Gene: SLC25A13

10165
ARALAR2|CITRIN|CTLN2
solute carrier family 25 member 13
protein-coding
7q21.3
Ensembl:ENSG00000004864 MIM:603859 Vega:OTTHUMG00000023074 UniprotKB:Q9UJS0
NG_012247.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.817e-2 (AD)  4.216e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4509239chr7:96264902 (GRCh38.p7)C>A / C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOCK100.867
MOSPD20.835
PSEN10.833
ZBED30.833
TMC70.832
TBC1D120.831
NEK30.824
ELOVL10.812
PDE8A0.811
COL4A50.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.355
OR4F29-0.341
EPPIN-0.321
KCNG1-0.271
BCL2L10-0.245
FOXD4L1-0.244
ESPN-0.234
RAX2-0.224
TDRG1-0.219
HCN4-0.217

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SLC25A13 mRNA28329830
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC25A13 mRNA]"19467301
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of SLC25A13 mRNA18544908
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC25A13 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of SLC25A13 mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of SLC25A13 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of SLC25A13 mRNA18544908
D020106AcrylamideAcrylamide results in increased expression of SLC25A13 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC25A13 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC25A13 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC25A13 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SLC25A13 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of SLC25A13 mRNA19483382
C015001arsenitearsenite affects the expression of SLC25A13 mRNA22959463
D001280AtrazineAtrazine results in decreased expression of SLC25A13 mRNA22378314
C547126AZM551248AZM551248 results in decreased expression of SLC25A13 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of SLC25A13 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC25A13 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC25A13 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC25A13 mRNA"19150397|2001819
C006780bisphenol Abisphenol A results in increased expression of SLC25A13 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC25A13 mRNA26472689
D002994ClofibrateClofibrate affects the expression of SLC25A13 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC25A13 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC25A13 mRNA24386269
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of SLC25A13 mRNA15467011
D003471CuprizoneCuprizone affects the expression of SLC25A13 mRNA26577399
D003471CuprizoneCuprizone results in decreased expression of SLC25A13 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of SLC25A13 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SLC25A13 mRNA17361019|2126653
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in increased expression of SLC25A13 mRNA]21858171
D002945CisplatinCisplatin results in decreased expression of SLC25A13 mRNA19561079
D002945CisplatinCisplatin results in increased expression of SLC25A13 protein22023808
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC25A13 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC25A13 mRNA19467301
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC25A13 mRNA25380136
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC25A13 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC25A13 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC25A13 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC25A13 mRNA17942748
D005001EthionineEthionine affects the expression of SLC25A13 mRNA19483382
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of SLC25A13 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of SLC25A13 mRNA24136188
D017313FenretinideFenretinide results in increased expression of SLC25A13 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SLC25A13 mRNA17183730
C029424hydrazinehydrazine results in increased expression of SLC25A13 mRNA15282401
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC25A13 protein24675778
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC25A13 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC25A13 mRNA25380136
D009853OmeprazoleOmeprazole affects the expression of SLC25A13 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A13 mRNA25729387
C006253pirinixic acidpirinixic acid results in increased expression of SLC25A13 mRNA23811191
C006253pirinixic acidpirinixic acid affects the expression of SLC25A13 mRNA19483382
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in increased expression of SLC25A13 mRNA]21858171
D010894PiroxicamPiroxicam results in increased expression of SLC25A13 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of SLC25A13 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC25A13 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC25A13 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of SLC25A13 mRNA22238285
D011441PropylthiouracilPropylthiouracil affects the expression of SLC25A13 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC25A13 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SLC25A13 mRNA27029645
D013629TamoxifenTamoxifen affects the expression of SLC25A13 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A13 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC25A13 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A13 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A13 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC25A13 mRNA18796159|2121527
D019284ThapsigarginThapsigargin results in decreased expression of SLC25A13 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of SLC25A13 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC25A13 mRNA28065790
C066340tolcaponetolcapone binds to SLC25A13 protein19783845
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SLC25A13 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of SLC25A13 mRNA23228038
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SLC25A13 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of SLC25A13 mRNA22378314
D014520UrethaneUrethane results in decreased expression of SLC25A13 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SLC25A13 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of SLC25A13 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of SLC25A13 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SLC25A13 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC25A13 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC25A13 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-NAS10642534  
GO:0005313L-glutamate transmembrane transporter activity-IBA21873635  
GO:0005313L-glutamate transmembrane transporter activity-IDA11566871  
GO:0005509calcium ion binding-IDA10642534  25410934  
GO:0015172acidic amino acid transmembrane transporter activity-TAS-  
GO:0015183L-aspartate transmembrane transporter activity-IBA21873635  
GO:0015183L-aspartate transmembrane transporter activity-IDA11566871  
GO:0042802identical protein binding-IDA25410934  
GO ID GO Term Qualifier Evidence PubMed
GO:0006094gluconeogenesis-TAS-  
GO:0006754ATP biosynthetic process-IDA12851387  
GO:0006839mitochondrial transport-NAS10642534  
GO:0015810aspartate transmembrane transport-IBA21873635  
GO:0015810aspartate transmembrane transport-IDA11566871  
GO:0015813L-glutamate transmembrane transport-IDA11566871  
GO:0043490malate-aspartate shuttle-IBA21873635  
GO:0043490malate-aspartate shuttle-IDA11566871  
GO:0045333cellular respiration-IDA12851387  
GO:0051592response to calcium ion-IDA11566871  
GO:0070778L-aspartate transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA10642534  11566871  
GO:0005743mitochondrial inner membrane-ISS-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS10642534  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1268020Mitochondrial protein importIEA
R-HSA-1430728MetabolismTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-70263GluconeogenesisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal