Gene: NAMPT

10135
1110035O14Rik|PBEF|PBEF1|VF|VISFATIN
nicotinamide phosphoribosyltransferase
protein-coding
7q22.3
Ensembl:ENSG00000105835 MIM:608764 Vega:OTTHUMG00000140388 UniprotKB:P43490
NC_000007.14
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.390e-1 (AD)  6.672e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOD20.873
SERPINB80.863
MYC0.859
FNDC3B0.855
DDX210.854
CHSY10.851
STAT30.846
RAP1B0.839
PLSCR10.836
SERPINB10.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.384
LYPD8-0.363
SCRT1-0.353
WNT7A-0.341
NKX6-3-0.34
CPLX3-0.337
EXTL1-0.335
PVALB-0.326
KCNIP3-0.326
ARSE-0.321

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05217GMX1777Small Molecule-InvestigationalTarget
DB12731DaporinadSmall Molecule658084-64-1InvestigationalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of NAMPT mRNA"26377693
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of NAMPT mRNA25596134
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NAMPT mRNA"21354444
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of NAMPT mRNA"22101062
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of NAMPT mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of NAMPT mRNA"16984957
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] which results in decreased expression of NAMPT mRNA20863820
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] which results in decreased expression of NAMPT protein20863820
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NAMPT mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of NAMPT mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NAMPT mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of NAMPT mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of NAMPT mRNA"19561079
C0138134-anisidine4-anisidine results in decreased expression of NAMPT mRNA12929121
C5505476-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased activity of NAMPT protein]"24603648
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of NAMPT mRNA"19936915
D019342Acetic AcidAcetic Acid results in decreased expression of NAMPT protein23810507
D019342Acetic AcidNicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein]23810507
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NAMPT mRNA27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of NAMPT mRNA"26018793
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased methylation of NAMPT gene"26018793
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NAMPT mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NAMPT mRNA16483693
C018453ammonium hexachloroplatinateammonium hexachloroplatinate results in increased expression of NAMPT mRNA19371601
D003913DextroamphetamineDextroamphetamine results in increased expression of NAMPT mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NAMPT mRNA24449571
C006632arsenic trioxidearsenic trioxide promotes the reaction [N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased expression of NAMPT mRNA]28501332
C006632arsenic trioxidearsenic trioxide results in decreased expression of NAMPT mRNA28501332
C006632arsenic trioxidearsenic trioxide results in decreased expression of NAMPT protein28501332
C006632arsenic trioxideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide promotes the reaction [arsenic trioxide results in decreased expression of NAMPT mRNA]28501332
C015001arsenitearsenite affects the expression of NAMPT mRNA22959463
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of NAMPT mRNA"25757056
D001205Ascorbic Acid[Ascorbic Acid co-treated with INS1 protein] results in increased expression of NAMPT mRNA20400526
D001280AtrazineAtrazine results in decreased expression of NAMPT mRNA25929836
D001554BenzeneBenzene results in increased expression of NAMPT mRNA15929907
D001572BenzofuransBenzofurans results in decreased expression of NAMPT mRNA20863820
D001572BenzofuransBenzofurans results in decreased expression of NAMPT protein20863820
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAMPT mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NAMPT mRNA21569818|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of NAMPT mRNA"19150397|2001819
D001599Berberine[Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein26712469
D001599BerberineBerberine results in decreased expression of NAMPT protein26712469
D001599BerberineSRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein]26712469
D004958EstradiolEstradiol affects the expression of NAMPT mRNA22574217
D004958EstradiolNAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Estradiol]23315983
D004958Estradiol[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]20004694
C006780bisphenol Abisphenol A results in increased expression of NAMPT mRNA25181051|2608855
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NAMPT mRNA25596134
D019256Cadmium ChlorideCadmium Chloride results in increased expression of NAMPT mRNA25993096
D002220CarbamazepineCarbamazepine affects the expression of NAMPT mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NAMPT mRNA17484886
C035377chlorendic acidchlorendic acid results in decreased expression of NAMPT mRNA22584684
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of NAMPT mRNA25596134
D002737ChloropreneChloroprene results in increased expression of NAMPT mRNA23125180
D002746ChlorpromazineChlorpromazine results in increased expression of NAMPT mRNA25596134
C059262cidofovircidofovir results in increased expression of NAMPT mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of NAMPT mRNA21139344
C018021cobaltous chloridecobaltous chloride results in increased expression of NAMPT mRNA24386269
D009243NADNAMPT protein results in increased chemical synthesis of NAD25505128
D009243NADNicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
D009243NAD[[MIR34A mRNA binds to NAMPT 3' UTR] which results in decreased expression of NAMPT mRNA] which results in decreased abundance of NAD23834033|2383403
D009243NADMIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]23834033
D009243NAD[N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased activity of NAMPT protein] which results in decreased abundance of NAD23834033
D009243NADNAMPT protein affects the reaction [MIR34A mRNA results in decreased abundance of NAD]23834033
D009243NADNicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
D009243NADresveratrol inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
D009243NADNAMPT protein results in increased chemical synthesis of NAD23834033
D019327Copper SulfateCopper Sulfate results in increased expression of NAMPT mRNA19549813
D003520CyclophosphamideCyclophosphamide results in increased expression of NAMPT mRNA21041162
D016572CyclosporineCyclosporine results in increased expression of NAMPT mRNA20106945|2559613
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of NAMPT mRNA23640034
D013759DronabinolDronabinol results in increased expression of NAMPT mRNA18454173
D003703DemecolcineDemecolcine results in increased expression of NAMPT mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of NAMPT mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of NAMPT mRNA19853017
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of NAMPT mRNA21041162
D003907Dexamethasone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D003981DiazoxideDiazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein]23536823
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NAMPT mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in increased expression of NAMPT mRNA20705681
D002945CisplatinCisplatin results in increased expression of NAMPT mRNA27594783
C000944dicrotophosdicrotophos results in decreased expression of NAMPT mRNA28302478
D004026DieldrinDieldrin affects the expression of NAMPT mRNA22546817
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of NAMPT mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of NAMPT mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of NAMPT mRNA27614199
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of NAMPT mRNA21041162
D002117CalcitriolCalcitriol results in increased expression of NAMPT mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of NAMPT mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of NAMPT mRNA17374397|1937160
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of NAMPT mRNA21362464
C076126disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of NAMPT mRNA"20184727
D004317DoxorubicinDoxorubicin affects the expression of NAMPT protein29385562
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of NAMPT mRNA"23811387
D004391DustDust results in increased expression of NAMPT mRNA17805423
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of NAMPT mRNA20064776
D004964Estriol[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]20004694
D004964EstriolEstriol results in increased expression of NAMPT mRNA20004694
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAMPT mRNA17942748
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of NAMPT mRNA26018793
C004912ethylbenzene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of NAMPT gene26018793
C024565ethylene dichlorideethylene dichloride results in decreased expression of NAMPT mRNA28189721
D005054EugenolEugenol results in increased expression of NAMPT mRNA17374397
D011345FenofibrateFenofibrate results in increased expression of NAMPT mRNA25596134
D018120FinasterideFinasteride results in decreased expression of NAMPT mRNA24136188
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of NAMPT mRNA22584684
D005485FlutamideFlutamide results in increased expression of NAMPT protein17311803
C039281furanfuran results in decreased expression of NAMPT mRNA25539665
D005947GlucoseDiazoxide inhibits the reaction [Glucose results in increased secretion of NAMPT protein]23536823
D005947GlucoseGlucose results in decreased expression of NAMPT mRNA20068143
D005947GlucoseGlucose results in increased expression of NAMPT mRNA23536823
D005947GlucoseGlucose results in increased secretion of NAMPT protein23536823
D005947GlucoseNifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein]23536823
C000591022GNE-617GNE-617 results in decreased activity of NAMPT protein25505128
C000591154GNE-618GNE-618 results in decreased activity of NAMPT protein25505128
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of NAMPT mRNA17183730
D006918HydroxyureaHydroxyurea results in decreased expression of NAMPT mRNA12929121
D007052IbuprofenIbuprofen results in increased expression of NAMPT mRNA25596134
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA16054899
D0150561-Methyl-3-isobutylxanthine[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
C544151jinfukangjinfukang results in decreased expression of NAMPT mRNA27392435
C410337K 7174K 7174 results in increased expression of NAMPT mRNA24086573
D007854LeadLead affects the expression of NAMPT mRNA28903495
C045463leflunomideleflunomide results in increased expression of NAMPT mRNA28988120
D064704LevofloxacinLevofloxacin results in increased expression of NAMPT mRNA24136188
D008070LipopolysaccharidesINS protein inhibits the reaction [Lipopolysaccharides results in increased expression of NAMPT protein]20699433
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NAMPT mRNA21362464
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NAMPT protein20699433
D008345ManganeseManganese results in increased expression of NAMPT mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of NAMPT mRNA17175027
C586321mansonone Gmansonone G analog results in decreased expression of NAMPT mRNA28625492
C586321mansonone Gmansonone G results in decreased expression of NAMPT mRNA28625492
D008687MetforminMetformin affects the expression of NAMPT mRNA23315983
D008687MetforminMetformin affects the expression of NAMPT protein23315983
D008687MetforminSIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]23315983
D008687MetforminMetformin results in increased expression of NAMPT mRNA25596134
D008727MethotrexateNAMPT protein affects the susceptibility to Methotrexate27166432
D008727MethotrexateMethotrexate affects the expression of NAMPT mRNA18502557
C005219methyl cellosolvemethyl cellosolve results in increased expression of NAMPT mRNA19643169
D008752Methylene ChlorideMethylene Chloride results in decreased expression of NAMPT mRNA28392392
D008942MitoxantroneNAMPT protein affects the susceptibility to Mitoxantrone16217747
D009151Mustard GasMustard Gas results in increased expression of NAMPT mRNA29129815
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NAMPT mRNA"29244179
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamidearsenic trioxide promotes the reaction [N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased expression of NAMPT mRNA]28501332
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide[N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide binds to and results in decreased activity of NAMPT protein] which results in increased abundance of Reactive Oxygen Species20133848
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide promotes the reaction [arsenic trioxide results in decreased expression of NAMPT mRNA]28501332
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased activity of NAMPT protein20133848|2392287
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased expression of NAMPT mRNA28501332
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased expression of NAMPT protein28501332
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide[N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased activity of NAMPT protein] which results in decreased abundance of NAD23834033
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideNAMPT protein binds to N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide16901503
C480543N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamideN-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased activity of NAMPT protein23834033|2550512
C401312N-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidineN-(6-chlorophenoxyhexyl)-N''-cyano-N''-4-pyridylguanidine results in decreased activity of NAMPT protein25505128
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NAMPT mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NAMPT mRNA"25554681|2562005
D009285NaphthoquinonesNaphthoquinones results in increased expression of NAMPT mRNA23811387
C051752nefazodonenefazodone results in increased expression of NAMPT mRNA24136188
D019829NevirapineNevirapine metabolite results in increased expression of NAMPT mRNA23947594
D009532NickelNickel results in increased expression of NAMPT mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of NAMPT mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of NAMPT mRNA17374397
D009537Nicotinamide MononucleotideNicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
D009537Nicotinamide MononucleotideNicotinamide Mononucleotide inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
D009537Nicotinamide MononucleotideNAMPT protein binds to Nicotinamide Mononucleotide16901503
D009538NicotineNicotine inhibits the reaction [Acetic Acid results in decreased expression of NAMPT protein]23810507
D009543NifedipineNifedipine inhibits the reaction [Glucose results in increased secretion of NAMPT protein]23536823
C012655nimesulidenimesulide results in increased expression of NAMPT mRNA24136188
C108709oleoyl-estroneoleoyl-estrone results in decreased expression of NAMPT mRNA20184727
D010081OxazoloneOxazolone results in increased expression of NAMPT mRNA17374397
D010100OxygenOxygen deficiency results in decreased expression of NAMPT mRNA25596134
D010100OxygenOxygen deficiency results in increased expression of NAMPT mRNA25596134
D010100OxygenOxygen results in increased expression of NAMPT mRNA25447406
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in increased expression of NAMPT mRNA20705681
D017239PaclitaxelPaclitaxel results in decreased expression of NAMPT mRNA12929121
D010168PalmitatesPalmitates results in decreased expression of NAMPT mRNA20068143
D010269ParaquatParaquat affects the expression of NAMPT mRNA16854511
D010416PentachlorophenolPentachlorophenol results in increased expression of NAMPT mRNA23892564
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of NAMPT mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NAMPT mRNA27153767
D010634PhenobarbitalPhenobarbital results in increased expression of NAMPT mRNA19270015
D010634PhenobarbitalPhenobarbital results in decreased expression of NAMPT mRNA22584684
D011374ProgesteroneProgesterone results in increased expression of NAMPT mRNA23012394
D011374ProgesteroneNAMPT protein promotes the reaction [IGF1 protein results in increased abundance of Progesterone]23315983
D011374Progesterone[Estradiol co-treated with Progesterone] promotes the reaction [Estriol results in increased expression of NAMPT mRNA]20004694
C037219quinolinequinoline analog results in increased expression of NAMPT protein18645022
D017382Reactive Oxygen Species[N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide binds to and results in decreased activity of NAMPT protein] which results in increased abundance of Reactive Oxygen Species20133848
C059514resveratrol"6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased activity of NAMPT protein]"24603648
C059514resveratrolPARP1 protein affects the reaction [resveratrol results in increased expression of NAMPT protein]25533949
C059514resveratrolresveratrol results in decreased activity of and results in increased secretion of NAMPT protein24603648
C059514resveratrolresveratrol results in increased acetylation of and results in increased expression of NAMPT protein25533949
C059514resveratrolresveratrol results in increased activity of NAMPT protein24603648
C059514resveratrolresveratrol results in increased expression of NAMPT mRNA24603648
C059514resveratrolSIRT1 protein inhibits the reaction [resveratrol results in increased secretion of NAMPT protein]24603648
C059514resveratrolSTF-118804 inhibits the reaction [resveratrol results in increased expression of NAMPT protein]25533949
C059514resveratrolresveratrol inhibits the reaction [MIR34A mRNA inhibits the reaction [NAMPT protein results in increased chemical synthesis of NAD]]23834033
C059514resveratrolresveratrol metabolite results in increased expression of NAMPT mRNA23717508
C059514resveratrolresveratrol results in increased expression of NAMPT mRNA23717508
C499731resveratrol-4'-O-glucuronideresveratrol-4'-O-glucuronide results in increased expression of NAMPT mRNA23717508
D015474IsotretinoinIsotretinoin results in decreased expression of NAMPT mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of NAMPT mRNA23315983
C089730rosiglitazonerosiglitazone inhibits the reaction [INS protein results in increased expression of NAMPT protein]21694775
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA16054899
C089730rosiglitazone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D012402RotenoneRotenone results in decreased activity of NAMPT protein18486613
C017947sodium arsenitesodium arsenite results in increased expression of NAMPT mRNA alternative form21281968
C017947sodium arsenitesodium arsenite results in increased stability of NAMPT mRNA25493608
C016104sodium bichromatesodium bichromate results in increased expression of NAMPT mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of NAMPT mRNA24383545
C525422SRT1720SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein]26712469
C000593977STF-118804STF-118804 inhibits the reaction [resveratrol results in increased expression of NAMPT protein]25533949
D013311StreptozocinStreptozocin results in increased expression of NAMPT mRNA25905778
D013467SulindacSulindac results in decreased expression of NAMPT mRNA24136188
D013629TamoxifenTamoxifen affects the expression of NAMPT mRNA20937368
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of NAMPT mRNA21592394
D013739TestosteroneTestosterone results in increased expression of NAMPT mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of NAMPT mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAMPT mRNA16697128|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NAMPT mRNA28922406
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] results in decreased expression of NAMPT mRNA16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NAMPT mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of NAMPT mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of NAMPT mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NAMPT mRNA16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NAMPT mRNA21041162
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NAMPT mRNA20959002|2121527
D013893ThiramThiram results in increased expression of NAMPT mRNA19371601
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NAMPT mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NAMPT mRNA28111298
C056583tolmetin glucuronidetolmetin glucuronide results in increased expression of NAMPT mRNA26528891
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of NAMPT mRNA26018793
D014050Toluene[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of NAMPT gene26018793
D014212TretinoinTretinoin results in increased expression of NAMPT mRNA17218384
C011559tributyltintributyltin results in increased expression of NAMPT mRNA19371601
C011559tributyltintributyltin results in decreased expression of NAMPT mRNA27614199
C012589trichostatin Atrichostatin A results in increased expression of NAMPT mRNA24935251
C057693troglitazonetroglitazone results in increased expression of NAMPT mRNA19140230
D014501UraniumUranium affects the expression of NAMPT mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of NAMPT mRNA15672453
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of NAMPT mRNA17183730
D014635Valproic AcidValproic Acid results in decreased expression of NAMPT mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of NAMPT mRNA17292431|1796380
C066075vanadium pentoxidevanadium pentoxide results in increased expression of NAMPT mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NAMPT gene25560391
C025643vinclozolinvinclozolin results in increased expression of NAMPT mRNA22570695
D014750VincristineVincristine results in increased expression of NAMPT mRNA23649840
D009536Niacinamide[Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein26712469
D009536NiacinamideNiacinamide results in decreased expression of NAMPT protein26712469
C111237vorinostatvorinostat results in decreased expression of NAMPT mRNA27188386
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in decreased expression of NAMPT mRNA26018793
D014992Xylenes[Toluene co-treated with ethylbenzene co-treated with Xylenes] results in increased methylation of NAMPT gene26018793
D015032ZincZinc deficiency results in increased expression of NAMPT mRNA19111725
C088658zoledronic acidzoledronic acid results in increased expression of NAMPT mRNA24714768|2559613
C027368zomepirac glucuronidezomepirac glucuronide results in increased expression of NAMPT mRNA26528891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity-IEA-  
GO:0005125cytokine activity-IEA-  
GO:0005515protein binding-IPI18486613  
GO:0008144drug binding-IEA-  
GO:0042802identical protein binding-IPI16783377  19666527  
GO:0042803protein homodimerization activity-IEA-  
GO:0047280nicotinamide phosphoribosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8289818  
GO:0007267cell-cell signaling-TAS8289818  
GO:0007565female pregnancy-IEA-  
GO:0007623circadian rhythm-TAS-  
GO:0008284positive regulation of cell proliferation-TAS8289818  
GO:0008286insulin receptor signaling pathwayNOTIDA17983582  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0034356NAD biosynthesis via nicotinamide riboside salvage pathway-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA23001182  
GO:0048661positive regulation of smooth muscle cell proliferation-IEA-  
GO:0051770positive regulation of nitric-oxide synthase biosynthetic process-IDA19727662  
GO:0060612adipose tissue developmentNOTIDA17983582  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016607nuclear speck-IDA-  
GO:0030054cell junction-IDA-  
GO:0070062extracellular exosome-HDA20458337  23533145  
KEGG ID KEGG Term
hsa00760Nicotinate and nicotinamide metabolism
Reactome ID Reactome Term Evidence
R-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expressionTAS
R-HSA-1430728MetabolismTAS
R-HSA-196807Nicotinate metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-197264Nicotinamide salvagingTAS
R-HSA-400253Circadian ClockTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics