Gene: ADAR

103
ADAR1|AGS6|DRADA|DSH|DSRAD|G1P1|IFI-4|IFI4|K88DSRBP|P136
adenosine deaminase, RNA specific
protein-coding
1q21.3
Ensembl:ENSG00000160710 MIM:146920 Vega:OTTHUMG00000037261 UniprotKB:P55265
NG_011844.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.517e-1 (AD)  6.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSNK2A10.948
TOX40.946
AP2B10.945
NRBP10.945
MBD10.945
WDR820.944
PRPF80.944
LARP4B0.943
QRICH10.941
GRB20.941

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.726
OR4F29-0.694
MTRNR2L6-0.277
MTRNR2L10-0.262
MTRNR2L9-0.257
SH2D1A-0.253
CTNNA3-0.24
KLRC2-0.232
KLRB1-0.23
ASB4-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADAR mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of ADAR mRNA21420995
D000082AcetaminophenAcetaminophen results in decreased expression of ADAR mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ADAR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADAR mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADAR mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of ADAR mRNA20458559
D001280AtrazineAtrazine results in decreased expression of ADAR mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADAR mRNA22228805|2373587
C044887beta-methylcholinebeta-methylcholine affects the expression of ADAR mRNA21179406
C006780bisphenol Abisphenol A affects the expression of ADAR mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ADAR mRNA14967926
C006780bisphenol Abisphenol A affects the expression of ADAR mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ADAR mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ADAR mRNA14729362|1500399
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ADAR mRNA17484886
D000068579CelecoxibCelecoxib results in decreased expression of ADAR mRNA28201806
D002994ClofibrateClofibrate results in decreased expression of ADAR mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ADAR mRNA17585979
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ADAR mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of ADAR mRNA28302478
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ADAR mRNA21658437
D004726EndosulfanEndosulfan results in increased expression of ADAR mRNA21036383
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ADAR protein23301498
D005485FlutamideFlutamide results in increased expression of ADAR mRNA24136188
D005839GentamicinsGentamicins results in increased expression of ADAR mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ADAR mRNA21179406
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAR mRNA25613284
D008727MethotrexateADAR protein results in decreased susceptibility to Methotrexate28188287
D008727Methotrexate[ADAR protein results in increased expression of DHFR protein] which results in decreased susceptibility to Methotrexate28188287
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADAR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAR mRNA"25554681
D010269Paraquat[ADAR gene mutant form results in increased expression of DHD mRNA] which results in decreased susceptibility to Paraquat15530657
D010269ParaquatADAR protein affects the susceptibility to Paraquat15530657
D010416PentachlorophenolPentachlorophenol results in increased expression of ADAR mRNA23892564
D012402RotenoneRotenone results in increased expression of ADAR mRNA19013527
D012834SilverSilver results in decreased expression of ADAR mRNA27131904
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of ADAR mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of ADAR mRNA20937368
D013749TetrachlorodibenzodioxinADAR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]26601943
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAR mRNA25613284
D014501UraniumUranium affects the expression of ADAR mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of ADAR mRNA15672453
D014635Valproic AcidValproic Acid affects the expression of ADAR mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ADAR mRNA19136453
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ADAR gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0003723RNA binding-HDA22658674  22681889  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003726double-stranded RNA adenosine deaminase activity-IBA21873635  
GO:0003726double-stranded RNA adenosine deaminase activity-IDA9020165  
GO:0003726double-stranded RNA adenosine deaminase activity-NAS7565688  
GO:0003726double-stranded RNA adenosine deaminase activity-TAS-  
GO:0005515protein binding-IPI18362360  22810585  23853584  24136289  28355180  
GO:0008251tRNA-specific adenosine deaminase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-IEA-  
GO:0001701in utero embryonic development-IEA-  
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0002566somatic diversification of immune receptors via somatic mutation-IEA-  
GO:0006382adenosine to inosine editing-IBA21873635  
GO:0006382adenosine to inosine editing-IDA15858013  19651874  21289159  
GO:0006382adenosine to inosine editing-IMP16475990  
GO:0006382adenosine to inosine editing-TAS-  
GO:0006396RNA processing-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO:0009615response to virus-IMP15858013  
GO:0016553base conversion or substitution editing-IDA9020165  
GO:0030218erythrocyte differentiation-IEA-  
GO:0031054pre-miRNA processing-IDA23622242  
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA-IDA23622242  
GO:0035455response to interferon-alpha-IDA16475990  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation-IDA19651874  
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation-IMP18362360  
GO:0045070positive regulation of viral genome replication-IDA19651874  
GO:0045070positive regulation of viral genome replication-IMP18362360  
GO:0045071negative regulation of viral genome replication-IEA-  
GO:0045087innate immune response-TAS16475990  
GO:0051607defense response to virus-IEA-  
GO:0060216definitive hemopoiesis-IEA-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0060339negative regulation of type I interferon-mediated signaling pathway-IEA-  
GO:0061484hematopoietic stem cell homeostasis-IEA-  
GO:0098586cellular response to virus-IEA-  
GO:1900369negative regulation of RNA interference-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA18362360  23622242  
GO:0005634nucleus-TAS7565688  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IBA21873635  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23622242  
GO:0005737cytoplasm-TAS7565688  
GO:0016020membrane-HDA19946888  
GO:0044530supraspliceosomal complex-IDA18362360  
KEGG ID KEGG Term
hsa04623Cytosolic DNA-sensing pathway
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-75064mRNA Editing: A to I ConversionTAS
R-HSA-75072mRNA EditingTAS
R-HSA-75102C6 deamination of adenosineTAS
R-HSA-77042Formation of editosomes by ADAR proteinsTAS
R-HSA-8953854Metabolism of RNATAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
13679660Juvenile arteritis revisited. Buerger's disease-Takayasu's disease. (2002 Sep-Dec)Fiessinger JNPathophysiol Haemost Thromb