Gene: GDF11

10220
BMP-11|BMP11
growth differentiation factor 11
protein-coding
12q13.2
Ensembl:ENSG00000135414 MIM:603936 Vega:OTTHUMG00000170188 UniprotKB:O95390
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.075e-1 (AD)  5.352e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22950598chr12:56139862GDF111.500e-10Smoking27651444
cg22950598chr12:56139862GDF113.370e-10Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MTSS1L0.792
CDK2AP10.749
TFDP10.688
ZBTB470.664
VEGFB0.656
WSCD10.655
ZNF8530.654
MT-ND4L0.648
OLFM20.646
DIO20.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.503
OR4F5-0.473
DLX4-0.382
MYBPHL-0.377
CLEC4F-0.348
OR52N4-0.345
CCR6-0.339
C5orf34-0.337
LAIR2-0.336
CDH3-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GDF11 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of GDF11 mRNA"23829299
D000082AcetaminophenAcetaminophen affects the expression of GDF11 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of GDF11 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GDF11 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of GDF11 mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of GDF11 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GDF11 mRNA16483693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GDF11 mRNA18164116
D004958EstradiolEstradiol affects the expression of GDF11 mRNA23557687
C006780bisphenol Abisphenol A affects the expression of GDF11 mRNA21786754|2355768
C006780bisphenol Abisphenol A results in decreased expression of GDF11 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GDF11 gene28505145
D002746ChlorpromazineChlorpromazine affects the expression of GDF11 mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of GDF11 mRNA24386269
D003300CopperCopper results in decreased expression of GDF11 mRNA21892792
D003471CuprizoneCuprizone results in decreased expression of GDF11 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of GDF11 mRNA25064622
C014347decitabinedecitabine results in increased expression of GDF11 mRNA27915011
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GDF11 mRNA18164116
D004237DiuronDiuron results in increased expression of GDF11 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GDF11 mRNA25064622
C039281furanfuran results in increased expression of GDF11 mRNA25539665
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of GDF11 mRNA23430699|2479639
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GDF11 mRNA23649840
D009966OrphenadrineOrphenadrine affects the expression of GDF11 mRNA23665939
D010269ParaquatParaquat affects the expression of GDF11 mRNA25064622
C100128phenmediphamphenmedipham results in decreased expression of GDF11 mRNA21892792
C005556propionaldehydepropionaldehyde results in increased expression of GDF11 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of GDF11 mRNA24780913
D011794QuercetinQuercetin results in increased expression of GDF11 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GDF11 mRNA26377647
D013752TetracyclineTetracycline affects the expression of GDF11 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of GDF11 mRNA25064622
D014212TretinoinTretinoin results in increased expression of GDF11 mRNA17196394
C012589trichostatin Atrichostatin A affects the expression of GDF11 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GDF11 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of GDF11 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of GDF11 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GDF11 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-IBA21873635  
GO:0005160transforming growth factor beta receptor binding-IBA21873635  
GO:0005515protein binding-IPI18596030  28257634  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS10391213  
GO:0001656metanephros development-IEA-  
GO:0001657ureteric bud development-IEA-  
GO:0007399nervous system development-TAS10075854  
GO:0007498mesoderm development-TAS10075854  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation-IBA21873635  
GO:0021512spinal cord anterior/posterior patterning-IEA-  
GO:0031016pancreas development-IEA-  
GO:0042981regulation of apoptotic process-IBA21873635  
GO:0043408regulation of MAPK cascade-IBA21873635  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0048468cell development-IBA21873635  
GO:0048469cell maturation-IEA-  
GO:0048593camera-type eye morphogenesis-IEA-  
GO:0060021roof of mouth development-IEA-  
GO:0060395SMAD protein signal transduction-IBA21873635  
GO:0060395SMAD protein signal transduction-IMP28257634  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005615extracellular space-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0032991protein-containing complex-IDA24019467  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27980621Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients. (2016)Radkowski PBMC Proc