Gene: OLIG2

10215
BHLHB1|OLIGO2|PRKCBP2|RACK17|bHLHe19
oligodendrocyte transcription factor 2
protein-coding
21q22.11
Ensembl:ENSG00000205927 MIM:606386 Vega:OTTHUMG00000065032 UniprotKB:Q13516
NG_011834.1
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.646e-1 (AD)  2.478e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX80.869
OLIG10.837
HIP1R0.788
SOX100.777
CMTM50.773
SNX220.769
CHADL0.764
MARCKSL10.76
NKX2-20.758
COL9A20.752

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.475
OR4F29-0.441
C16orf47-0.341
FAM20A-0.313
PTGS2-0.311
CDCP1-0.305
TXK-0.294
CD163L1-0.293
HRH2-0.289
PLA2G4A-0.289

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of OLIG2 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to OLIG2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to OLIG2 protein]26598702
D019342Acetic AcidAcetic Acid results in decreased expression of OLIG2 protein21296659
D020106AcrylamideAcrylamide affects the expression of OLIG2 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of OLIG2 mRNA21298039
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to OLIG2 protein]26598702
C015001arsenitearsenite results in increased methylation of OLIG2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of OLIG2 mRNA25929836
C006780bisphenol Abisphenol A affects the methylation of OLIG2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of OLIG2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of OLIG2 gene28505145
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of OLIG2 protein21296659
D002220CarbamazepineCarbamazepine affects the expression of OLIG2 mRNA25979313
C054133casticincasticin results in decreased expression of OLIG2 mRNA27862857
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OLIG2 gene20938992
C423222cotylenin Acotylenin A results in increased expression of OLIG2 mRNA16129123
D003471CuprizoneCuprizone results in decreased expression of OLIG2 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of OLIG2 mRNA26577399|2752363
C000541cyclopaminecyclopamine results in decreased expression of OLIG2 mRNA22265815
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of OLIG2 mRNA23640034
C014347decitabinedecitabine affects the expression of OLIG2 mRNA23300844
D002945CisplatinCisplatin affects the expression of OLIG2 mRNA23300844
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of OLIG2 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate affects the expression of OLIG2 mRNA26924002
C012301domoic aciddomoic acid results in decreased expression of OLIG2 mRNA18936300
D005472FluorouracilFluorouracil results in decreased expression of OLIG2 mRNA25178657
D005472FluorouracilFluorouracil results in decreased expression of OLIG2 protein21296659
D005472Fluorouracil[HDAC1 protein co-treated with HDAC2 protein] promotes the reaction [TCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]]25178657
D005472FluorouracilTCF7L2 protein inhibits the reaction [Fluorouracil results in decreased expression of OLIG2 mRNA]25178657
D005473FluoxetineFluoxetine results in increased expression of OLIG2 mRNA20857517
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OLIG2 gene20938992
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of OLIG2 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of OLIG2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of OLIG2 mRNA22555245
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of OLIG2 mRNA22555245
C517284monomethyl phthalatemonomethyl phthalate affects the expression of OLIG2 mRNA26924002
C568376MT19c compoundMT19c compound results in decreased expression of OLIG2 mRNA21781307
D010936Plant ExtractsPlant Extracts results in decreased expression of OLIG2 mRNA23557933
C043680ptaquilosideptaquiloside results in increased expression of OLIG2 mRNA23274088
D018038Sodium SeleniteSodium Selenite results in increased expression of OLIG2 mRNA23274088
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of OLIG2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OLIG2 mRNA24058054
D013792ThalidomideThalidomide results in increased expression of OLIG2 mRNA26217789
D014212Tretinoin[Tretinoin co-treated with SHH protein] results in increased expression of OLIG2 protein15996115
C012589trichostatin Atrichostatin A results in decreased expression of OLIG2 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of OLIG2 mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of OLIG2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of OLIG2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of OLIG2 mRNA28001369
C111237vorinostatvorinostat results in decreased expression of OLIG2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO:0071837HMG box domain binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0021522spinal cord motor neuron differentiation-IEA-  
GO:0021530spinal cord oligodendrocyte cell fate specification-IEA-  
GO:0021794thalamus development-IEA-  
GO:0042552myelination-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0048663neuron fate commitment-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24667898Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. (2015)Kim ABrain Struct Funct
25732140Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. (2015 May 7)Navarro AINeuroscience