic Acid results in decreased expression of TRAP1 protein21224350
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAP1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TRAP1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAP1 mRNA23649840
D052998MicrocystinsMicrocystins results in increased expression of TRAP1 protein22430071
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Polysorbates] results in increased expression of TRAP1 protein"28807745
C119536nickel acetatenickel acetate affects the expression of TRAP1 mRNA12915101
C012655nimesulidenimesulide results in decreased expression of TRAP1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of TRAP1 protein19716841
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of TRAP1 protein26168851
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TRAP1 protein26879310
C006253pirinixic acidpirinixic acid results in increased expression of TRAP1 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of TRAP1 mRNA23557933
D011136Polysorbates"[Nanotubes, Carbon co-treated with Polysorbates] results in increased expression of TRAP1 protein"28807745
D011192Potassium DichromatePotassium Dichromate results in increased expression of TRAP1 mRNA11678601
D011794QuercetinQuercetin results in decreased expression of TRAP1 protein19207037
D017382Reactive Oxygen SpeciesTRAP1 protein results in increased abundance of Reactive Oxygen Species16927372
D017382Reactive Oxygen SpeciesTRAP1 protein inhibits the reaction [Deferoxamine results in increased abundance of Reactive Oxygen Species]16927372
C059514resveratrolresveratrol results in increased expression of TRAP1 protein25505154
D012402RotenoneTRAP1 protein inhibits the reaction [SNCA protein affects the susceptibility to Rotenone]22319455
C534922SNX 2112SNX 2112 results in decreased expression of TRAP1 protein23777986
C009277sodium arsenatesodium arsenate results in increased expression of TRAP1 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of TRAP1 mRNA12377979
D013605T-2 ToxinT-2 Toxin affects the expression of TRAP1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRAP1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAP1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRAP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRAP1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRAP1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRAP1 mRNA21215274
D019284ThapsigarginThapsigargin results in decreased expression of TRAP1 mRNA22378314
D014241TrichloroethyleneTrichloroethylene affects the expression of TRAP1 mRNA21135412
D014415TunicamycinTunicamycin results in decreased expression of TRAP1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of TRAP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TRAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TRAP1 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of TRAP1 gene29154799
D014800VitalliumVitallium analog results in decreased expression of TRAP1 mRNA23825117
C111237vorinostatvorinostat results in decreased expression of TRAP1 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0005164tumor necrosis factor receptor binding-NAS7876093  
GO:0005515protein binding-IPI17579517  23564345  23747254  
GO:0005524ATP binding-IEA-  
GO:0019901protein kinase binding-IPI17579517  
GO:0051082unfolded protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006950response to stress-IEA-  
GO:0009386translational attenuation-IMP24113185  
GO:0061077chaperone-mediated protein folding-TAS24522549  
GO:1901856negative regulation of cellular respiration-IMP23564345  
GO:1903427negative regulation of reactive oxygen species biosynthetic process-TAS18221368  
GO:1903751negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide-ISS17579517  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA17579517  
GO:0005743mitochondrial inner membrane-IDA23564345  
GO:0005758mitochondrial intermembrane space-ISS17579517  
GO:0005759mitochondrial matrix-IDA23564345  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportIEA
R-HSA-1430728MetabolismIEA
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.IEA
R-HSA-611105Respiratory electron transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29491840Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels. (2018)Carrasco CFront Physiol