Gene info: ID 10298

Gene: PAK4

GENE ID: 10298

Synonyms: -

Description: p21 (RAC1) activated kinase 4

Gene type: protein-coding

Location: 19q13.2

dbXrefs: Ensembl:ENSG00000130669 MIM:605451 Vega:OTTHUMG00000182800 UniprotKB:O96013

RefSeq: NG_047118.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.667e-1 (AD) 6.963e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg12406027	chr19:39616818	PAK4		9.900e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EHD1	0.831
TCF3	0.826
SLC25A1	0.814
RBCK1	0.807
RAVER1	0.806
ABL1	0.792
GNAI2	0.788
ARAF	0.788
FBRS	0.785
COMT	0.782

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.564
OR4F29	-0.537
KLHL14	-0.272
CDH7	-0.272
TYRP1	-0.271
ATP12A	-0.262
IL1RAPL2	-0.258
PPEF1	-0.257
SLC35G1	-0.248
RAB3B	-0.247

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C569670	1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one	"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of PAK4 protein"	21981714
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of PAK4 protein"	27026707
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PAK4 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PAK4 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PAK4 mRNA]	28655636
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of PAK4 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PAK4 protein"	25670856
D000082	Acetaminophen	Acetaminophen results in decreased expression of PAK4 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of PAK4 mRNA	17562736
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PAK4 mRNA	22228805
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of PAK4 mRNA"	20162321
C006780	bisphenol A	bisphenol A affects the expression of PAK4 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of PAK4 mRNA	25181051
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PAK4 gene	20938992
D003471	Cuprizone	Cuprizone results in increased expression of PAK4 mRNA	26577399
C000944	dicrotophos	dicrotophos results in increased expression of PAK4 mRNA	28302478
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PAK4 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PAK4 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAK4 mRNA	17942748
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of PAK4 exon	16300676
D005485	Flutamide	Flutamide results in increased expression of PAK4 mRNA	21126777
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PAK4 gene	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PAK4 gene	20938992
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of PAK4 mRNA	20864626
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PAK4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PAK4 mRNA"	25554681
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of PAK4 mRNA]	28655636
D052638	Particulate Matter	Particulate Matter results in decreased expression of PAK4 mRNA	24769257\|2865563
D010936	Plant Extracts	Plant Extracts results in decreased expression of PAK4 mRNA	23557933
C045362	prochloraz	prochloraz results in increased expression of PAK4 mRNA	21470553
D011441	Propylthiouracil	Propylthiouracil results in increased expression of PAK4 mRNA	24780913
D012643	Selenium	Selenium results in increased expression of PAK4 mRNA	19244175
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of PAK4 mRNA"	26680231
D013629	Tamoxifen	Tamoxifen affects the expression of PAK4 mRNA	17555576
D013654	Taurine	Taurine results in decreased expression of PAK4 mRNA	16579726
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PAK4 mRNA	23152189
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAK4 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PAK4 mRNA	17942748
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of PAK4 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of PAK4 mRNA	28655636
C025643	vinclozolin	vinclozolin affects the expression of PAK4 mRNA	19015723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	NAS	9822598
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	IDA	26607847
GO:0004674	protein serine/threonine kinase activity	-	IMP	21788589
GO:0005515	protein binding	-	IPI	15161933 15324660 17353931 20936779 21044950 22653441 24255178 25074804 26607847
GO:0005524	ATP binding	-	IEA	-
GO:0048365	Rac GTPase binding	-	IBA	21873635
GO:0098641	cadherin binding involved in cell-cell adhesion	-	HDA	25468996

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	TAS	20070256
GO:0006915	apoptotic process	-	TAS	20070256
GO:0007010	cytoskeleton organization	-	TAS	20070256
GO:0007049	cell cycle	-	IEA	-
GO:0007165	signal transduction	-	TAS	20070256
GO:0007266	Rho protein signal transduction	-	IBA	21873635
GO:0007346	regulation of mitotic cell cycle	-	IBA	21873635
GO:0008283	cell proliferation	-	TAS	20070256
GO:0016477	cell migration	-	IBA	21873635
GO:0016477	cell migration	-	TAS	20070256
GO:0023014	signal transduction by protein phosphorylation	-	IBA	21873635
GO:0030036	actin cytoskeleton organization	-	IBA	21873635
GO:0032147	activation of protein kinase activity	-	IBA	21873635
GO:0043408	regulation of MAPK cascade	-	IBA	21873635
GO:0045766	positive regulation of angiogenesis	-	IMP	21788589
GO:0060996	dendritic spine development	-	IEA	-
GO:0071407	cellular response to organic cyclic compound	-	IEA	-
GO:0098609	cell-cell adhesion	-	IEA	-
GO:2000352	negative regulation of endothelial cell apoptotic process	-	IMP	21788589

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005794	Golgi apparatus	-	TAS	9822598
GO:0005913	cell-cell adherens junction	-	HDA	25468996
GO:0005925	focal adhesion	-	HDA	21423176

KEGG ID	KEGG Term
hsa04012	ErbB signaling pathway
hsa04360	Axon guidance
hsa04510	Focal adhesion
hsa04660	T cell receptor signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa05211	Renal cell carcinoma

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	IEA
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-422475	Axon guidance	IEA
R-HSA-428540	Activation of RAC1	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23652058	Gene polymorphisms of interleukin-28, p21-activated protein kinases 4, and response to interferon-alpha based therapy in Chinese patients with chronic hepatitis B. (2013)	Yu FX	Chin Med J (Engl)