Gene: ADAM10

102
AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz
ADAM metallopeptidase domain 10
protein-coding
15q21.3
Ensembl:ENSG00000137845 MIM:602192 Vega:OTTHUMG00000132633 UniprotKB:O14672
NG_033876.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.004e-1 (AD)  4.798e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PICALM0.913
UBXN40.88
USP10.878
DICER10.878
ZNF1460.877
TBC1D150.875
SMC30.87
SMARCA50.869
PRPF40A0.868
ARID4B0.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.651
OR4F5-0.634
HES5-0.222
SHISA8-0.207
GOLGA6L1-0.186
CHRNA2-0.169
SCTR-0.168
HOXD4-0.159
PRTN3-0.158
SPANXA2-0.157

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04991XL784Small Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of ADAM10 mRNA"25710175
C0415944-nonylphenolADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]28703301
C0415944-nonylphenolADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]28703301
C0415944-nonylphenolADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]28703301
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ADAM10 mRNA20829426
D000082AcetaminophenAcetaminophen results in decreased expression of ADAM10 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ADAM10 mRNA17562736
D000171AcroleinAcrolein results in decreased expression of ADAM10 protein23296102
D000171AcroleinAcrolein results in decreased expression of ADAM10 protein23296102
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADAM10 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADAM10 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADAM10 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ADAM10 mRNA24449571
D001151ArsenicArsenic results in decreased expression of ADAM10 mRNA19654921
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ADAM10 mRNA"19150397
C038328BEP protocolBEP protocol results in increased expression of ADAM10 mRNA18987330
D001688Biological ProductsBiological Products results in decreased expression of ADAM10 mRNA23041113
C006780bisphenol AADAM10 protein affects the reaction [ADAM17 protein affects the reaction [bisphenol A results in increased secretion of HBEGF protein]]28703301
C006780bisphenol A[ADAM17 protein co-treated with ADAM10 protein] affects the reaction [bisphenol A results in increased secretion of TGFA protein]28703301
C006780bisphenol Abisphenol A affects the expression of ADAM10 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of ADAM10 mRNA20977926
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ADAM10 mRNA18560533
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ADAM10 mRNA26472689
D002122Calcium ChlorideCalcium Chloride results in increased expression of ADAM10 mRNA20621845
D002122Calcium ChlorideCalcium Chloride results in increased expression of ADAM10 protein20621845
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ADAM10 mRNA12734012
C054133casticincasticin results in increased expression of ADAM10 mRNA28444820
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ADAM10 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADAM10 mRNA19320972|1937684
D003471CuprizoneCuprizone results in decreased expression of ADAM10 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ADAM10 mRNA25562108
D003907Dexamethasone[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA22484447
D003907Dexamethasoneginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]22484447
D003907DexamethasoneHuang Qi inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]22484447
D002945CisplatinADAM10 protein affects the susceptibility to Cisplatin16217747
C000944dicrotophosdicrotophos results in decreased expression of ADAM10 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ADAM10 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of ADAM10 mRNA26924002
D004237DiuronDiuron results in increased expression of ADAM10 mRNA21551480
D005419FlavonoidsFlavonoids results in increased expression of ADAM10 mRNA18035473
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ADAM10 mRNA]15016801
D005473FluoxetineFluoxetine results in increased expression of ADAM10 mRNA17033635
C035054ginsenoside Rg1ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]22484447
C492546GW280264XGW280264X results in decreased activity of ADAM10 protein19875451
C027492Huang QiHuang Qi inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA]22484447
D007213IndomethacinIndomethacin results in increased expression of ADAM10 mRNA16771604
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM10 mRNA25613284
D007529IsoflavonesIsoflavones results in increased expression of ADAM10 mRNA17374662
D048628KetolidesKetolides analog results in increased expression of ADAM10 mRNA24967691
D008555MelittenMelitten results in increased cleavage of and results in increased activity of ADAM10 protein22613720
D008731MethoxychlorMethoxychlor affects the expression of ADAM10 mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADAM10 mRNA28001369
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of ADAM10 mRNA12634122
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ADAM10 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of ADAM10 mRNA15674844
D009532NickelNickel results in increased expression of ADAM10 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of ADAM10 mRNA19167457
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ADAM10 protein26879310
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased expression of ADAM10 protein"19476501
C006253pirinixic acidpirinixic acid results in decreased expression of ADAM10 mRNA18445702
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADAM10 mRNA24780913
C059514resveratrolresveratrol results in increased expression of ADAM10 protein23129026
C009277sodium arsenatesodium arsenate results in increased expression of ADAM10 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of ADAM10 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ADAM10 mRNA22808131
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAM10 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of ADAM10 mRNA23411599
D014212TretinoinTretinoin affects the localization of ADAM10 protein19476501
D014212TretinoinTretinoin results in increased expression of ADAM10 mRNA15972296|1627994
D014212TretinoinTretinoin results in increased expression of ADAM10 protein16279945|1947650
D014212TretinoinTretinoin affects the localization of ADAM10 protein19476501
D014212TretinoinTretinoin results in increased expression of ADAM10 mRNA19476501
D014212TretinoinTretinoin results in increased expression of ADAM10 protein19476501
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ADAM10 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of ADAM10 mRNA25423262
C025643vinclozolinvinclozolin results in increased expression of ADAM10 mRNA23555832
C029297vinylidene chloridevinylidene chloride results in increased expression of ADAM10 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-ISS-  
GO:0004222metalloendopeptidase activity-IMP19114711  
GO:0004222metalloendopeptidase activity-NAS8694785  
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005102signaling receptor binding-NAS12176995  
GO:0005178integrin binding-NAS8694785  
GO:0005515protein binding-IPI10527948  15280379  17301176  23091066  
GO:0008237metallopeptidase activity-IDA12475894  
GO:0008237metallopeptidase activity-IMP12535668  
GO:0008237metallopeptidase activity-TAS-  
GO:0017124SH3 domain binding-IEA-  
GO:0019901protein kinase binding-ISS-  
GO:0042803protein homodimerization activity-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001701in utero embryonic development-ISS-  
GO:0006468protein phosphorylation-ISS-  
GO:0006509membrane protein ectodomain proteolysis-IDA12714508  17557115  18355449  18419754  18676862  19114711  
GO:0006509membrane protein ectodomain proteolysis-IMP17965014  18355445  18373975  20711474  
GO:0007162negative regulation of cell adhesion-IDA12714508  
GO:0007162negative regulation of cell adhesion-NAS8694785  
GO:0007219Notch signaling pathway-ISS-  
GO:0007219Notch signaling pathway-TAS-  
GO:0007220Notch receptor processing-TAS-  
GO:0007229integrin-mediated signaling pathway-NAS8694785  
GO:0007267cell-cell signaling-NAS12714508  
GO:0008284positive regulation of cell proliferation-IMP18373975  
GO:0010820positive regulation of T cell chemotaxis-IMP18373975  
GO:0016485protein processing-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030307positive regulation of cell growth-IMP18373975  
GO:0030335positive regulation of cell migration-IMP18373975  
GO:0034612response to tumor necrosis factor-IDA11831872  
GO:0035333Notch receptor processing, ligand-dependent-TAS-  
GO:0042117monocyte activation-IMP11831872  
GO:0043312neutrophil degranulation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0051088PMA-inducible membrane protein ectodomain proteolysis-IMP18676862  
GO:0051089constitutive protein ectodomain proteolysis-IDA12714508  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IDA12475894  
GO:0005798Golgi-associated vesicle-IDA12475894  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA12475894  23035126  23091066  
GO:0014069postsynaptic density-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS8694785  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  
GO:0070821tertiary granule membrane-TAS-  
GO:0097038perinuclear endoplasmic reticulum-IDA23091066  
GO:0097197tetraspanin-enriched microdomain-IDA23035126  
KEGG ID KEGG Term
hsa05010Alzheimer's disease
hsa05120Epithelial cell signaling in Helicobacter pylori infection
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1442490Collagen degradationIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-177929Signaling by EGFRIEA
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29721164Novel therapeutic features of disulfiram against hepatocellular carcinoma cells with inhibitory effects on a disintegrin and metalloproteinase 10. (2018 Apr 10)Goto KOncotarget
26325204Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes. (2015)Lee ACPLoS One
20443867Emphysema mediated by lung overexpression of ADAM10. (2009 Feb)Saitoh HClin Transl Sci
21611732Association of ADAM10 and CAMK2A polymorphisms with conduct disorder: evidence from family-based studies. (2011 Aug)Jian XQJ Abnorm Child Psychol