Gene: ABCC4

10257
MOAT-B|MOATB|MRP4
ATP binding cassette subfamily C member 4
protein-coding
13q32.1
Ensembl:ENSG00000125257 MIM:605250 Vega:OTTHUMG00000017216 UniprotKB:O15439
NG_050651.1
PubMed|SNP Mapped
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.800e-1 (AD)  7.041e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4148478chr13:95197426 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs16950632chr13:95109632 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10304534chr13:95844361ABCC43.100e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL13RA10.85
CTSS0.841
KCTD120.838
TRIM380.836
PROS10.831
PTPRC0.819
CYBB0.817
CARD60.817
HCK0.816
PLCG20.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.46
ASPDH-0.458
SOHLH1-0.45
RTN4R-0.439
BCL11A-0.429
DLK2-0.426
TMEM179-0.424
HAGHL-0.419
SPATA2L-0.414
MAGIX-0.412

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTransporter
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalTransporter
DB00198OseltamivirSmall Molecule196618-13-0ApprovedTransporter
DB00203SildenafilSmall Molecule139755-83-2Approved|InvestigationalTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00300Tenofovir disoproxilSmall Molecule201341-05-1Approved|InvestigationalTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00352TioguanineSmall Molecule154-42-7ApprovedTransporter
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalTransporter
DB00482CelecoxibSmall Molecule169590-42-5Approved|InvestigationalTransporter
DB00495ZidovudineSmall Molecule30516-87-1ApprovedTransporter
DB00533RofecoxibSmall Molecule162011-90-7Approved|Investigational|WithdrawnTransporter
DB00544FluorouracilSmall Molecule51-21-8ApprovedTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTransporter
DB00661VerapamilSmall Molecule52-53-9ApprovedTransporter
DB00709LamivudineSmall Molecule134678-17-4Approved|InvestigationalTransporter
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalTransporter
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalTransporter
DB00731NateglinideSmall Molecule105816-04-4Approved|InvestigationalTransporter
DB00770AlprostadilSmall Molecule745-65-3Approved|InvestigationalTransporter
DB00814MeloxicamSmall Molecule71125-38-7ApprovedTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00975DipyridamoleSmall Molecule58-32-2ApprovedTransporter
DB01009KetoprofenSmall Molecule22071-15-4ApprovedTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01033MercaptopurineSmall Molecule50-44-2ApprovedTransporter
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTransporter
DB01076AtorvastatinSmall Molecule134523-00-5ApprovedTransporter
DB01098RosuvastatinSmall Molecule287714-41-4ApprovedTransporter
DB01138SulfinpyrazoneSmall Molecule57-96-5ApprovedTransporter
DB01268SunitinibSmall Molecule557795-19-4Approved|InvestigationalTransporter
DB01327CefazolinSmall Molecule25953-19-9ApprovedTransporter
DB01586Ursodeoxycholic acidSmall Molecule128-13-2Approved|InvestigationalTransporter
DB02527Cyclic Adenosine MonophosphateSmall Molecule60-92-4ExperimentalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB08884Gadoxetic acidSmall Molecule135326-11-3ApprovedTransporter
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTransporter
DB13146Fluciclovine (18F)Small Molecule222727-39-1ApprovedTransporter
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of ABCC4 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of ABCC4 mRNA]"27071940
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC4 mRNA"17627975
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]"18032408
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of ABCC4 mRNA"15833929|2249639
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC4 mRNA"15833929|1598641
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC4 protein"15986414|2781899
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein"18032408
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABCC4 mRNA]"22496397
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ABCC4 mRNA19933214
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of ABCC4 mRNA"21920950
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCC4 mRNA"28433925
C0982672,4-dinitrophenyl-S-(N-acetylcysteine)"2,4-dinitrophenyl-S-(N-acetylcysteine) inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]"11856762
C08133124-norursodeoxycholic acid24-norursodeoxycholic acid results in increased expression of ABCC4 protein16472600
C0345932,6-dibromobenzoquinone"ABCC4 protein inhibits the reaction [2,6-dibromobenzoquinone results in increased abundance of Reactive Oxygen Species]"28885828
C0345932,6-dibromobenzoquinone"ABCC4 protein results in decreased susceptibility to 2,6-dibromobenzoquinone"28885828
C0345932,6-dibromobenzoquinone"ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]"28885828
C5827172,6-dichloro-(1,4)benzoquinone"ABCC4 protein inhibits the reaction [2,6-dichloro-(1,4)benzoquinone results in increased abundance of Reactive Oxygen Species]"28885828
C5827172,6-dichloro-(1,4)benzoquinone"ABCC4 protein results in decreased susceptibility to 2,6-dichloro-(1,4)benzoquinone"28885828
C5827172,6-dichloro-(1,4)benzoquinone"ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]"28885828
C0438292',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein"Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]"16004972
C0438292',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein"verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]"16004972
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCC4 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ABCC4 mRNA"21346803
C0027304-nitrophenylglucuronide4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]11856762
C1213584-phenylbutylamine4-phenylbutylamine results in increased expression of ABCC4 mRNA20395535
C1213584-phenylbutylamine4-phenylbutylamine results in increased expression of ABCC4 protein20395535
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCC4 mRNA"27188386
C4833216-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime results in increased expression of ABCC4 mRNA18624906
C4833216-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime results in increased expression of ABCC4 protein18624906
C0118647-hydroxymethotrexateABCC4 gene mutant form affects the susceptibility to 7-hydroxymethotrexate19426680
C4128527-hydroxytheonellasterol7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]]22291955
C4128527-hydroxytheonellasterol7-hydroxytheonellasterol inhibits the reaction [[Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]] which results in decreased expression of ABCC4 mRNA]22291955|2229195
C4128527-hydroxytheonellasterol7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of ABCC4 mRNA]22291955
C0170408-azidoadenosine 5'-triphosphate8-azidoadenosine 5'-triphosphate binds to ABCC4 protein14978246
C0170408-azidoadenosine 5'-triphosphateABCC4 protein binds to 8-azidoadenosine 5'-triphosphate16156793
C0170408-azidoadenosine 5'-triphosphateDisulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]14978246
D000082AcetaminophenAcetaminophen affects the expression of ABCC4 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of ABCC4 mRNA17627974
D000082AcetaminophenAcetaminophen results in increased expression of ABCC4 protein17627974
D000082AcetaminophenABCC4 protein results in decreased susceptibility to Acetaminophen18468992
D000082Acetaminophen[Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC4 mRNA17934960
D000082Acetaminophen[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC4 mRNA17934960
D000082AcetaminophenAcetaminophen results in increased expression of ABCC4 mRNA15496496|1793574
D000082AcetaminophenAcetaminophen results in increased expression of ABCC4 protein16177239|1793574
D000082AcetaminophenColchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein]18468992
D000082AcetaminophenNFE2L2 protein affects the reaction [Acetaminophen results in increased expression of ABCC4 mRNA]17935745
D000082AcetaminophenNFE2L2 protein affects the reaction [Acetaminophen results in increased expression of ABCC4 protein]17935745
D020106AcrylamideAcrylamide results in increased expression of ABCC4 mRNA28959563
C053001adefovirABCC4 protein affects the abundance of adefovir18364470
C053001adefovirABCC4 protein results in increased export of adefovir18364470
D000242Cyclic AMPABCC4 protein results in increased transport of Cyclic AMP11856762
D000242Cyclic AMPABCC4 protein affects the uptake of Cyclic AMP analog28587784
D000242Cyclic AMPProbenecid affects the reaction [ABCC4 protein affects the uptake of Cyclic AMP analog]28587784
D000255Adenosine TriphosphateABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate14978246
D000255Adenosine TriphosphateABCC4 protein results in increased hydrolysis of Adenosine Triphosphate16156793
D000255Adenosine Triphosphatedaidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine TriphosphateDisulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]14978246
D000255Adenosine Triphosphatehesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine Triphosphatenaringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine TriphosphateQuercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine TriphosphateQuercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
D000255Adenosine Triphosphateresveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine TriphosphateSilymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D000255Adenosine TriphosphateSilymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCC4 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of ABCC4 mRNA21757418
C008088alfacalcidolalfacalcidol results in increased expression of ABCC4 mRNA19581390
C008088alfacalcidolalfacalcidol results in increased expression of ABCC4 protein19581390
C006463allyl alcoholallyl alcohol results in increased expression of ABCC4 mRNA19371622
C006463allyl alcoholallyl alcohol results in increased expression of ABCC4 protein19371622
C038491allyl sulfideallyl sulfide results in decreased expression of ABCC4 mRNA22397993
C038491allyl sulfideallyl sulfide results in increased expression of ABCC4 mRNA12920174
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ABCC4 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ABCC4 mRNA17003774
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ABCC4 protein17003774
D000583AmikacinAmikacin results in decreased expression of ABCC4 mRNA27765674
D009762o-AminoazotolueneNR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]21672546
D009762o-Aminoazotolueneo-Aminoazotoluene results in increased expression of ABCC4 mRNA21672546
D000638AmiodaroneAmiodarone affects the expression of ABCC4 mRNA25064622
D000638AmiodaroneAmiodarone results in decreased expression of ABCC4 mRNA27765674
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABCC4 mRNA16483693
D000667AmpicillinABCC4 protein results in increased transport of Ampicillin17939016
C030419andrographolide[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA19737545
C011659angelicinangelicin affects the expression of ABCC4 mRNA22173200
D000806Angiotensin-Converting Enzyme InhibitorsABCC4 protein results in increased transport of Angiotensin-Converting Enzyme Inhibitors17939016
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABCC4 mRNA24449571
D001151ArsenicABCC4 protein results in increased transport of Arsenic25752797
D001151ArsenicArsenic affects the methylation of ABCC4 gene25304211
D001151ArsenicArsenic results in increased expression of ABCC4 protein25752797
D001151Arsenicoltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]25752797
C006632arsenic trioxidearsenic trioxide results in decreased expression of ABCC4 mRNA19142964
C006632arsenic trioxidearsenic trioxide results in increased expression of ABCC4 mRNA22580103
D001241AspirinAspirin results in increased expression of ABCC4 mRNA21900887
D001241AspirinAspirin results in increased expression of ABCC4 protein21900887
D001280AtrazineAtrazine results in increased expression of ABCC4 mRNA23358194
D001379AzathioprineAzathioprine results in increased expression of ABCC4 mRNA27765674
C547126AZM551248AZM551248 results in decreased expression of ABCC4 mRNA22323515
D001418BaclofenABCC4 protein results in increased transport of Baclofen17939016
C017228benzo(a)pyrene 7,8-dihydrodiol"ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol"22155354
C017228benzo(a)pyrene 7,8-dihydrodiol"[ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol] which results in decreased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"22155354
C017228benzo(a)pyrene 7,8-dihydrodiol"benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 mRNA"22155354
C017228benzo(a)pyrene 7,8-dihydrodiol"benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 protein"22155354
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"[ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol] which results in decreased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"22155354
D019324beta-Naphthoflavone[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA19737545
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABCC4 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ABCC4 mRNA26271895
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABCC4 mRNA19770486
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ABCC4 mRNA20660070
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ABCC4 mRNA19619570|2301914
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ABCC4 mRNA26496021
D001629BezafibrateABCC4 protein results in increased transport of Bezafibrate17939016
D001647Bile Acids and SaltsABCC4 protein affects the transport of Bile Acids and Salts15841457
D001647Bile Acids and SaltsTAK-875 inhibits the reaction [ABCC4 protein results in increased transport of Bile Acids and Salts]28108665
C006780bisphenol Abisphenol A results in increased expression of ABCC4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of ABCC4 promoter27312807
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCC4 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC4 promoter23359474
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ABCC4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ABCC4 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ABCC4 mRNA26982218
D000069286BortezomibBortezomib results in decreased expression of ABCC4 mRNA20977926
C086232bosentanbosentan results in increased expression of ABCC4 mRNA27765674
D002034BumetanideABCC4 protein results in increased transport of Bumetanide17939016
D002083Butylated Hydroxyanisole[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA15833929
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of ABCC4 mRNA15833929
D002101Cacodylic AcidABCC4 gene SNP affects the export of Cacodylic Acid27659809
D002101Cacodylic AcidABCC4 protein results in increased export of Cacodylic Acid24870404|2765980
D002101Cacodylic AcidABCC4 protein results in increased transport of Cacodylic Acid25752797
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ABCC4 mRNA22580103
C037123cadmium sulfatecadmium sulfate results in increased expression of ABCC4 mRNA16221973
C085925calcein AMGlutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM]15210835
D002220CarbamazepineCarbamazepine affects the expression of ABCC4 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABCC4 mRNA15496496|2733941
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABCC4 protein16177239
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABCC4 protein17544377
D015311CefmetazoleABCC4 protein results in increased transport of Cefmetazole17939016
D002442CeftazidimeABCC4 protein results in increased transport of Ceftazidime17939016
D000068579CelecoxibCelecoxib results in increased expression of ABCC4 mRNA18690847
D000068579CelecoxibCelecoxib results in increased expression of ABCC4 protein18690847
C025163cephalosporin CABCC4 protein results in increased transport of cephalosporin C17939016
D002635Chenodeoxycholic Acid7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]]22291955
D002635Chenodeoxycholic Acid7-hydroxytheonellasterol inhibits the reaction [[Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]] which results in decreased expression of ABCC4 mRNA]22291955|2229195
D002635Chenodeoxycholic Acid7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of ABCC4 mRNA]22291955
D002635Chenodeoxycholic AcidChenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]22291955
D002635Chenodeoxycholic Acid[Chenodeoxycholic Acid promotes the reaction [NR1H4 protein binds to ABCC4 promoter]] which results in decreased expression of ABCC4 mRNA22291955|2229195
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of ABCC4 mRNA22291955
D002706ChlordanChlordan results in increased expression of ABCC4 mRNA20403969
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ABCC4 mRNA26272509
D002746ChlorpromazineChlorpromazine affects the expression of ABCC4 mRNA25064622
D002794CholineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D002794CholineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABCC4 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA18952117|2438491
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 protein24384915
D002794CholineRXRA affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]18952117
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA17640958|2438491
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 protein17640958|2438491
C027113chrysophanic acidchrysophanic acid results in increased expression of ABCC4 mRNA28161596
C027113chrysophanic acidchrysophanic acid results in increased expression of ABCC4 protein28161596
D002939Ciprofloxacin[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin22162766
D002939CiprofloxacinGemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]22162766
D002939CiprofloxacinABCC4 protein results in increased export of Ciprofloxacin19307362
D002939CiprofloxacinCiprofloxacin results in increased expression of ABCC4 mRNA22162766
D002939CiprofloxacinCiprofloxacin results in increased expression of ABCC4 protein22162766
D002939Ciprofloxacin[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin22162766
D002994Clofibrate[Clofibrate results in increased activity of PPARA protein] which results in increased expression of ABCC4 mRNA22496397
D002994ClofibrateClofibrate results in increased expression of ABCC4 mRNA16467456|2249639
D002994ClofibrateClofibrate results in increased expression of ABCC4 protein16467456
D002994ClofibratePPARA promotes the reaction [Clofibrate results in increased expression of ABCC4 mRNA]16467456
D002994ClofibratePPARA promotes the reaction [Clofibrate results in increased expression of ABCC4 protein]16467456
D002994ClofibratePPARA protein affects the reaction [Clofibrate results in increased expression of ABCC4 mRNA]22496397
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABCC4 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of ABCC4 mRNA24386269
D003078ColchicineColchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein]18468992
D003471CuprizoneCuprizone results in decreased expression of ABCC4 mRNA27523638
D003471CuprizoneCuprizone results in increased expression of ABCC4 mRNA26577399
D016572CyclosporineCyclosporine affects the expression of ABCC4 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of ABCC4 mRNA24973091
D016572CyclosporineCyclosporine results in increased expression of ABCC4 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of ABCC4 mRNA27765674
C093628cyproconazolecyproconazole results in increased expression of ABCC4 mRNA22334560|2397080
C004742daidzeindaidzein inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
C004742daidzeindaidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D003907DexamethasoneDexamethasone results in decreased expression of ABCC4 mRNA19922765
D003907DexamethasoneDexamethasone results in decreased expression of ABCC4 protein19922765
D016264Dextran Sulfate[Benzo(a)pyrene co-treated with Dextran Sulfate] results in increased expression of ABCC4 mRNA26271895
D016264Dextran SulfateDextran Sulfate results in decreased expression of ABCC4 mRNA27580383
D016264Dextran SulfateDextran Sulfate results in decreased expression of ABCC4 protein27580383
C028009diallyl disulfidediallyl disulfide results in decreased expression of ABCC4 mRNA22397993
C028009diallyl disulfidediallyl disulfide results in increased expression of ABCC4 mRNA22397993
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of ABCC4 mRNA22397993
C042577diallyl trisulfidediallyl trisulfide results in increased expression of ABCC4 mRNA22397993
D003976DiazinonDiazinon results in increased methylation of ABCC4 gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC4 promoter23359474
D002945CisplatinABCC4 protein results in decreased susceptibility to Cisplatin17982673
D002945CisplatinCisplatin results in decreased expression of ABCC4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ABCC4 mRNA20605904
D002945CisplatinCisplatin results in increased expression of ABCC4 protein20605904|2377041
D002945CisplatinLuteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein]23770416
D002945CisplatinNFE2L2 protein promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]20605904
D002945CisplatinNFE2L2 protein promotes the reaction [Cisplatin results in increased expression of ABCC4 protein]20605904
D002945CisplatinCisplatin results in increased expression of ABCC4 mRNA28414026
D002945Cisplatinformononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]28414026
D004008DiclofenacDiclofenac affects the expression of ABCC4 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of ABCC4 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of ABCC4 mRNA23041725
D004041Dietary FatsDietary Fats affects the expression of ABCC4 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with sodium arsenite] results in increased expression of ABCC4 mRNA26890134
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCC4 mRNA"28433925
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ABCC4 promoter23359474
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA24535843
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of ABCC4 mRNA19690152
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCC4 mRNA22129741
D002117CalcitriolCalcitriol results in increased activity of ABCC4 protein21240898|2134128
D002117CalcitriolCalcitriol results in increased expression of ABCC4 protein21240898|2134128
C024629dimethyl phthalatedimethyl phthalate affects the expression of ABCC4 mRNA26924002
D004147DioxinsDioxins affects the expression of ABCC4 mRNA20463971
D004176DipyridamoleDipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]11856762
D004176DipyridamoleDipyridamole results in decreased activity of ABCC4 protein15827327
D004221DisulfiramDisulfiram results in decreased expression of ABCC4 mRNA20530235
D004221DisulfiramDisulfiram inhibits the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC4 protein]14978246
D004221DisulfiramDisulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]14978246
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which results in decreased expression of ABCC4 mRNA19944135
D004317DoxorubicinDoxorubicin affects the methylation of ABCC4 gene28962528
D004318DoxycyclineDoxycycline results in decreased expression of ABCC4 mRNA27765674
D004642EmodinEmodin results in decreased expression of ABCC4 mRNA28161596
D004642EmodinEmodin results in decreased expression of ABCC4 protein28161596
D004656EnalaprilABCC4 protein results in increased transport of Enalapril17939016
C118739entinostatentinostat results in increased expression of ABCC4 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of ABCC4 protein23146761
C109476epoxiconazoleepoxiconazole results in increased expression of ABCC4 mRNA22334560|2397080
C025483estradiol-17 beta-glucuronideABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide27659809
C025483estradiol-17 beta-glucuronideABCC4 protein results in increased export of estradiol-17 beta-glucuronide27659809
C025483estradiol-17 beta-glucuronideABCC4 protein results in increased transport of estradiol-17 beta-glucuronide11856762
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased expression of ABCC4 protein23707492
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of ABCC4 mRNA23707492
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased expression of ABCC4 protein23707492
C074283estradiol 3-benzoatefulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCC4 mRNA]23707492
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ABCC4 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ABCC4 protein23146761
D005015Ethoxyquin[Ethoxyquin results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA15833929
D005015EthoxyquinEthoxyquin results in increased expression of ABCC4 mRNA15833929
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ABCC4 mRNA23649840
D015025Zearalenonefulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC4 mRNA]23707492
D015025ZearalenoneZearalenone results in decreased expression of ABCC4 protein23707492
D015025ZearalenoneZearalenone results in increased expression of ABCC4 mRNA23707492
D015025ZearalenoneZearalenone results in increased expression of ABCC4 protein23707492
D011345FenofibrateFenofibrate results in increased expression of ABCC4 mRNA27765674
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of ABCC4 mRNA18617210
D005363FicusinFicusin results in increased expression of ABCC4 mRNA22173200
D005363FicusinFicusin results in increased expression of ABCC4 protein22173200
D005485FlutamideFlutamide results in decreased expression of ABCC4 mRNA24793618
D005485FlutamideFlutamide results in increased expression of ABCC4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABCC4 mRNA20938992
C007768formononetinformononetin promotes the reaction [Cisplatin results in increased expression of ABCC4 mRNA]28414026
C070081fulvestrantfulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCC4 mRNA]23707492
C070081fulvestrantfulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCC4 mRNA]23707492
C039281furanfuran results in increased expression of ABCC4 mRNA25539665
D005665FurosemideABCC4 protein results in increased transport of Furosemide17939016
D005665FurosemideABCC4 protein results in increased export of Furosemide17135398
C038958gadolinium chloridegadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]18757529
D015248GemfibrozilGemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]22162766
D005978GlutathioneABCC4 protein affects the transport of Glutathione analog20584751
D005978Glutathione"ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]"28885828
D005978Glutathione"ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]"28885828
D005978GlutathioneGlutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM]15210835
D005978GlutathioneABCC4 protein affects the export of Glutathione15845416
D006152Cyclic GMPABCC4 protein results in increased export of Cyclic GMP16156793
D006152Cyclic GMPABCC4 protein results in increased transport of Cyclic GMP11856762
D006152Cyclic GMPdaidzein inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D006152Cyclic GMPDipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]11856762
D006152Cyclic GMPhesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D006152Cyclic GMPnaringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D006152Cyclic GMPProbenecid inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]11856762
D006152Cyclic GMPQuercetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D006152Cyclic GMPresveratrol inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D006152Cyclic GMPSilymarin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
C013015hesperetinhesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
C013015hesperetinhesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
C013015hesperetinhesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
C000625835HFPO2 compoundHFPO2 compound results in increased expression of ABCC4 mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of ABCC4 mRNA27553808
C030514hippuric acidhippuric acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D017313FenretinideFenretinide results in increased expression of ABCC4 mRNA28973697
D006852HydrochlorothiazideABCC4 protein results in increased transport of Hydrochlorothiazide17939016
D006852HydrochlorothiazideABCC4 protein results in increased export of Hydrochlorothiazide17135398
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ABCC4 mRNA26846883
D007200IndicanIndican inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
C016517indole-3-carbinolindole-3-carbinol affects the expression of ABCC4 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCC4 mRNA22129741
C030737indoleacetic acidindoleacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCC4 mRNA25613284
C051890irinotecanABCC4 protein affects the export of irinotecan15827327
D007529IsoflavonesIsoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA]19025659
C055542isoimperatorinisoimperatorin results in increased expression of ABCC4 mRNA22173200
D007545IsoproterenolIsoproterenol results in increased expression of ABCC4 mRNA20003209
D007559IvermectinABCC4 protein results in decreased susceptibility to Ivermectin21895817
D007559IvermectinIvermectin results in increased expression of ABCC4 mRNA21895817
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ABCC4 mRNA21889194
D007736Kynurenic AcidKynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D001556LindaneABCC4 protein results in decreased susceptibility to Lindane25478949
D001556LindaneLindane inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]25478949
D001556LindaneLindane results in increased expression of ABCC4 mRNA25478949
D001556Lindaneverlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Lindane]25478949
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of ABCC4 protein"22942241
D008095Lithocholic Acid"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]"18032408
D008095Lithocholic Acid"[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein"18032408
D008095Lithocholic Acid[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein18032408
D008095Lithocholic AcidLithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]17256725
D008095Lithocholic AcidLithocholic Acid results in decreased expression of ABCC4 mRNA17256725
D008095Lithocholic AcidLithocholic Acid results in increased expression of ABCC4 mRNA18032408|2097746
D008095Lithocholic AcidNFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]20977460
D008095Lithocholic AcidSMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]23034213
D047311LuteolinLuteolin inhibits the reaction [Cisplatin results in increased expression of ABCC4 protein]23770416
D015767Mefloquine"Mefloquine inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]"16004972
D015767MefloquineMefloquine inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]16004972
D015767MefloquineMefloquine inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]16004972
D015767MefloquineMefloquine results in decreased activity of ABCC4 protein16004972
C065757meloxicamABCC4 protein binds to meloxicam17939016
C042720mercuric bromidemercuric bromide results in decreased expression of ABCC4 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ABCC4 mRNA27720909
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ABCC4 mRNA22580103
D008627Mercuric ChlorideMercuric Chloride results in increased expression of ABCC4 mRNA28536007
D008628MercuryMercury results in increased expression of ABCC4 mRNA24486881
D008701MethapyrileneMethapyrilene results in increased expression of ABCC4 mRNA28529062
D008715MethionineLEP gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D008715MethionineLEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]24384915
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ABCC4 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA18952117|2438491
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 protein24384915
D008715MethionineRXRA affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA]18952117
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA17640958|2438491
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 protein17640958|2438491
D008727Methotrexate"2,4-dinitrophenyl-S-(N-acetylcysteine) inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]"11856762
D008727Methotrexate4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]11856762
D008727MethotrexateABCC4 gene SNP affects the susceptibility to Methotrexate23222202
D008727MethotrexateABCC4 protein results in decreased susceptibility to Methotrexate17003774
D008727MethotrexateABCC4 protein results in increased export of Methotrexate21483698
D008727MethotrexateABCC4 protein results in increased transport of Methotrexate11856762
D008727Methotrexatehippuric acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D008727MethotrexateIndican inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D008727Methotrexateindoleacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D008727MethotrexateKynurenic Acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D008727MethotrexateMethotrexate results in decreased expression of ABCC4 mRNA23897011
D008727Methotrexatenaphthyl glucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]11856762
D008727Methotrexatephenylacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D008727Methotrexate"S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]"11856762
D008727MethotrexateUric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate]15454390
D008730MethoxsalenMethoxsalen affects the expression of ABCC4 protein22173200
D008730MethoxsalenMethoxsalen results in increased expression of ABCC4 mRNA22173200
C571174methylarsenic diglutathioneABCC4 protein results in increased export of methylarsenic diglutathione24870404
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ABCC4 mRNA20395535
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ABCC4 protein20395535
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ABCC4 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ABCC4 mRNA27720909
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ABCC4 mRNA28536007
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ABCC4 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ABCC4 mRNA23649840
D008743Methyl Parathion[Methyl Parathion co-treated with Verapamil] results in increased expression of ABCC4 mRNA25286004
C008493methylselenic acidAR protein inhibits the reaction [methylselenic acid results in decreased expression of ABCC4 mRNA]16020662
C008493methylselenic acidmethylselenic acid affects the expression of ABCC4 mRNA14617803
C008493methylselenic acidmethylselenic acid results in decreased expression of ABCC4 mRNA16020662|1854812
D015741MetriboloneMetribolone results in increased expression of ABCC4 mRNA17010675
C059539midostaurinmidostaurin results in decreased expression of ABCC4 mRNA20980353
C059597monochlorobimaneABCC4 protein results in increased export of monochlorobimane25478949
C059597monochlorobimaneLindane inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]25478949
C059597monochlorobimane"o,p'-DDT inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]"25478949
C059597monochlorobimaneverlukast inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]25478949
C406082monomethylarsonous acidABCC4 gene SNP affects the export of monomethylarsonous acid metabolite27659809
C406082monomethylarsonous acidABCC4 protein results in increased export of monomethylarsonous acid metabolite27659809
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ABCC4 mRNA26924002
D037742Nanotubes, Carbon"MYC protein inhibits the reaction [Nanotubes, Carbon results in decreased expression of ABCC4 protein]"25461681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of and results in decreased activity of ABCC4 protein"25461681
C029091naphthyl glucuronidenaphthyl glucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]11856762
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ABCC4 mRNA27765674
C005273naringeninnaringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
C005273naringeninnaringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
C060142nateglinideABCC4 protein binds to nateglinide17939016
C026209oltiprazoltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]25752797
C026209oltiprazoltipraz results in increased expression of ABCC4 mRNA20395535
C026209oltiprazoltipraz results in increased expression of ABCC4 protein20395535|2575279
C026209oltipraz[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein18032408
C026209oltiprazNFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]22496397
C026209oltipraz[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA15833929|2249639
C026209oltiprazoltipraz results in increased expression of ABCC4 mRNA15833929|2249639
C016340o,p'-DDT"ABCC4 protein results in decreased susceptibility to o,p'-DDT"25478949
C016340o,p'-DDT"o,p'-DDT inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]"25478949
C016340o,p'-DDT"o,p'-DDT results in increased expression of ABCC4 mRNA"25478949
C016340o,p'-DDT"verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to o,p'-DDT]"25478949
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ABCC4 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of ABCC4 mRNA25536518
D017239PaclitaxelPaclitaxel results in increased expression of ABCC4 mRNA15585946
D000073878Palm OilPalm Oil affects the expression of ABCC4 mRNA19680557
D010269ParaquatParaquat affects the expression of ABCC4 mRNA25064622
D010269ParaquatParaquat affects the expression of ABCC4 mRNA16854511
D052638Particulate MatterParticulate Matter results in increased expression of ABCC4 protein18474546
D010400Penicillin GABCC4 protein results in increased transport of Penicillin G17939016
D010416PentachlorophenolPentachlorophenol results in increased expression of ABCC4 mRNA23892564
C036567perfluorodecanoic acidgadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]18757529
C036567perfluorodecanoic acidNFE2L2 protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]18757529
C036567perfluorodecanoic acidperfluorodecanoic acid results in increased expression of ABCC4 mRNA18757529|2734434
C036567perfluorodecanoic acidPPARA protein affects the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]18757529
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of ABCC4 mRNA23567314
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of ABCC4 mRNA29112762
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of ABCC4 protein24014645
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased activity of ABCC4 protein24014645
D015232DinoprostoneABCC4 gene SNP affects the export of Dinoprostone27659809
D015232DinoprostoneABCC4 protein results in increased export of Dinoprostone22155354|2765980
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABCC4 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of ABCC4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ABCC4 mRNA15986414|1927001
D010634PhenobarbitalPhenobarbital results in increased expression of ABCC4 protein15986414
C025136phenylacetic acidphenylacetic acid inhibits the reaction [ABCC4 protein results in increased export of Methotrexate]21483698
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ABCC4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ABCC4 mRNA26272509
D010876Pipemidic AcidABCC4 protein results in increased transport of Pipemidic Acid17939016
D010878PiperacillinABCC4 protein results in increased transport of Piperacillin17939016
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of ABCC4 mRNA19690152
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of ABCC4 mRNA19690152
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABCC4 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ABCC4 mRNA18301758|2081375
D011192Potassium DichromatePotassium Dichromate results in increased expression of ABCC4 mRNA22580103
D017035PravastatinABCC4 protein results in increased transport of Pravastatin17939016
D011339ProbenecidProbenecid inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]11856762
D011339ProbenecidProbenecid affects the reaction [ABCC4 protein affects the uptake of Cyclic AMP analog]28587784
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ABCC4 mRNA20660070
D019946Propylene Glycol[Acetaminophen co-treated with Propylene Glycol] results in increased expression of ABCC4 mRNA17934960
C045950propiconazolepropiconazole results in increased expression of ABCC4 mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil results in decreased expression of ABCC4 mRNA24780913
D000527AlprostadilQuercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
D000527AlprostadilSilymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
D011458Prostaglandins EMefloquine inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]16004972
D011458Prostaglandins Everlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]16004972
D011794QuercetinABCC4 protein results in decreased susceptibility to Quercetin16156793
D011794QuercetinMefloquine inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]16004972
D011794QuercetinQuercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D011794QuercetinQuercetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
D011794QuercetinQuercetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D011794QuercetinQuercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
D011794QuercetinQuercetin results in decreased expression of ABCC4 mRNA18624906
D011794QuercetinQuercetin results in decreased expression of ABCC4 protein18624906
D011794Quercetinverlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]16004972
C012526quercitrinquercitrin results in decreased expression of ABCC4 mRNA25193878
D017382Reactive Oxygen Species"ABCC4 protein inhibits the reaction [2,6-dibromobenzoquinone results in increased abundance of Reactive Oxygen Species]"28885828
D017382Reactive Oxygen Species"ABCC4 protein inhibits the reaction [2,6-dichloro-(1,4)benzoquinone results in increased abundance of Reactive Oxygen Species]"28885828
C052785rebamipideABCC4 protein results in increased transport of rebamipide17939016
C059514resveratrolABCC4 protein results in decreased susceptibility to resveratrol16156793
C059514resveratrolresveratrol inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
C059514resveratrolresveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D012312RitodrineRitodrine results in increased expression of ABCC4 mRNA23370008
C030190S-(2,4-dinitrophenyl)glutathione"S-(2,4-dinitrophenyl)glutathione inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]"11856762
C002979selenomethylselenocysteineIsoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA]19025659
C002979selenomethylselenocysteineselenomethylselenocysteine results in decreased expression of ABCC4 mRNA19025659
D012834SilverSilver results in increased expression of ABCC4 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]16156793
D012838SilymarinSilymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]16156793
D012838SilymarinSilymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]]16156793
C009277sodium arsenatesodium arsenate results in decreased expression of ABCC4 mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of ABCC4 mRNA16882884
C017947sodium arsenite[Dietary Fats co-treated with sodium arsenite] results in increased expression of ABCC4 mRNA26890134
C017947sodium arsenitesodium arsenite results in increased expression of ABCC4 mRNA26890134
C017947sodium arsenite"[soybean oil, phospholipid emulsion co-treated with sodium arsenite] results in increased expression of ABCC4 mRNA"26890134
C016104sodium bichromatesodium bichromate results in increased expression of ABCC4 mRNA22155349
D012965Sodium Chloride[Acetaminophen co-treated with Sodium Chloride] results in increased expression of ABCC4 mRNA17934960
C545823soybean oil, phospholipid emulsion"[soybean oil, phospholipid emulsion co-treated with sodium arsenite] results in increased expression of ABCC4 mRNA"26890134
C025906stilbene oxidestilbene oxide results in increased expression of ABCC4 mRNA12920174
D013311StreptozocinStreptozocin results in increased expression of ABCC4 mRNA23319174
D013311StreptozocinStreptozocin results in increased expression of ABCC4 protein22531820|2331917
D013407SulbactamABCC4 protein results in increased transport of Sulbactam17939016
C016766sulforafansulforafan results in increased expression of ABCC4 mRNA21803983
C016766sulforafansulforafan results in increased expression of ABCC4 protein21803983
C446685systhanesysthane results in increased expression of ABCC4 mRNA23970803
C557331TAK-875TAK-875 inhibits the reaction [ABCC4 protein results in increased transport of Bile Acids and Salts]28108665
C557331TAK-875TAK-875 results in decreased activity of ABCC4 protein28108665
C013698tallowtallow affects the expression of ABCC4 mRNA19680557
D013629TamoxifenTamoxifen results in decreased expression of ABCC4 mRNA27765674
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of ABCC4 protein24014645
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCC4 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCC4 mRNA19619570|2039553
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCC4 protein20395535|2215535
D013749Tetrachlorodibenzodioxin"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Tetrachlorodibenzodioxin] results in increased expression of ABCC4 mRNA"17627975
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCC4 mRNA26377647
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ABCC4 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABCC4 promoter]19654925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of ABCC4 mRNA22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABCC4 mRNA19770486|1993321
D013752TetracyclineTetracycline affects the expression of ABCC4 mRNA25064622
D013752TetracyclineABCC4 protein results in increased transport of Tetracycline17939016
D013752TetracyclineTetracycline results in increased expression of ABCC4 mRNA27765674
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of ABCC4 mRNA19142964
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ABCC4 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ABCC4 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of ABCC4 mRNA23411599|2622270
D013866Thioguaninehesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
D013866ThioguanineQuercetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
D013866Thioguanineverlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
D013893ThiramThiram results in decreased expression of ABCC4 mRNA20530235
D013988TiclopidineTiclopidine results in increased expression of ABCC4 mRNA27765674
D014028Tobacco Smoke PollutionAHR protein promotes the reaction [Tobacco Smoke Pollution results in increased expression of ABCC4 mRNA]27450509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ABCC4 mRNA27450509
C116664tolvaptantolvaptan metabolite results in decreased activity of ABCC4 protein26507107
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ABCC4 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ABCC4 mRNA18230668
D014212TretinoinTretinoin results in decreased expression of ABCC4 mRNA21934132
D014212TretinoinTretinoin results in increased expression of ABCC4 mRNA23830798
D014212TretinoinTretinoin results in increased expression of ABCC4 mRNA20488242
C032910triadimefontriadimefon results in increased expression of ABCC4 mRNA23970803
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ABCC4 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ABCC4 mRNA19042947
C057693troglitazonetroglitazone results in increased expression of ABCC4 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of ABCC4 mRNA27765674
D014527Uric AcidABCC4 protein affects the export of Uric Acid15454390
D014527Uric AcidUric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate]15454390
D014580Ursodeoxycholic AcidNFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 mRNA]18687751
D014580Ursodeoxycholic AcidNFE2L2 affects the reaction [Ursodeoxycholic Acid results in increased expression of ABCC4 protein]18687751
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid affects the expression of ABCC4 protein16472600
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of ABCC4 mRNA18687751|2558270
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of ABCC4 protein18687751
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid promotes the reaction [NFE2L2 protein binds to ABCC4 promoter]18687751
D014635Valproic AcidValproic Acid affects the expression of ABCC4 mRNA25064622
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABCC4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ABCC4 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of ABCC4 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ABCC4 mRNA27765674
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of ABCC4 mRNA15541757
D001335Vehicle EmissionsVehicle Emissions results in increased expression of ABCC4 protein18474546
D014700Verapamil[Methyl Parathion co-treated with Verapamil] results in increased expression of ABCC4 mRNA25286004
C059141verlukastverlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Lindane]25478949
C059141verlukast"verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to o,p'-DDT]"25478949
C059141verlukastverlukast inhibits the reaction [ABCC4 protein results in increased export of monochlorobimane]25478949
C059141verlukast"verlukast inhibits the reaction [ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]"16004972
C059141verlukastverlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]16156793
C059141verlukastverlukast inhibits the reaction [Prostaglandins E results in increased activity of ABCC4 protein]16004972
C059141verlukastverlukast inhibits the reaction [Quercetin results in increased activity of ABCC4 protein]16004972
C059141verlukastverlukast results in decreased activity of ABCC4 protein16004972
C025643vinclozolinvinclozolin results in decreased expression of ABCC4 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of ABCC4 mRNA22570695
D014750Vincristine[Vincristine results in decreased susceptibility to Vincristine] which results in decreased expression of ABCC4 mRNA19944135
D002762CholecalciferolCholecalciferol results in decreased expression of ABCC4 mRNA19142964
D015215ZidovudineABCC4 protein affects the abundance of Zidovudine18364470
D015215ZidovudineABCC4 protein results in increased export of Zidovudine18364470|1853515
D015215ZidovudineZidovudine results in increased expression of ABCC4 mRNA15456083
D015215ZidovudineABCC4 protein results in increased export of Zidovudine15456083

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism-TAS-  
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activity-NAS7557451  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0043225ATPase-coupled anion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0008150biological_process-ND-  
GO:0032310prostaglandin secretion-IDA25173977  
GO:0055085transmembrane transport-IBA21873635  
GO:0055085transmembrane transport-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:0060271cilium assembly-IMP25173977  
GO:0099131ATP hydrolysis coupled ion transmembrane transport-IEA-  
GO:0099133ATP hydrolysis coupled anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA15297306  25173977  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016020membrane-IBA21873635  
GO:0016020membrane-IDA15297306  
GO:0016323basolateral plasma membrane-IDA24130369  
GO:0031088platelet dense granule membrane-IDA15297306  
GO:0031088platelet dense granule membrane-TAS-  
KEGG ID KEGG Term
hsa02010ABC transporters
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23462698Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver. (2013 May)More VRDrug Metab Dispos
14978246The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1). (2004 Mar)Sauna ZEMol Pharmacol
24694755Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development. (2014)Pereira CPLoS One
24343710Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. (2014 May)Nicol MRJ Clin Pharmacol