Gene: TNIP1

10318
ABIN-1|NAF1|VAN|nip40-1
TNFAIP3 interacting protein 1
protein-coding
5q33.1
Ensembl:ENSG00000145901 MIM:607714 Vega:OTTHUMG00000163722 UniprotKB:Q15025
NG_030590.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.963e-1 (AD)  9.941e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDX230.9
NUCB10.896
CD2BP20.893
U2AF20.892
SRSF40.891
CIZ10.884
SSRP10.881
SMG50.881
HDLBP0.88
ZC3H180.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.754
OR4F5-0.752
MTRNR2L6-0.206
P2RY14-0.18
MTRNR2L9-0.18
PON1-0.176
CRISP3-0.17
HMHB1-0.169
MTRNR2L10-0.168
LYZL2-0.168

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of TNIP1 mRNA"23826121
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in increased expression of TNIP1 protein"23826121
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of TNIP1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of TNIP1 mRNA]28655636
D000082AcetaminophenAcetaminophen affects the expression of TNIP1 mRNA17562736
D001151ArsenicArsenic results in decreased expression of TNIP1 mRNA27838757
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of TNIP1 mRNA"24160326
D001280AtrazineAtrazine results in decreased expression of TNIP1 mRNA27614199
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNIP1 mRNA"19150397
D004958EstradiolEstradiol affects the expression of TNIP1 mRNA14699072
C006780bisphenol Abisphenol A affects the expression of TNIP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TNIP1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TNIP1 mRNA26191083
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNIP1 mRNA]18038451
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNIP1 gene20938992
C031180chrysenechrysene results in increased expression of TNIP1 mRNA26377693
C018021cobaltous chloridecobaltous chloride results in increased expression of TNIP1 mRNA19320972|1937684
D003300Copper[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein24690739
D003300Copper[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein24690739
D016572CyclosporineCyclosporine results in increased expression of TNIP1 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of TNIP1 mRNA]27941970
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein24690739
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of TNIP1 protein24690739
D004391DustDust results in increased expression of TNIP1 mRNA17805423
D005485FlutamideFlutamide results in decreased expression of TNIP1 mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNIP1 gene20938992
C069837fullerene C60fullerene C60 results in increased expression of TNIP1 mRNA19167457
C010974glyphosateglyphosate results in increased expression of TNIP1 mRNA25636363
D017313FenretinideFenretinide results in increased expression of TNIP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TNIP1 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of TNIP1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNIP1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNIP1 mRNA24796395
D048628KetolidesKetolides analog results in increased expression of TNIP1 mRNA24967691
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNIP1 mRNA25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNIP1 mRNA25613284
C018091maduramicinmaduramicin results in increased expression of TNIP1 mRNA29128925
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNIP1 mRNA21641980
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TNIP1 gene20938992
D008727MethotrexateTNIP1 mRNA affects the susceptibility to Methotrexate22753658
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TNIP1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNIP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNIP1 mRNA"25554681
D009532NickelNickel results in increased expression of TNIP1 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of TNIP1 mRNA17312168
C028007nickel monoxidenickel monoxide results in increased expression of TNIP1 mRNA19167457
D010100OxygenOxygen deficiency results in increased expression of TNIP1 mRNA26516004
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of TNIP1 mRNA"23246600
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of TNIP1 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of TNIP1 mRNA28341207|2865563
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TNIP1 mRNA27614199
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of TNIP1 mRNA19710929
D008926PlicamycinPlicamycin results in decreased expression of TNIP1 mRNA23464785
C059514resveratrolresveratrol results in increased expression of TNIP1 mRNA17257620
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of TNIP1 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TNIP1 mRNA23806026|2589566
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNIP1 mRNA23221170
D012834SilverSilver results in increased expression of TNIP1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of TNIP1 mRNA23922661
D018038Sodium SeleniteSodium Selenite results in increased expression of TNIP1 mRNA18175754
D053260SootSoot results in increased expression of TNIP1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of TNIP1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNIP1 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNIP1 mRNA26232522
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNIP1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of TNIP1 mRNA27188386
C011559tributyltintributyltin results in decreased expression of TNIP1 mRNA27614199
D014415TunicamycinTunicamycin results in decreased expression of TNIP1 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of TNIP1 mRNA25979313
D014640VancomycinVancomycin results in decreased expression of TNIP1 mRNA18930951
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of TNIP1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of TNIP1 mRNA28655636
C029297vinylidene chloridevinylidene chloride results in increased expression of TNIP1 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of TNIP1 mRNA27188386
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of TNIP1 mRNA"23246600
C088658zoledronic acidzoledronic acid results in increased expression of TNIP1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11389905  15474016  16189514  20010814  21516116  21988832  
23414517  25416956  25609649  25910212  26871637  27107014  
GO:0042802identical protein binding-IPI21988832  25416956  
GO:0051019mitogen-activated protein kinase binding-IDA12220502  
GO ID GO Term Qualifier Evidence PubMed
GO:0002755MyD88-dependent toll-like receptor signaling pathway-ISS-  
GO:0006412translation-TAS9923610  
GO:0006952defense response-TAS9923610  
GO:0006954inflammatory response-IEA-  
GO:0007159leukocyte cell-cell adhesion-IMP17632516  
GO:0009101glycoprotein biosynthetic process-IDA9923610  
GO:0016579protein deubiquitination-TAS-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-IDA16684768  
GO:0045071negative regulation of viral genome replication-TAS9923610  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0050729positive regulation of inflammatory response-ISS-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IDA12220502  
GO:0085032modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade-IDA20010814  
GO:1903003positive regulation of protein deubiquitination-IDA16684768  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-TAS9923610  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5688426DeubiquitinationTAS
R-HSA-5689896Ovarian tumor domain proteasesTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci