Gene: CDKN2B

1030
CDK4I|INK4B|MTS2|P15|TP15|p15INK4b
cyclin dependent kinase inhibitor 2B
protein-coding
9p21.3
Ensembl:ENSG00000147883 MIM:600431 Vega:OTTHUMG00000019691 UniprotKB:P42772
NG_023297.1
PubMed
0   ANCO-SNPs
ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.251e-1 (AD)  3.489e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WWTR10.788
SPOCD10.78
TNFRSF12A0.778
TCF70.773
DRAM10.771
SLC43A30.764
MAPKAPK20.761
MYD880.748
TIMP10.745
RDH100.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.559
BCL11A-0.547
HAS1-0.539
KCNB2-0.539
CNNM1-0.525
CALHM1-0.524
MARCH4-0.522
MYADML2-0.522
SLITRK5-0.518
KLHL35-0.518

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDKN2B mRNA"26988655
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased expression of CDKN2B protein17513607
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneCDKN2B protein affects the susceptibility to 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one17513607
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CDKN2B mRNA"19167446
C5191322-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride"2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]"22869556
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CDKN2B mRNA16788091
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in increased expression of CDKN2B mRNA"19916542
C4949143,5,3',4',5'-pentamethoxystilbene"3,5,3',4',5'-pentamethoxystilbene results in increased expression of CDKN2B protein"19916542
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN2B protein]"12421932
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CDKN2B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN2B mRNA"27188386
C5805985-OH-BDE-475-OH-BDE-47 results in decreased expression of CDKN2B mRNA26988655
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN2B mRNA"27188386
C5805996-OH-BDE-476-OH-BDE-47 results in decreased expression of CDKN2B mRNA26988655
D000082AcetaminophenAcetaminophen affects the expression of CDKN2B mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of CDKN2B mRNA29067470
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN2B mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDKN2B protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDKN2B mRNA21641981|2715375
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDKN2B mRNA16483693
D001151ArsenicArsenic results in decreased expression of CDKN2B mRNA19945496
C006632arsenic trioxidearsenic trioxide results in decreased methylation of CDKN2B gene12679007|1729472
C006632arsenic trioxide[arsenic trioxide results in decreased methylation of CDKN2B promoter] which results in increased expression of CDKN2B mRNA20596618|2059661
C006632arsenic trioxidearsenic trioxide results in increased expression of CDKN2B mRNA11877046|1266734
C006632arsenic trioxide[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CDKN2B mRNA19099629
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of CDKN2B mRNA"25757056
C105832auraptenaurapten affects the expression of CDKN2B mRNA23320178
D001374AzacitidineAzacitidine results in decreased methylation of CDKN2B promoter19194470
D001374AzacitidineCDKN2B promoter modified form affects the susceptibility to Azacitidine17611569
D001374Azacitidine[metacept-1 co-treated with Azacitidine] results in increased expression of CDKN2B19148494
D001379AzathioprineAzathioprine results in increased expression of CDKN2B mRNA22623647
D001554BenzeneBenzene results in decreased expression of CDKN2B mRNA20044985
D001554Benzene[Benzene results in increased methylation of CDKN2B promoter] which results in decreased expression of CDKN2B mRNA20044985|2004498
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CDKN2B mRNA22687991
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA21295105
D019324beta-Naphthoflavoneisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]21295105
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDKN2B mRNA20064835|2187194
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDKN2B22410783
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CDKN2B gene22410783
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDKN2B mRNA19770486|2222880
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN2B mRNA25820237
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CDKN2B mRNA"19150397
D004958Estradiol[Estradiol co-treated with EGF protein] results in decreased expression of CDKN2B mRNA24758408
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CDKN2B mRNA20660070
D004958EstradiolEstradiol results in decreased expression of CDKN2B mRNA24758408
D004958EstradiolEstradiol results in increased expression of CDKN2B mRNA23094148
C006780bisphenol Abisphenol A results in increased expression of CDKN2B mRNA21932408
C006780bisphenol Abisphenol A affects the expression of CDKN2B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CDKN2B gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDKN2B mRNA12419474
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CDKN2B mRNA14729362
D002087ButyratesButyrates results in increased expression of CDKN2B mRNA14674679
D002101Cacodylic AcidCacodylic Acid results in decreased expression of CDKN2B mRNA17720352
D002104CadmiumCadmium results in increased expression of CDKN2B mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CDKN2B mRNA26525392
D002185CannabidiolCannabidiol results in increased expression of CDKN2B mRNA21542829
D002220CarbamazepineCarbamazepine affects the expression of CDKN2B mRNA25979313
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of CDKN2B mRNA18636392
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of CDKN2B mRNA25820237
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CDKN2B protein21621607
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CDKN2B mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of CDKN2B mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of CDKN2B mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of CDKN2B mRNA21632981|2556210
C089595cylindrospermopsincylindrospermopsin results in increased expression of CDKN2B mRNA23726867
C017160cypermethrincypermethrin results in increased expression of CDKN2B mRNA22528246
D003630DaunorubicinDaunorubicin results in increased expression of CDKN2B mRNA12656675
C014347decitabinedecitabine affects the expression of CDKN2B mRNA16882708
C014347decitabinedecitabine affects the expression of CDKN2B protein17056112
C014347decitabinedecitabine affects the methylation of CDKN2B gene17056112
C014347decitabine[decitabine affects the methylation of CDKN2B promoter] which affects the expression of CDKN2B mRNA18704418|1870441
C014347decitabinedecitabine promotes the reaction [trichostatin A results in increased expression of CDKN2B mRNA]18718068
C014347decitabinedecitabine results in decreased methylation of CDKN2B gene17294728
C014347decitabinedecitabine results in decreased methylation of CDKN2B promoter19194470
C014347decitabinedecitabine results in increased expression of CDKN2B mRNA17679729|1778557
C014347decitabinedecitabine results in increased expression of CDKN2B mRNA27915011
D013759DronabinolDronabinol results in increased expression of CDKN2B mRNA21542829
D002945Cisplatin[Cisplatin co-treated with Quercetin] results in increased expression of CDKN2B mRNA27514524
C121718dicyclanildicyclanil results in increased expression of CDKN2B mRNA15664270
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CDKN2B mRNA18691550
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of CDKN2B mRNA24535843
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN2B mRNA]18691550
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA21295105
D004052Diethylnitrosamineisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]21295105
D002117CalcitriolCalcitriol results in increased expression of CDKN2B mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CDKN2B mRNA21592394
C472511dimethylarsinous aciddimethylarsinous acid results in decreased expression of CDKN2B mRNA19945496
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CDKN2B mRNA"19480007
D0198131,2-Dimethylhydrazine"[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of CDKN2B mRNA"26388957
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CDKN2B mRNA15138612
D004391DustDust results in decreased expression of CDKN2B mRNA17805423
D004726EndosulfanEndosulfan results in increased expression of CDKN2B mRNA26615145
C118739entinostatentinostat results in increased expression of CDKN2B mRNA27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of CDKN2B mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of CDKN2B mRNA21233418
D005273FenbendazoleFenbendazole results in increased expression of CDKN2B mRNA23411599
D005419FlavonoidsFlavonoids results in increased expression of CDKN2B mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CDKN2B mRNA17317680
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of CDKN2B mRNA22213190
D005473FluoxetineFluoxetine results in increased expression of CDKN2B mRNA21497159
D005557FormaldehydeFormaldehyde results in increased expression of CDKN2B mRNA20655997
D005557FormaldehydeFormaldehyde results in decreased expression of CDKN2B mRNA12679049
C056933fumonisin B1fumonisin B1 results in increased expression of CDKN2B mRNA16221962
C039281furanfuran results in increased expression of CDKN2B mRNA20562052|2207923
C419708gefitinibgefitinib results in increased expression of CDKN2B mRNA17513607
C419708gefitinibgefitinib results in increased expression of CDKN2B protein17513607
D019833GenisteinGenistein results in increased expression of CDKN2B mRNA22228119
D005938GlucocorticoidsGlucocorticoids results in increased expression of CDKN2B protein15034294
C500810GW8510GW8510 results in increased expression of CDKN2B mRNA22242153
D006247HarmineHarmine results in decreased expression of CDKN2B mRNA25751815
D017313FenretinideFenretinide results in decreased expression of CDKN2B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDKN2B mRNA12419474
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDKN2B mRNA14729362
D006918HydroxyureaHydroxyurea results in increased expression of CDKN2B mRNA27208086
C016517indole-3-carbinolindole-3-carbinol results in increased expression of CDKN2B16082211
C016527isoquercitrinisoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]21295105
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CDKN2B mRNA25961927
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CDKN2B mRNA26752646
C533894LG 100815LG 100815 results in increased expression of CDKN2B mRNA16951191
C018584linaloollinalool results in increased expression of CDKN2B mRNA19922762
D018021Lithium ChlorideLithium Chloride results in increased expression of CDKN2B mRNA23527032
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CDKN2B mRNA16507785
C527236metacept-1[metacept-1 co-treated with Azacitidine] results in increased expression of CDKN2B19148494
C527236metacept-1metacept-1 results in increased expression of CDKN2B19148494
D008694MethamphetamineMethamphetamine results in increased expression of CDKN2B mRNA15644446
D009151Mustard GasMustard Gas results in increased expression of CDKN2B mRNA25102026
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of CDKN2B mRNA]16361081
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CDKN2B mRNA"25554681
C022838nickel chloridenickel chloride affects the expression of CDKN2B mRNA22546817
C025589ochratoxin Aochratoxin A results in decreased acetylation of CDKN2B promoter29098329
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of CDKN2B mRNA"16951191
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of CDKN2B mRNA18636392
C500026palbociclib"2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [palbociclib results in increased expression of CDKN2B protein]"22869556
C500026palbociclibCDKN2B protein results in decreased susceptibility to palbociclib22711607
C500026palbociclibpalbociclib results in increased expression of CDKN2B protein22869556
C500026palbociclibCDKN2B protein affects the susceptibility to palbociclib23898052
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of CDKN2B mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of CDKN2B mRNA19442831
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of CDKN2B mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CDKN2B mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDKN2B mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CDKN2B mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CDKN2B mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CDKN2B mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of CDKN2B mRNA16221962
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of CDKN2B mRNA]16221962
D028321Plant PreparationsPlant Preparations results in increased expression of CDKN2B mRNA24973489
D011241PrednisonePrednisone results in increased expression of CDKN2B protein15034294
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CDKN2B mRNA20660070
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CDKN2B mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDKN2B mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDKN2B mRNA"21152443
D011794Quercetin[Cisplatin co-treated with Quercetin] results in increased expression of CDKN2B mRNA27514524
D011794QuercetinQuercetin results in increased expression of CDKN2B mRNA21632981|2751452
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of CDKN2B mRNA19167446
C059514resveratrolresveratrol results in increased expression of CDKN2B mRNA25888808
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of CDKN2B mRNA21127053
D019438RitonavirRitonavir results in increased expression of CDKN2B mRNA19386116
D012906SmokeSmoke results in decreased expression of CDKN2B mRNA21095227
D012906SmokeSmoke affects the expression of CDKN2B mRNA23693141
C017947sodium arsenitesodium arsenite affects the expression of CDKN2B mRNA16507464
C017947sodium arsenitesodium arsenite results in decreased expression of CDKN2B mRNA16014739
C016104sodium bichromatesodium bichromate results in increased expression of CDKN2B mRNA12325037
D018038Sodium SeleniteSodium Selenite results in increased expression of CDKN2B mRNA16705456
C471405sorafenibsorafenib results in increased expression of CDKN2B protein19139124
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CDKN2B mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CDKN2B mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CDKN2B mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDKN2B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDKN2B mRNA17070097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDKN2B protein17070097
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CDKN2B mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CDKN2B mRNA16611356|2080547
D013755Tetradecanoylphorbol Acetate"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN2B protein]"12421932
D013853ThioacetamideThioacetamide results in increased expression of CDKN2B mRNA22659510|2341159
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDKN2B mRNA17070097
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDKN2B protein17070097
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of CDKN2B promoter25214829
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of CDKN2B mRNA"17951470
D014212TretinoinTretinoin results in increased expression of CDKN2B mRNA17138961|2193413
C012589trichostatin Adecitabine promotes the reaction [trichostatin A results in increased expression of CDKN2B mRNA]18718068
C012589trichostatin Atrichostatin A results in increased expression of CDKN2B mRNA18718068
D014520UrethaneUrethane results in increased expression of CDKN2B mRNA28818685
D014520UrethaneUrethane results in decreased expression of CDKN2B mRNA12117781
D014635Valproic Acid[Valproic Acid co-treated with arsenic trioxide] results in increased expression of CDKN2B mRNA19099629
D014635Valproic AcidValproic Acid results in increased expression of CDKN2B mRNA22083351|2317975
D014635Valproic AcidValproic Acid results in increased expression of CDKN2B protein22083351
D002762CholecalciferolCholecalciferol results in increased expression of CDKN2B mRNA16508948
C111237vorinostatvorinostat results in increased expression of CDKN2B mRNA22083351
C111237vorinostatvorinostat results in increased expression of CDKN2B protein22083351
C016837zinc chloridezinc chloride results in decreased expression of CDKN2B mRNA21540303
C088658zoledronic acidzoledronic acid results in increased expression of CDKN2B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-IBA21873635  
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-IDA8078588  
GO:0004861cyclin-dependent protein serine/threonine kinase inhibitor activity-NAS9230210  
GO:0005515protein binding-IPI16169070  16189514  19447967  21900206  23455922  23602568  
25416956  25910212  26496610  
GO:0019901protein kinase binding-IPI8078588  
GO ID GO Term Qualifier Evidence PubMed
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IDA8078588  
GO:0000086G2/M transition of mitotic cell cycle-IMP17553787  
GO:0007050cell cycle arrest-IMP17553787  
GO:0007093mitotic cell cycle checkpoint-IMP17553787  
GO:0008285negative regulation of cell proliferation-IMP17553787  
GO:0030219megakaryocyte differentiation-IEP10812241  
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway-IMP16943770  
GO:0031658negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0031668cellular response to extracellular stimulus-IMP17553787  
GO:0031670cellular response to nutrient-IMP17597576  
GO:0042326negative regulation of phosphorylation-IDA8078588  
GO:0045944positive regulation of transcription by RNA polymerase II-TAS-  
GO:0048536spleen development-IEA-  
GO:0050680negative regulation of epithelial cell proliferation-IMP16943770  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA9230210  18564286  
GO:0005737cytoplasm-IDA9230210  16943770  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1640170Cell CycleTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2173793Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerTAS
R-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559585Oncogene Induced SenescenceTAS
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-69231Cyclin D associated events in G1TAS
R-HSA-69236G1 PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22199344Clinical significance of hypermethylation status in NSCLC: evaluation of a 30-gene panel in patients with advanced disease. (2011 Dec)Pesek MAnticancer Res
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One
21889114Association of copy number loss of CDKN2B and PTCH1 with poor overall survival in patients with pulmonary squamous cell carcinoma. (2011 Sep)Zhao YClin Lung Cancer
25592106Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population. (2015 Sep)Nawaz SKAnatol J Cardiol
28264723Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. (2017 Mar 7)Lin XBMC Med
21347282Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (2011 Feb 10)Lettre GPLoS Genet
21742680Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. (2011 Sep 1)Lachance DHAm J Epidemiol