Gene: RBM5

10181
G15|H37|LUCA15|RMB5
RNA binding motif protein 5
protein-coding
3p21.31
Ensembl:ENSG00000003756 MIM:606884 Vega:OTTHUMG00000156785 UniprotKB:P52756
NG_030403.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.078e-2 (AD)  5.009e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2624834chr3:50094698 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARGLU10.95
METTL30.946
MAU20.945
SRSF50.941
DDX170.939
POGZ0.937
EXOSC100.937
EZH10.932
DMTF10.931
CSAD0.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.636
OR4F29-0.606
KLRC2-0.258
TRDN-0.25
MTRNR2L6-0.249
MTRNR2L9-0.243
MTRNR2L10-0.24
OR4F16-0.211
VAX2-0.207
PAGE4-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of RBM5 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RBM5 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RBM5 mRNA24449571
D001151ArsenicArsenic affects the methylation of RBM5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RBM5 mRNA20504355|2222880
D001663BilirubinBilirubin results in decreased expression of RBM5 mRNA20196124
C006780bisphenol Abisphenol A affects the expression of RBM5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of RBM5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of RBM5 mRNA27571134
C584509C646 compoundC646 compound results in increased expression of RBM5 mRNA26191083
D002211CapsaicinCapsaicin results in increased expression of RBM5 mRNA20349343
D002737ChloropreneChloroprene results in increased expression of RBM5 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in decreased expression of RBM5 mRNA20350560
D019327Copper SulfateCopper Sulfate results in increased expression of RBM5 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RBM5 mRNA21266533
C029402diphenylcyclopropenonediphenylcyclopropenone results in decreased expression of RBM5 mRNA25236440
D004237DiuronDiuron results in decreased expression of RBM5 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of RBM5 mRNA25896364
D000431EthanolEthanol affects the expression of RBM5 mRNA24355176
D000431EthanolEthanol affects the expression of RBM5 mRNA26730594
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of RBM5 mRNA17557909
D005472FluorouracilRBM5 protein affects the susceptibility to Fluorouracil15548681
D005485FlutamideFlutamide results in decreased expression of RBM5 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of RBM5 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of RBM5 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RBM5 mRNA25613284
D007854LeadLead affects the splicing of RBM5 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RBM5 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RBM5 mRNA26378955
D008694MethamphetamineMethamphetamine results in decreased methylation of RBM5 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of RBM5 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RBM5 mRNA23103053
D008777MethyltestosteroneMethyltestosterone results in decreased expression of RBM5 mRNA29191790
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of RBM5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RBM5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RBM5 mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of RBM5 mRNA24136188
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of RBM5 mRNA28973697
D010634PhenobarbitalPhenobarbital results in decreased expression of RBM5 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of RBM5 mRNA18445702
D010936Plant ExtractsPlant Extracts results in increased expression of RBM5 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of RBM5 protein23718831
D011374ProgesteroneProgesterone results in decreased expression of RBM5 mRNA20631399
C059514resveratrolresveratrol results in decreased expression of RBM5 protein25505154
C059514resveratrolresveratrol results in decreased expression of RBM5 mRNA25905778
D012643SeleniumSelenium results in increased expression of RBM5 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of RBM5 mRNA29191790
D012834SilverSilver results in increased expression of RBM5 mRNA26014281
C009277sodium arsenatesodium arsenate results in decreased expression of RBM5 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of RBM5 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of RBM5 protein28918527
D012999SomanSoman results in decreased expression of RBM5 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of RBM5 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of RBM5 mRNA26378955
D013749TetrachlorodibenzodioxinRBM5 promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]23997114
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RBM5 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RBM5 mRNA16267337
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RBM5 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of RBM5 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of RBM5 mRNA23557971
C012589trichostatin Atrichostatin A affects the expression of RBM5 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of RBM5 mRNA15901671
D014303TrinitrotolueneTrinitrotoluene affects the expression of RBM5 mRNA21346803
C406224valdecoxibvaldecoxib results in increased expression of RBM5 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of RBM5 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RBM5 mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in decreased expression of RBM5 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RBM5 gene25560391
C025643vinclozolinvinclozolin affects the expression of RBM5 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of RBM5 mRNA20566332|2303416
D014750VincristineVincristine results in decreased expression of RBM5 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of RBM5 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of RBM5 mRNA22083351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS10352938  
GO:0003723RNA binding-HDA22681889  
GO:0003729mRNA binding-IDA18840686  
GO:0005515protein binding-IPI18951082  22365833  22569250  24304693  26871637  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000245spliceosomal complex assembly-IDA18951082  
GO:0000381regulation of alternative mRNA splicing, via spliceosome-IDA18840686  18951082  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006396RNA processing-TAS10352938  
GO:0006915apoptotic process-IEA-  
GO:0008285negative regulation of cell proliferation-TAS18951082  
GO:0043065positive regulation of apoptotic process-IDA18840686  
GO:0043065positive regulation of apoptotic process-TAS18951082  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA18951082  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-TAS18951082  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25738917RNA-binding motif protein 5 negatively regulates the activity of Wnt/beta-catenin signaling in cigarette smoke-induced alveolar epithelial injury. (2015 May)Hao YQOncol Rep
22882865Downregulating activated epidermal growth factor receptor has no effect on RBM5 expression. (2012 Jul)Masilamani TJChin Med J (Engl)
26782095RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis. (2016 Apr)Lv XJOncol Rep
22537942Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues. (2012 Apr 26)Liang HJ Exp Clin Cancer Res
20186023RBM5 as a putative tumor suppressor gene for lung cancer. (2010 Mar)Sutherland LCJ Thorac Oncol