Gene: RGS19

10287
GAIP|RGSGAIP
regulator of G protein signaling 19
protein-coding
20q13.33
Ensembl:ENSG00000171700 MIM:605071 Vega:OTTHUMG00000033024 UniprotKB:P49795
NC_000020.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.565e-1 (AD)  5.752e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNASET20.801
DEF60.787
CD680.786
LAT20.784
ARPC1B0.782
TYROBP0.782
IRF50.781
CD530.78
CD140.779
ABI30.778

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.387
OR4F29-0.349
IGFN1-0.289
SOX3-0.267
HPDL-0.254
FAM180B-0.253
TEX38-0.247
FBXL22-0.241
C16orf96-0.24
GLIPR1L2-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of RGS19 mRNA"18648102
D000499AllylamineAllylamine affects the expression of RGS19 mRNA15910882
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RGS19 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of RGS19 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RGS19 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of RGS19 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RGS19 mRNA19770486
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of RGS19 mRNA20404318
C044887beta-methylcholinebeta-methylcholine affects the expression of RGS19 mRNA21179406
C006780bisphenol Abisphenol A affects the methylation of RGS19 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of RGS19 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of RGS19 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RGS19 mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of RGS19 mRNA23125180
D002794CholineCholine affects the expression of RGS19 mRNA17616785
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS19 mRNA20938992
D002995Clofibric AcidClofibric Acid affects the expression of RGS19 mRNA17602206
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RGS19 mRNA20971185
C009160cyclonitecyclonite results in increased expression of RGS19 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of RGS19 mRNA20106945
D003976DiazinonDiazinon results in increased methylation of RGS19 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of RGS19 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of RGS19 mRNA27392435
D002945CisplatinCisplatin results in increased expression of RGS19 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of RGS19 mRNA18042831
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RGS19 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS19 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RGS19 mRNA17351261
D005419FlavonoidsFlavonoids results in decreased expression of RGS19 mRNA18035473
C061365flusilazoleflusilazole affects the expression of RGS19 mRNA21195148
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS19 mRNA20938992
C409722hexaconazolehexaconazole affects the expression of RGS19 mRNA21195148
D017313FenretinideFenretinide results in decreased expression of RGS19 mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of RGS19 mRNA27392435
C544151jinfukangjinfukang results in increased expression of RGS19 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RGS19 mRNA23086925|2343069
D007649KetamineKetamine results in decreased expression of RGS19 mRNA20080153
C008261lead acetatelead acetate results in decreased expression of RGS19 mRNA21829687
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RGS19 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS19 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RGS19 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RGS19 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RGS19 mRNA"25554681
D009532NickelNickel results in increased expression of RGS19 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of RGS19 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RGS19 mRNA20971185
D000073878Palm OilPalm Oil results in decreased expression of RGS19 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of RGS19 mRNA18445702
D059808PolyphenolsPolyphenols results in decreased expression of RGS19 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in increased expression of RGS19 mRNA24780913
D011794QuercetinQuercetin results in increased expression of RGS19 mRNA21632981
C016104sodium bichromatesodium bichromate results in decreased expression of RGS19 mRNA17685462
D012999SomanSoman results in increased expression of RGS19 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS19 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS19 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RGS19 mRNA17942748|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RGS19 mRNA22298810
D013853ThioacetamideThioacetamide results in increased expression of RGS19 mRNA23411599
C032910triadimefontriadimefon affects the expression of RGS19 mRNA21195148
C012589trichostatin Atrichostatin A affects the expression of RGS19 mRNA28542535
D014520UrethaneUrethane results in decreased expression of RGS19 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of RGS19 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of RGS19 mRNA20546886|2142705
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RGS19 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of RGS19 mRNA26682919
D015032ZincZinc results in decreased expression of RGS19 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of RGS19 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IEA-  
GO:0005515protein binding-IPI8524874  9770488  
GO ID GO Term Qualifier Evidence PubMed
GO:0006914autophagy-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS8524874  
GO:0007264small GTPase mediated signal transduction-TAS9571244  
GO:0009968negative regulation of signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-TAS9571244  
GO:0005834heterotrimeric G-protein complexcolocalizes_withTAS8524874  
GO:0005903brush border-IEA-  
GO:0016020membrane-TAS9571244  
GO:0030136clathrin-coated vesicle-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418597G alpha (z) signalling eventsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23799031Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. (2013)Zhang HPLoS One