Gene: TCIRG1

10312
ATP6N1C|ATP6V0A3|Atp6i|OC-116kDa|OC116|OPTB1|Stv1|TIRC7|Vph1|a3
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
protein-coding
11q13.2
Ensembl:ENSG00000110719 MIM:604592 Vega:OTTHUMG00000167358 UniprotKB:Q13488
NG_007878.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.069e-1 (AD)  6.692e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LGALS90.895
ARPC1B0.891
TNFRSF1B0.889
RHBDF20.888
GPSM30.887
STK100.886
CYBA0.881
STXBP20.88
PTPN60.878
FXYD50.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.44
CRH-0.431
SLC7A4-0.428
SMIM18-0.427
PPEF1-0.421
KIT-0.417
NEUROD6-0.409
ABCC12-0.406
ST6GAL2-0.405
KCNB2-0.403

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TCIRG1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TCIRG1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCIRG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCIRG1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TCIRG1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TCIRG1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TCIRG1 mRNA24449571
D001151ArsenicArsenic affects the methylation of TCIRG1 gene25304211
D001241AspirinAspirin results in increased expression of TCIRG1 mRNA11906190
C547126AZM551248AZM551248 results in increased expression of TCIRG1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TCIRG1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of TCIRG1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of TCIRG1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride affects the methylation of TCIRG1 promoter22457795
D003471CuprizoneCuprizone results in increased expression of TCIRG1 mRNA27523638
D003703DemecolcineDemecolcine results in decreased expression of TCIRG1 mRNA23649840
D003976DiazinonDiazinon results in increased methylation of TCIRG1 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of TCIRG1 protein22705712
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TCIRG1 mRNA27392435
D004026DieldrinDieldrin results in increased expression of TCIRG1 mRNA28385952
C118739entinostatentinostat results in increased expression of TCIRG1 mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TCIRG1 mRNA"27188386
C540355fenamidonefenamidone results in increased expression of TCIRG1 mRNA27029645
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TCIRG1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of TCIRG1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TCIRG1 mRNA23086925
D064704LevofloxacinLevofloxacin results in decreased expression of TCIRG1 mRNA24136188
D008777MethyltestosteroneMethyltestosterone results in increased expression of TCIRG1 mRNA29191790
C568376MT19c compoundMT19c compound results in decreased expression of TCIRG1 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TCIRG1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TCIRG1 mRNA"25554681
D009532NickelNickel results in increased expression of TCIRG1 mRNA24768652|2558310
D010416PentachlorophenolPentachlorophenol results in increased expression of TCIRG1 mRNA23892564
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TCIRG1 mRNA28973697
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TCIRG1 protein26879310
C045362prochlorazprochloraz results in increased expression of TCIRG1 mRNA21470553
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TCIRG1 mRNA27029645
D012402RotenoneRotenone results in increased expression of TCIRG1 mRNA19013527
C017947sodium arsenitesodium arsenite affects the expression of TCIRG1 mRNA19590694
C061133tamibarotenetamibarotene results in increased expression of TCIRG1 mRNA15498508
D013629TamoxifenTamoxifen results in increased expression of TCIRG1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TCIRG1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TCIRG1 mRNA21570461
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of TCIRG1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TCIRG1 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of TCIRG1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of TCIRG1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TCIRG1 mRNA28065790
D014212TretinoinTretinoin results in increased expression of TCIRG1 mRNA15498508
C080163trovafloxacintrovafloxacin results in decreased expression of TCIRG1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TCIRG1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TCIRG1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of TCIRG1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of TCIRG1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TCIRG1 gene25560391
D014750VincristineVincristine results in decreased expression of TCIRG1 mRNA23649840
C104536xanthohumolxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of TCIRG1 mRNA]23994090

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS8579597  
GO:0046961proton-transporting ATPase activity, rotational mechanism-IBA21873635  
GO:0051117ATPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006968cellular defense response-TAS9806637  
GO:0007035vacuolar acidification-IBA21873635  
GO:0007039protein catabolic process in the vacuole-ISS-  
GO:0008284positive regulation of cell proliferation-TAS9806637  
GO:0008286insulin receptor signaling pathway-TAS-  
GO:0015991ATP hydrolysis coupled proton transport-IEA-  
GO:0016236macroautophagy-ISS-  
GO:0033572transferrin transport-TAS-  
GO:0034220ion transmembrane transport-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:1902600proton transmembrane transport-TAS8579597  
GO ID GO Term Qualifier Evidence PubMed
GO:0000220vacuolar proton-transporting V-type ATPase, V0 domain-IEA-  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS10329006  
GO:0010008endosome membrane-TAS-  
GO:0016324apical plasma membrane-IDA15800125  
GO:0016471vacuolar proton-transporting V-type ATPase complex-IBA21873635  
GO:0030670phagocytic vesicle membrane-TAS-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04142Lysosome
hsa04145Phagosome
hsa04966Collecting duct acid secretion
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1222556ROS, RNS production in phagocytesTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-77387Insulin receptor recyclingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-917937Iron uptake and transportTAS
R-HSA-917977Transferrin endocytosis and recyclingTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14523594Association between a polymorphism affecting an AP1 binding site in the promoter of the TCIRG1 gene and bone mass in women. (2004 Jan)Sobacchi CCalcif Tissue Int