Gene: TRIM28

10155
KAP1|PPP1R157|RNF96|TF1B|TIF1B
tripartite motif containing 28
protein-coding
19q13.43
Ensembl:ENSG00000130726 MIM:601742 Vega:OTTHUMG00000183546 UniprotKB:Q13263
NG_046945.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.505e-1 (AD)  8.452e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EIF3B0.944
MARK30.943
HNRNPL0.938
SF3B20.933
KHSRP0.932
SF10.928
AUP10.927
PHF10.927
XAB20.926
ALKBH50.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.827
OR4F29-0.786
IFNG-0.205
HMHB1-0.201
KLRB1-0.199
CETP-0.186
OR6C74-0.184
C9orf153-0.176
FCRL1-0.174
CHP2-0.169

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5461932-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide"2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]"25977998
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRIM28 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TRIM28 mRNA"21346803
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]]24933654
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]22003191
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRIM28 protein]22003191
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TRIM28 mRNA"21346803
C0185114-dichlorobenzene4-dichlorobenzene results in increased expression of TRIM28 mRNA26975756
D000082AcetaminophenAcetaminophen affects the expression of TRIM28 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [resveratrol results in increased phosphorylation of TRIM28 protein]24933654
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TRIM28 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRIM28 mRNA16483693
D016590Aphidicolin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRIM28 protein]22003191
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
D001280AtrazineAtrazine results in increased expression of TRIM28 mRNA25929836
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of TRIM28 mRNA"20162321
C006780bisphenol Abisphenol A affects the expression of TRIM28 mRNA25181051
D001761BleomycinBleomycin results in increased phosphorylation of TRIM28 protein24933654
C584509C646 compoundC646 compound results in decreased expression of TRIM28 mRNA26191083
D002166CamptothecinCamptothecin results in increased expression of TRIM28 protein modified form25977998
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TRIM28 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of TRIM28 mRNA17585979|2381119
D003042CocaineCocaine affects the expression of TRIM28 mRNA20187946
C007262deoxynivalenoldeoxynivalenol results in increased phosphorylation of TRIM28 protein23352502
D003976DiazinonDiazinon results in increased methylation of TRIM28 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TRIM28 mRNA17361019|2126653
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of TRIM28 mRNA21858171
D002945Cisplatin[2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased activity of ATM protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRIM28 protein]22003191
D002945CisplatinCisplatin results in increased phosphorylation of TRIM28 protein22006019
C000944dicrotophosdicrotophos results in increased expression of TRIM28 mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TRIM28 mRNA21658437
D004317DoxorubicinDoxorubicin results in decreased sumoylation of TRIM28 protein17079232
D004317DoxorubicinTRIM28 protein modified form inhibits the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]17079232
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TRIM28 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TRIM28 mRNA17351261
C069837fullerene C60fullerene C60 results in increased expression of TRIM28 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of TRIM28 mRNA22061828
D006861Hydrogen Peroxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]24933654
D006861Hydrogen Peroxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]]24933654
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of TRIM28 protein24933654
D006861Hydrogen Peroxideresveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]24933654
C492448ICG 001ICG 001 results in decreased expression of TRIM28 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRIM28 mRNA25613284
D007854LeadLead affects the expression of TRIM28 mRNA28903495
D008727MethotrexateTRIM28 protein affects the susceptibility to Methotrexate16217747
D008741Methyl MethanesulfonateMethyl Methanesulfonate inhibits the reaction [TRIM28 protein binds to CDKN1A promoter]17079232
D015741MetriboloneMetribolone results in decreased expression of TRIM28 protein17152098
C028007nickel monoxidenickel monoxide results in increased expression of TRIM28 mRNA19167457
D009538NicotineNicotine results in increased splicing of TRIM28 mRNA alternative form23825647
D010416PentachlorophenolPentachlorophenol results in decreased expression of TRIM28 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of TRIM28 protein26178269
C006253pirinixic acidpirinixic acid results in decreased expression of TRIM28 mRNA18445702
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of TRIM28 mRNA21858171
C027373potassium chromate(VI)"2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]"25977998
C027373potassium chromate(VI)2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C027373potassium chromate(VI)Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C027373potassium chromate(VI)ATM protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C027373potassium chromate(VI)CHEK2 protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]25977998
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TRIM28 protein modified form25977998
C059514resveratrol2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [resveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]]24933654
C059514resveratrolAcetylcysteine inhibits the reaction [resveratrol results in increased phosphorylation of TRIM28 protein]24933654
C059514resveratrolresveratrol promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of TRIM28 protein]24933654
C059514resveratrolresveratrol results in increased phosphorylation of TRIM28 protein24933654
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TRIM28 mRNA21427059
D012643SeleniumSelenium results in increased expression of TRIM28 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRIM28 mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased phosphorylation of TRIM28 protein23298284
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRIM28 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of TRIM28 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of TRIM28 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased expression of TRIM28 mRNA19448997
D014501UraniumUranium affects the expression of TRIM28 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of TRIM28 mRNA15672453
D014635Valproic AcidValproic Acid results in decreased expression of TRIM28 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased expression of TRIM28 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of TRIM28 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-IDA9016654  
GO:0003682chromatin binding-IDA27029610  
GO:0003700DNA-binding transcription factor activitycontributes_toISS-  
GO:0003713transcription coactivator activity-ISS-  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA8769649  
GO:0003723RNA binding-HDA22681889  
GO:0004672protein kinase activity-IEA-  
GO:0004842ubiquitin-protein transferase activity-IBA21873635  
GO:0004842ubiquitin-protein transferase activity-IDA18082607  
GO:0005515protein binding-IPI10330177  11013263  16169070  17314511  17353931  17704056  
18060868  18675275  18854139  19498464  20424263  20562864  
20858735  20864041  20936779  21170338  21277283  21549307  
21642969  21888893  23543754  23665872  24018422  24657165  
26496610  27029610  27705803  
GO:0008270zinc ion binding-IDA10653693  11226167  
GO:0031625ubiquitin protein ligase binding-IDA18082607  
GO:0035851Krueppel-associated box domain binding-IDA23665872  
GO:0043565sequence-specific DNA bindingcontributes_toISS-  
GO:0070087chromo shadow domain binding-IPI15882967  
GO:1990841promoter-specific chromatin binding-IBA21873635  
GO:1990841promoter-specific chromatin binding-IDA24623306  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001837epithelial to mesenchymal transition-ISS-  
GO:0006281DNA repair-IDA17178852  
GO:0006325chromatin organization-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0007265Ras protein signal transduction-IMP24623306  
GO:0007566embryo implantation-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0016925protein sumoylation-IBA21873635  
GO:0016925protein sumoylation-IDA18082607  
GO:0016925protein sumoylation-IEA-  
GO:0042307positive regulation of protein import into nucleus-IDA23665872  
GO:0043045DNA methylation involved in embryo development-IEA-  
GO:0043388positive regulation of DNA binding-IEA-  
GO:0045087innate immune response-IDA18248090  
GO:0045739positive regulation of DNA repair-IDA17178852  
GO:0045869negative regulation of single stranded viral RNA replication via double stranded DNA intermediate-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IDA9016654  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0046777protein autophosphorylation-IEA-  
GO:0051259protein complex oligomerization-IDA17512541  
GO:0060028convergent extension involved in axis elongation-IEA-  
GO:0060669embryonic placenta morphogenesis-IEA-  
GO:0090309positive regulation of methylation-dependent chromatin silencing-IMP24623306  
GO:1901536negative regulation of DNA demethylation-IEA-  
GO:1902187negative regulation of viral release from host cell-IDA18248090  
GO:2000653regulation of genetic imprinting-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000785chromatin-IBA21873635  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8769649  9016654  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005719nuclear euchromatin-IEA-  
GO:0005720nuclear heterochromatin-IEA-  
GO:0090575RNA polymerase II transcription factor complex-IBA21873635  
GO:0090575RNA polymerase II transcription factor complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics