Gene: MSLN

10232
MPF|SMRP
mesothelin
protein-coding
16p13.3
Ensembl:ENSG00000102854 MIM:601051 Vega:OTTHUMG00000047992 UniprotKB:Q13421
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.746e-2 (AD)  5.370e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB10.901
LILRA10.88
RUNX10.868
SCIN0.867
PARVG0.857
CMTM70.855
NFAM10.854
WAS0.854
MYO1F0.853
LILRB40.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FUT9-0.469
OMG-0.439
ATP2C2-0.433
ST6GAL2-0.428
ZNF835-0.427
B3GALT2-0.426
SLC7A4-0.421
ANKRD55-0.417
TMEM179-0.417
BDH1-0.416

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB12845AmatuximabBiotechDrug931402-35-6InvestigationalTarget
ID Drug Name Action PubMed
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of MSLN mRNA"20713471
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of MSLN mRNA25088246
C0299552-nitrotoluene2-nitrotoluene results in increased expression of MSLN mRNA16460773
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MSLN gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of MSLN mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSLN mRNA16483693
D001194AsbestosAsbestos results in increased expression of MSLN protein19190155
D001194AsbestosAsbestos results in increased expression of MSLN protein modified form27032653
D017636Asbestos, Amphibole"Asbestos, Amphibole results in increased expression of MSLN mRNA"22251266
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of MSLN mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MSLN mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MSLN mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MSLN mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MSLN mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSLN mRNA20713471
C006780bisphenol Abisphenol A results in increased expression of MSLN mRNA23798566
C006780bisphenol Abisphenol A affects the expression of MSLN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MSLN gene28505145
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of MSLN mRNA16460773
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MSLN mRNA15336504
D002737ChloropreneChloroprene results in decreased expression of MSLN mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MSLN mRNA27858113
D002945CisplatinCisplatin results in decreased expression of MSLN mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MSLN mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MSLN mRNA21658437
D004237DiuronDiuron results in decreased expression of MSLN mRNA21551480|2515243
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MSLN mRNA17557909
C503823forsteriteforsterite results in increased expression of MSLN protein20933535
C039281furanfuran results in increased expression of MSLN mRNA27387713
C056507gemcitabinegemcitabine results in decreased expression of and results in decreased secretion of MSLN protein alternative form25347530
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MSLN mRNA22634610
D017313FenretinideFenretinide results in decreased expression of MSLN mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of MSLN mRNA"26377693
C016517indole-3-carbinolindole-3-carbinol affects the expression of MSLN mRNA21396975
D008727MethotrexateMSLN protein affects the susceptibility to Methotrexate16217747
D008748MethylcholanthreneMethylcholanthrene results in increased expression of MSLN mRNA20713471
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MSLN mRNA"26251327
C523799MRK 003MSLN results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MSLN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MSLN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MSLN mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of MSLN mRNA22714537
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of MSLN mRNA17616710
C025589ochratoxin Aochratoxin A results in increased acetylation of MSLN promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of MSLN promoter] which results in increased expression of MSLN mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of MSLN mRNA29098329
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of MSLN mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in increased expression of MSLN mRNA"16823509
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of MSLN mRNA23212921
D010126OzoneOzone results in increased expression of MSLN mRNA12763052
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MSLN mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of MSLN mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of MSLN mRNA24780913
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MSLN protein"20933535
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MSLN mRNA22431001
D012834SilverSilver results in increased expression of MSLN mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of MSLN mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of MSLN mRNA22714537
C017947sodium arsenitesodium arsenite results in decreased methylation of MSLN gene24570342
C017947sodium arsenitesodium arsenite results in increased expression of MSLN mRNA24570342
D012999SomanSoman results in increased expression of MSLN mRNA19281266
D053260SootSoot results in decreased expression of MSLN mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSLN mRNA21570461
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MSLN mRNA16979875
D019284ThapsigarginThapsigargin results in increased expression of MSLN protein24648495
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MSLN mRNA28943392
C009495titanium dioxidetitanium dioxide affects the expression of MSLN mRNA17656681|2355797
C009495titanium dioxidetitanium dioxide results in increased expression of MSLN mRNA27760801
C057693troglitazonetroglitazone results in increased expression of MSLN mRNA19140230
D014520UrethaneUrethane results in increased expression of MSLN mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of MSLN gene29154799
D014635Valproic AcidValproic Acid affects the expression of MSLN mRNA17292431
D014638VanadatesVanadates results in increased expression of MSLN mRNA22714537
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MSLN mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14676194  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-NAS8552591  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0031016pancreas development-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-IBA21873635  
GO:0016020membrane-NAS8552591  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24334761Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. (2014 Feb 15)Kachala SSClin Cancer Res