Gene: KLRG1

10219
2F1|CLEC15A|MAFA|MAFA-2F1|MAFA-L|MAFA-LIKE
killer cell lectin like receptor G1
protein-coding
12p13.31
Ensembl:ENSG00000139187 MIM:604874 Vega:OTTHUMG00000168277 UniprotKB:Q96E93
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
7.224e-1 (AD)  9.108e-1 (ND)   (Frontal_Cortex)
6.627e-1 (AD)  8.684e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHORDC10.705
RBM40.693
AHSA10.683
STIP10.671
NUDT90.666
HSPA40.665
SPR0.664
PPID0.663
C10orf1110.662
GOLPH3L0.661

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENDOU-0.472
CCT6B-0.447
CD38-0.44
TMEM220-0.433
OPLAH-0.426
ADHFE1-0.418
PBLD-0.416
SLC25A35-0.413
CD109-0.412
ALDH1L1-AS2-0.412

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of KLRG1 mRNA"20959002
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of KLRG1 mRNA"20959002
D000082AcetaminophenAcetaminophen results in increased expression of KLRG1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLRG1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLRG1 mRNA16483693
C547126AZM551248AZM551248 results in increased expression of KLRG1 mRNA22323515
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of KLRG1 mRNA19737606
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of KLRG1 mRNA26377693
C044887beta-methylcholinebeta-methylcholine affects the expression of KLRG1 mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of KLRG1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of KLRG1 mRNA25181051
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of KLRG1 mRNA28628672
D005557FormaldehydeFormaldehyde results in increased expression of KLRG1 mRNA24304932
C039281furanfuran results in increased expression of KLRG1 mRNA25539665
D005839GentamicinsGentamicins results in increased expression of KLRG1 mRNA22061828
C010176halofuginonehalofuginone results in increased expression of KLRG1 mRNA17180598
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of KLRG1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLRG1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of KLRG1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLRG1 mRNA23086925
C045463leflunomideleflunomide results in decreased expression of KLRG1 mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of KLRG1 mRNA18192897
D009151Mustard GasMustard Gas results in increased expression of KLRG1 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of KLRG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of KLRG1 mRNA"25554681
D009532NickelNickel affects the expression of KLRG1 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of KLRG1 mRNA]14575637
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of KLRG1 mRNA19162173
C045950propiconazolepropiconazole results in increased expression of KLRG1 mRNA16643972
C005556propionaldehydepropionaldehyde results in increased expression of KLRG1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLRG1 mRNA25895662
C446685systhanesysthane results in increased expression of KLRG1 mRNA16643972
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLRG1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KLRG1 mRNA25613284
D014212TretinoinTretinoin results in decreased expression of KLRG1 mRNA16604517
C032910triadimefontriadimefon results in increased expression of KLRG1 mRNA16643972
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of KLRG1 mRNA]14575637
D014303TrinitrotolueneTrinitrotoluene affects the expression of KLRG1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KLRG1 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of KLRG1 mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of KLRG1 mRNA24136188
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KLRG1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  25416956  
GO:0030246carbohydrate binding-IEA-  
GO:0038023signaling receptor activity-TAS9765598  
GO ID GO Term Qualifier Evidence PubMed
GO:0006954inflammatory response-TAS9842918  
GO:0006968cellular defense response-TAS9842918  
GO:0007166cell surface receptor signaling pathway-TAS9842918  
GO:0045087innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26894484PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. (2016 May)Aiello AEPsychoneuroendocrinology