Gene: CDKN1B

1027
CDKN4|KIP1|MEN1B|MEN4|P27KIP1
cyclin dependent kinase inhibitor 1B
protein-coding
12p13.1
Ensembl:ENSG00000111276 MIM:600778 Vega:OTTHUMG00000149914 UniprotKB:P46527
NG_016341.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.382e-1 (AD)  9.208e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAD210.925
PAIP10.923
YWHAQ0.923
GPBP10.92
TMEM590.915
MFF0.915
CBX10.914
STAU10.912
LMBRD10.909
UBE2R20.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.782
OR4F5-0.782
MTRNR2L3-0.258
MTRNR2L10-0.258
MTRNR2L6-0.234
KLRB1-0.233
FCER2-0.231
C8orf74-0.225
RNF223-0.223
DPPA4-0.216

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one affects the expression of CDKN1B protein"21903591
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDKN1B protein"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]"20637255
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of CDKN1B mRNA"22101062
C0741531,4-phenylenebis(methylene)selenocyanate"1,4-phenylenebis(methylene)selenocyanate results in increased expression of CDKN1B mRNA"12844480
C4779411,4-phenylenebis(methylene)selenocyanate, glutathione conjugate"1,4-phenylenebis(methylene)selenocyanate, glutathione conjugate results in increased expression of CDKN1B mRNA"12844480
C09724015-deoxy-delta(12,14)-prostaglandin J2"15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein"15729575
C44865917-(dimethylaminoethylamino)-17-demethoxygeldanamycin17-(dimethylaminoethylamino)-17-demethoxygeldanamycin results in increased expression of CDKN1B protein19440035
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [sorafenib results in increased expression of CDKN1B protein]"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [U 0126 results in increased expression of CDKN1B protein]"22101421
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of CDKN1B protein"22101421|2303648
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[OGT mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which affects the expression of CDKN1B protein"23029544
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CDKN1B mRNA"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of CDKN1B protein"20453058
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"sorafenib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of CDKN1B protein]"23036488
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[U 0126 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in increased expression of CDKN1B protein"22101421
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"U 0126 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of CDKN1B protein]"22101421
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of CDKN1B mRNA"26988655
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein17513607
C5465712,2'-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)diphenoldichloroplatinum(II)"2,2'-cyclohexane-1,2-diylbis(azanediyl)bis(methylene)diphenoldichloroplatinum(II) results in decreased expression of CDKN1B mRNA"19694485
C5877342,3,5-trichloro-6-phenyl-(1,4)benzoquinone"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of CDKN1B protein"26451628
C0787652,3,5-(triglutathion-S-yl)hydroquinone"2,3,5-(triglutathion-S-yl)hydroquinone affects the localization of and results in increased expression of CDKN1B protein"21693435
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein11322924|1714867
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA18622747
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein21179458
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein15601625
C0899462,4-thiazolidinedione"2,4-thiazolidinedione results in increased expression of CDKN1B protein"15916743
C00799725-hydroxycholesterol25-hydroxycholesterol results in increased expression of CDKN1B mRNA17161435
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene results in increased expression of CDKN1B mRNA"26251320
C5706622-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one"2-amino-8-(4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido(2,3-d)pyrimidin-7(8H)-one results in increased expression of CDKN1B protein"23639247
C4574992-chloro-5-nitrobenzanilide"2-chloro-5-nitrobenzanilide inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of CDKN1B protein]"28834734
C5224582-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid"2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid results in increased expression of CDKN1B protein"17475810
C0228302-methoxyestradiol2-methoxyestradiol results in increased expression of CDKN1B protein23967052
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]24013123
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of CDKN1B protein"22290291
C513485(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester"(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester analog results in increased expression of CDKN1B protein"16039525
C513485(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester"(3-(4-(bis(2-chloroethyl)amino)phenyl)-3-propyl)carbamic acid 2-(6-(17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-11-yl)hexylamino)ethyl ester results in increased expression of CDKN1B protein"16039525
C4781003,4-di-O-caffeoylquinic acid"3,4-di-O-caffeoylquinic acid results in increased expression of CDKN1B protein"21872580
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in increased expression of CDKN1B mRNA"19916542
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in increased expression of CDKN1B protein"19916542
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]24013123
C5810043-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile"2-chloro-5-nitrobenzanilide inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of CDKN1B protein]"28834734
C5810043-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile"3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of CDKN1B protein"28834734
C5810043-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile"3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of CDKN1B protein"28834734
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]"11348869
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased stability of CDKN1B protein"11348869
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1B protein]18805435
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]18805435
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamidegefitinib promotes the reaction [[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein]16322342
C1191304-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein16322342
C1163224-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine results in decreased expression of CDKN1B mRNA21352547
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1B protein]18805435
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CDKN1B protein18805435
C0415944-nonylphenol4-nonylphenol results in decreased expression of CDKN1B mRNA26804032
C0415944-nonylphenol4-nonylphenol results in increased expression of CDKN1B protein26804764
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of CDKN1B mRNA20829426
C5732335,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein]"24646949
C0342145-iodotubercidin5-iodotubercidin results in decreased phosphorylation of CDKN1B protein26953159
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of CDKN1B mRNA26988655
C1078756-(methylamino)pyrido(3,4-d)pyrimidine"6-(methylamino)pyrido(3,4-d)pyrimidine results in increased expression of CDKN1B protein"15572027
C5319376-O-angeloylenolin6-O-angeloylenolin results in decreased expression of CDKN1B protein21192922
C0257249-methoxycamptothecin9-methoxycamptothecin results in increased expression of CDKN1B mRNA23369935
C0257249-methoxycamptothecin9-methoxycamptothecin results in increased expression of CDKN1B protein23369935
C503142ABT-100ABT-100 results in decreased phosphorylation of CDKN1B protein15930366
C503142ABT-100ABT-100 results in increased expression of CDKN1B protein15930366
C542662AC 93253AC 93253 results in decreased expression of CDKN1B mRNA25912555
D000082AcetaminophenAcetaminophen affects the expression of CDKN1B mRNA16701773
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]18022818
D000111AcetylcysteineAcetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]18022818
D000111AcetylcysteineAcetylcysteine results in increased expression of CDKN1B protein17602960
D000111AcetylcysteineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]17602960
D000171Acrolein[ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein24847785
D020106AcrylamideAcrylamide results in decreased expression of CDKN1B protein20734998
C058956acteosideacteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]17634406
C058956acteosideacteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]17634406
C058956acteosideacteoside results in increased expression of CDKN1B mRNA17634406
C058956acteosideacteoside results in increased expression of CDKN1B protein17634406
D000242Cyclic AMP[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
D000242Cyclic AMP[Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
D000242Cyclic AMPsorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]21693435
D000242Cyclic AMP[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
C016601afimoxifene[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C016601afimoxifene[afimoxifene co-treated with lapatinib] results in increased expression of CDKN1B protein15665275
C016601afimoxifeneafimoxifene promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C016601afimoxifeneafimoxifene results in increased expression of CDKN1B protein15665275
C016601afimoxifeneafimoxifene results in increased expression of CDKN1B mRNA17640349
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDKN1B gene27153756
C412373AG 1879AG 1879 inhibits the reaction [CDKN1B protein binds to SRC protein]28215542
C430898AGN 194204AGN 194204 inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
C430898AGN 194204AGN 194204 results in increased stability of CDKN1B protein11348869
C103303alitretinoinalitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
C103303alitretinoinalitretinoin results in increased expression of CDKN1B protein16340750
C103303alitretinoinalitretinoin results in increased stability of CDKN1B protein11348869
C103303alitretinoinseocalcitol inhibits the reaction [alitretinoin results in increased expression of CDKN1B protein]16340750
C002055alloseallose results in increased expression of CDKN1B protein18930000
D013196DihydrotestosteroneDihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]27132804
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of CDKN1B mRNA26804032
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]22266097
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]15157999
C077990alvocidibalvocidib results in increased cleavage of CDKN1B protein10537362
C077990alvocidibalvocidib results in increased expression of CDKN1B protein12589031|1518095
C077990alvocidib[alvocidib results in increased expression of TP53 protein] which results in increased expression of CDKN1B protein12589031
C077990alvocidibalvocidib results in increased expression of CDKN1B protein15180955
C068073Am 580Am 580 affects the localization of CDKN1B protein16618747
D000499AllylamineAllylamine results in increased expression of CDKN1B protein15048878
D000499Allylaminepyrrolidine dithiocarbamic acid inhibits the reaction [Allylamine results in increased expression of CDKN1B protein]15048878
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDKN1B mRNA16483693
D000814Aniline CompoundsAniline Compounds results in increased expression of CDKN1B protein25123791
C053442annonacinannonacin results in increased expression of CDKN1B protein21840388
D000872AnthocyaninsAnthocyanins results in increased expression of CDKN1B protein27444805
C102351apicidinapicidin results in increased expression of CDKN1B protein18313654
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CDKN1B mRNA18585445
D001151ArsenicArsenic affects the methylation of CDKN1B gene25304211
D001151Arsenic[silybin co-treated with Arsenic] results in increased expression of CDKN1B protein25868784
D001151ArsenicArsenic results in decreased expression of CDKN1B mRNA19654921
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein27430728
C006632arsenic trioxidearsenic trioxide results in decreased expression of CDKN1B mRNA19769630
C006632arsenic trioxidearsenic trioxide results in increased expression of and results in increased localization of CDKN1B protein20698225
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN1B gene21544632
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN1B mRNA19236751|2045855
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN1B protein20458559|2095313
C006632arsenic trioxidesalvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]23239002
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN1B mRNA19379560
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN1B protein19379560
C015001arsenitearsenite results in increased methylation of CDKN1B promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18544905
D001241Aspirin[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein19908241
D001241AspirinAspirin results in increased expression of CDKN1B protein16880202
D000069059Atorvastatin Calcium[Atorvastatin Calcium co-treated with Celecoxib] results in increased expression of CDKN1B protein18172863
D000069059Atorvastatin CalciumAtorvastatin Calcium results in increased expression of CDKN1B protein16470222
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CDKN1B mRNA18585445
D001397AzoxymethaneAzoxymethane results in decreased expression of CDKN1B mRNA12189186
D001397AzoxymethaneAzoxymethane results in decreased expression of CDKN1B protein12189186
D001397AzoxymethaneCalcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
D001397AzoxymethanePiroxicam inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
D001397AzoxymethaneSulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
D001554BenzeneBenzene results in decreased expression of CDKN1B mRNA20018183
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1B mRNA]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CDKN1B promoter]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDKN1B mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDKN1B mRNA21995607
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN1B mRNA25820237
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene results in decreased expression of CDKN1B protein]17141280
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDKN1B protein17141280
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of CDKN1B protein17283133
C038328BEP protocolBEP protocol results in increased expression of CDKN1B mRNA18987330
D001599BerberineBerberine results in increased expression of CDKN1B protein16505103
D004958Estradiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CDKN1B mRNA22064387
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1B protein9705214
D004958EstradiolEstradiol promotes the reaction [Medroxyprogesterone Acetate results in increased expression of CDKN1B protein]17283133
D004958EstradiolEstradiol results in decreased expression of and results in increased degradation of CDKN1B protein23029392
D004958EstradiolEstradiol results in decreased expression of CDKN1B mRNA22064387
D004958EstradiolEstradiol results in increased degradation of CDKN1B protein17283133
D004958EstradiolEstradiol results in increased phosphorylation of CDKN1B protein23029392
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133|2302939
D004958Estradiollactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133|2302939
D004958EstradiolMAPK1 protein affects the reaction [Estradiol results in increased phosphorylation of CDKN1B protein]23029392
D004958EstradiolMAPK3 protein affects the reaction [Estradiol results in increased phosphorylation of CDKN1B protein]23029392
D004958EstradiolMifepristone inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CDKN1B protein]17283133
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of and results in increased stability of CDKN1B protein23029392
D004958EstradiolSKP2 mutant form inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]23029392
D004958EstradiolEstradiol affects the expression of CDKN1B mRNA15598610
D004958EstradiolEstradiol results in increased expression of CDKN1B mRNA17640349
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of CDKN1B mRNA17640349
C053541bicalutamidebicalutamide results in increased expression of CDKN1B11845989
C519495BIM 23120[BIM 23120 results in increased activity of SSTR2 protein] which results in increased expression of CDKN1B protein16954443
C519496BIM 23206[BIM 23206 results in increased activity of SSTR5 protein] which results in increased expression of CDKN1B protein16954443
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDKN1B mRNA28628672
C006780bisphenol Abisphenol A affects the expression of CDKN1B mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CDKN1B protein25130739
C006780bisphenol Abisphenol A results in decreased expression of CDKN1B mRNA27998958
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1B mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of CDKN1B mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of CDKN1B protein24809654
C006780bisphenol Abisphenol A results in increased expression of CDKN1B protein21722727
C006780bisphenol Abisphenol A results in increased expression of CDKN1B mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CDKN1B protein20692330
C006780bisphenol Abisphenol A results in increased expression of CDKN1B mRNA28988043
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDKN1B mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CDKN1B mRNA17553608
C492810BL1521BL1521 results in decreased expression of CDKN1B protein15733867
D000069286Bortezomib[Bortezomib co-treated with Butyrates] results in increased cleavage of CDKN1B protein15173093
D000069286Bortezomib[Bortezomib co-treated with vorinostat] results in increased cleavage of CDKN1B protein15173093
D000069286BortezomibBortezomib promotes the reaction [lapatinib results in increased expression of CDKN1B protein]20701607
D000069286BortezomibBortezomib results in increased expression of CDKN1B protein14749476|1517309
D000069286BortezomibBortezomib results in increased stability of CDKN1B protein15543232
D000069286BortezomibCisplatin promotes the reaction [Bortezomib results in increased expression of CDKN1B protein]19636294
D000069286Bortezomiblapatinib promotes the reaction [Bortezomib results in increased expression of CDKN1B protein]20701607
D000069286Bortezomib[vorinostat co-treated with Bortezomib] results in increased expression of CDKN1B protein19220424
D000069286BortezomibBortezomib affects the localization of CDKN1B protein17148762
D000069286BortezomibBortezomib results in increased expression of CDKN1B protein18451165
C471992bosutinibbosutinib results in increased expression of CDKN1B protein17129604
C471992bosutinibImatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]17129604
C023623brassinolidebrassinolide results in decreased expression of CDKN1B protein20833159
C013418bromfenacoumbromfenacoum results in decreased expression of CDKN1B protein28903499
D019819BudesonideBudesonide inhibits the reaction [vinyl carbamate results in decreased expression of CDKN1B protein]12117777
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]17602960
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]17602960
C026105butylidenephthalidebutylidenephthalide results in increased expression of CDKN1B protein16987298
D002087Butyrates[Bortezomib co-treated with Butyrates] results in increased cleavage of CDKN1B protein15173093
D002087ButyratesButyrates results in increased expression of CDKN1B mRNA16112107|1743112
D002087ButyratesButyrates results in increased expression of CDKN1B protein17431121
D002087ButyratesPPARG protein affects the reaction [Butyrates results in increased expression of CDKN1B mRNA]16112107
D002087ButyratesTretinoin promotes the reaction [Butyrates results in increased expression of CDKN1B mRNA]17431121
D002087ButyratesTretinoin promotes the reaction [Butyrates results in increased expression of CDKN1B protein]17431121
D002104CadmiumCadmium results in decreased expression of CDKN1B protein27658547
D002104CadmiumCadmium results in increased expression of CDKN1B protein16730872
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDKN1B protein27510461
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]11516527|1213562
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA]12135628
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CDKN1B mRNA18636176
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDKN1B protein16730872
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in increased expression of CDKN1B protein15885897
D002122Calcium ChlorideCalcium Chloride inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
C071482calpeptincalpeptin results in decreased expression of CDKN1B protein modified form22432027
D002211CapsaicinCapsaicin results in decreased expression of CDKN1B protein22226932
D002211CapsaicinCapsaicin results in increased expression of CDKN1B protein19855437
D002211CapsaicinCapsaicin results in increased expression of CDKN1B20069556
D002220CarbamazepineCarbamazepine affects the expression of CDKN1B mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CDKN1B protein12759355
D002251Carbon TetrachlorideCDKN1B protein affects the reaction [Carbon Tetrachloride results in increased expression of CDKN1A protein]12759355
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone promotes the reaction [CDKN1B protein binds to CDK4 protein]19819288
D002259Carbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCarbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in increased expression of CDKN1B protein19819288
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of CDKN1B mRNA19395590
C054133casticincasticin results in increased expression of CDKN1B mRNA27862857
C103436CB 1093CB 1093 promotes the reaction [CDKN1B protein binds to CDK2 protein]12907249
C103436CB 1093CB 1093 results in increased expression of and results in decreased degradation of CDKN1B protein12907249
C103436CB 1093CB 1093 results in increased expression of CDKN1B mRNA12907249
D000068579Celecoxib[Atorvastatin Calcium co-treated with Celecoxib] results in increased expression of CDKN1B protein18172863
D000068579CelecoxibCelecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]21737646
D000068579CelecoxibCelecoxib results in increased expression of CDKN1B mRNA19428934
D000068579CelecoxibCelecoxib results in increased expression of CDKN1B protein19428934|2173764
D000068579CelecoxibValproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]21737646
D000068579CelecoxibCelecoxib results in increased activity of CDKN1B19706164
C532683CellfoodCellfood results in increased expression of CDKN1B protein24598211
D002509CephaloridineCephaloridine results in decreased expression of CDKN1B mRNA18500788
D002635Chenodeoxycholic AcidChenodeoxycholic Acid affects the localization of CDKN1B protein20818264
C100187chloropicrinchloropicrin results in increased expression of CDKN1B protein24548678
D004390ChlorpyrifosChlorpyrifos results in increased expression of CDKN1B mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDKN1B gene20938992
C074702chromium hexavalent ionAKT1 protein affects the reaction [Vanadates inhibits the reaction [chromium hexavalent ion affects the localization of CDKN1B protein]]19377290
C074702chromium hexavalent ionAKT1 protein modified form inhibits the reaction [chromium hexavalent ion affects the localization of CDKN1B protein]19377290
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of and affects the localization of CDKN1B protein19377290
C074702chromium hexavalent ionVanadates inhibits the reaction [chromium hexavalent ion results in decreased expression of and affects the localization of CDKN1B protein]19377290
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN1B mRNA25820237
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CDKN1B protein21621607
C039671ciglitazoneciglitazone results in increased expression of CDKN1B mRNA20578043
C086108clobenpropit[HRH4 protein results in increased susceptibility to clobenpropit] which results in increased expression of CDKN1B protein22363581
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDKN1B mRNA17602206
D003022ClotrimazoleClotrimazole results in increased expression of CDKN1B20724915
D009243NADNAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
D009243NADSIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CDKN1B protein24690739
D003300Copper[Disulfiram binds to Copper] which results in increased expression of CDKN1B protein24690739
D003345CorticosteroneCorticosterone promotes the reaction [CDKN1B protein binds to CDK4 protein]12807724
D003345CorticosteroneCorticosterone results in increased expression of CDKN1B protein12807724
C477330CP-654577CP-654577 results in increased expression of CDKN1B protein12907618
C542041cudraflavone Bcudraflavone B results in increased expression of CDKN1B protein23881456
C542041cudraflavone Bresveratrol inhibits the reaction [cudraflavone B results in increased expression of CDKN1B protein]23881456
C542041cudraflavone Bsirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein]23881456
C029892cupric chloridecupric chloride affects the expression of CDKN1B protein23313662
C030973cupric oxidecupric oxide results in decreased expression of CDKN1B mRNA22077320
D003474CurcuminAR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]27132804
D003474Curcumin[arsenic trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein27430728
D003474Curcumin[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein27132804
D003474CurcuminCurcumin results in decreased expression of CDKN1B protein18593936
D003474CurcuminCurcumin results in increased expression of CDKN1B mRNA15713895
D003474CurcuminCurcumin results in increased expression of CDKN1B protein18156803|1822626
D003474CurcuminDihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]27132804
D003474CurcuminTNFSF10 protein promotes the reaction [Curcumin results in increased expression of CDKN1B protein]18226269
D003474CurcuminCurcumin results in increased expression of CDKN1B mRNA25822711
D003474CurcuminCurcumin results in increased expression of CDKN1B protein21594647
D003474CurcuminButhionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein]17602960
D003474CurcuminCurcumin results in increased expression of CDKN1B protein17602960
C038459curdlancurdlan results in decreased expression of CDKN1B mRNA23543010
C009160cyclonitecyclonite results in decreased expression of CDKN1B mRNA19417177
C013905cyclopentenonecyclopentenone results in increased expression of CDKN1B16061222
D003520Cyclophosphamide[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA16322899
D016572CyclosporineCyclosporine results in decreased expression of CDKN1B mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of CDKN1B mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of CDKN1B mRNA21865292
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [VEGFC protein results in decreased expression of CDKN1B protein]24184161
D003545CysteineCysteine analog results in decreased expression of CDKN1B protein15890017
D003571Cytochalasin BCytochalasin B results in increased expression of CDKN1B protein27640744
D003609DactinomycinDactinomycin inhibits the reaction [Mimosine results in increased expression of CDKN1B mRNA]10623466
C109268darbufelonedarbufelone results in increased expression of CDKN1B mRNA20352217
C109268darbufelonedarbufelone results in increased expression of CDKN1B protein20352217
D000069439DasatinibDasatinib results in increased expression of CDKN1B protein16740687|2014516
D003630DaunorubicinDaunorubicin affects the expression of CDKN1B mRNA20037814
D003630Daunorubicinfasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA]20037814
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CDKN1B protein28572024
C014347decitabine[decitabine affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNA18544619
C014347decitabine[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA18622747
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of CDKN1B mRNA17185465
C014347decitabinedecitabine results in decreased expression of CDKN1B mRNA27915011
D013759DronabinolDronabinol results in increased expression of CDKN1B mRNA18454173
D013759DronabinolJUND mutant form inhibits the reaction [Dronabinol results in increased expression of CDKN1B mRNA]18454173
D013759DronabinolTES mutant form inhibits the reaction [Dronabinol results in increased expression of CDKN1B mRNA]18454173
D003907DexamethasoneDexamethasone results in increased expression of CDKN1B mRNA19428934
D003907DexamethasoneDexamethasone results in increased expression of CDKN1B protein19428934
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDKN1B mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1B mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDKN1B mRNA28628672
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein25559859
D003907Dexamethasone"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein]"24646949
D003907Dexamethasone[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein24646949
D003907Dexamethasonesilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]25559859
C004717diacetylmonoximediacetylmonoxime results in increased expression of CDKN1B protein15252113
C042577diallyl trisulfidediallyl trisulfide results in increased expression of CDKN1B protein14693049
C023614dibenzofuranAHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1B mRNA]20566336
C023614dibenzofurandibenzofuran analog results in increased expression of CDKN1B mRNA20566336
C023614dibenzofurandibenzofuran analog results in increased expression of CDKN1B protein20566336
D003994BucladesineBucladesine results in increased expression of CDKN1B protein16718685|2169343
D002945CisplatinCDKN1B results in decreased susceptibility to Cisplatin21652059
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CDKN1B mRNA27514524
D002945Cisplatin[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein21092744
D002945CisplatinCisplatin promotes the reaction [Bortezomib results in increased expression of CDKN1B protein]19636294
D002945CisplatinCisplatin promotes the reaction [MIR630 mRNA results in increased expression of CDKN1B protein]20145152
D002945CisplatinCisplatin results in increased expression of CDKN1B mRNA21092744
D002945CisplatinCisplatin results in increased expression of CDKN1B protein21274007
D002945CisplatinSirolimus promotes the reaction [Cisplatin results in increased expression of CDKN1B mRNA]21092744
D002945CisplatinCisplatin results in decreased expression of CDKN1B mRNA21151649
D004008DiclofenacDiclofenac affects the expression of CDKN1B mRNA24752500
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA15784690
C020283diethanolaminediethanolamine results in decreased expression of CDKN1B mRNA16014740
C020283diethanolaminediethanolamine results in decreased expression of CDKN1B mRNA16014740
D004052DiethylnitrosamineCDKN1B protein inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK2 protein]17620307
D004052DiethylnitrosamineCDKN1B results in decreased susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]17620307
D004052Diethylnitrosamine2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]17582756
D004052Diethylnitrosamine[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CDKN1B mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18544905
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CDKN1B protein17582756
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18253720
D004052Diethylnitrosaminepioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]17582756
D004052Diethylnitrosaminepioglitazone promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]17582756
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CDKN1B protein21722727
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CDKN1B mRNA21658437
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CDKN1B mRNA17292805
D004074DigitoxinDigitoxin analog results in decreased expression of CDKN1B protein22037315
D004074DigitoxinDigitoxin results in decreased expression of CDKN1B protein22037315
D002117CalcitriolCalcitriol promotes the reaction [CDKN1B protein binds to CDK4 protein]16322758
D002117CalcitriolCalcitriol results in decreased phosphorylation of and results in decreased degradation of and results in increased stability of CDKN1B protein12954644
D002117CalcitriolCalcitriol results in increased expression of CDKN1B11519864
D002117CalcitriolCalcitriol results in increased expression of CDKN1B mRNA11270487|9783903
D002117CalcitriolCalcitriol results in increased expression of CDKN1B protein10825140|1603911
D004125Dimethyldithiocarbamate[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein17079469
D004221DisulfiramDisulfiram results in decreased expression of CDKN1B mRNA20530235
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CDKN1B protein24690739
D004221DisulfiramDisulfiram results in increased expression of CDKN1B protein17079463
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of CDKN1B protein24690739
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in increased expression of CDKN1B protein19272428
D004317DoxorubicinCDKN1B results in decreased susceptibility to Doxorubicin21652059
D004317DoxorubicinDoxorubicin affects the expression of CDKN1B mRNA16705698
D004317DoxorubicinDoxorubicin affects the expression of CDKN1B protein16036217|1789351
D004317Doxorubicin[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CDKN1B mRNA16322899
D004317DoxorubicinDoxorubicin results in increased expression of CDKN1B protein17935137
D004317Doxorubicinwortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]17935137
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CDKN1B protein"23239598|2331583
C034192ellipticineellipticine results in decreased expression of CDKN1B protein21843585
C070609EMD 53998EMD 53998 analog results in increased expression of CDKN1B mRNA24977338
C118739entinostat[fludarabine co-treated with entinostat] results in decreased expression of CDKN1B protein15059916
C551471EPI 001EPI 001 results in increased expression of CDKN1B protein25669987
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDKN1B mRNA22079256
C498475equiguardequiguard results in decreased expression of CDKN1B protein15547720
C498475equiguardequiguard results in increased expression of CDKN1B protein15547720
C472787erucylphospho-N,N,N-trimethylpropylammonium"erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of CDKN1B"24987858
C472787erucylphospho-N,N,N-trimethylpropylammonium"RB1 mutant form inhibits the reaction [erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of CDKN1B]"24987858
D004967Estrogens[Estrogens co-treated with INS protein] inhibits the reaction [PTEN protein results in increased expression of CDKN1B protein]11230179
D004967EstrogensEstrogens inhibits the reaction [PTEN protein results in increased expression of CDKN1B protein]11230179
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDKN1B mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CDKN1B mRNA17557909
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of CDKN1B mRNA22711419
D005047EtoposideEtoposide results in increased expression of CDKN1B protein17935137
D005047Etoposidewortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]17935137
D005054EugenolEugenol results in increased expression of CDKN1B protein22686307
C049347fasudilfasudil affects the reaction [Daunorubicin affects the expression of CDKN1B mRNA]20037814
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18253720
C017690fenvalerateCDKN1B protein inhibits the reaction [fenvalerate results in increased expression of CDK2 mRNA]22850687
C017690fenvalerateCDKN1B protein results in decreased susceptibility to fenvalerate22850687
C017690fenvaleratefenvalerate results in decreased expression of CDKN1B mRNA22850687
C017690fenvaleratefenvalerate results in decreased expression of CDKN1B protein22850687
C000499ferric oxide[ferric oxide analog co-treated with Acrolein] results in decreased expression of CDKN1B protein24847785
D005411Flame RetardantsFlame Retardants results in increased expression of CDKN1B protein18952254
C028610flavanoneflavanone results in increased expression of CDKN1B protein22056764
C544127flavomannin-6,6'-dimethylether"flavomannin-6,6'-dimethylether results in increased expression of CDKN1B protein"19686795
C024352fludarabine[fludarabine co-treated with entinostat] results in decreased expression of CDKN1B protein15059916
D0150732-Acetylaminofluorene2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]17582756
D0150732-Acetylaminofluorenepioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]17582756
D005472FluorouracilCDKN1B protein affects the susceptibility to Fluorouracil17217824
D005472FluorouracilFluorouracil results in decreased expression of CDKN1B mRNA18930000
D005473FluoxetineFluoxetine affects the expression of CDKN1B mRNA18371935
D005473Fluoxetine[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B protein18371935
D005473FluoxetineFluoxetine results in increased expression of CDKN1B mRNA21497159
D005485FlutamideFlutamide results in decreased expression of CDKN1B mRNA24136188
D005492Folic AcidFolic Acid affects the expression of CDKN1B mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDKN1B gene20938992
C096856FTI 277[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133|2302939
C070081fulvestrantfulvestrant results in increased expression of CDKN1B protein21367843
D062610Fungal PolysaccharidesFungal Polysaccharides results in increased expression of CDKN1B mRNA24060681
D062610Fungal PolysaccharidesFungal Polysaccharides results in increased expression of CDKN1B protein24060681
C039281furanfuran results in increased expression of CDKN1B mRNA22079235
D005707Gallic AcidGallic Acid results in increased expression of CDKN1B protein22245431
D024504gamma-Tocopherolgamma-Tocopherol results in decreased expression of CDKN1B protein12368234
C419708gefitinibgefitinib promotes the reaction [[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein]16322342
C419708gefitinibgefitinib results in decreased expression of CDKN1B14679152
C419708gefitinibgefitinib results in increased expression of CDKN1B protein16740687|1751360
C056507gemcitabineCDKN1B results in decreased susceptibility to gemcitabine21652059
D019833GenisteinGenistein results in increased expression of CDKN1B protein15829497
D019833GenisteinGenistein results in increased expression of CDKN1B mRNA21048042
D019833GenisteinGenistein results in increased expression of CDKN1B mRNA28988043
C007845gingerolgingerol results in decreased expression of CDKN1B mRNA28249781
D005897GlafenineGlafenine results in decreased expression of CDKN1B mRNA24136188
D005938GlucocorticoidsGlucocorticoids results in increased expression of CDKN1B protein15034294
D005944GlucosamineGlucosamine results in decreased expression of CDKN1B protein15654767
D005947GlucoseGlucose results in increased expression of CDKN1B protein22561310
D005947GlucoseNAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
D005947GlucoseNiacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
D005947GlucoseSirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
D005947GlucoseSIRT1 protein promotes the reaction [NAD inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D005947GlucoseSIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D005947GlucoseSIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D005678G(M2) GangliosideG(M2) Ganglioside results in decreased expression of CDKN1B protein15654767
D006046Gold[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein17079469
C568713GSK1210151AGSK1210151A results in increased expression of CDKN1B protein26254443
D006247HarmineHarmine results in decreased phosphorylation of CDKN1B protein26953159
D006427HeminHemin results in decreased degradation of CDKN1B protein17283133
D006493HeparinHeparin analog results in decreased expression of CDKN1B protein20201787
D006493HeparinHeparin analog results in increased expression of CDKN1B protein18057711
C013015hesperetinhesperetin results in increased expression of CDKN1B17927510
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of CDKN1B mRNA26804032
D006581HexachlorobenzeneHexachlorobenzene affects the reaction [CDKN1B protein binds to SRC protein]28215542
D006581HexachlorobenzeneHexachlorobenzene promotes the reaction [CDKN1B protein binds to CCNE1 protein]28215542
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of CDKN1B protein25093615
C014026hexamethylene bisacetamidehexamethylene bisacetamide results in increased expression of CDKN1B mRNA17349212
D006632Histamine[HRH4 protein results in increased susceptibility to Histamine] which results in increased expression of CDKN1B protein22363581
C070164homocastasteronehomocastasterone results in increased expression of CDKN1B protein20833159
D017313FenretinideFenretinide results in increased expression of CDKN1B protein16270382
D006830Hydralazine[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein11318962
D006835HydrazonesHydrazones results in increased expression of CDKN1B protein22056764
D006851Hydrochloric AcidHydrochloric Acid affects the localization of CDKN1B protein20818264
D006852Hydrochlorothiazide[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein11318962
D006918HydroxyureaHydroxyurea results in increased expression of CDKN1B protein10961388
D006918Hydroxyurea[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA17653085
C559745hyperforin dicyclohexylammoniumhyperforin dicyclohexylammonium results in increased expression of CDKN1B protein21376709
C492448ICG 001ICG 001 results in decreased expression of CDKN1B mRNA26191083
D000068877Imatinib Mesylate[vorinostat co-treated with Imatinib Mesylate] results in increased expression of CDKN1B protein12446442
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]17129604
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]17129604
C027185indirubinindirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C027185indirubinindirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]18344322
C027185indirubinindirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]18344322
C027185indirubinindirubin results in increased expression of CDKN1B protein18344322
C027185indirubintanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C027185indirubintetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]]18344322
C016517indole-3-carbinolindole-3-carbinol analog results in increased expression of CDKN1B protein20570586
C016517indole-3-carbinolindole-3-carbinol results in increased expression of CDKN1B16082211
D007213IndomethacinIndomethacin results in decreased expression of CDKN1B mRNA16984733
D007213IndomethacinIndomethacin results in increased expression of CDKN1B mRNA19428934
D007213IndomethacinIndomethacin results in increased expression of CDKN1B protein11260862|1942893
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDKN1B mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1B mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDKN1B mRNA28628672
C409043inecalcitolinecalcitol results in increased expression of CDKN1B protein10825140
C572449INK128INK128 results in increased expression of CDKN1B protein26536665
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDKN1B mRNA25613284
C506002ircinin-1ircinin-1 results in increased expression of CDKN1B mRNA16163705
C506002ircinin-1ircinin-1 results in increased expression of CDKN1B protein16163705
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of CDKN1B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDKN1B mRNA28628672
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein25559859
D0150561-Methyl-3-isobutylxanthine"5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein]"24646949
D0150561-Methyl-3-isobutylxanthine[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein24646949
D0150561-Methyl-3-isobutylxanthinesilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]25559859
C036643isoeugenolisoeugenol results in increased expression of CDKN1B protein22686307
D007529IsoflavonesIsoflavones results in increased expression of CDKN1B protein17374662
C040920isoliquiritigeninisoliquiritigenin results in decreased expression of CDKN1B mRNA27702603
C550177isoliquiritigenin 2'-methyl etherisoliquiritigenin 2'-methyl ether results in decreased expression of CDKN1B protein20040371
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CDKN1B protein27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDKN1B mRNA26830473
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDKN1B26575167|2725637
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDKN1B mRNA24796395|2527752
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDKN1B protein23792448|2443544
D007654KetoconazoleKetoconazole results in increased expression of CDKN1B mRNA25808816
C074279KH 1060KH 1060 promotes the reaction [CDKN1B protein binds to CDK2 protein]12907249
C074279KH 1060KH 1060 results in increased expression of and results in decreased degradation of CDKN1B protein12907249
C074279KH 1060KH 1060 results in increased expression of CDKN1B mRNA12907249
C011890kojic acid[Ascorbic Acid co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA18544905
C500368labedipinedilol Alabedipinedilol A results in increased expression of CDKN1B protein19056458
C067713lactacystinlactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]17283133|2302939
C067713lactacystinlactacystin results in increased expression of CDKN1B protein12149143
C490728lapatinib[afimoxifene co-treated with lapatinib] promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C490728lapatinib[afimoxifene co-treated with lapatinib] results in increased expression of CDKN1B protein15665275
C490728lapatinibBortezomib promotes the reaction [lapatinib results in increased expression of CDKN1B protein]20701607
C490728lapatiniblapatinib promotes the reaction [Bortezomib results in increased expression of CDKN1B protein]20701607
C490728lapatiniblapatinib promotes the reaction [CDKN1B protein binds to and results in decreased activity of [CCNE1 protein binds to CDK2 protein]]15665275
C490728lapatiniblapatinib results in increased expression of CDKN1B protein15665275|2070160
D008012LidocaineLidocaine affects the expression of CDKN1B mRNA18931217
C018584linaloollinalool results in increased expression of CDKN1B mRNA19922762
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CDKN1B protein12883080
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CDKN1B mRNA12883080
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CDKN1B protein alternative form12883080
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides affects the expression of CDKN1B protein]12883080
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B mRNA]12883080
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B protein alternative form]12883080
D008094LithiumLithium results in decreased expression of CDKN1B mRNA15687245
D008094LithiumLithium results in decreased expression of CDKN1B protein15687245|1829663
D018021Lithium ChlorideLithium Chloride results in decreased expression of CDKN1B mRNA17440966
D008148LovastatinLovastatin results in increased expression of CDKN1B protein10502407|1511840
D008148LovastatinLovastatin results in increased expression of CDKN1B mRNA20578043
D008148LovastatinLovastatin results in increased expression of CDKN1B protein20578043|9848777
D047311LuteolinLuteolin results in increased expression of CDKN1B protein11322924
C094099LY 293111LY 293111 results in increased expression of CDKN1B protein16151469
C051883maxacalcitolmaxacalcitol results in increased expression of CDKN1B protein16039115
D017258Medroxyprogesterone AcetateEstradiol promotes the reaction [Medroxyprogesterone Acetate results in increased expression of CDKN1B protein]17283133
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of CDKN1B protein17283133
D017258Medroxyprogesterone AcetateMifepristone inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CDKN1B protein]17283133
D008627Mercuric ChlorideMercuric Chloride affects the expression of CDKN1B mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of CDKN1B gene20938992
D008727MethotrexateCDKN1B protein affects the susceptibility to Methotrexate17217824
D008727MethotrexateMethotrexate results in increased expression of CDKN1B mRNA22183962
D008730MethoxsalenMethoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]15157999
C005219methyl cellosolvemethyl cellosolve results in increased expression of CDKN1B mRNA19643169
D008748MethylcholanthreneAcetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]18022818
D008748MethylcholanthreneCDKN1B protein results in increased susceptibility to Methylcholanthrene18022818
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CDKN1B protein18022818
D008748Methylcholanthreneresveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]18022818
D008769MethylnitronitrosoguanidineCadmium Chloride inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CDKN1B protein]11516527|1213562
D008769MethylnitronitrosoguanidineCadmium Chloride promotes the reaction [Methylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA]12135628
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of CDKN1B mRNA12135628
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of CDKN1B protein11516527|1213562
C008493methylselenic acidKLF4 protein affects the reaction [methylselenic acid results in increased expression of CDKN1B mRNA]18314491
C008493methylselenic acidmethylselenic acid promotes the reaction [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]17847021
C008493methylselenic acidmethylselenic acid results in decreased activity of [CDKN1A protein binds to CDKN1B protein binds to CDK2 protein]17847021
C008493methylselenic acidmethylselenic acid results in increased expression of CDKN1B mRNA17847021|1831449
C008493methylselenic acidmethylselenic acid results in increased expression of CDKN1B protein17847021
C008493methylselenic acidmethylselenic acid affects the expression of CDKN1B protein12017302
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CDKN1B mRNA29191790
D015735MifepristoneMifepristone inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CDKN1B protein]17283133
D015735MifepristoneMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]22266097
D015735MifepristoneMifepristone promotes the reaction [CDK2 protein binds to CDKN1B protein]17545545
D015735MifepristoneMifepristone promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]17545545
D015735MifepristoneMifepristone results in increased expression of and results in increased localization of CDKN1B protein17545545
D008898MimosineMimosine results in increased expression of CDKN1B10530763
D008898MimosineDactinomycin inhibits the reaction [Mimosine results in increased expression of CDKN1B mRNA]10623466
D008898MimosineMimosine results in increased expression of CDKN1B mRNA10623466
D008898MimosineMimosine results in increased expression of CDKN1B protein10623466
D016685MitomycinCDKN1B protein affects the susceptibility to Mitomycin17217824
C070571ML 7ML 7 results in increased expression of CDKN1B protein15252113
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of CDKN1B mRNA20024957
D005677G(M1) GangliosideG(M1) Ganglioside results in decreased expression of CDKN1B protein15654767
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of CDKN1B mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA16357179
C523799MRK 003CDKN1B results in increased susceptibility to MRK 00319318552
C523799MRK 003MRK 003 results in increased expression of CDKN1B mRNA19318552
C523799MRK 003MRK 003 results in increased expression of CDKN1B protein19318552
D009151Mustard GasMustard Gas results in decreased expression of CDKN1B mRNA15674843
D009173Mycophenolic AcidMycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]12193749
D009173Mycophenolic AcidMycophenolic Acid inhibits the reaction [IL2 protein results in decreased expression of CDKN1B protein]20736080
C562255N-(2-(4-hydroxyphenyl)ethyl)-2-(2,5-dimethoxyphenyl)-3-(3-methoxy-4-hydroxyphenyl)acrylamide"N-(2-(4-hydroxyphenyl)ethyl)-2-(2,5-dimethoxyphenyl)-3-(3-methoxy-4-hydroxyphenyl)acrylamide results in increased expression of CDKN1B protein"21835169
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [VEGFC protein results in decreased expression of CDKN1B protein]24184161
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of CDKN1B protein14567460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDKN1B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CDKN1B mRNA"25554681
C031721naphthalenenaphthalene results in decreased expression of CDKN1B protein18687389
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CDKN1B mRNA20551477
C498045NCX 4040NCX 4040 results in decreased expression of CDKN1B mRNA20188076
C022838nickel chlorideHIF1A protein promotes the reaction [nickel chloride results in increased expression of CDKN1B protein]28552779
C022838nickel chloridenickel chloride results in increased expression of CDKN1B protein28552779
C022838nickel chloridenickel chloride affects the expression of CDKN1B mRNA22546817
C017557nickel subsulfidenickel subsulfide results in decreased expression of CDKN1B23447020
D009538Nicotine4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of CDKN1B protein]18805435
D009538NicotineNicotine results in decreased expression of CDKN1B protein18805435
D009538NicotineNicotine results in increased expression of and results in increased stability of CDKN1B protein15231866
C021277nilutamidenilutamide results in decreased expression of CDKN1B protein16616092
C012655nimesulidenimesulide results in increased expression of CDKN1B12717830
C012655nimesulidenimesulide results in increased expression of CDKN1B protein14567460
D005996NitroglycerinNitroglycerin results in increased expression of CDKN1B mRNA12102619
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of CDKN1B mRNA22561872
C090577N,N'-bis(salicylideneamino)ethane-manganese(II)"N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [SOD2 gene mutant form results in increased expression of CDKN1B protein]"21195081
C466913NU2058NU2058 results in increased expression of CDKN1B protein17599054
C064976O(6)-benzylguanine[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of CDKN1B protein20980775
C064976O(6)-benzylguanine[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of CDKN1B protein20980775
C055122orlistatorlistat results in increased expression of CDKN1B protein15138278
C030110oxaliplatinoxaliplatin results in increased expression of CDKN1B protein15204521
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKN1B mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of CDKN1B mRNA17914565
C570200P61-E7 compoundP61-E7 compound results in increased expression of and results in decreased phosphorylation of CDKN1B protein22028818
C570200P61-E7 compoundRHOA protein affects the reaction [P61-E7 compound results in increased expression of CDKN1B protein]22028818
C500026palbociclibpalbociclib promotes the reaction [CCND1 protein binds to CDKN1B protein binds to CDK4 protein]20473330
C500026palbociclibpalbociclib results in decreased expression of CDKN1B protein17537993
C500026palbociclibpalbociclib results in increased expression of CDKN1B mRNA17537993
C500026palbociclibpalbociclib results in increased expression of CDKN1B protein20473330
C482884panduratin Apanduratin A results in increased expression of CDKN1B mRNA16497706
C482884panduratin Apanduratin A results in increased expression of CDKN1B protein16497706
C496932panobinostatpanobinostat results in increased expression of CDKN1B protein18445700
D052638Particulate MatterParticulate Matter results in increased expression of CDKN1B mRNA23454527
D010431Pentoxifylline[Pentoxifylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
D010634PhenobarbitalCDKN1B protein inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK2 protein]17620307
D010634PhenobarbitalCDKN1B results in decreased susceptibility to [Diethylnitrosamine co-treated with Phenobarbital]17620307
D010656PhenylephrinePhenylephrine results in increased expression of CDKN1B15603588
D010713Phosphatidylcholines[rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein21695227
D010833Phytic AcidPhytic Acid results in decreased expression of CDKN1B protein15868430
D010862PilocarpinePilocarpine results in increased expression of CDKN1B mRNA17971868
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased degradation of CDKN1B protein]26643070
C060836pioglitazonepioglitazone results in increased expression of CDKN1B protein26643070
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone results in increased expression of CDKN1B protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [2-Acetylaminofluorene promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]]17582756
C060836pioglitazonepioglitazone promotes the reaction [Diethylnitrosamine results in decreased expression of CDKN1B protein]17582756
D010894PiroxicamPiroxicam inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
D010936Plant ExtractsPlant Extracts results in decreased degradation of CDKN1B protein24095829
D010936Plant ExtractsPlant Extracts results in increased expression of CDKN1B mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of CDKN1B protein26122529
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CDKN1B mRNA21334430
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CDKN1B mRNA24583197
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CDKN1B mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDKN1B mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of CDKN1B mRNA26348139
D011241PrednisonePrednisone results in increased expression of CDKN1B protein15034294
C023617pregna-4,17-diene-3,16-dione"pregna-4,17-diene-3,16-dione results in increased expression of CDKN1B protein"17475222
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CDKN1B mRNA22064387
D011374ProgesteroneFZR1 mutant form inhibits the reaction [Progesterone affects the localization of CDKN1B protein]23029392
D011374ProgesteroneProgesterone affects the localization of CDKN1B protein23029392
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of and results in increased stability of CDKN1B protein23029392
D011374ProgesteroneProgesterone promotes the reaction [CDK2 protein binds to CDKN1B protein]18850315
D011374ProgesteroneProgesterone results in increased expression of CDKN1B mRNA18850315
D011374ProgesteroneProgesterone results in increased expression of CDKN1B protein18850315
D011374ProgesteroneTP53 mutant form inhibits the reaction [Progesterone results in increased expression of CDKN1B mRNA]18850315
D011374ProgesteroneTP53 mutant form inhibits the reaction [Progesterone results in increased expression of CDKN1B protein]18850315
C107773pterostilbenepterostilbene results in increased expression of CDKN1B protein23313376
D011743PyrimidinesPyrimidines affects the splicing of CDKN1B mRNA25281741
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [Allylamine results in increased expression of CDKN1B protein]15048878
D011794QuercetinAR protein affects the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]27132804
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CDKN1B mRNA27514524
D011794Quercetin[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein27132804
D011794QuercetinDihydrotestosterone inhibits the reaction [[Curcumin co-treated with Quercetin] results in increased expression of CDKN1B protein]27132804
D011794QuercetinQuercetin promotes the reaction [CDKN1B protein binds to CDK2 protein]11322924
D011794QuercetinQuercetin results in increased expression of CDKN1B protein11322924|1582949
D011799QuinazolinesQuinazolines affects the splicing of CDKN1B mRNA25281741
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of CDKN1B protein16536755
D012110Reserpine[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein11318962
C059514resveratrolFOXO1 protein affects the reaction [resveratrol results in increased expression of CDKN1B protein]21179458
C059514resveratrolFOXO3 protein affects the reaction [resveratrol results in increased expression of CDKN1B protein]21179458
C059514resveratrolFOXO4 protein affects the reaction [resveratrol results in increased expression of CDKN1B protein]21179458
C059514resveratrol[resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein21179458
C059514resveratrolresveratrol inhibits the reaction [cudraflavone B results in increased expression of CDKN1B protein]23881456
C059514resveratrolresveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]18022818
C059514resveratrolresveratrol promotes the reaction [FOXO3 protein binds to CDKN1B promoter]17513867
C059514resveratrolresveratrol results in increased expression of CDKN1B mRNA16761963|1808983
C059514resveratrolresveratrol results in increased expression of CDKN1B protein15829497|1676196
C059514resveratrolresveratrol results in increased expression of CDKN1B protein21980390
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
C059514resveratrolresveratrol results in decreased expression of CDKN1B mRNA25905778
C059514resveratrolSIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
C059514resveratrolTNFSF10 protein promotes the reaction [resveratrol results in increased expression of CDKN1B protein]21209944
C089032rimonabantrimonabant results in increased expression of CDKN1B protein16822929
D019438RitonavirRitonavir results in increased expression of CDKN1B mRNA19386116
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]]12421932
C089730rosiglitazonerosiglitazone results in increased expression of CDKN1B protein20210794
C079905rubitecan[rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein21695227
C079905rubitecanrubitecan results in increased expression of CDKN1B protein21695227
C018381salvinsalvin promotes the reaction [arsenic trioxide results in increased expression of CDKN1B protein]23239002
C018381salvinsalvin results in increased expression of CDKN1B protein23239002
C410958sauchinonesauchinone results in increased expression of CDKN1B protein27871897
C093642SB 203580SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein]19082730
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of CDKN1B protein11396176|1927616
C078903seocalcitolseocalcitol inhibits the reaction [alitretinoin results in increased expression of CDKN1B protein]16340750
C078903seocalcitolseocalcitol promotes the reaction [CDKN1B protein binds to CDK2 protein]12907249
C078903seocalcitolseocalcitol results in increased expression of and results in decreased degradation of CDKN1B protein12907249
C078903seocalcitolseocalcitol results in increased expression of CDKN1B mRNA12907249
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of CDKN1B mRNA"16251409
D012715Sesame OilSesame Oil results in increased expression of CDKN1B mRNA29191790
C516024SH-6 compoundSH-6 compound results in increased expression of CDKN1B protein17513607
D012834SilverSilver results in decreased expression of CDKN1B mRNA27131904
C440975silybin[silybin co-treated with Arsenic] results in increased expression of CDKN1B protein25868784
C440975silybinsilybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein]25559859
D019821Simvastatin[Simvastatin results in decreased degradation of CDKN1B protein] which results in decreased activity of CDK2 protein17928568
D019821SimvastatinSimvastatin results in increased expression of CDKN1B mRNA18337644
D019821SimvastatinSimvastatin results in increased expression of CDKN1B protein17428261|2087809
D019821SimvastatinSimvastatin results in increased expression of CDKN1B mRNA12963647
D019821SimvastatinSimvastatin results in increased expression of CDKN1B protein18804536
D020123Sirolimus[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein21092744
D020123Sirolimus[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA18622747
D020123Sirolimus[Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein14979923
D020123SirolimusSirolimus promotes the reaction [Cisplatin results in increased expression of CDKN1B mRNA]21092744
D020123SirolimusSirolimus results in decreased degradation of CDKN1B protein12565877
D020123SirolimusSirolimus results in increased expression of CDKN1B protein15070696|1645508
D020123Sirolimus[TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]12417722
D020123Sirolimus[Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein14979923
D020123Sirolimus[Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]14979923
D020123Sirolimus[TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]12417722
D020123SirolimusNiacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D020123SirolimusSirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]19105244
D020123SirolimusSirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]22561310
D020123SirolimusSirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1B protein]19105244
D020123SirolimusSirolimus results in decreased expression of CDKN1B protein22561310
D020123SirolimusSIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
C439060sirtinolsirtinol promotes the reaction [cudraflavone B results in increased expression of CDKN1B protein]23881456
C009277sodium arsenatesodium arsenate results in increased expression of CDKN1B mRNA16882884
C009277sodium arsenatesodium arsenate results in increased expression of CDKN1B mRNA14713550
C009277sodium arsenatesodium arsenate results in increased expression of CDKN1B protein14713550
C017947sodium arseniteSB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein]19082730
C017947sodium arsenitesodium arsenite affects the expression of CDKN1B mRNA24535192
C017947sodium arsenite[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein19082730
C017947sodium arseniteCDKN1B protein affects the reaction [sodium arsenite results in increased activity of CASP3 protein]20566634
C017947sodium arseniteCDKN1B protein affects the reaction [sodium arsenite results in increased cleavage of PARP1 protein]20566634
C017947sodium arseniteCDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of JUN protein]20566634
C017947sodium arseniteCDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein]20566634
C017947sodium arseniteCDKN1B protein affects the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of AKT1 protein]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased activity of MAP2K4 protein]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 mRNA]20566634
C017947sodium arseniteCDKN1B protein inhibits the reaction [sodium arsenite results in increased expression of HSPB1 protein]20566634
C017947sodium arsenitesodium arsenite results in decreased expression of CDKN1B protein10764629
D018038Sodium SeleniteSodium Selenite results in increased expression of CDKN1B protein19276161
C471405sorafenib"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [sorafenib results in increased expression of CDKN1B protein]"23036488
C471405sorafenib"sorafenib promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of CDKN1B protein]"23036488
C471405sorafenibsorafenib results in increased expression of CDKN1B protein19878585|2303648
C471405sorafenibsorafenib results in increased expression of CDKN1B protein19139124
C471405sorafenibsorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]21693435
C471405sorafenibsorafenib results in decreased expression of CDKN1B protein21693435
C530804S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea"S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea results in increased expression of CDKN1B protein"19497413
D019311StaurosporineStaurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein]16618747
D013267StilbenesStilbenes analog results in increased expression of CDKN1B mRNA25980588
D013267StilbenesStilbenes analog results in increased expression of CDKN1B protein25980588
D013467SulindacSulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein]12189186
C025463sulindac sulfonesulindac sulfone results in increased expression of CDKN1B mRNA18593937
C025463sulindac sulfonesulindac sulfone results in increased expression of CDKN1B protein18593937
D014284TriiodothyronineTriiodothyronine results in decreased expression of CDKN1B protein16021636
D014284TriiodothyronineTHRB protein promotes the reaction [Triiodothyronine results in decreased expression of CDKN1B protein]20638743
D014284TriiodothyronineTriiodothyronine results in decreased expression of CDKN1B protein20638743
D014284TriiodothyronineTriiodothyronine results in decreased expression of CDKN1B mRNA16021636
D014284TriiodothyronineTriiodothyronine results in decreased expression of CDKN1B protein16021636
C112689TAC 101TAC 101 results in increased expression of CDKN1B mRNA10225456
C112689TAC 101TAC 101 results in increased expression of CDKN1B protein10225456
D016559TacrolimusTacrolimus results in increased expression of CDKN1B mRNA21865292
C467766taiwanin Ctaiwanin C results in increased expression of CDKN1B protein26537528
C467766taiwanin CTetradecanoylphorbol Acetate inhibits the reaction [taiwanin C results in increased expression of CDKN1B protein]26537528
D013629Tamoxifen[Tamoxifen co-treated with FTI 277] promotes the reaction [CDKN1B protein binds to [CCNE1 protein binds to CDK2 protein]]12866041
D013629Tamoxifen[Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein17876043
D013629TamoxifenTamoxifen results in increased activity of CDKN1B protein15665275
C021751tanshinoneindirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C021751tanshinoneindirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]18344322
C021751tanshinonetanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C021751tanshinonetanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]18344322
C021751tanshinonetanshinone results in increased expression of CDKN1B protein18344322
C021751tanshinonetetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]]18344322
C047246temozolomide[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of CDKN1B protein20980775
C047246temozolomide[temozolomide co-treated with O(6)-benzylguanine] results in decreased expression of CDKN1B protein20980775
C041226TerazosinTerazosin results in increased expression of CDKN1B protein12883741
D016593TerfenadineTerfenadine results in increased expression of CDKN1B protein12244568
D013729TerpenesTerpenes affects the phosphorylation of CDKN1B protein18281026
D013739TestosteroneTestosterone results in decreased expression of CDKN1B mRNA15788153
C534735tetraarsenic tetrasulfideindirubin promotes the reaction [tanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C534735tetraarsenic tetrasulfideindirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]18344322
C534735tetraarsenic tetrasulfidetanshinone promotes the reaction [indirubin promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]]18344322
C534735tetraarsenic tetrasulfidetanshinone promotes the reaction [tetraarsenic tetrasulfide results in increased expression of CDKN1B protein]18344322
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide promotes the reaction [indirubin promotes the reaction [tanshinone results in increased expression of CDKN1B protein]]18344322
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of CDKN1B protein18344322
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]22266097
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]15157999
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1B protein9705214
D013749TetrachlorodibenzodioxinMethoxsalen inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]15157999
D013749TetrachlorodibenzodioxinMifepristone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]22266097
D013749TetrachlorodibenzodioxinPGR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of and results in decreased activity of CDKN1B protein22266097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN1B protein15157999
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]24013123
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]24013123
D013749TetrachlorodibenzodioxinAHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA]21995607
D013749TetrachlorodibenzodioxinCDKN1B protein affects the susceptibility to Tetrachlorodibenzodioxin20805476
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the localization of CDKN1B protein20805476
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CDKN1B protein20486776
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with IGF1 protein] results in increased expression of CDKN1B protein20486776
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with SHH protein] results in increased expression of CDKN1B protein20486776
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of CDKN1B mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides affects the expression of CDKN1B protein]12883080
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B mRNA]12883080
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CDKN1B protein alternative form]12883080
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]"20637255
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNA2 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
D013749Tetrachlorodibenzodioxin"Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]"20637255
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK2 protein binds to CCNE1 protein binds to CDKN1B protein]]] which results in decreased activity of CDK2 protein"20637255
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA10398686|1180433
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN1B protein10398686|1822710
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN1B mRNA20566336
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN1B protein14742689|2363962
D013755Tetradecanoylphorbol AcetateRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]]12421932
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein12421932
D013755Tetradecanoylphorbol AcetateTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]12421932
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [taiwanin C results in increased expression of CDKN1B protein]26537528
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDKN1B mRNA25613284
D013806Theophylline[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
D013806Theophyllinesorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein]21693435
D013806Theophylline[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CDKN1B protein21693435
D013853ThioacetamideThioacetamide affects the localization of CDKN1B protein22659510
D013876ThiophenesThiophenes analog promotes the reaction [Tretinoin results in increased expression of CDKN1B protein]16140954
D013893ThiramThiram results in decreased expression of CDKN1B mRNA20530235
C402769tipifarnib[Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein17876043
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CDKN1B protein27087172
D014044TolbutamideTolbutamide results in increased expression of CDKN1B protein16718685
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKN1B mRNA25729387
D019772TopotecanTopotecan results in decreased expression of CDKN1B mRNA25729387
D014212TretinoinRo 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]]12421932
D014212TretinoinStaurosporine inhibits the reaction [Tretinoin results in increased phosphorylation of CDKN1B protein]16618747
D014212TretinoinThiophenes analog promotes the reaction [Tretinoin results in increased expression of CDKN1B protein]16140954
D014212TretinoinTretinoin affects the expression of CDKN1B mRNA21924320
D014212TretinoinTretinoin affects the localization of CDKN1B protein16618747
D014212Tretinoin[Tretinoin co-treated with IFNG protein] results in increased expression of CDKN1B protein17960384
D014212TretinoinTretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
D014212TretinoinTretinoin promotes the reaction [Butyrates results in increased expression of CDKN1B mRNA]17431121
D014212TretinoinTretinoin promotes the reaction [Butyrates results in increased expression of CDKN1B protein]17431121
D014212TretinoinTretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]12421932
D014212TretinoinTretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B mRNA]17431121
D014212TretinoinTretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B protein]17431121
D014212TretinoinTretinoin promotes the reaction [vorinostat results in increased expression of CDKN1B mRNA]17431121
D014212TretinoinTretinoin promotes the reaction [vorinostat results in increased expression of CDKN1B protein]17431121
D014212TretinoinTretinoin results in increased expression of and results in decreased degradation of CDKN1B protein15695403
D014212TretinoinTretinoin results in increased expression of CDKN1B11519864
D014212TretinoinTretinoin results in increased expression of CDKN1B mRNA17349212|2372400
D014212TretinoinTretinoin results in increased expression of CDKN1B protein11595732|1519442
D014212TretinoinTretinoin results in increased phosphorylation of CDKN1B protein16618747
D014212TretinoinTretinoin results in increased stability of CDKN1B protein11348869
D014212Tretinoin[Tretinoin results in increased ubiquitination of and results in increased degradation of SKP2 protein] which results in increased expression of CDKN1B protein11595732
D014212TretinoinTretinoin affects the localization of CDKN1B protein16618747
D014212TretinoinTretinoin results in increased phosphorylation of CDKN1B protein16618747
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of CDKN1B mRNA17185465
C012589trichostatin ATretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B mRNA]17431121
C012589trichostatin ATretinoin promotes the reaction [trichostatin A results in increased expression of CDKN1B protein]17431121
C012589trichostatin A[trichostatin A affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNA18544619
C012589trichostatin Atrichostatin A results in increased expression of CDKN1B mRNA17431121|2377000
C012589trichostatin Atrichostatin A results in increased expression of CDKN1B protein17431121|2377000
C080938tris(2-carboxyethyl)phosphinetris(2-carboxyethyl)phosphine results in increased expression of CDKN1B protein18952254
D014315TriterpenesTriterpenes results in increased expression of CDKN1B mRNA18544911
C057693troglitazoneCDKN1B protein affects the susceptibility to troglitazone11034103
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased degradation of CDKN1B protein14618613
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of and results in increased ubiquitination of CDKN1B protein14618613
C057693troglitazone[troglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of CDKN1B protein11034103
C057693troglitazone[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein19908241
C057693troglitazonetroglitazone promotes the reaction [CDKN1B protein binds to CDK2 protein]12717389
C057693troglitazonetroglitazone results in decreased expression of CDKN1B mRNA12680223
C057693troglitazonetroglitazone results in decreased expression of CDKN1B protein12680223
C057693troglitazonetroglitazone results in increased expression of CDKN1B mRNA17143939
C057693troglitazonetroglitazone results in increased expression of CDKN1B protein11343236|1214914
C057693troglitazone[troglitazone co-treated with [Hydrochlorothiazide co-treated with Hydralazine co-treated with Reserpine]] results in decreased expression of CDKN1B protein11318962
C057693troglitazonetroglitazone results in decreased expression of CDKN1B protein11318962
C113580U 0126"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine promotes the reaction [U 0126 results in increased expression of CDKN1B protein]"22101421
C113580U 0126"[U 0126 co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in increased expression of CDKN1B protein"22101421
C113580U 0126"U 0126 promotes the reaction [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of CDKN1B protein]"22101421
C113580U 0126U 0126 results in increased expression of CDKN1B mRNA15930308
C113580U 0126U 0126 results in increased expression of CDKN1B protein15930308|2210142
D014520UrethaneUrethane results in decreased expression of CDKN1B mRNA12117781
C005466ursolic acidursolic acid results in increased expression of CDKN1B protein24802810
D014635Valproic AcidCelecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1B protein]21737646
D014635Valproic AcidValproic Acid affects the expression of CDKN1B mRNA25979313
D014635Valproic Acid[Valproic Acid co-treated with Hydroxyurea] results in increased expression of CDKN1B mRNA17653085
D014635Valproic AcidValproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1B protein]21737646
D014635Valproic AcidValproic Acid results in decreased expression of CDKN1B mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of CDKN1B protein21737646
D014635Valproic AcidValproic Acid results in increased expression of CDKN1B protein21708246
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]19225232
D014638VanadatesAKT1 protein affects the reaction [Vanadates inhibits the reaction [chromium hexavalent ion affects the localization of CDKN1B protein]]19377290
D014638VanadatesVanadates inhibits the reaction [chromium hexavalent ion results in decreased expression of and affects the localization of CDKN1B protein]19377290
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of CDKN1B mRNA17459161
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CDKN1B mRNA23454527
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of CDKN1B protein27169980
C017963vinyl carbamateBudesonide inhibits the reaction [vinyl carbamate results in decreased expression of CDKN1B protein]12117777
C017963vinyl carbamatevinyl carbamate results in decreased expression of CDKN1B protein12117777
D009536NiacinamideNiacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]22561310
D009536NiacinamideNiacinamide results in increased expression of CDKN1B protein22561310
D002762CholecalciferolCholecalciferol promotes the reaction [CDKN1B protein binds to CDK2 protein]12907249
D002762CholecalciferolCholecalciferol results in increased expression of and results in decreased degradation of CDKN1B protein12907249
D002762CholecalciferolCholecalciferol results in increased expression of CDKN1B mRNA12907249
D014810Vitamin EVitamin E results in increased expression of CDKN1B protein12352461
D024483Vitamin K 3SB 203580 inhibits the reaction [[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein]19082730
D024483Vitamin K 3[sodium arsenite co-treated with Vitamin K 3] results in increased expression of CDKN1B protein19082730
C111237vorinostat[Bortezomib co-treated with vorinostat] results in increased cleavage of CDKN1B protein15173093
C111237vorinostatTretinoin promotes the reaction [vorinostat results in increased expression of CDKN1B mRNA]17431121
C111237vorinostatTretinoin promotes the reaction [vorinostat results in increased expression of CDKN1B protein]17431121
C111237vorinostat[vorinostat co-treated with Bortezomib] results in increased expression of CDKN1B protein19220424
C111237vorinostat[vorinostat co-treated with Imatinib Mesylate] results in increased expression of CDKN1B protein12446442
C111237vorinostatvorinostat results in increased expression of CDKN1B mRNA17431121
C111237vorinostatvorinostat results in increased expression of CDKN1B protein12446442|1614494
C085514wogoninwogonin results in increased expression of CDKN1B protein23872260
C085514wogoninwogonin results in increased expression of CDKN1B protein23872260
C009687wortmanninwortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]17935137
C009687wortmanninwortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]17935137
C009687wortmanninImatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]17129604
C009687wortmanninwortmannin results in increased expression of CDKN1B protein17129604
C108830Y 27632Y 27632 results in increased expression of CDKN1B mRNA20578043
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1B mRNA15784690
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of CDKN1B mRNA16357179
C016837zinc chloridezinc chloride results in decreased expression of CDKN1B mRNA21540303
C088658zoledronic acidgefitinib promotes the reaction [[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein]16322342
C088658zoledronic acid[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein16322342
C088658zoledronic acidzoledronic acid promotes the reaction [CYR61 protein affects the expression of CDKN1B protein]19530242

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004693cyclin-dependent protein serine/threonine kinase activity-EXP9190208  
GO:0004860protein kinase inhibitor activity-IMP8684460  
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-IBA21873635  
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-IDA28666995  
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-TAS-  
GO:0005072transforming growth factor beta receptor, cytoplasmic mediator activity-TAS8033212  
GO:0005515protein binding-IPI8684460  8756624  9106657  9840943  11961546  12042314  
12082530  12093740  15057270  15480426  15652749  15890360  
16189514  16209941  16289477  16326706  17053782  17254966  
17254967  17418410  17470459  18281517  18593906  18805092  
19470470  20596027  21423214  21423803  22632967  22770219  
23455922  23602409  23602568  24358021  25241761  25852190  
25910212  26496610  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IPI15024385  
GO:0019903protein phosphatase binding-IBA21873635  
GO:0019903protein phosphatase binding-IPI19838216  
GO:0030332cyclin binding-IPI15024385  
GO:0030544Hsp70 protein binding-IBA21873635  
GO:0030544Hsp70 protein binding-IEA-  
GO:0044877protein-containing complex binding-IPI8684460  15024385  
GO:0051087chaperone binding-IBA21873635  
GO:0051087chaperone binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-TAS8033212  
GO:0000082G1/S transition of mitotic cell cycle-IBA21873635  
GO:0000082G1/S transition of mitotic cell cycle-IDA10208428  
GO:0000082G1/S transition of mitotic cell cycle-TAS-  
GO:0001666response to hypoxia-IBA21873635  
GO:0001666response to hypoxia-IEA-  
GO:0001890placenta development-IEA-  
GO:0006813potassium ion transport-IBA21873635  
GO:0006813potassium ion transport-IEA-  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007050cell cycle arrest-IMP12093740  
GO:0007096regulation of exit from mitosis-IBA21873635  
GO:0007096regulation of exit from mitosis-IEA-  
GO:0007219Notch signaling pathway-IBA21873635  
GO:0007219Notch signaling pathway-IEA-  
GO:0007605sensory perception of sound-IBA21873635  
GO:0007605sensory perception of sound-IEA-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008285negative regulation of cell proliferation-IBA21873635  
GO:0008285negative regulation of cell proliferation-IDA19266349  
GO:0008285negative regulation of cell proliferation-IMP19838216  
GO:0009749response to glucose-IBA21873635  
GO:0009749response to glucose-IEA-  
GO:0010942positive regulation of cell death-IDA19266349  
GO:0030308negative regulation of cell growth-IBA21873635  
GO:0030308negative regulation of cell growth-IDA10208428  
GO:0031116positive regulation of microtubule polymerization-IBA21873635  
GO:0031116positive regulation of microtubule polymerization-IEA-  
GO:0032355response to estradiol-IBA21873635  
GO:0032355response to estradiol-IEA-  
GO:0033673negative regulation of kinase activity-IDA19170105  
GO:0042326negative regulation of phosphorylation-IBA21873635  
GO:0042326negative regulation of phosphorylation-IDA10208428  
GO:0042493response to drug-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043200response to amino acid-IBA21873635  
GO:0043200response to amino acid-IEA-  
GO:0043434response to peptide hormone-IBA21873635  
GO:0043434response to peptide hormone-IEA-  
GO:0045732positive regulation of protein catabolic process-IBA21873635  
GO:0045732positive regulation of protein catabolic process-IDA19056892  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity-IDA28666995  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IEA-  
GO:0045786negative regulation of cell cycle-IMP18305109  
GO:0045787positive regulation of cell cycle-TAS-  
GO:0045892negative regulation of transcription, DNA-templated-IBA21873635  
GO:0045892negative regulation of transcription, DNA-templated-IDA19170105  
GO:0045930negative regulation of mitotic cell cycle-IDA19266349  
GO:0046686response to cadmium ion-IBA21873635  
GO:0046686response to cadmium ion-IEA-  
GO:0048102autophagic cell death-IBA21873635  
GO:0048102autophagic cell death-IDA12698196  
GO:0048839inner ear development-IEA-  
GO:0051271negative regulation of cellular component movement-IEA-  
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development-IEA-  
GO:0071236cellular response to antibiotic-IEA-  
GO:0071285cellular response to lithium ion-IDA19056892  
GO:0071407cellular response to organic cyclic compound-IBA21873635  
GO:0071407cellular response to organic cyclic compound-IEA-  
GO:0071850mitotic cell cycle arrest-IBA21873635  
GO:0071850mitotic cell cycle arrest-IDA19266349  
GO:1902746regulation of lens fiber cell differentiation-IBA21873635  
GO:1902746regulation of lens fiber cell differentiation-IEA-  
GO:1904030negative regulation of cyclin-dependent protein kinase activity-IMP8684460  
GO:1904706negative regulation of vascular smooth muscle cell proliferation-IMP19088079  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA11800646  12093740  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA12093740  
GO:0005768endosome-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IBA21873635  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IDA21628527  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04110Cell cycle
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleTAS
R-HSA-1643685DiseaseTAS
R-HSA-187577SCF(Skp2)-mediated degradation of p27/p21TAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-198323AKT phosphorylates targets in the cytosolTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-5625900RHO GTPases activate CITIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerTAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestTAS
R-HSA-69202Cyclin E associated events during G1/S transition TAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69563p53-Dependent G1 DNA Damage ResponseTAS
R-HSA-69580p53-Dependent G1/S DNA damage checkpointTAS
R-HSA-69615G1/S DNA Damage CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-69656Cyclin A:Cdk2-associated events at S phase entryTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849470PTK6 Regulates Cell CycleTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. (2018 Mar 1)Sung YJAm J Hum Genet