Gene: SF3A1

10291
PRP21|PRPF21|SAP114|SF3A120
splicing factor 3a subunit 1
protein-coding
22q12.2
Ensembl:ENSG00000099995 MIM:605595 Vega:OTTHUMG00000151005 UniprotKB:Q15459
NG_032902.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.196e-1 (AD)  1.844e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPF80.95
GANAB0.942
CS0.934
SRP680.933
PSAP0.93
APLP20.928
UBAP2L0.927
SMG70.926
ADAR0.924
DHX90.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.738
OR4F29-0.7
KLF17-0.304
CTNNA3-0.288
KLRC2-0.286
SH2D1A-0.273
KLRB1-0.272
SLAMF6-0.271
TFPI2-0.267
GZMK-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55281910-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of SF3A1 protein23001822
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SF3A1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SF3A1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SF3A1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SF3A1 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SF3A1 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SF3A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SF3A1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of SF3A1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SF3A1 gene27153756
D001280AtrazineAtrazine results in decreased expression of SF3A1 mRNA22378314
C006780bisphenol Abisphenol A affects the expression of SF3A1 mRNA21786754
C013418bromfenacoumbromfenacoum results in decreased expression of SF3A1 protein28903499
C515564bromovaninbromovanin results in increased expression of SF3A1 protein21419150
C018475butyraldehydebutyraldehyde results in decreased expression of SF3A1 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of SF3A1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of SF3A1 promoter27989131
D003976DiazinonDiazinon results in increased methylation of SF3A1 gene22964155
D002945CisplatinCisplatin results in decreased expression of SF3A1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of SF3A1 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SF3A1 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SF3A1 mRNA17942748
C010974glyphosateglyphosate results in increased expression of SF3A1 mRNA26302742
D017313FenretinideFenretinide results in increased expression of SF3A1 mRNA28973697
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SF3A1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SF3A1 mRNA"27188386
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SF3A1 protein26558463
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of SF3A1 mRNA"23246600
D010936Plant ExtractsPlant Extracts results in decreased expression of SF3A1 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of SF3A1 mRNA19693291
C059514resveratrolresveratrol results in decreased expression of SF3A1 protein25505154
C009277sodium arsenatesodium arsenate results in decreased expression of SF3A1 mRNA23922661
D018038Sodium SeleniteSodium Selenite results in increased expression of SF3A1 mRNA18175754
D013739TestosteroneTestosterone results in increased expression of SF3A1 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SF3A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SF3A1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SF3A1 promoter]19654925
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SF3A1 mRNA19042947
D014415TunicamycinTunicamycin results in increased expression of SF3A1 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of SF3A1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SF3A1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of SF3A1 mRNA23034163
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of SF3A1 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003723RNA binding-IBA21873635  
GO:0003723RNA binding-IDA10882114  
GO:0005515protein binding-IPI10976766  16055720  17098193  17332742  20562859  22365833  
23793891  26420826  28838205  
GO ID GO Term Qualifier Evidence PubMed
GO:0000389mRNA 3'-splice site recognition-TAS15647371  
GO:0000398mRNA splicing, via spliceosome-IC9731529  11991638  
GO:0000398mRNA splicing, via spliceosome-IDA10882114  
GO:0000398mRNA splicing, via spliceosome-TAS-  
GO:0006397mRNA processing-IMP15647371  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005681spliceosomal complex-IDA9731529  
GO:0005684U2-type spliceosomal complex-IDA10882114  
GO:0005686U2 snRNP-IBA21873635  
GO:0005686U2 snRNP-IDA23793891  
GO:0016607nuclear speck-IDA-  
GO:0071004U2-type prespliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IBA21873635  
GO:0071013catalytic step 2 spliceosome-IDA11991638  
KEGG ID KEGG Term
hsa03040Spliceosome
Reactome ID Reactome Term Evidence
R-HSA-72163mRNA Splicing - Major PathwayTAS
R-HSA-72172mRNA SplicingTAS
R-HSA-72203Processing of Capped Intron-Containing Pre-mRNATAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26498691SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer. (2015 Nov 10)Tian JOncotarget
26079486The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population. (2015)Chen XPLoS One
26564640[Research on the association between U2-dependent spliceosome gene and hepatocellular cancer]. (2015 Jun)Song WZhonghua Liu Xing Bing Xue Za Zhi