Gene: DLEU1

10301
BCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6
deleted in lymphocytic leukemia 1
ncRNA
13q14.2-q14.3
Ensembl:ENSG00000176124 MIM:605765 Vega:OTTHUMG00000016934 UniprotKB:O43261
NC_000013.11
SNP Mapped
1   ANCO-SNPs
ND
0   
9.013e-1 (AD)  3.716e-1 (ND)   (Frontal_Cortex)
4.688e-3 (AD)  2.509e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12874278chr13:50361786 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGARP0.611
RPS27L0.61
CCNG10.599
RCC10.579
CCDC102A0.576
MIA0.572
EBPL0.565
PUS30.564
PAPOLA0.564
UBXN2A0.562

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INHA-0.484
FOXP3-0.454
ANKMY1-0.438
TECTA-0.438
ALOX12B-0.437
SLC25A45-0.432
CYP4A11-0.424
SPDEF-0.422
RFX8-0.419
KREMEN2-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DLEU1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DLEU1 mRNA27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of DLEU1 mRNA27829220
D019327Copper SulfateCopper Sulfate results in decreased expression of DLEU1 mRNA19549813
D016572CyclosporineCyclosporine affects the expression of DLEU1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of DLEU1 mRNA27989131
C000944dicrotophosdicrotophos results in decreased expression of DLEU1 mRNA28302478
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DLEU1 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of DLEU1 mRNA26191083
D012822Silicon DioxideSilicon Dioxide results in decreased expression of DLEU1 mRNA25351596
D014635Valproic AcidValproic Acid affects the expression of DLEU1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DLEU1 mRNA23179753|2800136
C111237vorinostatvorinostat results in increased expression of DLEU1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal