Gene: FAM13A

10144
ARHGAP48|FAM13A1
family with sequence similarity 13 member A
protein-coding
4q22.1
Ensembl:ENSG00000138640 MIM:613299 Vega:OTTHUMG00000161006 UniprotKB:O94988
NC_000004.12
PubMed
0   ANCO-SNPs
ND
17   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.710e-1 (AD)  1.350e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNST0.9
TIAM20.899
ACVR1B0.887
KCND30.886
FBXO330.884
FBXO340.883
CNTN30.882
NEDD4L0.881
USP280.88
SRPK10.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX3-0.444
SH2D1A-0.438
C5orf64-0.424
OR4F5-0.423
RBP1-0.421
LRAT-0.418
HEY2-0.414
AQP5-0.411
BCL7C-0.405
RAI14-0.403

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FAM13A mRNA"20453058
D000082AcetaminophenAcetaminophen results in decreased expression of FAM13A mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of FAM13A mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of FAM13A mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM13A mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FAM13A mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FAM13A gene27153756
D000447AldehydesAldehydes results in decreased expression of FAM13A mRNA25014914
D001507BeclomethasoneBeclomethasone results in increased expression of FAM13A mRNA23656298
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FAM13A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM13A mRNA19770486|2222880
D004958EstradiolEstradiol results in decreased expression of FAM13A mRNA20106945|2163298
D004958EstradiolEstradiol results in decreased expression of FAM13A mRNA19484750
C095105bexarotenebexarotene results in decreased expression of FAM13A mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of FAM13A mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of FAM13A mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of FAM13A mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FAM13A mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FAM13A gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of FAM13A mRNA26079696
D000068579CelecoxibCelecoxib results in decreased expression of FAM13A mRNA28201806
D002737ChloropreneChloroprene results in increased expression of FAM13A mRNA23125180
D002737ChloropreneChloroprene results in increased expression of FAM13A mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of FAM13A mRNA28472532
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of FAM13A mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of FAM13A mRNA16197558
C018021cobaltous chloridecobaltous chloride results in increased expression of FAM13A mRNA19320972|1937684
C029892cupric chloridecupric chloride results in decreased expression of FAM13A mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of FAM13A mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of FAM13A mRNA19770486
D003703DemecolcineDemecolcine results in increased expression of FAM13A mRNA23649840
D002945CisplatinFAM13A protein affects the susceptibility to Cisplatin16217747
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM13A mRNA22129741
C039281furanfuran results in increased expression of FAM13A mRNA26194646
D017313FenretinideFenretinide results in increased expression of FAM13A mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FAM13A mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM13A mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FAM13A mRNA23086925|2343069
C500085muraglitazarmuraglitazar results in increased expression of FAM13A mRNA21515302
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of FAM13A mRNA16052530
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM13A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM13A mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of FAM13A mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of FAM13A mRNA21455298
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of FAM13A mRNA"12756304
C558013NSC 689534NSC 689534 results in increased expression of FAM13A mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of FAM13A mRNA24236059|2651600
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of FAM13A mRNA23948077
C046012pentanalpentanal results in decreased expression of FAM13A mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of FAM13A mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of FAM13A mRNA19270015
C006253pirinixic acidpirinixic acid results in decreased expression of FAM13A mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of FAM13A mRNA19690047
C005556propionaldehydepropionaldehyde results in decreased expression of FAM13A mRNA26079696
D011794QuercetinQuercetin results in decreased expression of FAM13A mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of FAM13A mRNA21632981
C031389resorcinolresorcinol results in increased expression of FAM13A mRNA22623647
C089730rosiglitazonerosiglitazone results in increased expression of FAM13A mRNA21515302
C017947sodium arsenitesodium arsenite results in increased expression of FAM13A mRNA22714537
D013629TamoxifenTamoxifen results in increased expression of FAM13A mRNA25123088
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of FAM13A mRNA26496021
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of FAM13A mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM13A mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM13A mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM13A mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of FAM13A mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FAM13A mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of FAM13A mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of FAM13A mRNA20133372
D014212TretinoinTretinoin results in increased expression of FAM13A mRNA23724009|2383079
C012589trichostatin Atrichostatin A results in increased expression of FAM13A mRNA28542535
C057693troglitazonetroglitazone results in increased expression of FAM13A mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of FAM13A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of FAM13A mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of FAM13A mRNA29154799
D014638VanadatesVanadates results in decreased expression of FAM13A mRNA22714537
C111237vorinostatvorinostat results in increased expression of FAM13A mRNA27188386
D019287Zinc SulfateZinc Sulfate results in decreased expression of FAM13A mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28929109Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease. (2017)Zhang ZBiomed Res Int
20656943Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. (2010 Dec 15)Pillai SGAm J Respir Crit Care Med
28287180Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)Morrow JDSci Rep
21778810Genetics of COPD. (2011 Sep)Nakamura HAllergol Int
25608829Identification of FAM13A gene associated with the ratio of FEV1 to FVC in Korean population by genome-wide association studies including gene-environment interactions. (2015 Mar)Kim SJ Hum Genet
26986948An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)Accordini SPLoS One
24163739Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)Yang IAJ Thorac Dis
26310313Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases. (2015 Aug 27)Ziolkowska-Suchanek ISci Rep
22080838A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (2012 Feb 15)Cho MHHum Mol Genet
25154699Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. (2014 Oct)Lee JHRespir Med
23776362FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. (2011)Young RPAppl Clin Genet
28248572Transcriptomic Analysis of Lung Tissue from Cigarette Smoke-Induced Emphysema Murine Models and Human Chronic Obstructive Pulmonary Disease Show Shared and Distinct Pathways. (2017 Jul)Yun JHAm J Respir Cell Mol Biol
27612410Genome-wide association study on the FEV1/FVC ratio in never-smokers identifies HHIP and FAM13A. (2017 Feb)van der Plaat DAJ Allergy Clin Immunol
24651745Quantitative analysis of lungs and airways with CT in subjects with the chronic obstructive pulmonary disease (COPD) candidate FAM13A gene: case control study for CT quantification in COPD risk gene. (2014 Jul-Aug)Choo JYJ Comput Assist Tomogr
28137485FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis. (2017 Feb)Hirano CRespir Med
25241909Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. (2014 Sep 21)Lee JHRespir Res
22461431CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)Hardin MAm J Respir Cell Mol Biol