Gene info: ID 1022

Gene: CDK7

GENE ID: 1022

Synonyms: CAK|CAK1|CDKN7|HCAK|MO15|STK1|p39MO15

Description: cyclin dependent kinase 7

Gene type: protein-coding

Location: 5q13.2

dbXrefs: Ensembl:ENSG00000134058 MIM:601955 Vega:OTTHUMG00000099358 UniprotKB:P50613

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.984e-1 (AD) 6.571e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PSMA1	0.939
CDC123	0.936
CCT8	0.932
PSMC1	0.93
MED6	0.927
GARS	0.925
MED19	0.925
RTCA	0.924
COPS3	0.924
PSMA5	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.608
OR4F29	-0.558
MTRNR2L6	-0.38
MTRNR2L9	-0.372
MTRNR2L10	-0.358
KLRB1	-0.344
P2RY14	-0.332
ASB4	-0.321
CTNNA3	-0.316
TRPV5	-0.316

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02482	Phosphonothreonine	Small Molecule		Experimental	Target
DB03496	Alvocidib	Small Molecule	146426-40-6	Experimental\|Investigational	Target
DB05969	SNS-032	Small Molecule	345627-80-7	Investigational	Target
DB06195	Seliciclib	Small Molecule	186692-46-6	Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDK7 mRNA"	26988655
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDK7 protein"	26988655
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of CDK7 mRNA"	21346803
C527793	3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane	"3-methyl-9-(2-oxa-2lambda(5)-2H-1,3,2-oxazaphosphorine-2-cyclohexyl)-3,6,9-triazaspiro(5.5)undecane results in decreased expression of CDK7 protein"	18176113
C580598	5-OH-BDE-47	5-OH-BDE-47 results in increased expression of CDK7 protein	26988655
C580599	6-OH-BDE-47	6-OH-BDE-47 results in increased expression of CDK7 protein	26988655
C121707	7,3'-dihydroxy-4'-methoxyisoflavone	"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CDK7 mRNA"	24455688
C553817	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of CDK7 mRNA"	19936915
C559145	7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine	"7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine results in decreased activity of CDK7 protein"	21417417
D000082	Acetaminophen	Acetaminophen affects the expression of CDK7 mRNA	25704631
D000082	Acetaminophen	Acetaminophen results in decreased expression of CDK7 mRNA	21807079
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CDK7 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CDK7 mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CDK7 mRNA	16483693
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of CDK7 protein	16483693
D001151	Arsenic	Arsenic promotes the reaction [ERCC2 protein binds to and results in decreased activity of CDK7 protein]	24473091
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of CDK7 mRNA"	17331233
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK7 mRNA"	19150397\|2038263
D004958	Estradiol	Estradiol results in increased expression of and results in increased activity of CDK7 protein	9705214
D004958	Estradiol	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of and results in increased activity of CDK7 protein]	9705214
C006780	bisphenol A	bisphenol A affects the expression of CDK7 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CDK7 mRNA	29275510
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDK7 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of CDK7 mRNA	12233820
C006780	bisphenol A	bisphenol A affects the expression of CDK7 mRNA	21786754
D002220	Carbamazepine	Carbamazepine affects the expression of CDK7 mRNA	24752500
D002235	Carbofuran	CDK7 gene SNP affects the susceptibility to Carbofuran	22102698
C100187	chloropicrin	chloropicrin results in increased expression of CDK7 mRNA	26352163
D002746	Chlorpromazine	Chlorpromazine analog results in increased expression of CDK7 mRNA	15924885
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in decreased expression of CDK7 protein	20931265
D019327	Copper Sulfate	Copper Sulfate results in increased expression of CDK7 mRNA	19549813
D003474	Curcumin	Curcumin analog results in decreased expression of CDK7 mRNA	26409325
D016572	Cyclosporine	Cyclosporine results in increased expression of CDK7 mRNA	20106945\|2556210
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of CDK7 mRNA	23726867
C014347	decitabine	decitabine results in increased expression of CDK7 mRNA	27915011
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDK7 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CDK7 mRNA	21266533
D002945	Cisplatin	CDK7 results in decreased susceptibility to Cisplatin	22006019
D004008	Diclofenac	Diclofenac affects the expression of CDK7 mRNA	24752500
C000944	dicrotophos	dicrotophos results in decreased expression of CDK7 mRNA	28302478
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA	15784690
D005485	Flutamide	Flutamide results in increased expression of CDK7 mRNA	24136188
D006046	Gold	[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA	19695318
D017313	Fenretinide	Fenretinide results in decreased expression of CDK7 mRNA	28973697
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of CDK7 mRNA	19376150
C492448	ICG 001	ICG 001 results in decreased expression of CDK7 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDK7 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK7 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CDK7 mRNA	28628672
C410337	K 7174	K 7174 results in increased expression of CDK7 mRNA	24086573
C000589248	LL-202	LL-202 results in decreased expression of CDK7 protein	24752227
C015329	lycopene	lycopene results in decreased expression of CDK7 protein	17337101
D008345	Manganese	Manganese results in increased expression of CDK7 mRNA	18284614
D008713	Methimazole	Methimazole results in decreased expression of CDK7 mRNA	17403546
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CDK7 mRNA	26011545
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of CDK7 mRNA	20886546
C005246	myristicin	myristicin results in increased expression of CDK7 mRNA	24792648
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CDK7 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CDK7 mRNA"	25554681
C051752	nefazodone	nefazodone results in increased expression of CDK7 mRNA	24136188
C475587	olomoucine II	olomoucine II results in decreased activity of CDK7 protein	16003486
D017239	Paclitaxel	CDK7 protein affects the reaction [Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]]	14646529
D017239	Paclitaxel	Paclitaxel results in increased activity of CDK7 protein	14646529
C500026	palbociclib	palbociclib results in increased expression of CDK7 mRNA	24606660
C494474	perchlorate	perchlorate results in decreased expression of CDK7 mRNA	17403546
D010634	Phenobarbital	Phenobarbital affects the expression of CDK7 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of CDK7 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of CDK7 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of CDK7 mRNA	16940010
D011092	Polyethylene Glycols	[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA	19695318
D011374	Progesterone	Progesterone results in increased expression of CDK7 mRNA	23012394\|2301818
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CDK7 mRNA	17403546
D011794	Quercetin	Quercetin results in increased expression of CDK7 mRNA	25862958
C547185	riccardin D	riccardin D results in increased expression of CDK7 mRNA	24069304
C089730	rosiglitazone	rosiglitazone results in decreased expression of CDK7 mRNA	17639046
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of CDK7 mRNA	16705456
D014284	Triiodothyronine	Triiodothyronine results in increased expression of CDK7 mRNA	17403546
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of and results in increased activity of CDK7 protein]	9705214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of CDK7 protein	9705214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDK7 mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CDK7 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of CDK7 protein	24648495
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in decreased expression of CDK7 protein	20931265
C012589	trichostatin A	trichostatin A affects the expression of CDK7 mRNA	28542535
C001899	triptolide	triptolide results in increased expression of CDK7 mRNA	23639586
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CDK7 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in increased expression of CDK7 mRNA	17127020
D014520	Urethane	Urethane results in increased expression of CDK7 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of CDK7 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDK7 mRNA	22580532
D014638	Vanadates	Vanadates results in increased expression of CDK7 mRNA	22714537
C066075	vanadium pentoxide	vanadium pentoxide results in decreased expression of CDK7 mRNA	17459161
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CDK7 gene	25560391
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA	15784690

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003713	transcription coactivator activity	-	NAS	15572661
GO:0004672	protein kinase activity	-	TAS	7533895
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	15530371 16327805 23393140 23397142 23455922
GO:0005524	ATP binding	-	IEA	-
GO:0008022	protein C-terminus binding	-	IPI	10801852
GO:0008094	DNA-dependent ATPase activity	-	IDA	9852112
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	-	IDA	9852112 12721286
GO:0016301	kinase activity	-	TAS	-
GO:0050681	androgen receptor binding	-	NAS	15572661

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	-	TAS	7533895
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	-
GO:0006363	termination of RNA polymerase I transcription	-	TAS	-
GO:0006366	transcription by RNA polymerase II	-	IDA	9852112
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0006370	7-methylguanosine mRNA capping	-	TAS	-
GO:0006468	protein phosphorylation	-	IBA	21873635
GO:0006468	protein phosphorylation	-	IEA	-
GO:0007050	cell cycle arrest	-	TAS	15876871
GO:0008283	cell proliferation	-	TAS	7533895
GO:0030521	androgen receptor signaling pathway	-	NAS	15572661
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	-
GO:0045893	positive regulation of transcription, DNA-templated	-	NAS	15572661
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	8692841
GO:0050821	protein stabilization	-	IMP	23393140
GO:0051301	cell division	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	16109376
GO:0005654	nucleoplasm	-	TAS	-
GO:0005675	holo TFIIH complex	-	IDA	9852112
GO:0005737	cytoplasm	-	IBA	21873635
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	-	IMP	23393140
GO:0048471	perinuclear region of cytoplasm	-	IEA	-
GO:0070985	TFIIK complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa03420	Nucleotide excision repair
hsa04110	Cell cycle

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-113418	Formation of the Early Elongation Complex	TAS
R-HSA-162587	HIV Life Cycle	IEA
R-HSA-162599	Late Phase of HIV Life Cycle	IEA
R-HSA-162906	HIV Infection	IEA
R-HSA-1640170	Cell Cycle	TAS
R-HSA-1643685	Disease	IEA
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	IEA
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	IEA
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	IEA
R-HSA-167161	HIV Transcription Initiation	IEA
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	IEA
R-HSA-167169	HIV Transcription Elongation	IEA
R-HSA-167172	Transcription of the HIV genome	IEA
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	IEA
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5663205	Infectious disease	IEA
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	TAS
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	IEA
R-HSA-69202	Cyclin E associated events during G1/S transition	TAS
R-HSA-69206	G1/S Transition	TAS
R-HSA-69231	Cyclin D associated events in G1	TAS
R-HSA-69236	G1 Phase	TAS
R-HSA-69242	S Phase	TAS
R-HSA-69273	Cyclin A/B1/B2 associated events during G2/M transition	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	TAS
R-HSA-72086	mRNA Capping	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	TAS
R-HSA-73772	RNA Polymerase I Promoter Escape	TAS
R-HSA-73776	RNA Polymerase II Promoter Escape	TAS
R-HSA-73777	RNA Polymerase I Chain Elongation	TAS
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	TAS
R-HSA-73854	RNA Polymerase I Promoter Clearance	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-73863	RNA Polymerase I Transcription Termination	TAS
R-HSA-73864	RNA Polymerase I Transcription	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75953	RNA Polymerase II Transcription Initiation	TAS
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	TAS
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
17707548	Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. (2007 Nov)	Li Y	Lung Cancer