Gene: B3GALT5

10317
B3GalT-V|B3GalTx|B3T5|GLCT5|beta-1,3-GalTase 5|beta-3-Gx-T5|beta3Gal-T5
beta-1,3-galactosyltransferase 5
protein-coding
21q22.2
Ensembl:ENSG00000183778 MIM:604066 Vega:OTTHUMG00000086725 UniprotKB:Q9Y2C3
NC_000021.9
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.301e-1 (AD)  6.867e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs79978308chr21:39648618 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOF0.839
GPR1010.832
DRD20.831
DRD30.831
TMPRSS60.82
SAG0.819
ANKRD34B0.815
SLC35D30.809
DGKK0.803
GPR10.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1A1-0.394
NANOS3-0.28
GSDMC-0.249
CDKN2C-0.242
ASCL1-0.222
KLRB1-0.221
TNNT1-0.22
HPSE2-0.211
MYL3-0.211
RNF182-0.21

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of B3GALT5 mRNA"26377693
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of B3GALT5 mRNA21983209
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of B3GALT5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of B3GALT5 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of B3GALT5 mRNA21298039
D047310ApigeninApigenin results in increased expression of B3GALT5 protein22906706
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of B3GALT5 mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of B3GALT5 mRNA25181051
D007631ChlordeconeChlordecone results in decreased expression of B3GALT5 protein22906706
D019327Copper SulfateCopper Sulfate results in decreased expression of B3GALT5 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of B3GALT5 mRNA27523638
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of B3GALT5 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of B3GALT5 mRNA21266533
D002945CisplatinCisplatin results in increased expression of B3GALT5 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of B3GALT5 mRNA26924002
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA22129741
C039281furanfuran results in increased expression of B3GALT5 mRNA27387713
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA22129741
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of B3GALT5 mRNA26752646
C006552kaempferolkaempferol results in decreased expression of B3GALT5 protein22906706
C523799MRK 003B3GALT5 results in decreased susceptibility to MRK 00319903844
C006253pirinixic acidpirinixic acid results in increased expression of B3GALT5 mRNA12832660
C541923sandostatinLARsandostatinLAR results in increased expression of B3GALT5 mRNA17210224
C016104sodium bichromatesodium bichromate results in decreased expression of B3GALT5 mRNA22561333
D013629TamoxifenTamoxifen results in decreased expression of B3GALT5 protein22906706
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of B3GALT5 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of B3GALT5 mRNA24680724
D014635Valproic AcidValproic Acid results in increased methylation of B3GALT5 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of B3GALT5 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of B3GALT5 mRNA26682919
C088658zoledronic acidzoledronic acid results in decreased expression of B3GALT5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008375acetylglucosaminyltransferase activity-IBA21873635  
GO:0008376acetylgalactosaminyltransferase activity-IBA21873635  
GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity-IBA21873635  
GO:0008499UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity-TAS10212226  
GO:0016758transferase activity, transferring hexosyl groups-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006486protein glycosylation-IBA21873635  
GO:0006486protein glycosylation-IEA-  
GO:0006487protein N-linked glycosylation-IBA21873635  
GO:0006493protein O-linked glycosylation-IBA21873635  
GO:0009312oligosaccharide biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005783endoplasmic reticulum-HDA16780588  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005794Golgi apparatus-HDA16780588  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016020membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00601Glycosphingolipid biosynthesis - lacto and neolacto series
hsa00603Glycosphingolipid biosynthesis - globo series
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal