Gene: EFS

10278
CAS3|CASS3|EFS1|EFS2|HEFS|SIN
embryonal Fyn-associated substrate
protein-coding
14q11.2
Ensembl:ENSG00000100842 MIM:609906 Vega:OTTHUMG00000028741 UniprotKB:O43281
NC_000014.9
PubMed
0   ANCO-SNPs
CD|ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.913e-3 (AD)  4.804e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMTM50.882
PLXNB30.881
SEMA3B0.872
PLEKHG30.872
PHLDB10.865
KIAA17550.862
HSPA20.86
TTYH20.858
LLGL10.857
TSPAN150.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.391
OR4F5-0.381
GPR26-0.351
WNT2-0.348
KCNH5-0.345
PRSS12-0.345
HCN4-0.344
BEND4-0.341
CUX2-0.338
CNTN5-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of EFS mRNA"23829299
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of EFS mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EFS mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EFS mRNA24449571
D001104ArbutinArbutin results in decreased expression of EFS mRNA17103032
C547126AZM551248AZM551248 results in increased expression of EFS mRNA22323515
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of EFS mRNA17404688
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFS mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of EFS mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of EFS mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of EFS mRNA25979313
C031180chrysenechrysene results in increased expression of EFS mRNA26377693
D003471CuprizoneCuprizone results in increased expression of EFS mRNA26577399
D013759DronabinolDronabinol results in decreased expression of EFS mRNA12237329
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFS mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EFS mRNA17361019|2126653
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EFS mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of EFS mRNA17557909
D005047EtoposideEtoposide results in increased expression of EFS mRNA25270620
C039281furanfuran results in increased expression of EFS mRNA27387713
D005839GentamicinsGentamicins results in decreased expression of EFS mRNA22061828
D017313FenretinideFenretinide results in decreased expression of EFS mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFS mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of EFS mRNA28628672
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of EFS mRNA25270620
D016685MitomycinMitomycin results in increased expression of EFS mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EFS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFS mRNA"25554681
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of EFS mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of EFS mRNA23018184
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of EFS mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of EFS mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EFS mRNA27029645
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of EFS mRNA21427059
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EFS mRNA21354282
C009495titanium dioxidetitanium dioxide results in increased expression of EFS mRNA23557971
D014212TretinoinTretinoin results in decreased expression of EFS mRNA21934132
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of EFS mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of EFS mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EFS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EFS mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in increased methylation of EFS gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of EFS mRNA19136453|2054688
C070417Win 55212-2Win 55212-2 results in decreased expression of EFS mRNA12237329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0017124SH3 domain binding-IEA-  
GO:0019904protein domain specific binding-IPI11984006  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0035556intracellular signal transduction-TAS9349509  
GO:0090527actin filament reorganization-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9349509  
GO:0005886plasma membraneCOLOCALIZES_WITHIBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23582695Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and its implication in executive functions in adult offspring of alcohol-dependent probands. (2013 Jun)Benzerouk FAlcohol
9072555Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. (1997 Mar)Xie YJ Urol
20132198Chronic alcoholism associated with diabetes impairs erectile function in rats. (2010 Jun)Lizarte FSBJU Int
23478152Childhood physical neglect associated with executive functions impairments in crack cocaine-dependent women. (2013 Sep 1)Viola TWDrug Alcohol Depend
24467410Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors. (2014 Jun)Grassin-Delyle SBr J Pharmacol