Gene info: ID 10253

Gene: SPRY2

GENE ID: 10253

Synonyms: IGAN3|hSPRY2

Description: sprouty RTK signaling antagonist 2

Gene type: protein-coding

Location: 13q31.1

dbXrefs: Ensembl:ENSG00000136158 MIM:602466 Vega:OTTHUMG00000017140 UniprotKB:O43597

RefSeq: NG_050650.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.201e-1 (AD) 2.176e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WBP1L	0.808
SPRED2	0.804
TMEM9B	0.801
RAB5C	0.799
SLC35F6	0.797
ELMO2	0.779
SLC35A4	0.779
GALNT2	0.776
SCG3	0.773
PTPN9	0.765

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.694
OR4F29	-0.624
OR6C74	-0.269
CHP2	-0.248
CTNNA3	-0.238
TNFRSF13B	-0.236
TRPV5	-0.234
IFNG	-0.228
C19orf33	-0.226
DPEP2	-0.222

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SPRY2 mRNA	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of SPRY2 mRNA"	19095052
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of SPRY2 protein]	26026961
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in decreased expression of SPRY2 protein]"	26026961
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of SPRY2 mRNA"	18648102
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of SPRY2 mRNA"	19561079
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNA	12419474
D000079	Acetaldehyde	Acetaldehyde affects the expression of SPRY2 mRNA	22634333
D000082	Acetaminophen	Acetaminophen results in increased expression of SPRY2 mRNA	26690555\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of SPRY2 mRNA	17562736
D001151	Arsenic	Arsenic affects the methylation of SPRY2 gene	25304211
C015001	arsenite	arsenite results in decreased expression of SPRY2 protein	22387281
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of SPRY2 mRNA"	25757056
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of SPRY2 mRNA"	18687144
D001280	Atrazine	Atrazine results in decreased expression of SPRY2 mRNA	22378314
C044887	beta-methylcholine	beta-methylcholine affects the expression of SPRY2 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of SPRY2 mRNA	20170705
C006780	bisphenol A	bisphenol A results in decreased expression of SPRY2 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of SPRY2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of SPRY2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of SPRY2 gene	28505145
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SPRY2 mRNA	22079614
C584509	C646 compound	C646 compound results in decreased expression of SPRY2 mRNA	26191083
D002220	Carbamazepine	Carbamazepine affects the expression of SPRY2 mRNA	22634333
C007020	chlorophyllin	"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of SPRY2 mRNA"	22485181
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SPRY2 mRNA	19320972
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SPRY2 mRNA	19549813
D016572	Cyclosporine	Cyclosporine results in increased expression of SPRY2 mRNA	20106945
C093628	cyproconazole	cyproconazole results in decreased expression of SPRY2 mRNA	22045034
D000069439	Dasatinib	Dasatinib results in decreased expression of SPRY2 mRNA	20579391
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SPRY2 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SPRY2 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SPRY2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SPRY2 mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of SPRY2 mRNA	26924002
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of SPRY2 mRNA	24535843
D002117	Calcitriol	Calcitriol results in increased expression of SPRY2 mRNA	16002434
D015127	9,10-Dimethyl-1,2-benzanthracene	"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of SPRY2 mRNA"	22485181
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of SPRY2 mRNA	23649840
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of SPRY2 mRNA	28329830
C061365	flusilazole	flusilazole affects the expression of SPRY2 mRNA	22634333
D005557	Formaldehyde	Formaldehyde results in decreased expression of SPRY2 mRNA	20655997
C039281	furan	furan results in increased expression of SPRY2 mRNA	27387713
D005947	Glucose	Glucose results in increased expression of SPRY2 mRNA	17178593
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of SPRY2 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SPRY2 mRNA	12419474
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SPRY2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of SPRY2 mRNA	24796395
C561695	(+)-JQ1 compound	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPRY2 mRNA	25119042
C008261	lead acetate	lead acetate results in decreased expression of SPRY2 mRNA	22609695
C045463	leflunomide	leflunomide results in increased expression of SPRY2 mRNA	28988120
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SPRY2 mRNA	26378955
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of SPRY2 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SPRY2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SPRY2 mRNA	23649840
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of SPRY2 mRNA	17412507
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of SPRY2 mRNA	26924002
C500085	muraglitazar	muraglitazar results in decreased expression of SPRY2 mRNA	21515302
D009532	Nickel	Nickel results in decreased expression of SPRY2 mRNA	20881000
D009532	Nickel	Nickel results in decreased expression of SPRY2 protein	20881000
D009532	Nickel	SPRY2 mRNA affects the reaction [Nickel results in increased phosphorylation of MAPK1 protein]	20881000
D009532	Nickel	SPRY2 mRNA affects the reaction [Nickel results in increased phosphorylation of MAPK3 protein]	20881000
D009532	Nickel	SPRY2 protein inhibits the reaction [Nickel results in increased phosphorylation of MAPK1 protein]	20881000
D009532	Nickel	SPRY2 protein inhibits the reaction [Nickel results in increased phosphorylation of MAPK3 protein]	20881000
C022838	nickel chloride	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [nickel chloride results in decreased expression of SPRY2 protein]	26026961
C022838	nickel chloride	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [nickel chloride results in decreased expression of SPRY2 protein]"	26026961
C022838	nickel chloride	nickel chloride results in decreased expression of SPRY2 protein	26026961
C022838	nickel chloride	[nickel chloride results in increased expression of MIR21 mRNA] which results in decreased expression of SPRY2 protein	26026961
C007350	nitrofen	nitrofen results in decreased expression of and results in decreased phosphorylation of SPRY2 protein	24210189
C007350	nitrofen	nitrofen results in decreased expression of SPRY2 mRNA	23982388\|2421018
C570897	NSC668394	NSC668394 results in increased expression of SPRY2 mRNA	27137931
D010100	Oxygen	Oxygen deficiency promotes the reaction [KDM3A protein binds to SPRY2 promoter]	20881000
D010100	Oxygen	Oxygen deficiency results in decreased expression of SPRY2 mRNA	20881000
D010100	Oxygen	Oxygen deficiency results in decreased expression of SPRY2 protein	20881000
C506614	PD 0325901	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of SPRY2 mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of SPRY2 mRNA	25119042
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of SPRY2 mRNA	19095052
D010634	Phenobarbital	Phenobarbital affects the expression of SPRY2 mRNA	19159669
C018637	phorone	phorone affects the expression of SPRY2 mRNA	18198479
C006253	pirinixic acid	pirinixic acid results in increased expression of SPRY2 mRNA	17426115
D010938	Plant Oils	Plant Oils results in increased expression of SPRY2 mRNA	23370395
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of SPRY2 mRNA	22714537
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SPRY2 mRNA	21427059
D012834	Silver	Silver results in decreased expression of SPRY2 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in decreased expression of SPRY2 mRNA	19072884
D012999	Soman	Soman results in increased expression of SPRY2 mRNA	19281266
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SPRY2 mRNA	26378955
C061133	tamibarotene	tamibarotene results in increased expression of SPRY2 mRNA	15498508
D013629	Tamoxifen	Tamoxifen affects the expression of SPRY2 mRNA	20937368
D013654	Taurine	Taurine results in increased expression of SPRY2 mRNA	16579726
C501413	tesaglitazar	tesaglitazar results in decreased expression of SPRY2 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SPRY2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SPRY2 mRNA	21215274
D019284	Thapsigargin	Thapsigargin results in decreased expression of SPRY2 mRNA	22378314
C483909	torcetrapib	torcetrapib results in increased expression of SPRY2 mRNA	23228038
D014212	Tretinoin	Tretinoin affects the expression of SPRY2 mRNA	15498508
D014212	Tretinoin	Tretinoin results in decreased expression of SPRY2 mRNA	23724009
C012589	trichostatin A	trichostatin A results in decreased expression of SPRY2 mRNA	26272509
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of SPRY2 mRNA	19042947
D014415	Tunicamycin	Tunicamycin results in decreased expression of SPRY2 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of SPRY2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of SPRY2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of SPRY2 mRNA	23179753\|2519280
D014635	Valproic Acid	Valproic Acid results in increased expression of SPRY2 mRNA	24935251\|2800136
D014635	Valproic Acid	Valproic Acid results in decreased expression of SPRY2 mRNA	21427059\|2204503
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]	19225232
D014638	Vanadates	Vanadates results in increased expression of SPRY2 mRNA	22714537
C025643	vinclozolin	vinclozolin results in increased expression of SPRY2 mRNA	23034163
D024483	Vitamin K 3	Vitamin K 3 affects the expression of SPRY2 mRNA	20044591
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of SPRY2 mRNA	25270620
C111237	vorinostat	vorinostat results in decreased expression of SPRY2 mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	12815057 15962011 16189514 16893902 18273061 21516116 21784977 25416956 25910212 27107014
GO:0019901	protein kinase binding	-	IPI	20736167
GO:0030291	protein serine/threonine kinase inhibitor activity	-	IC	20736167
GO:0043539	protein serine/threonine kinase activator activity	-	IMP	18070883

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000132	establishment of mitotic spindle orientation	-	IEA	-
GO:0007605	sensory perception of sound	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IMP	18070883
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	-	IDA	20736167
GO:0016525	negative regulation of angiogenesis	-	IMP	24177325
GO:0030335	positive regulation of cell migration	-	IMP	20489163
GO:0031345	negative regulation of cell projection organization	-	ISS	-
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IMP	18070883
GO:0034260	negative regulation of GTPase activity	-	IEA	-
GO:0035924	cellular response to vascular endothelial growth factor stimulus	-	IDA	21536891
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	-	IBA	21873635
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	-	IEA	-
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	-	TAS	-
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IMP	18070883
GO:0043407	negative regulation of MAP kinase activity	-	IBA	21873635
GO:0043407	negative regulation of MAP kinase activity	-	IEA	-
GO:0045165	cell fate commitment	-	IEA	-
GO:0045595	regulation of cell differentiation	-	IEA	-
GO:0046580	negative regulation of Ras protein signal transduction	-	IBA	21873635
GO:0046580	negative regulation of Ras protein signal transduction	-	IEA	-
GO:0048513	animal organ development	-	IBA	21873635
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	IMP	18070883
GO:0060437	lung growth	-	IEA	-
GO:0060449	bud elongation involved in lung branching	-	IEA	-
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IDA	21536891
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IMP	20489163
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	18070883
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IEA	-
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	-	IDA	21536891
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	-
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	ISS	-
GO:0005874	microtubule	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0015630	microtubule cytoskeleton	-	IDA	-
GO:0016020	membrane	-	ISS	-
GO:0032587	ruffle membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04630	Jak-STAT signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1295596	Spry regulation of FGF signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-177929	Signaling by EGFR	TAS
R-HSA-182971	EGFR downregulation	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654727	Negative regulation of FGFR2 signaling	TAS
R-HSA-5654732	Negative regulation of FGFR3 signaling	TAS
R-HSA-5654733	Negative regulation of FGFR4 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5654738	Signaling by FGFR2	TAS
R-HSA-5654741	Signaling by FGFR3	TAS
R-HSA-5654743	Signaling by FGFR4	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26026961	Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression. (2015 Aug 19)	Chiou YH	Toxicol Lett