Gene: CDK6

1021
MCPH12|PLSTIRE
cyclin dependent kinase 6
protein-coding
7q21.2
Ensembl:ENSG00000105810 MIM:603368 Vega:OTTHUMG00000131697 UniprotKB:Q00534
NG_015888.1
PubMed
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.721e-1 (AD)  5.383e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07413467chr7:92238086CDK63.840e-8Maternal smoking in pregnancy27040690
cg15261712chr7:92238248CDK64.740e-8Maternal smoking in pregnancy27040690
cg07413467chr7:92238086CDK65.390e-8Maternal smoking in pregnancy27040690
cg07413467chr7:92238086CDK66.900e-15Smoking27651444
cg15261712chr7:92238248CDK66.900e-12Smoking27651444
cg25284397chr7:92238156CDK63.300e-10Smoking27651444
cg06688763chr7:92238207CDK66.200e-10Smoking27651444
cg19103429chr7:92460784CDK61.770e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZEB20.86
GAB20.853
MITF0.845
WNK10.844
CDK190.842
LACC10.839
SMARCC10.837
SLC44A10.837
ZNF3260.828
MAP4K40.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC29A4-0.44
NGB-0.416
CALB2-0.412
PRTN3-0.405
CUX2-0.381
SHISA8-0.378
CHRNA2-0.366
ZFPM1-0.357
CDH22-0.352
GRIN2D-0.351

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03496AlvocidibSmall Molecule146426-40-6Experimental|InvestigationalTarget
DB07379(2S)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-olSmall Molecule-ExperimentalTarget
DB077953,7,3',4'-TETRAHYDROXYFLAVONESmall MoleculeExperimentalTarget
DB09073PalbociclibSmall Molecule571190-30-2Approved|InvestigationalTarget
DB11730RibociclibSmall Molecule1211441-98-3Approved|InvestigationalTarget
DB12001AbemaciclibSmall Molecule1231929-97-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CDK6 mRNA"20195699
C478160(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane"Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CDK6 mRNA]"20195699
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CDK6 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of CDK6 mRNA]"27071940
C0449851',2'-dihydrorotenone"1',2'-dihydrorotenone results in decreased expression of CDK6 protein"24615755
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of CDK6 mRNA25596134
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CDK6 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDK6 mRNA"26988655
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in decreased expression of CDK6 protein"26451628
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of CDK6 mRNA"20702594
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
C0005892902-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone"2-hydroxy-1-(2-((9-(4-methylcyclohexyl)-9H-pyrido(4',3'-4,5)pyrrolo(2,3-d)pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone results in decreased activity of CDK6 protein"24526162
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in decreased expression of CDK6 protein"22290291|2251469
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CDK6 mRNA"28973690
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in decreased expression of CDK6 protein"19916542
C5810043-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile"3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of CDK6 protein"28834734
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone promotes the reaction [CDK6 protein binds to CCND1 protein]18805435
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK6 protein]"24646949
C5805985-OH-BDE-475-OH-BDE-47 results in increased expression of CDK6 mRNA26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in increased expression of CDK6 mRNA26988655
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of CDK6 mRNA"19936915
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of CDK6 protein"19936915
C0548527-hydroxystaurosporine7-hydroxystaurosporine results in decreased activity of CDK6 protein14653808
D000082AcetaminophenAcetaminophen results in decreased expression of CDK6 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of CDK6 mRNA17562736
C058956acteosideacteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]17634406
C058956acteosideacteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]17634406
C058956acteosideacteoside results in decreased expression of and results in decreased activity of CDK6 protein17634406
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of CDK6 mRNA25596134
C430898AGN 194204AGN 194204 results in decreased expression of CDK6 protein15318936
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDK6 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of CDK6 protein16483693
C023650anilineaniline results in increased expression of CDK6 protein21070798
D001151ArsenicArsenic affects the methylation of CDK6 gene25304211
D001151ArsenicArsenic results in increased expression of CDK6 mRNA20654705
D001151Arsenic[silybin co-treated with Arsenic] results in decreased expression of CDK6 protein25868784
C006632arsenic trioxidearsenic trioxide promotes the reaction [CDK6 protein binds to CDKN1A protein]10850458
C006632arsenic trioxidearsenic trioxide results in decreased activity of CDK6 protein10850458
C006632arsenic trioxide[arsenic trioxide results in decreased activity of CDK6 protein] which results in decreased phosphorylation of RB1 protein10850458
C006632arsenic trioxidearsenic trioxide results in decreased expression of and results in decreased activity of CDK6 protein12480548
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDK6 protein10850458
C015001arsenitearsenite results in increased methylation of CDK6 promoter23974009
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK6 protein]21621607
D001280AtrazineAtrazine results in decreased expression of CDK6 mRNA23358194
D001280AtrazineAtrazine results in decreased expression of CDK6 mRNA22378314
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK6 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK6 mRNA19770486|2156981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK6 mRNA"19150397|2001819
D001599BerberineBerberine results in decreased expression of CDK6 protein16505103
D004958EstradiolEstradiol results in increased expression of CDK6 mRNA23094148
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CDK6 mRNA26496021
C044887beta-methylcholinebeta-methylcholine affects the expression of CDK6 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CDK6 mRNA27998958
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CDK6 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of CDK6 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CDK6 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK6 mRNA28628672
C545990BMS 754807[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 75480724986516
C545990BMS 754807[[CDK4 mutant form co-treated with CDK6 mutant form] results in increased susceptibility to BMS 754807] which results in decreased phosphorylation of RPS6KB1 protein24986516
C026105butylidenephthalidebutylidenephthalide results in decreased expression of CDK6 protein16987298
C026105butylidenephthalidebutylidenephthalide results in decreased expression of CDK6 protein16987298
D020148Butyric AcidButyric Acid results in decreased expression of CDK6 mRNA19435910
D020148Butyric AcidButyric Acid results in decreased expression of CDK6 protein19435910
C584509C646 compoundC646 compound inhibits the reaction [BRD4 protein binds to CDK6 promoter]25982114
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDK6 mRNA25596134
D002193CantharidinCantharidin results in decreased expression of CDK6 protein27113412
D002220CarbamazepineCarbamazepine affects the expression of CDK6 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CDK6 mRNA17484886
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of CDK6 mRNA25596134
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of CDK6 mRNA26272509
C100187chloropicrinchloropicrin results in decreased expression of CDK6 mRNA26352163|2847649
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDK6 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CDK6 mRNA23940686
C074702chromium hexavalent ionAscorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CDK6 protein]21621607
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of CDK6 protein21621607
D004002Clodronic AcidClodronic Acid affects the expression of CDK6 mRNA25596134
D060729Coal AshCoal Ash results in increased expression of CDK6 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of CDK6 mRNA19320972
C055786columbaminecolumbamine results in decreased expression of CDK6 mRNA23124089
C055786columbaminecolumbamine results in decreased expression of CDK6 protein23124089
D003300CopperCopper results in increased expression of CDK6 mRNA24403277
D003300CopperCopper deficiency results in decreased expression of CDK6 mRNA17418555
D019327Copper SulfateCopper Sulfate results in decreased expression of CDK6 mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of CDK6 protein17209053
C030973cupric oxidecupric oxide results in decreased expression of CDK6 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of CDK6 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of CDK6 protein18156803
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of CDK6 mRNA28414124
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of CDK6 protein28414124
D016572CyclosporineCyclosporine results in decreased expression of CDK6 mRNA25562108|2559613
D000069439Dasatinib[NVP-AEW541 co-treated with Dasatinib] results in decreased expression of CDK6 protein20664932
C014347decitabinedecitabine results in increased expression of CDK6 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK6 mRNA28628672
D003907Dexamethasone"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK6 protein]"24646949
D003907Dexamethasone[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK6 protein24646949
D003976DiazinonDiazinon affects the expression of CDK6 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CDK6 mRNA27392435
D002945Cisplatin"Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CDK6 mRNA]"20195699
D002945CisplatinCisplatin results in decreased expression of CDK6 mRNA20195699|2559613
D004008DiclofenacDiclofenac affects the expression of CDK6 mRNA24752500
D004026DieldrinDieldrin affects the expression of CDK6 mRNA22546817
D004041Dietary FatsDietary Fats results in increased expression of CDK6 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of CDK6 mRNA]21852083
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CDK6 mRNA22129741
C010945embelinembelin results in decreased expression of CDK6 protein24694877
D004726EndosulfanEndosulfan results in decreased expression of CDK626714676
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of CDK6 protein23301498
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of CDK6 protein15142168
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDK6 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CDK6 mRNA17555576
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of CDK6 mRNA22711419
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CDK6 mRNA23649840
D005054EugenolEugenol results in decreased expression of CDK6 protein22686307
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDK6 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CDK6 mRNA23649840
C070081fulvestrantCDK6 affects the susceptibility to fulvestrant24169358
C070081fulvestrant[CDK6 affects the susceptibility to fulvestrant] which affects the expression of CCNA1 protein24169358
C070081fulvestrant[CDK6 affects the susceptibility to fulvestrant] which affects the phosphorylation of RB1 protein24169358
C070081fulvestrantfulvestrant results in increased expression of CDK6 protein24169358
D005664FurazolidoneFurazolidone results in increased expression of CDK6 mRNA23112108|2609581
D005664FurazolidoneFurazolidone results in increased expression of CDK6 protein23112108|2609581
D005664FurazolidoneGADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]26095818
D005664FurazolidoneGADD45A mutant form inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]26095818
D005664FurazolidoneSB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]23112108
D005664FurazolidoneSB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]23112108
C037032galangingalangin results in decreased expression of CDK6 protein25450235
C001277geldanamycingeldanamycin results in increased expression of CDK6 mRNA26705709
D019833GenisteinGenistein results in decreased expression of CDK6 mRNA22228119
C010974glyphosateglyphosate results in increased expression of CDK6 protein24073338
C568713GSK1210151AGSK1210151A results in decreased expression of CDK6 protein26254443
C538724HhAntag691HhAntag691 results in decreased expression of CDK6 mRNA24973920
D017313FenretinideFenretinide results in increased expression of CDK6 mRNA28973697
C403899HS 1030HS 1030 results in decreased expression of CDK6 protein15202011
C403900HS 1183HS 1183 results in decreased expression of CDK6 protein15202011
C503536HS-1199HS-1199 results in decreased expression of CDK6 protein15202011
C479128HS 1200HS 1200 results in decreased expression of CDK6 protein15202011
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of CDK6 mRNA19376150
D007052IbuprofenIbuprofen results in decreased expression of CDK6 mRNA25596134
C492448ICG 001ICG 001 results in increased expression of CDK6 mRNA26191083
D007069IfosfamideIfosfamide affects the expression of CDK6 mRNA25596134
D000068877Imatinib MesylateCDK6 protein results in decreased susceptibility to Imatinib Mesylate21536647
D000068877Imatinib MesylateCDK6 protein inhibits the reaction [Imatinib Mesylate results in increased expression of PAX5 mRNA]21536647
D000068877Imatinib MesylateCDK6 protein inhibits the reaction [Imatinib Mesylate results in increased expression of RAG2 mRNA]21536647
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [TCF3 protein binds to CDK6 promoter]21536647
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CDK6 mRNA21536647
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of CDK6 protein21536647
C016517indole-3-carbinolindole-3-carbinol analog inhibits the reaction [SP1 protein binds to CDK6 promoter]20570586
C016517indole-3-carbinolindole-3-carbinol analog results in decreased activity of CDK6 promoter18023427
C016517indole-3-carbinolindole-3-carbinol analog results in decreased activity of CDK6 protein20570586
C016517indole-3-carbinolindole-3-carbinol analog results in decreased expression of CDK6 mRNA18023427
C016517indole-3-carbinolindole-3-carbinol analog results in decreased expression of CDK6 protein20570586
C016517indole-3-carbinolindole-3-carbinol analog results in increased expression of CDK6 mRNA20570586
C016517indole-3-carbinolindole-3-carbinol results in decreased expression of CDK616082211
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CDK6 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK6 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK6 mRNA25613284
C506002ircinin-1ircinin-1 results in decreased expression of CDK6 mRNA16163705
C506002ircinin-1ircinin-1 results in decreased expression of CDK6 protein16163705
C051890irinotecanirinotecan analog affects the expression of CDK6 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of CDK6 mRNA28628672
D0150561-Methyl-3-isobutylxanthine"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK6 protein]"24646949
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CDK6 protein24646949
C036643isoeugenolisoeugenol results in decreased expression of CDK6 protein22686307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CDK6 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CDK6 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with panobinostat] results in decreased expression of CDK6 protein24435446
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to CDK6 promoter]24435446
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK6 protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDK6 mRNA23086925|2443544
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDK6 protein24435446|2505382
C561695(+)-JQ1 compoundponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]25053825
C561695(+)-JQ1 compoundquizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]25053825
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDK6 mRNA24973920|2598211
C410337K 7174K 7174 results in decreased expression of CDK6 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of CDK6 mRNA24967691
C500368labedipinedilol Alabedipinedilol A results in decreased expression of CDK6 protein19056458
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA16415329
C506643liposomal doxorubicinliposomal doxorubicin results in decreased expression of CDK6 protein27923599
C042720mercuric bromidemercuric bromide results in increased expression of CDK6 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
D008687MetforminMetformin results in increased expression of CDK6 mRNA25596134
D008694MethamphetamineMethamphetamine results in increased expression of CDK6 mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDK6 gene20938992
D008727MethotrexateMethotrexate results in increased expression of CDK6 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDK6 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CDK6 mRNA28001369
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDK6 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDK6 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CDK6 mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CDK6 protein24806433
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDK6 mRNA]12710931
C008493methylselenic acidmethylselenic acid promotes the reaction [CDKN2A protein binds to CDK6 protein]17847021
C008493methylselenic acidmethylselenic acid results in decreased activity of [CDKN2A protein binds to CDK6 protein]17847021
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CDK6 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDK6 mRNA"15585362
C022838nickel chloridenickel chloride affects the expression of CDK6 mRNA22546817
C029938nickel sulfatenickel sulfate results in decreased expression of CDK6 mRNA22714537
D009538NicotineNicotine promotes the reaction [CDK6 protein binds to CCND1 protein]18805435
D009538NicotineNicotine results in increased expression of CDK6 mRNA16949557
C501177NVP-AEW541[NVP-AEW541 co-treated with Dasatinib] results in decreased expression of CDK6 protein20664932
D010100OxygenOxygen deficiency results in increased expression of CDK6 mRNA25596134
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of MEF2D protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RB1 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of RBL2 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of SENP3 protein]22094256
C500026palbociclibpalbociclib inhibits the reaction [[CDK6 protein binds to CCND3 protein] which results in increased phosphorylation of ZEB1 protein]22094256
C500026palbociclibpalbociclib results in increased expression of CDK6 protein20473330|2286955
C500026palbociclib[CDKN2A gene mutant form results in increased expression of CDK6 protein] which results in increased susceptibility to palbociclib24098593
C500026palbociclibpalbociclib analog results in decreased activity of CDK6 protein15542782
C500026palbociclibpalbociclib results in decreased expression of CDK622508966
C482884panduratin Apanduratin A results in decreased expression of CDK6 protein16497706
C496932panobinostat[(+)-JQ1 compound co-treated with panobinostat] results in decreased expression of CDK6 protein24435446
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of CDK6 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CDK6 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CDK6 mRNA26272509
C008922piperinepiperine inhibits the reaction [IL2 protein results in increased expression of CDK6 protein]25655587
C498077piperlongumininepiperlonguminine results in decreased expression of CDK6 protein29109039
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDK6 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of CDK6 protein15930460|2467777
D010936Plant ExtractsPlant Extracts results in increased expression of CDK6 mRNA23557933
C108953platycodin Dplatycodin D results in decreased expression of CDK6 protein28711525
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CDK6 mRNA24583197
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CDK6 protein24583197
C545373ponatinib(+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]25053825
C545373ponatinibponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]25053825
C545373ponatinibponatinib results in decreased expression of CDK6 protein25053825
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDK6 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDK6 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDK6 protein23718831
D011192Potassium DichromatePotassium Dichromate results in increased expression of CDK6 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of CDK6 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CDK6 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of CDK6 mRNA23727915
D011794QuercetinQuercetin results in decreased expression of CDK6 protein25293876
C544967quizartinib(+)-JQ1 compound promotes the reaction [quizartinib results in decreased expression of CDK6 protein]25053825
C544967quizartinibquizartinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein]25053825
C544967quizartinibquizartinib results in decreased expression of CDK6 protein25053825
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA16415329
C059514resveratrolresveratrol results in decreased expression of CDK6 mRNA23750556
C059514resveratrolresveratrol results in decreased expression of CDK6 protein16761963|1834718
C059514resveratrolresveratrol results in decreased expression of CDK6 protein15122319
C059514resveratrolresveratrol results in increased expression of CDK6 protein25505154
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of CDK6 mRNA]21852083
D019438RitonavirRitonavir results in decreased expression of CDK6 mRNA19386116
D019438RitonavirRitonavir results in decreased expression of CDK6 protein16551874
C089730rosiglitazonerosiglitazone results in decreased expression of CDK6 mRNA25596134
C085746rottlerin[sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein16959960
C039961S-(1,2-dichlorovinyl)cysteine"S-(1,2-dichlorovinyl)cysteine results in increased expression of CDK6 protein"16495211
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of CDK6 mRNA21427059
C093642SB 203580SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 mRNA]23112108
C093642SB 203580SB 203580 inhibits the reaction [Furazolidone results in increased expression of CDK6 protein]23112108
C440975silybin[silybin co-treated with Arsenic] results in decreased expression of CDK6 protein25868784
C017947sodium arsenitesodium arsenite results in decreased expression of CDK6 mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased expression of CDK6 protein20336670
C471405sorafenib[sorafenib co-treated with rottlerin] results in decreased expression of CDK6 protein16959960
C471405sorafenibsorafenib results in decreased expression of CDK6 protein16959960
D013467SulindacSulindac results in decreased expression of CDK6 protein16488075
D013629TamoxifenTamoxifen affects the expression of CDK6 mRNA17555576
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of CDK6 mRNA26496021
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of CDK6 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDK6 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK6 mRNA20702594|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDK6 mRNA19933214
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CDK6 protein24073338
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK6 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of CDK6 mRNA27188386
C483909torcetrapibtorcetrapib results in increased expression of CDK6 mRNA23228038
D014212TretinoinTretinoin results in increased expression of CDK6 mRNA21934132
D014212TretinoinTretinoin inhibits the reaction [FGF2 protein results in increased expression of CDK6 mRNA]11675954
D014212TretinoinTretinoin results in decreased expression of CDK6 protein11675954
D014241TrichloroethyleneTrichloroethylene results in increased expression of CDK6 mRNA15363585
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of CDK6 mRNA17905399
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CDK6 mRNA23770000
C012589trichostatin Atrichostatin A results in increased expression of CDK6 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CDK6 mRNA19042947
C001899triptolidetriptolide results in increased expression of CDK6 protein26990902
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDK6 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CDK6 mRNA19140230
C046243tryptanthrinetryptanthrine results in decreased expression of CDK6 protein23500671
D014415TunicamycinTunicamycin results in decreased expression of CDK6 mRNA17127020
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDK6 mRNA]12710931
C113580U 0126U 0126 results in decreased expression of CDK6 mRNA21536647
C073339usnic acidusnic acid results in decreased expression of CDK6 protein27369375
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CDK6 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of CDK6 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of CDK6 mRNA24383497|2493525
D014635Valproic AcidValproic Acid results in decreased expression of CDK6 mRNA21427059
D014639VanadiumVanadium results in increased expression of CDK6 mRNA19000753
D014640VancomycinVancomycin results in decreased expression of CDK6 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of CDK6 mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDK6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CDK6 mRNA26272509
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of CDK6 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IDA8114739  
GO:0005515protein binding-IPI8001816  8078588  8741839  8840966  9150368  9751050  
15232106  17353931  17431401  17517622  17909018  17955473  
18394558  21516116  22094256  22939624  23602568  24855949  
25036637  25241761  25416956  25910212  27107012  
GO:0005524ATP binding-IDA9751050  
GO:0030332cyclin binding-IPI8114739  
GO:0098770FBXO family protein binding-IPI18495667  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-TAS16294322  
GO:0001954positive regulation of cell-matrix adhesion-IDA10205165  
GO:0003323type B pancreatic cell development-IDA20668294  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IDA8114739  
GO:0007050cell cycle arrest-TAS16294322  
GO:0008285negative regulation of cell proliferation-TAS16294322  
GO:0009615response to virus-IEP16548883  
GO:0010468regulation of gene expression-IDA15254224  
GO:0010468regulation of gene expression-IMP17420273  
GO:0014002astrocyte development-ISS16767702  
GO:0021542dentate gyrus development-ISS21319271  
GO:0021670lateral ventricle development-ISS21319271  
GO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0042063gliogenesis-IMP12861051  
GO:0043697cell dedifferentiation-IMP12861051  
GO:0045596negative regulation of cell differentiation-TAS16294322  
GO:0045638negative regulation of myeloid cell differentiation-IDA17431401  
GO:0045646regulation of erythrocyte differentiation-IMP12833137  
GO:0045656negative regulation of monocyte differentiation-IDA26542173  
GO:0045668negative regulation of osteoblast differentiation-IDA15254224  
GO:0045786negative regulation of cell cycle-IDA14985467  
GO:0048146positive regulation of fibroblast proliferation-IMP17420273  
GO:0048699generation of neurons-ISS21319271  
GO:0050680negative regulation of epithelial cell proliferation-IMP14985467  
GO:0051301cell division-IEA-  
GO:2000145regulation of cell motility-ISS16767702  
GO:2000773negative regulation of cellular senescence-IDA17420273  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IDA17420273  
GO:0001726ruffle-IDA10205165  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA14985467  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA14985467  
GO:0005813centrosome-IDA23918663  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05214Glioma
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8934593Regulation of RUNX1 Expression and ActivityTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28672917Downregulation of P16 promotes cigarette smoke extract-induced vascular smooth muscle cell proliferation via preventing G1/S phase transition. (2017 Jul)Guo TExp Ther Med
16584776Cigarette tar phenols impede T cell cycle progression by inhibiting cyclin-dependent kinases. (2007 Jan)Frazer-Abel AAMol Immunol
18361427Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. (2008 Jun)Ye YCancer
23644744Imputation-based association analyses identify new lung cancer susceptibility variants in CDK6 and SH3RF1 and their interactions with smoking in Chinese populations. (2013 Sep)Deng QCarcinogenesis
12185599A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. (2002 Aug 29)Zhang ZOncogene
20439292Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)van der Helm-van Mil AHAnn Rheum Dis