Gene: LPAR6

10161
ARWH1|HYPT8|LAH3|P2RY5|P2Y5
lysophosphatidic acid receptor 6
protein-coding
13q14.2
Ensembl:ENSG00000139679 MIM:609239 Vega:OTTHUMG00000016895 UniprotKB:P43657
NG_012874.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.478e-1 (AD)  5.700e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs544475121chr13:48442207-48442218 (GRCh38.p7)delTalcohol dependenceIndel(Insertion and Deletion)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.918
BIN20.911
PTPRC0.903
CD370.902
APBB1IP0.899
CLEC7A0.898
NCKAP1L0.894
LAPTM50.89
TRAF3IP30.89
TBXAS10.889

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.422
MAGIX-0.414
CHRNA4-0.414
TMEM191C-0.41
KCNB2-0.405
TMEM179-0.405
HAS1-0.402
DLK2-0.401
YBX2-0.4
ASPDH-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of LPAR6 mRNA28522335
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LPAR6 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LPAR6 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of LPAR6 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LPAR6 gene27153756
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of LPAR6 mRNA"23195993
D001151ArsenicArsenic affects the methylation of LPAR6 gene25304211
D001379AzathioprineAzathioprine results in decreased expression of LPAR6 mRNA22623647
C487081belinostatbelinostat results in increased expression of LPAR6 mRNA26272509
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of LPAR6 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of LPAR6 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LPAR6 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LPAR6 mRNA21715664
C006780bisphenol Abisphenol A results in decreased expression of LPAR6 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of LPAR6 mRNA25594700
C006780bisphenol Abisphenol A results in increased expression of LPAR6 mRNA25181051
D002104CadmiumCadmium results in decreased expression of LPAR6 mRNA24376830
D002220CarbamazepineCarbamazepine affects the expression of LPAR6 mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of LPAR6 mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of LPAR6 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of LPAR6 mRNA25562108
D002945CisplatinCisplatin results in increased expression of LPAR6 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of LPAR6 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of LPAR6 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of LPAR6 mRNA16002434
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of LPAR6 mRNA"22485181
D004237DiuronDiuron results in increased expression of LPAR6 mRNA21551480
D004726EndosulfanEndosulfan results in decreased expression of LPAR6 mRNA28108160
D005472FluorouracilFluorouracil results in decreased expression of LPAR6 mRNA17039268
C039281furanfuran results in increased methylation of LPAR6 gene22079235
C056507gemcitabinegemcitabine results in decreased expression of LPAR6 mRNA17039268
D005897GlafenineGlafenine results in decreased expression of LPAR6 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LPAR6 mRNA25613284
C008261lead acetatelead acetate results in decreased expression of LPAR6 mRNA21829687
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LPAR6 mRNA25890327|2658214
C032881lysophosphatidic acidlysophosphatidic acid binds to and results in increased activity of LPAR6 protein18297070
C042720mercuric bromidemercuric bromide results in increased expression of LPAR6 mRNA26272509
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LPAR6 mRNA28001369
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LPAR6 mRNA"29244179
D009532NickelNickel results in decreased expression of LPAR6 mRNA23195993
C029938nickel sulfatenickel sulfate results in decreased expression of LPAR6 mRNA16780908
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of LPAR6 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LPAR6 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of LPAR6 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of LPAR6 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of LPAR6 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of LPAR6 mRNA22714537
C513428pyrachlostrobinpyrachlostrobin results in increased expression of LPAR6 mRNA27029645
C012526quercitrinquercitrin results in decreased expression of LPAR6 mRNA25193878
C031389resorcinolresorcinol results in increased expression of LPAR6 mRNA22623647
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LPAR6 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of LPAR6 mRNA16014739
C004648testosterone enanthatetestosterone enanthate affects the expression of LPAR6 mRNA17440010
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of LPAR6 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LPAR6 mRNA21889950
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LPAR6 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of LPAR6 gene26756918|2686493
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LPAR6 mRNA25729387
D014212TretinoinTretinoin results in increased expression of LPAR6 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of LPAR6 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of LPAR6 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of LPAR6 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of LPAR6 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of LPAR6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of LPAR6 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in decreased methylation of LPAR6 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of LPAR6 mRNA24383497|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of LPAR6 gene25560391
C025643vinclozolinvinclozolin affects the expression of LPAR6 mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LPAR6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of LPAR6 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0070915lysophosphatidic acid receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0035025positive regulation of Rho protein signal transduction-IBA21873635  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA18297070  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-417957P2Y receptorsTAS
R-HSA-418038Nucleotide-like (purinergic) receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal