Gene: TRIB1

10221
C8FW|GIG-2|GIG2|SKIP1|TRB-1|TRB1
tribbles pseudokinase 1
protein-coding
8q24.13
Ensembl:ENSG00000173334 MIM:609461 Vega:OTTHUMG00000165007 UniprotKB:Q96RU8
NC_000008.11
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.715e-1 (AD)  9.245e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22644321chr8:126446923TRIB15.550e-12Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MIDN0.76
AXL0.657
ARHGEF400.645
CSRNP10.64
SPRY20.639
PLEKHO20.636
SLC3A20.633
SLC7A100.629
EFNB10.627
PLCB30.627

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGEE2-0.359
OR4F5-0.35
RSPO3-0.342
KCNH6-0.339
SOSTDC1-0.332
FBXO40-0.328
TLL2-0.318
MCF2-0.317
CIDEA-0.315
MC4R-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TRIB1 mRNA"26377693
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TRIB1 mRNA28329830
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of TRIB1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of TRIB1 mRNA"19095052
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of TRIB1 mRNA"21920950
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of TRIB1 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TRIB1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TRIB1 mRNA"21346803
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene affects the expression of TRIB1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TRIB1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in increased expression of TRIB1 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of TRIB1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of TRIB1 mRNA17562736
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRIB1 mRNA22129741
D020106AcrylamideAcrylamide results in decreased expression of TRIB1 mRNA28959563
C016601afimoxifeneTRIB1 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TRIB1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRIB1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRIB1 mRNA19770486
D000393Air PollutantsAir Pollutants results in increased expression of TRIB1 mRNA23649983
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TRIB1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TRIB1 mRNA24449571
D001151ArsenicArsenic affects the expression of TRIB1 mRNA25304211
D001151ArsenicArsenic affects the methylation of TRIB1 gene25304211
C015001arsenitearsenite results in decreased methylation of TRIB1 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TRIB1 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of TRIB1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of TRIB1 mRNA22378314
D001374AzacitidineAzacitidine results in decreased expression of TRIB1 mRNA19194470
D001379AzathioprineAzathioprine results in increased expression of TRIB1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRIB1 mRNA20064835|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TRIB1 mRNA"26238291
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of TRIB1 mRNA20404318
D004958EstradiolEstradiol results in decreased expression of TRIB1 mRNA19167446
D004958EstradiolEstradiol results in increased expression of TRIB1 mRNA20106945
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIB1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of TRIB1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of TRIB1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TRIB1 mRNA15336504
D002104CadmiumCadmium results in decreased expression of TRIB1 mRNA24376830
C100187chloropicrinchloropicrin results in increased expression of TRIB1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRIB1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of TRIB1 mRNA19320972
D003042CocaineCocaine affects the expression of TRIB1 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of TRIB1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TRIB1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of TRIB1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of TRIB1 mRNA20106945|2163298
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIB1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TRIB1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TRIB1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TRIB1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TRIB1 mRNA27392435|2759478
D004041Dietary FatsDietary Fats results in increased expression of TRIB1 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of TRIB1 mRNA18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRIB1 mRNA]18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRIB1 mRNA]18691550
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRIB1 mRNA22129741
D002117CalcitriolCalcitriol results in increased expression of TRIB1 mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of TRIB1 mRNA17547211
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of TRIB1 mRNA23999411
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of TRIB1 mRNA"23811387
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TRIB1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TRIB1 mRNA23649840
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of TRIB1 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRIB1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of TRIB1 mRNA17938736|2766457
C069837fullerene C60fullerene C60 results in increased expression of TRIB1 mRNA19167457
C004312glycidolglycidol results in decreased expression of TRIB1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of TRIB1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TRIB1 mRNA20044591
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRIB1 mRNA22129741
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIB1 mRNA28628672
C051890irinotecanirinotecan analog results in increased expression of TRIB1 mRNA18927307
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of TRIB1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TRIB1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TRIB1 mRNA23086925
C410337K 7174K 7174 results in increased expression of TRIB1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of TRIB1 mRNA28988120
D008558MelphalanMelphalan results in increased expression of TRIB1 mRNA22363485
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of TRIB1 mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRIB1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of TRIB1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRIB1 mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of TRIB1 mRNA18548127
D008942MitoxantroneTRIB1 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TRIB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TRIB1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TRIB1 mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of TRIB1 mRNA23811387
C022838nickel chloridenickel chloride results in increased expression of TRIB1 mRNA17547211
C028007nickel monoxidenickel monoxide results in increased expression of TRIB1 mRNA19167457
C570897NSC668394NSC668394 results in increased expression of TRIB1 mRNA27137931
C507134ON 01910ON 01910 results in increased expression of TRIB1 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TRIB1 mRNA25729387
D010081OxazoloneOxazolone results in increased expression of TRIB1 mRNA23999411
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of TRIB1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of TRIB1 mRNA19095052
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of TRIB1 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of TRIB1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in decreased expression of TRIB1 mRNA19270015
D019800PhenolPhenol results in increased expression of TRIB1 mRNA17547211
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TRIB1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of TRIB1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of TRIB1 mRNA18445702
D010938Plant OilsPlant Oils results in increased expression of TRIB1 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of TRIB1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TRIB1 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of TRIB1 mRNA28903501
C502851quinocetonequinocetone results in decreased expression of TRIB1 mRNA27046791
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA19059307
D012822Silicon DioxideSilicon Dioxide results in increased expression of TRIB1 mRNA19073995
D012834SilverSilver results in increased expression of TRIB1 mRNA28959546
D053260SootSoot results in increased expression of TRIB1 mRNA22461453|2655175
C061133tamibarotenetamibarotene affects the expression of TRIB1 mRNA15498508
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA19059307
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRIB1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRIB1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRIB1 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased methylation of TRIB1 gene26756918
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TRIB1 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TRIB1 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of TRIB1 mRNA23228038
D014212TretinoinTretinoin affects the expression of TRIB1 mRNA15498508
D014212TretinoinTretinoin results in increased expression of TRIB1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TRIB1 mRNA24935251|2627250
D014280TriglyceridesTRIB1 gene SNP affects the abundance of Triglycerides24097064
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TRIB1 mRNA"26179874
D014520UrethaneUrethane results in increased expression of TRIB1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TRIB1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TRIB1 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of TRIB1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of TRIB1 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRIB1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TRIB1 mRNA23034163
D014750VincristineVincristine results in decreased expression of TRIB1 mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRIB1 mRNA"27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of TRIB1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activityNOTTAS20410507  
GO:0004860protein kinase inhibitor activity-IMP15299019  
GO:0005515protein binding-IPI25852190  
GO:0005524ATP bindingNOTTAS20410507  
GO:0008134transcription factor binding-IPI17724128  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0031434mitogen-activated protein kinase kinase binding-IDA15299019  17452330  
GO:0031625ubiquitin protein ligase binding-ISS20410507  
GO:0055106ubiquitin-protein transferase regulator activity-ISS20410507  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylationNOTTAS20410507  
GO:0006469negative regulation of protein kinase activity-IMP15299019  
GO:0007254JNK cascade-IMP17452330  
GO:0014912negative regulation of smooth muscle cell migration-IMP17452330  
GO:0031665negative regulation of lipopolysaccharide-mediated signaling pathway-IMP17452330  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-IBA21873635  
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process-ISS20410507  
GO:0032496response to lipopolysaccharide-IMP17452330  
GO:0032496response to lipopolysaccharide-ISS17724128  
GO:0043405regulation of MAP kinase activity-IBA21873635  
GO:0043405regulation of MAP kinase activity-IDA15299019  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP15299019  
GO:0043433negative regulation of DNA-binding transcription factor activity-ISS17724128  
GO:0045645positive regulation of eosinophil differentiation-IEA-  
GO:0045651positive regulation of macrophage differentiation-IEA-  
GO:0045659negative regulation of neutrophil differentiation-IEA-  
GO:0048662negative regulation of smooth muscle cell proliferation-IMP17452330  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17452330  
GO:0005737cytoplasm-IDA17452330  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21589926Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. (2011 May 11)Turner SDPLoS One
20692138Polymorphism at the TRIB1 gene modulates plasma lipid levels: insight from the Spanish familial hypercholesterolemia cohort study. (2011 Dec)Garcia-Rios ANutr Metab Cardiovasc Dis
21071687TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. (2011 Feb)Varbo AArterioscler Thromb Vasc Biol
28128572[Genetic determination of dyslipidemia - What tell us the results of genome-wide association studies?] (Fall 2016)Hubacek JAVnitr Lek
25986010Association study of genetic variants at newly identified lipid gene TRIB1 with coronary heart disease in Chinese Han population. (2015 May 19)Wang LLipids Health Dis