Gene info: ID 1028

Gene: CDKN1C

GENE ID: 1028

Synonyms: BWCR|BWS|KIP2|WBS|p57|p57Kip2

Description: cyclin dependent kinase inhibitor 1C

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000129757 MIM:600856 Vega:OTTHUMG00000010040 UniprotKB:P49918

RefSeq: NG_008022.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.893e-1 (AD) 3.356e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NINJ2	0.853
LIPE	0.841
CLDN11	0.838
GALNT6	0.83
SLC45A3	0.827
PLD1	0.826
NKX6-2	0.825
MAG	0.824
TMEM165	0.824
TF	0.823

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHRNA2	-0.402
CUX2	-0.379
CCDC85C	-0.376
CNGB1	-0.374
EPHA6	-0.364
ZNF469	-0.36
SP8	-0.36
FAM163A	-0.359
WTIP	-0.359
NEUROD1	-0.356

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CDKN1C mRNA"	21346803
C006593	2-anthramine	2-anthramine results in increased expression of CDKN1C mRNA	23038007
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CDKN1C mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of CDKN1C mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN1C mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of CDKN1C mRNA"	19561079
C013813	4-anisidine	4-anisidine results in increased expression of CDKN1C mRNA	12929121
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA	12419474
C041594	4-nonylphenol	4-nonylphenol results in increased expression of CDKN1C protein	26027920
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in increased expression of CDKN1C mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN1C mRNA"	27188386
C121707	7,3'-dihydroxy-4'-methoxyisoflavone	"7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1C mRNA"	24455688
D000082	Acetaminophen	Acetaminophen affects the expression of CDKN1C mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of CDKN1C mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of CDKN1C mRNA	21420995
D020106	Acrylamide	Acrylamide results in decreased expression of CDKN1C mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CDKN1C mRNA	23630614
C103303	alitretinoin	alitretinoin results in decreased expression of CDKN1C mRNA	15982314
D000638	Amiodarone	Amiodarone affects the expression of CDKN1C mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride results in decreased expression of CDKN1C protein	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of CDKN1C mRNA	24449571
D001149	Arsenates	[Atrazine co-treated with Arsenates] results in increased expression of CDKN1C mRNA	18585445
D001151	Arsenic	Arsenic affects the methylation of CDKN1C gene	25304211
C015001	arsenite	arsenite results in decreased expression of CDKN1C mRNA	18191166
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of CDKN1C mRNA"	20831825
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of CDKN1C mRNA"	25351596
D001280	Atrazine	[Atrazine co-treated with Arsenates] results in increased expression of CDKN1C mRNA	18585445
D001280	Atrazine	Atrazine results in increased expression of CDKN1C mRNA	22378314
D001280	Atrazine	Atrazine results in decreased expression of CDKN1C mRNA	26331294
D001374	Azacitidine	Azacitidine results in increased expression of CDKN1C mRNA	19194470
D001554	Benzene	Benzene results in increased expression of CDKN1C mRNA	15050406
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in decreased expression of CDKN1C mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CDKN1C mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDKN1C mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDKN1C mRNA"	20018196
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CDKN1C mRNA"	19150397
D001599	Berberine	Berberine results in increased expression of CDKN1C mRNA	26478571
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of CDKN1C mRNA	22064387
D004958	Estradiol	Estradiol results in decreased expression of CDKN1C mRNA	22064387\|2301914
D004958	Estradiol	Estradiol results in increased expression of CDKN1C mRNA	23094148
D004958	Estradiol	Estradiol affects the expression of CDKN1C mRNA	15598610
C006780	bisphenol A	bisphenol A results in increased expression of CDKN1C protein	26027920
C006780	bisphenol A	bisphenol A results in increased methylation of CDKN1C gene	28582417
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1C mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of CDKN1C mRNA	23593014
C006780	bisphenol A	bisphenol A affects the expression of CDKN1C mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of CDKN1C mRNA	24988533
C006780	bisphenol A	bisphenol A results in increased expression of CDKN1C mRNA	18180321
D002083	Butylated Hydroxyanisole	[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of CDKN1C mRNA	25086368
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
D020122	tert-Butylhydroperoxide	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CDKN1C promoter]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of CDKN1C mRNA	12419474
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA	20847119
D020122	tert-Butylhydroperoxide	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CDKN1C promoter]]	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]	20847119
C018475	butyraldehyde	butyraldehyde results in increased expression of CDKN1C mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of CDKN1C promoter	28823913
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CDKN1C mRNA	28823913
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of CDKN1C protein	28823913
D002330	Carmustine	CDKN1C mRNA affects the susceptibility to Carmustine	16365179
D002737	Chloroprene	Chloroprene results in increased expression of CDKN1C mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of CDKN1C mRNA	25064622
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN1C mRNA	20938992
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of CDKN1C mRNA	20971185
D003300	Copper	[Thiosemicarbazones binds to Copper] which results in increased expression of CDKN1C protein	20931265
D019327	Copper Sulfate	Copper Sulfate affects the expression of CDKN1C mRNA	19549813
D003375	Coumestrol	Coumestrol results in decreased expression of CDKN1C mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of CDKN1C mRNA	26577399
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of CDKN1C mRNA	21041162
D016572	Cyclosporine	Cyclosporine affects the expression of CDKN1C mRNA	25064622
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDKN1C mRNA	27989131
D003561	Cytarabine	Cytarabine results in decreased expression of CDKN1C mRNA	21198554
C014347	decitabine	decitabine affects the expression of CDKN1C mRNA	17145863
C014347	decitabine	[decitabine affects the methylation of CDKN1C promoter] which affects the expression of CDKN1C mRNA	18454857\|1845485
C014347	decitabine	decitabine results in increased expression of CDKN1C mRNA	19194470
C014347	decitabine	[vorinostat co-treated with decitabine] results in increased expression of CDKN1C mRNA	17417771
D003907	Dexamethasone	Dexamethasone results in increased expression of CDKN1C mRNA	22064387
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1C mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDKN1C mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of CDKN1C mRNA	21041162
D003976	Diazinon	Diazinon results in increased methylation of CDKN1C gene	22964155
D003976	Diazinon	Diazinon affects the expression of CDKN1C mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDKN1C mRNA	17379624\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of CDKN1C mRNA	21745491
D002945	Cisplatin	Cisplatin results in decreased expression of CDKN1C mRNA	27392435
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA	15784690
D004026	Dieldrin	Dieldrin affects the expression of CDKN1C mRNA	22546817
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDKN1C mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CDKN1C mRNA]	17854601
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDKN1C mRNA	15766595
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CDKN1C mRNA	21041162
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDKN1C mRNA"	22485181
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CDKN1C mRNA	20146380
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of CDKN1C mRNA	21853993\|2893901
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of CDKN1C mRNA	24690739
D004237	Diuron	Diuron results in increased expression of CDKN1C mRNA	21551480
D000431	Ethanol	Ethanol results in increased expression of CDKN1C mRNA	19167417
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CDKN1C mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CDKN1C mRNA	17557909
D015025	Zearalenone	Zearalenone results in decreased expression of CDKN1C mRNA	28965971
C540355	fenamidone	fenamidone results in increased expression of CDKN1C mRNA	27029645
D005472	Fluorouracil	CDKN1C affects the susceptibility to Fluorouracil	15067352
D005472	Fluorouracil	Fluorouracil results in increased expression of CDKN1C mRNA	19272435
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN1C mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of CDKN1C mRNA	17938736
D019833	Genistein	Genistein results in decreased expression of CDKN1C mRNA	23019147
D019833	Genistein	Genistein results in increased expression of CDKN1C mRNA	22228119
C103280	goniothalamin	goniothalamin results in increased expression of CDKN1C mRNA	26522230
D006247	Harmine	Harmine results in decreased expression of CDKN1C mRNA	25751815
D006247	Harmine	Harmine results in decreased expression of CDKN1C protein	25751815
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CDKN1C mRNA	20044591\|2117940
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of CDKN1C protein	21179406
D006918	Hydroxyurea	Hydroxyurea results in increased expression of CDKN1C mRNA	12929121
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1C mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDKN1C mRNA	28628672
D007501	Iron	Iron deficiency results in decreased expression of CDKN1C mRNA	16629162
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1C mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CDKN1C mRNA	28628672
C040920	isoliquiritigenin	isoliquiritigenin results in decreased expression of CDKN1C mRNA	27702603
C544151	jinfukang	jinfukang results in increased expression of CDKN1C mRNA	27392435
C561695	(+)-JQ1 compound	CDKN1C mutant form inhibits the reaction [[(+)-JQ1 compound co-treated with vorinostat] results in increased cleavage of PARP1 protein]	26390243
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CDKN1C mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of CDKN1C mRNA	25277525\|2675264
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of CDKN1C protein	25277525
C561695	(+)-JQ1 compound	CDKN1C protein results in increased susceptibility to [(+)-JQ1 compound co-treated with vorinostat]	26390243
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vorinostat] affects the expression of CDKN1C mRNA	26390243
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vorinostat] affects the expression of CDKN1C protein	26390243
C018584	linalool	linalool results in increased expression of CDKN1C mRNA	19922762
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CDKN1C mRNA	18192897
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CDKN1C mRNA	12057914
D018021	Lithium Chloride	Lithium Chloride results in increased expression of CDKN1C mRNA	17440966
C019003	methaneselenol	methaneselenol results in increased expression of CDKN1C mRNA	19625696
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN1C mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDKN1C mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CDKN1C mRNA	28001369
C008493	methylselenic acid	methylselenic acid affects the expression of CDKN1C mRNA	14617803
C008493	methylselenic acid	methylselenic acid results in increased expression of CDKN1C mRNA	18548127
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CDKN1C mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of CDKN1C mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CDKN1C mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CDKN1C mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of CDKN1C mRNA	24768652\|2558310
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of CDKN1C	23447020
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of CDKN1C mRNA	24952340
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of CDKN1C mRNA	17616710
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of CDKN1C mRNA	20971185
C000594117	ON123300	ON123300 results in decreased expression of CDKN1C mRNA	26873845
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CDKN1C mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of CDKN1C mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of CDKN1C mRNA	17914565\|2004264
D010269	Paraquat	Paraquat affects the expression of CDKN1C mRNA	25064622
D010269	Paraquat	Paraquat results in decreased expression of CDKN1C mRNA	21371552
C046012	pentanal	pentanal results in increased expression of CDKN1C mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of CDKN1C mRNA	18692542
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of CDKN1C mRNA	15728792
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDKN1C mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of CDKN1C mRNA	23811191
D010938	Plant Oils	Plant Oils results in increased expression of CDKN1C mRNA	23370395
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of CDKN1C mRNA	24583197
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of CDKN1C mRNA	22064387
D011374	Progesterone	Progesterone results in increased expression of CDKN1C mRNA	20726854
C006068	propylparaben	[propylparaben co-treated with Butylated Hydroxyanisole] results in increased expression of CDKN1C mRNA	25086368
D011441	Propylthiouracil	Propylthiouracil affects the expression of CDKN1C mRNA	24780913
D011748	Pyrogallol	Pyrogallol results in decreased expression of CDKN1C mRNA	20362636
D011748	Pyrogallol	Silymarin inhibits the reaction [Pyrogallol results in decreased expression of CDKN1C mRNA]	20362636
D011794	Quercetin	Quercetin results in increased expression of CDKN1C mRNA	14715546\|2751452
D017382	Reactive Oxygen Species	Reactive Oxygen Species results in increased expression of CDKN1C mRNA	25800948
C059514	resveratrol	resveratrol results in increased expression of CDKN1C mRNA	12569576\|2087809
D015474	Isotretinoin	Isotretinoin results in decreased expression of CDKN1C mRNA	15982314
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
C089730	rosiglitazone	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]	20847119
D012643	Selenium	Selenium results in decreased expression of CDKN1C mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CDKN1C mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CDKN1C mRNA	25351596
D012838	Silymarin	Silymarin inhibits the reaction [Pyrogallol results in decreased expression of CDKN1C mRNA]	20362636
D019821	Simvastatin	Simvastatin results in increased expression of CDKN1C mRNA	17428261
D012906	Smoke	Smoke results in decreased expression of CDKN1C mRNA	21095227
C017947	sodium arsenite	sodium arsenite results in increased expression of CDKN1C mRNA	17451858
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of CDKN1C mRNA	27257137
D018038	Sodium Selenite	Sodium Selenite results in increased expression of CDKN1C mRNA	16705456
C047246	temozolomide	CDKN1C mRNA affects the susceptibility to temozolomide	16365179
D013739	Testosterone	Testosterone results in decreased expression of CDKN1C mRNA	20403060
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDKN1C mRNA	16443690
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDKN1C mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDKN1C mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CDKN1C mRNA	19465110\|1968428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CDKN1C mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CDKN1C mRNA	21215274
D013752	Tetracycline	Tetracycline affects the expression of CDKN1C mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDKN1C mRNA	16979875
D013806	Theophylline	Theophylline results in increased expression of CDKN1C mRNA	16083514
D013849	Thimerosal	Thimerosal results in decreased expression of CDKN1C mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of CDKN1C mRNA	25064622
D013853	Thioacetamide	Thioacetamide results in increased expression of CDKN1C mRNA	22659510
D013882	Thiosemicarbazones	[Thiosemicarbazones binds to Copper] which results in increased expression of CDKN1C protein	20931265
C009495	titanium dioxide	titanium dioxide results in decreased expression of CDKN1C mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased methylation of CDKN1C promoter	25214829
D019772	Topotecan	CDKN1C protein affects the susceptibility to Topotecan	16217747
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CDKN1C mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CDKN1C mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of CDKN1C mRNA"	19682533
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of CDKN1C mRNA"	17951470
D014212	Tretinoin	Tretinoin results in increased expression of CDKN1C mRNA	18230668
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of CDKN1C mRNA	15982314
D014212	Tretinoin	Tretinoin results in decreased expression of CDKN1C mRNA	15982314\|2372400
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN1C mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of CDKN1C mRNA	27188386
C012589	trichostatin A	trichostatin A results in increased expression of CDKN1C mRNA	26272509
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of CDKN1C mRNA	19042947
C057693	troglitazone	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of CDKN1C mRNA	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide promotes the reaction [PPARG protein binds to CDKN1C promoter]]	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1C mRNA]	20847119
D014415	Tunicamycin	Tunicamycin results in decreased expression of CDKN1C mRNA	17127020
D014520	Urethane	Urethane results in decreased expression of CDKN1C mRNA	12117781
D014635	Valproic Acid	Valproic Acid affects the expression of CDKN1C mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of CDKN1C mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of CDKN1C mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of CDKN1C mRNA	22083351\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of CDKN1C protein	22083351
D014635	Valproic Acid	Valproic Acid results in increased methylation of CDKN1C gene	29154799
C066075	vanadium pentoxide	vanadium pentoxide results in decreased expression of CDKN1C mRNA	17459161
C025643	vinclozolin	vinclozolin affects the expression of CDKN1C mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of CDKN1C mRNA	26682919
D014800	Vitallium	Vitallium analog results in increased expression of CDKN1C mRNA	23825117
D024483	Vitamin K 3	Vitamin K 3 affects the expression of CDKN1C mRNA	20044591
C111237	vorinostat	CDKN1C mutant form inhibits the reaction [[(+)-JQ1 compound co-treated with vorinostat] results in increased cleavage of PARP1 protein]	26390243
C111237	vorinostat	[vorinostat co-treated with decitabine] results in increased expression of CDKN1C mRNA	17417771
C111237	vorinostat	vorinostat results in decreased expression of CDKN1C mRNA	27188386
C111237	vorinostat	vorinostat results in increased expression of CDKN1C mRNA	17417771\|2208335
C111237	vorinostat	vorinostat results in increased expression of CDKN1C protein	22083351
C111237	vorinostat	CDKN1C protein results in increased susceptibility to [(+)-JQ1 compound co-treated with vorinostat]	26390243
C111237	vorinostat	[(+)-JQ1 compound co-treated with vorinostat] affects the expression of CDKN1C mRNA	26390243
C111237	vorinostat	[(+)-JQ1 compound co-treated with vorinostat] affects the expression of CDKN1C protein	26390243
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine] results in decreased expression of CDKN1C mRNA	15784690
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CDKN1C mRNA	16979875
D015032	Zinc	Zinc results in increased expression of CDKN1C mRNA	19071009
C088658	zoledronic acid	zoledronic acid results in increased expression of CDKN1C mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004860	protein kinase inhibitor activity	-	IMP	11746698
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	16289477 18660753 19170105 22634751
GO:0044877	protein-containing complex binding	-	IPI	11746698

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007050	cell cycle arrest	-	IEA	-
GO:0007346	regulation of mitotic cell cycle	-	IEA	-
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	-	IMP	16943770
GO:0033673	negative regulation of kinase activity	-	IDA	19170105
GO:0042326	negative regulation of phosphorylation	-	IDA	19170105
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	19170105
GO:0045893	positive regulation of transcription, DNA-templated	-	IGI	19170105
GO:0050680	negative regulation of epithelial cell proliferation	-	IMP	16943770
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	-
GO:1904030	negative regulation of cyclin-dependent protein kinase activity	-	IMP	11746698

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	16943770
GO:0005737	cytoplasm	-	IDA	16943770

KEGG ID	KEGG Term
hsa04110	Cell cycle

Reactome ID	Reactome Term	Evidence
R-HSA-1640170	Cell Cycle	TAS
R-HSA-453279	Mitotic G1-G1/S phases	TAS
R-HSA-69231	Cyclin D associated events in G1	TAS
R-HSA-69236	G1 Phase	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26614807	Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)	Martin F	Hum Exp Toxicol