Gene info: ID 1020

Gene: CDK5

GENE ID: 1020

Synonyms: LIS7|PSSALRE

Description: cyclin dependent kinase 5

Gene type: protein-coding

Location: 7q36.1

dbXrefs: Ensembl:ENSG00000164885 MIM:123831 Vega:OTTHUMG00000158414 UniprotKB:Q00535

RefSeq: NG_042167.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 16

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.287e-1 (AD) 4.462e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BSCL2	0.975
THY1	0.971
STOML1	0.966
ACOT7	0.966
SYNGR3	0.961
PGP	0.96
RAB3A	0.96
MAPRE3	0.96
TMEM59L	0.96
UCHL1	0.957

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.599
TFPI2	-0.547
OR4F29	-0.546
REST	-0.537
WWTR1	-0.519
IL18RAP	-0.518
RAI14	-0.517
KCNJ15	-0.51
EBF1	-0.505
TFPI	-0.5

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02052	Indirubin-3'-Monoxime	Small Molecule		Experimental	Target
DB02116	Olomoucine	Small Molecule	101622-51-9	Experimental	Target
DB02950	Hymenialdisine	Small Molecule		Experimental	Target
DB03428	SU9516	Small Molecule		Experimental	Target
DB03496	Alvocidib	Small Molecule	146426-40-6	Experimental\|Investigational	Target
DB04014	Alsterpaullone	Small Molecule		Experimental	Target
DB07364	6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of CDK5 mRNA"	19162173
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein]	24481447
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of CDK5 mRNA	21983209
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of CDK5 mRNA"	26186136
C559145	7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine	"7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine results in decreased activity of CDK5 protein"	21417417
D000082	Acetaminophen	Acetaminophen results in decreased expression of CDK5 mRNA	29067470
C512484	AG-012986	AG-012986 results in decreased activity of CDK5 protein	22095879
C077990	alvocidib	alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]	12941380
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDK5 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in increased cleavage of CDK5 protein	18722528
D000643	Ammonium Chloride	CDK5 protein affects the susceptibility to Ammonium Chloride	18722528
D003913	Dextroamphetamine	Dextroamphetamine results in increased activity of CDK5 protein	18991853
D001151	Arsenic	Arsenic affects the methylation of CDK5 gene	25304211
D001151	Arsenic	Arsenic results in increased expression of CDK5 mRNA	20654705
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CDK5 mRNA	22801079\|2464185
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CDK5 protein	24641850
D001280	Atrazine	Atrazine results in decreased expression of CDK5 mRNA	22378314
C006780	bisphenol A	bisphenol A affects the expression of CDK5 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CDK5 mRNA	25181051
D019256	Cadmium Chloride	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of CDK5 promoter	22457795
D019256	Cadmium Chloride	pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
D019256	Cadmium Chloride	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]	24481447
D019256	Cadmium Chloride	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of CDK5 protein	24481447
D002220	Carbamazepine	Carbamazepine affects the expression of CDK5 mRNA	24752500
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of CDK5 mRNA	15924885
D002994	Clofibrate	Clofibrate results in decreased expression of CDK5 mRNA	17585979
D003024	Clozapine	Clozapine results in increased expression of CDK5 mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDK5 mRNA	19376846
D003042	Cocaine	Cocaine affects the expression of CDK5 mRNA	20187946
D003042	Cocaine	Cocaine affects the expression of CDK5 protein	12787079\|1733908
D003042	Cocaine	Cocaine results in decreased expression of CDK5 protein	16263094
D003042	Cocaine	Cocaine results in increased expression of CDK5 mRNA	11268215
D003042	Cocaine	Cocaine results in increased expression of CDK5 protein	11268215
D003078	Colchicine	alvocidib inhibits the reaction [Colchicine results in increased expression of CDK5 protein]	12941380
D003078	Colchicine	Colchicine results in increased expression of CDK5 protein	12941380
D003078	Colchicine	Colchicine results in increased expression of and results in increased cleavage of CDK5 protein	15979805
D003078	Colchicine	Lithium inhibits the reaction [Colchicine results in increased expression of and results in increased cleavage of CDK5 protein]	15979805
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CDK5 mRNA	19549813
D003474	Curcumin	Curcumin analog results in decreased expression of CDK5 mRNA	26409325
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDK5 mRNA	20106945\|2556210
C037304	cyhalothrin	cyhalothrin results in increased expression of CDK5 protein	28487251
D013759	Dronabinol	Dronabinol results in increased expression of CDK5 protein	29082320
D013759	Dronabinol	[Dronabinol results in increased susceptibility to Dronabinol] which results in increased expression of CDK5 protein	29082320
D003976	Diazinon	Diazinon affects the expression of CDK5 mRNA	22546817
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CDK5 mRNA	27392435
D004008	Diclofenac	Diclofenac affects the expression of CDK5 mRNA	24752500
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of CDK5 mRNA	26924002
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDK5 mRNA	15766595
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of CDK5 mRNA	26924002
D007980	Levodopa	Levodopa results in increased expression of CDK5 protein	20504213
D007980	Levodopa	[Oxidopamine co-treated with Levodopa] results in increased expression of CDK5 protein	17188499
D007980	Levodopa	roscovitine inhibits the reaction [Levodopa results in increased expression of CDK5 protein]	20504213
D004317	Doxorubicin	Doxorubicin results in increased expression of CDK5 mRNA	22008532
D005473	Fluoxetine	Fluoxetine results in decreased expression of CDK5 mRNA	17105902
D005485	Flutamide	Flutamide results in decreased expression of CDK5 mRNA	24793618
D019833	Genistein	Genistein results in decreased expression of CDK5 mRNA	22228119
D019833	Genistein	Genistein results in increased expression of CDK5 protein	16149052
D006220	Haloperidol	Haloperidol results in increased expression of CDK5 mRNA	15860345
C517828	hexabrominated diphenyl ether 153	hexabrominated diphenyl ether 153 affects the expression of and affects the activity of CDK5 protein	28559121
C517828	hexabrominated diphenyl ether 153	hexabrominated diphenyl ether 153 affects the localization of CDK5 protein	28559121
C517828	hexabrominated diphenyl ether 153	hexabrominated diphenyl ether 153 results in increased expression of CDK5 mRNA	28559121
C517828	hexabrominated diphenyl ether 153	PD 150606 affects the reaction [hexabrominated diphenyl ether 153 affects the activity of CDK5 protein]	28559121
C517828	hexabrominated diphenyl ether 153	roscovitine affects the reaction [hexabrominated diphenyl ether 153 affects the activity of CDK5 protein]	28559121
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CDK5 mRNA	20044591
C503753	Indolinone A	Indolinone A results in decreased activity of CDK5 protein	15712243\|1583887
C503753	Indolinone A	Indolinone A results in decreased activity of CDK5 protein	18491313\|1978275
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CDK5 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CDK5 mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of CDK5 protein	23973560
C008261	lead acetate	lead acetate results in increased expression of CDK5 mRNA	24954411
C008261	lead acetate	lead acetate results in increased expression of CDK5 protein	24954411\|2729318
C008261	lead acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C008261	lead acetate	lead acetate results in increased cleavage of CDK5 protein	27012722
C008261	lead acetate	pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C008261	lead acetate	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]	24481447
C008261	lead acetate	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of CDK5 protein	24481447
D008094	Lithium	Lithium inhibits the reaction [Colchicine results in increased expression of and results in increased cleavage of CDK5 protein]	15979805
D008148	Lovastatin	Lovastatin results in decreased cleavage of CDK5 protein	19741129
C015329	lycopene	lycopene results in decreased expression of CDK5 protein	17337101
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of CDK5 mRNA	20864626
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDK5 mRNA"	20188158
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in increased expression of CDK5 mRNA	12634122
D015655	1-Methyl-4-phenylpyridinium	CDK5 protein affects the reaction [LRRK2 protein mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium]	26930193
C008493	methylselenic acid	methylselenic acid results in increased expression of CDK5 mRNA	11830524
D008777	Methyltestosterone	Methyltestosterone results in increased expression of CDK5 mRNA	29191790
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CDK5 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CDK5 mRNA"	25554681
C022838	nickel chloride	nickel chloride affects the expression of CDK5 mRNA	22546817
D016627	Oxidopamine	[Oxidopamine co-treated with Levodopa] results in increased expression of CDK5 protein	17188499
C100442	PD 150606	PD 150606 affects the reaction [hexabrominated diphenyl ether 153 affects the activity of CDK5 protein]	28559121
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein]	24481447
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased activity of CDK5 protein]	21736731
C059514	resveratrol	resveratrol results in decreased activity of CDK5 protein	21736731
C059514	resveratrol	resveratrol results in decreased expression of and results in decreased activity of CDK5 protein	23129026
C059514	resveratrol	resveratrol results in decreased activity of CDK5 protein	21736731
C059514	resveratrol	[resveratrol results in decreased expression of CDK5R1 protein] which results in decreased activity of CDK5 protein	21736731
D015474	Isotretinoin	Isotretinoin results in decreased expression of CDK5 mRNA	20436886
D019438	Ritonavir	Ritonavir results in decreased expression of CDK5 mRNA	19386116
C104586	roscovitine	roscovitine results in decreased activity of CDK5 protein	15741232
C104586	roscovitine	roscovitine affects the reaction [hexabrominated diphenyl ether 153 affects the activity of CDK5 protein]	28559121
C104586	roscovitine	roscovitine inhibits the reaction [Levodopa results in increased expression of CDK5 protein]	20504213
C104586	roscovitine	roscovitine results in decreased activity of CDK5 protein	11268215\|2050421
D012524	Sarin	Sarin results in decreased expression of CDK5 mRNA	19522546
D012524	Sarin	Sarin results in increased expression of CDK5 mRNA	19522546
D019821	Simvastatin	Simvastatin results in increased expression of CDK5	19461118
C017947	sodium arsenite	sodium arsenite affects the methylation of CDK5 gene	28589171
C017947	sodium arsenite	sodium arsenite results in increased expression of CDK5 mRNA	17879257
C017947	sodium arsenite	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C017947	sodium arsenite	pyrazolanthrone inhibits the reaction [[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of CDK5 protein]	24481447
C017947	sodium arsenite	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]	24481447
C017947	sodium arsenite	[sodium arsenite co-treated with lead acetate co-treated with Cadmium Chloride] results in increased phosphorylation of and results in increased activity of CDK5 protein	24481447
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of CDK5 mRNA	16705456
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDK5 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDK5 mRNA	21215274
D014212	Tretinoin	Tretinoin results in increased expression of CDK5 protein	16149052
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDK5 mRNA"	26179874
C057693	troglitazone	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein]	24481447
C057693	troglitazone	pyrazolanthrone inhibits the reaction [troglitazone results in increased phosphorylation of CDK5 protein]	24481447
C057693	troglitazone	troglitazone promotes the reaction [CDK5 protein results in increased phosphorylation of PPARG protein]	24481447
C057693	troglitazone	troglitazone results in increased phosphorylation of and results in increased activity of CDK5 protein	24481447
D014415	Tunicamycin	Tunicamycin results in decreased expression of CDK5 mRNA	22378314
D014635	Valproic Acid	Valproic Acid affects the expression of CDK5 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CDK5 mRNA	23179753\|2718838

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002039	p53 binding	-	IEA	-
GO:0004672	protein kinase activity	-	TAS	1639063 7834371
GO:0004674	protein serine/threonine kinase activity	-	IDA	20357208 21145489
GO:0004674	protein serine/threonine kinase activity	-	ISS	-
GO:0004674	protein serine/threonine kinase activity	-	NAS	28386764
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	-	IBA	21873635
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	-	TAS	-
GO:0005176	ErbB-2 class receptor binding	-	ISS	-
GO:0005515	protein binding	-	IPI	12223541 14521924 15689152 15890360 20133653 20559324 21220307 22078880 23455922 23602568 25416956 25852190 26871637 27107012
GO:0005524	ATP binding	-	IEA	-
GO:0008017	microtubule binding	NOT	TAS	17491008
GO:0016301	kinase activity	-	ISS	-
GO:0019901	protein kinase binding	-	IEA	-
GO:0030549	acetylcholine receptor activator activity	-	ISS	-
GO:0043125	ErbB-3 class receptor binding	-	ISS	-
GO:0046875	ephrin receptor binding	-	IEA	-
GO:0050321	tau-protein kinase activity	-	ISS	-
GO:0051879	Hsp90 protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000226	microtubule cytoskeleton organization	-	TAS	17491008
GO:0001764	neuron migration	-	TAS	21473899
GO:0001963	synaptic transmission, dopaminergic	-	IEA	-
GO:0006468	protein phosphorylation	-	IBA	21873635
GO:0006468	protein phosphorylation	-	TAS	17491008
GO:0006886	intracellular protein transport	-	IEA	-
GO:0006913	nucleocytoplasmic transport	-	IEA	-
GO:0007005	mitochondrion organization	-	IEA	-
GO:0007049	cell cycle	-	IEA	-
GO:0007160	cell-matrix adhesion	-	IEA	-
GO:0007268	chemical synaptic transmission	-	TAS	21473899
GO:0007409	axonogenesis	-	IBA	21873635
GO:0007416	synapse assembly	-	TAS	21473899
GO:0007519	skeletal muscle tissue development	-	IEA	-
GO:0008045	motor neuron axon guidance	-	IEA	-
GO:0008283	cell proliferation	-	TAS	8090221
GO:0008542	visual learning	-	IEA	-
GO:0009611	response to wounding	-	IEA	-
GO:0014044	Schwann cell development	-	IEA	-
GO:0016079	synaptic vesicle exocytosis	-	TAS	21473899
GO:0016192	vesicle-mediated transport	-	IBA	21873635
GO:0016241	regulation of macroautophagy	-	TAS	21499257
GO:0016310	phosphorylation	-	IDA	20357208
GO:0018105	peptidyl-serine phosphorylation	-	IDA	21145489
GO:0018105	peptidyl-serine phosphorylation	-	ISS	-
GO:0018107	peptidyl-threonine phosphorylation	-	ISS	-
GO:0019233	sensory perception of pain	-	IEA	-
GO:0021697	cerebellar cortex formation	-	IEA	-
GO:0021766	hippocampus development	-	IEA	-
GO:0021819	layer formation in cerebral cortex	-	IEA	-
GO:0021954	central nervous system neuron development	-	IEA	-
GO:0022038	corpus callosum development	-	IEA	-
GO:0030182	neuron differentiation	-	ISS	-
GO:0030182	neuron differentiation	-	TAS	21473899
GO:0030334	regulation of cell migration	-	IEA	-
GO:0030517	negative regulation of axon extension	-	IEA	-
GO:0030866	cortical actin cytoskeleton organization	-	IEA	-
GO:0031175	neuron projection development	-	ISS	-
GO:0031175	neuron projection development	-	TAS	17491008
GO:0031397	negative regulation of protein ubiquitination	-	IEA	-
GO:0031914	negative regulation of synaptic plasticity	-	IEA	-
GO:0032092	positive regulation of protein binding	-	IEA	-
GO:0032801	receptor catabolic process	-	IEA	-
GO:0034352	positive regulation of glial cell apoptotic process	-	IEA	-
GO:0035249	synaptic transmission, glutamatergic	-	IEA	-
GO:0035418	protein localization to synapse	-	IEA	-
GO:0042501	serine phosphorylation of STAT protein	-	IEA	-
GO:0042981	regulation of apoptotic process	-	TAS	21473899
GO:0043113	receptor clustering	-	IEA	-
GO:0043525	positive regulation of neuron apoptotic process	-	ISS	-
GO:0045786	negative regulation of cell cycle	-	IEA	-
GO:0045860	positive regulation of protein kinase activity	-	IEA	-
GO:0045861	negative regulation of proteolysis	-	IMP	24548080
GO:0045892	negative regulation of transcription, DNA-templated	-	IMP	20357208
GO:0045956	positive regulation of calcium ion-dependent exocytosis	-	IEA	-
GO:0046777	protein autophosphorylation	-	IEA	-
GO:0046826	negative regulation of protein export from nucleus	-	IEA	-
GO:0048148	behavioral response to cocaine	-	IEA	-
GO:0048167	regulation of synaptic plasticity	-	ISS	-
GO:0048167	regulation of synaptic plasticity	-	TAS	21473899 24607229
GO:0048488	synaptic vesicle endocytosis	-	TAS	21473899
GO:0048489	synaptic vesicle transport	-	IBA	21873635
GO:0048511	rhythmic process	-	IEA	-
GO:0048675	axon extension	-	TAS	21473899
GO:0048709	oligodendrocyte differentiation	-	IDA	18042622
GO:0048813	dendrite morphogenesis	-	IEA	-
GO:0051301	cell division	-	IEA	-
GO:0051402	neuron apoptotic process	-	IBA	21873635
GO:0051402	neuron apoptotic process	-	TAS	21473899
GO:0051966	regulation of synaptic transmission, glutamatergic	-	ISS	-
GO:0060079	excitatory postsynaptic potential	-	IEA	-
GO:0061001	regulation of dendritic spine morphogenesis	-	ISS	-
GO:0070509	calcium ion import	-	IEA	-
GO:0071156	regulation of cell cycle arrest	-	TAS	21473899
GO:0090314	positive regulation of protein targeting to membrane	-	IEA	-
GO:1901215	negative regulation of neuron death	-	IDA	24548080
GO:1903076	regulation of protein localization to plasma membrane	-	ISS	-
GO:1903421	regulation of synaptic vesicle recycling	-	NAS	22745285
GO:1904646	cellular response to amyloid-beta	-	ISS	-
GO:2000251	positive regulation of actin cytoskeleton reorganization	-	TAS	21473899
GO:2000273	positive regulation of signaling receptor activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	-
GO:0005634	nucleus	-	ISS	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	ISS	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005874	microtubule	colocalizes_with	ISS	-
GO:0005886	plasma membrane	-	IDA	-
GO:0014069	postsynaptic density	-	ISS	-
GO:0016020	membrane	-	ISS	-
GO:0016533	protein kinase 5 complex	-	IEA	-
GO:0030027	lamellipodium	-	IEA	-
GO:0030054	cell junction	-	IDA	-
GO:0030175	filopodium	-	IEA	-
GO:0030424	axon	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0030426	growth cone	-	ISS	-
GO:0031594	neuromuscular junction	-	ISS	-
GO:0043005	neuron projection	-	ISS	-
GO:0043025	neuronal cell body	-	ISS	-
GO:0043204	perikaryon	-	IEA	-
GO:0045211	postsynaptic membrane	-	IEA	-
GO:0098793	presynapse	-	IEA	-

KEGG ID	KEGG Term
hsa04360	Axon guidance
hsa05010	Alzheimer's disease

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-111885	Opioid Signalling	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-1266738	Developmental Biology	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1643685	Disease	IEA
R-HSA-166520	Signaling by NTRKs	IEA
R-HSA-180024	DARPP-32 events	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373755	Semaphorin interactions	IEA
R-HSA-373755	Semaphorin interactions	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-399956	CRMPs in Sema3A signaling	IEA
R-HSA-399956	CRMPs in Sema3A signaling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	TAS
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	IEA
R-HSA-8863678	Neurodegenerative Diseases	TAS
R-HSA-8863678	Neurodegenerative Diseases	IEA
R-HSA-9006115	Signaling by NTRK2 (TRKB)	IEA
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	IEA
R-HSA-9032845	Activated NTRK2 signals through CDK5	IEA
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16094620	Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia. (2005 Aug)	Zechel JL	Birth Defects Res B Dev Reprod Toxicol
15665076	Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. (2005 Feb 1)	Takahashi S	Proc Natl Acad Sci U S A
12637947	Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. (2003 May)	Ferrer-Alcon M	Neuropsychopharmacology
26377474	Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. (2015 Sep 16)	Li Y	J Neurosci
26640531	Protective effect of Xingnaojia formulation on rats with brain and liver damage caused by chronic alcoholism. (2015 Nov)	Li S	Exp Ther Med
27734601	Cocaine-induced synaptic structural modification is differentially regulated by dopamine D1 and D3 receptors-mediated signaling pathways. (2017 Nov)	Zhang L	Addict Biol
26248414	[Effects of polydatin on learning and memory and Cdk5 kinase activity in the hippocampus of rats with chronic alcoholism]. (2015 Mar)	Li XJ	Zhongguo Ying Yong Sheng Li Xue Za Zhi
11268215	Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. (2001 Mar 15)	Bibb JA	Nature
14749431	Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. (2004 Jan 28)	Morabito MA	J Neurosci
26019323	Role of DNA methylation in the nucleus accumbens in incubation of cocaine craving. (2015 May 27)	Massart R	J Neurosci
29354053	Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and DeltaFosB. (2017)	Hasbi A	Front Pharmacol
12706249	Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. (2003 Apr 25)	Peakman MC	Brain Res
23867772	Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? (2013 Oct 22)	Villalba RM	Neuroscience
22737920	[Effect of polydatin on expression of cdk5 in the prefrontal cortex of rats with chronic alcoholism]. (2012 Mar)	Xu CY	Zhongguo Ying Yong Sheng Li Xue Za Zhi
27056740	Pharmacological modulation of protein kinases as a new approach to treat addiction to cocaine and opiates. (2016 Jun 15)	Garcia-Pardo MP	Eur J Pharmacol
16899035	Neuroadaptations of Cdk5 in cholinergic interneurons of the nucleus accumbens and prefrontal cortex of inbred alcohol-preferring rats following voluntary alcohol drinking. (2006 Aug)	Camp MC	Alcohol Clin Exp Res