Gene: RBM6

10180
3G2|DEF-3|DEF3|HLC-11|NY-LU-12|g16
RNA binding motif protein 6
protein-coding
3p21.31
Ensembl:ENSG00000004534 MIM:606886 Vega:OTTHUMG00000156736 UniprotKB:P78332
NC_000003.12
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
1   
9.038e-2 (AD)  7.175e-1 (ND)   (Frontal_Cortex)
6.290e-2 (AD)  4.290e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2240328chr3:50075571 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2624821chr3:49976681 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2681779chr3:49973588 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCNL20.896
LUC7L0.883
SNRNP700.872
KAT2A0.87
CLK20.868
ACIN10.865
LENG80.862
MAN2C10.86
SRRM20.86
FAM193B0.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.675
OR4F29-0.662
PAGE4-0.244
SIM1-0.231
FOXB1-0.23
HMX2-0.229
LHX5-0.229
NTS-0.224
C22orf42-0.222
OTP-0.22

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of RBM6 protein26194647
D000082AcetaminophenAcetaminophen results in increased expression of RBM6 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of RBM6 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of RBM6 mRNA"23195993
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RBM6 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBM6 mRNA"19150397
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RBM6 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of RBM6 mRNA25047013
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM6 gene20938992
C031180chrysenechrysene results in increased expression of RBM6 mRNA26377693
D016572CyclosporineCyclosporine results in increased expression of RBM6 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RBM6 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RBM6 mRNA17361019|2126653
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of RBM6 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of RBM6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RBM6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBM6 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM6 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of RBM6 mRNA20655997
C010974glyphosateglyphosate results in increased expression of RBM6 mRNA25636363
D017313FenretinideFenretinide results in increased expression of RBM6 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RBM6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of RBM6 mRNA28628672
C410337K 7174K 7174 results in increased expression of RBM6 mRNA24086573
D007854LeadLead affects the splicing of RBM6 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RBM6 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of RBM6 mRNA28001369
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of RBM6 mRNA12634122
D015741MetriboloneMetribolone results in increased expression of RBM6 mRNA17010196
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RBM6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RBM6 mRNA"25554681
D009532NickelNickel results in decreased expression of RBM6 mRNA23195993
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RBM6 mRNA25729387
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of RBM6 mRNA21133357
C017947sodium arsenitesodium arsenite results in increased stability of RBM6 mRNA25493608
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RBM6 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBM6 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RBM6 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RBM6 mRNA17942748|2135428
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RBM6 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RBM6 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of RBM6 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of RBM6 mRNA23179753|2915479
D014750VincristineVincristine results in decreased expression of RBM6 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS10352938  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006396RNA processing-TAS10352938  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20186023RBM5 as a putative tumor suppressor gene for lung cancer. (2010 Mar)Sutherland LCJ Thorac Oncol