Gene: UBE4B

10277
E4|HDNB1|UBOX3|UFD2|UFD2A
ubiquitination factor E4B
protein-coding
1p36.22
Ensembl:ENSG00000130939 MIM:613565 Vega:OTTHUMG00000001797 UniprotKB:O95155
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.842e-1 (AD)  9.945e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11121524chr1:10172476 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFASC0.952
SORT10.936
HERC10.936
TSC10.933
DROSHA0.932
UBE3B0.931
MGAT50.931
EZH10.928
YEATS20.928
HERC20.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.568
OR4F29-0.544
TFPI2-0.407
KLRB1-0.399
GJB2-0.374
MTRNR2L6-0.368
MTRNR2L10-0.368
LRAT-0.367
PDZK1IP1-0.36
AQP5-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of UBE4B mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of UBE4B mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of UBE4B mRNA19191707
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of UBE4B mRNA"19936915
D000082AcetaminophenAcetaminophen results in decreased expression of UBE4B mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of UBE4B mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of UBE4B mRNA28959563
C006632arsenic trioxidearsenic trioxide results in increased expression of UBE4B mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UBE4B mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of UBE4B gene25435355
C006780bisphenol Abisphenol A results in increased expression of UBE4B mRNA29275510
C006780bisphenol Abisphenol A affects the expression of UBE4B mRNA21786754
C006780bisphenol Abisphenol A affects the expression of UBE4B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of UBE4B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of UBE4B mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of UBE4B mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UBE4B gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of UBE4B mRNA24386269
D003471CuprizoneCuprizone results in increased expression of UBE4B mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of UBE4B mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of UBE4B mRNA21266533
D002945CisplatinCisplatin results in decreased expression of UBE4B mRNA27594783
D004221DisulfiramDisulfiram results in decreased expression of UBE4B mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UBE4B mRNA17606305
D005485FlutamideFlutamide results in increased expression of UBE4B mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UBE4B gene20938992
D048628KetolidesKetolides analog results in increased expression of UBE4B mRNA24967691
C045463leflunomideleflunomide results in decreased expression of UBE4B mRNA28988120
C045463leflunomideleflunomide results in increased expression of UBE4B mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of UBE4B gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of UBE4B mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UBE4B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UBE4B mRNA"25620056
C051752nefazodonenefazodone results in increased expression of UBE4B mRNA24136188
D019319Okadaic AcidOkadaic Acid results in decreased expression of UBE4B mRNA25270620
C018620oleoresinsoleoresins results in decreased expression of UBE4B mRNA20008804
C006253pirinixic acidpirinixic acid results in increased expression of UBE4B mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of UBE4B mRNA]21318169
C031280pyrazolepyrazole results in increased expression of UBE4B mRNA17945193
D011748PyrogallolPyrogallol results in increased expression of UBE4B mRNA20362636
D012643SeleniumSelenium results in increased expression of UBE4B mRNA19244175
D020280SertralineSertraline results in decreased expression of UBE4B mRNA24865413
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE4B mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE4B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UBE4B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UBE4B mRNA18796159|2234250
D013893ThiramThiram results in decreased expression of UBE4B mRNA20530235
D014112ToxapheneToxaphene results in increased expression of UBE4B mRNA23153324
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of UBE4B mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of UBE4B mRNA28973697
C406224valdecoxibvaldecoxib results in increased expression of UBE4B mRNA24136188
D014635Valproic AcidValproic Acid results in decreased methylation of UBE4B gene29154799
C025643vinclozolinvinclozolin results in decreased expression of UBE4B mRNA23034163
D014810Vitamin EVitamin E results in increased expression of UBE4B mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0019899enzyme binding-ISS-  
GO:0034450ubiquitin-ubiquitin ligase activity-IBA21873635  
GO:0051117ATPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-IBA21873635  
GO:0003222ventricular trabecula myocardium morphogenesis-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-TAS11802788  
GO:0006513protein monoubiquitination-IEA-  
GO:0008626granzyme-mediated apoptotic signaling pathway-IDA11802788  
GO:0009411response to UV-IDA11802788  
GO:0030433ubiquitin-dependent ERAD pathway-IBA21873635  
GO:0031175neuron projection development-IEA-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-IDA23509263  
GO:0051865protein autoubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-TAS11802788  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
hsa04120Ubiquitin mediated proteolysis
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal