Gene: MBNL2

10150
MBLL|MBLL39|PRO2032
muscleblind like splicing regulator 2
protein-coding
13q32.1
Ensembl:ENSG00000139793 MIM:607327 Vega:OTTHUMG00000017239 UniprotKB:Q5VZF2
NC_000013.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.113e-1 (AD)  7.836e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9556711chr13:97364162 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1556086chr13:97326231 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24714606chr13:98019621MBNL22.700e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGFR1OP20.94
WASL0.939
COPS20.939
CAMSAP20.938
ARL6IP50.937
CSE1L0.937
ATF20.937
GOPC0.935
CD470.934
FAM8A10.933

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.666
OR4F29-0.635
KLRB1-0.357
TFPI2-0.343
CSAG1-0.34
KLRF1-0.319
MTRNR2L10-0.311
FZD10-0.311
FOXL1-0.307
IL2RB-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MBNL2 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MBNL2 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MBNL2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MBNL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MBNL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MBNL2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MBNL2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MBNL2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MBNL2 mRNA19770486
D000452AldrinAldrin results in decreased expression of MBNL2 mRNA18579281
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MBNL2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of MBNL2 mRNA22521957
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MBNL2 mRNA"25757056
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MBNL2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MBNL2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MBNL2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MBNL2 mRNA"19150397|2001819
C044887beta-methylcholinebeta-methylcholine affects the expression of MBNL2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of MBNL2 mRNA21932408|2559470
C006780bisphenol Abisphenol A results in increased methylation of MBNL2 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MBNL2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MBNL2 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MBNL2 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MBNL2 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of MBNL2 mRNA23650126|2527062
D002922CiguatoxinsCiguatoxins affects the expression of MBNL2 mRNA18353800
D003010ClorgylineClorgyline results in increased expression of MBNL2 mRNA19691856
D019327Copper SulfateCopper Sulfate results in increased expression of MBNL2 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of MBNL2 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of MBNL2 mRNA19770486
C093628cyproconazolecyproconazole results in increased expression of MBNL2 mRNA22334560
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MBNL2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MBNL2 mRNA21266533
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of MBNL2 mRNA17490981
D004041Dietary FatsDietary Fats results in increased expression of MBNL2 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL2 mRNA]19030233
D004221DisulfiramDisulfiram results in decreased expression of MBNL2 mRNA20530235
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MBNL2 mRNA"23811387
C118739entinostatentinostat results in decreased expression of MBNL2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MBNL2 mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MBNL2 mRNA22079256
C109476epoxiconazoleepoxiconazole results in increased expression of MBNL2 mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MBNL2 mRNA18936297
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBNL2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MBNL2 mRNA28196854
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MBNL2 mRNA17108234
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MBNL2 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of MBNL2 mRNA26705709
D005897GlafenineGlafenine results in decreased expression of MBNL2 mRNA24136188
D006046GoldGold results in decreased expression of MBNL2 mRNA25523186
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MBNL2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of MBNL2 mRNA27392435
C410337K 7174K 7174 results in increased expression of MBNL2 mRNA24086573
D048628KetolidesKetolides analog results in decreased expression of MBNL2 mRNA24967691
C045463leflunomideleflunomide results in increased expression of MBNL2 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MBNL2 mRNA"24972896
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MBNL2 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MBNL2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MBNL2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MBNL2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MBNL2 mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of MBNL2 mRNA18548127
D009285NaphthoquinonesNaphthoquinones results in increased expression of MBNL2 mRNA23811387
C022838nickel chloridenickel chloride results in increased expression of MBNL2 mRNA17312168
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MBNL2 mRNA"12756304
C507134ON 01910ON 01910 results in increased expression of MBNL2 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MBNL2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MBNL2 mRNA20042640
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MBNL2 mRNA19095052
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of MBNL2 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of MBNL2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MBNL2 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MBNL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MBNL2 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of MBNL2 mRNA21278054|2233456
D011794QuercetinQuercetin results in decreased expression of MBNL2 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA19059307
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of MBNL2 mRNA]19030233
C541923sandostatinLARsandostatinLAR results in decreased expression of MBNL2 mRNA17210224
D012834SilverSilver results in decreased expression of MBNL2 mRNA27131904
D020123SirolimusSirolimus inhibits the reaction [TP73 protein results in increased expression of MBNL2 mRNA]21245298
C017947sodium arsenitesodium arsenite results in decreased expression of MBNL2 mRNA28595984
D053260SootSoot results in increased expression of MBNL2 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of MBNL2 mRNA26378955
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of MBNL2 mRNA"26680231
D016559TacrolimusTacrolimus results in decreased expression of MBNL2 mRNA25270620
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA19059307
C004648testosterone enanthatetestosterone enanthate affects the expression of MBNL2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MBNL2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBNL2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MBNL2 mRNA25270620
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of MBNL2 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of MBNL2 mRNA27188386
D013893ThiramThiram results in decreased expression of MBNL2 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MBNL2 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of MBNL2 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of MBNL2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of MBNL2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of MBNL2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MBNL2 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of MBNL2 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of MBNL2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in increased expression of MBNL2 mRNA28973697
D014520UrethaneUrethane results in increased expression of MBNL2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MBNL2 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MBNL2 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of MBNL2 mRNA24935251|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MBNL2 gene25560391
C025643vinclozolinvinclozolin affects the expression of MBNL2 mRNA19015723
D019287Zinc SulfateZinc Sulfate results in decreased expression of MBNL2 mRNA12756304

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IBA21873635  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IEA-  
GO:0006397mRNA processing-IEA-  
GO:0008380RNA splicing-IEA-  
GO:0032502developmental process-IBA21873635  
GO:0043484regulation of RNA splicing-IDA15257297  16946708  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal