Gene: IKZF1

10320
CVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1
IKAROS family zinc finger 1
protein-coding
7p12.2
Ensembl:ENSG00000185811 MIM:603023 Vega:OTTHUMG00000155907 UniprotKB:Q13422
NG_034231.1
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.091e-4 (AD)  7.918e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYTH40.935
RUNX10.93
SYK0.923
HCK0.923
LILRB10.922
CCR10.921
PTPRC0.92
TLR10.92
IRF80.92
LILRA10.916

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGIX-0.481
ASPDH-0.468
TMEM179-0.455
KCNIP3-0.454
HAS1-0.445
ATP2C2-0.443
ZNF835-0.437
TM7SF2-0.435
WNT7A-0.432
KCNK4-0.43

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4923222-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole"2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Ascorbic Acid results in decreased activity of IKZF1 protein]"17664058
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Acrylamide results in decreased activity of IKZF1 protein]"20708675
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA19191707
C0716445,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate"5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate inhibits the reaction [Ascorbic Acid results in decreased activity of IKZF1 protein]"17664058
D000082AcetaminophenAcetaminophen results in increased expression of IKZF1 mRNA26690555
D020106Acrylamide"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [Acrylamide results in decreased activity of IKZF1 protein]"20708675
D020106AcrylamideAcrylamide results in decreased activity of IKZF1 protein20708675
D020106AcrylamideAcrylamide results in decreased expression of IKZF1 protein20708675
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IKZF1 gene28458013
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IKZF1 mRNA24449571
D001205Ascorbic Acid"2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction [Ascorbic Acid results in decreased activity of IKZF1 protein]"17664058
D001205Ascorbic Acid"5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-3',5'-monophosphorothioate inhibits the reaction [Ascorbic Acid results in decreased activity of IKZF1 protein]"17664058
D001205Ascorbic AcidAscorbic Acid results in decreased activity of IKZF1 protein17664058
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IKZF1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of IKZF1 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of IKZF1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of IKZF1 mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of IKZF1 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of IKZF1 protein22941245
D002737ChloropreneChloroprene results in decreased expression of IKZF1 mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of IKZF1 mRNA12851107
C029892cupric chloridecupric chloride results in increased expression of IKZF1 protein21641295
D003471CuprizoneCuprizone results in increased expression of IKZF1 mRNA27523638
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IKZF1 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of IKZF1 mRNA26485663
D004147DioxinsDioxins affects the expression of IKZF1 mRNA20463971
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of IKZF1 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of IKZF1 gene15790496
D005557FormaldehydeFormaldehyde results in decreased expression of IKZF1 mRNA23649840
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of IKZF1 mRNA20846436
C546771gardiquimodgardiquimod results in increased expression of IKZF1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IKZF1 mRNA]28003376
D017313FenretinideFenretinide results in decreased expression of IKZF1 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of IKZF1 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IKZF1 mRNA25613284
D008070Lipopolysaccharides[lipoteichoic acid co-treated with Lipopolysaccharides] results in increased expression of IKZF1 mRNA21069465
C009900lipoteichoic acid[lipoteichoic acid co-treated with Lipopolysaccharides] results in increased expression of IKZF1 mRNA21069465
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IKZF1 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IKZF1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IKZF1 mRNA23649840
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of IKZF1 mRNA16616109
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IKZF1 mRNA"25554681
D009532NickelNickel results in increased expression of IKZF1 mRNA24768652|2558310
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IKZF1 mRNA]28003376
C017947sodium arsenitesodium arsenite results in increased expression of IKZF1 protein21925251
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IKZF1 mRNA26378955
C061133tamibarotenetamibarotene affects the expression of IKZF1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IKZF1 mRNA24058054
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IKZF1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of IKZF1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in increased expression of IKZF1 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of IKZF1 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of IKZF1 mRNA15498508
D014635Valproic AcidValproic Acid results in increased expression of IKZF1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased methylation of IKZF1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of IKZF1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IDA21548011  22106042  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI21516116  25416956  
GO:0019904protein domain specific binding-IPI15491138  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007498mesoderm development-TAS8543809  
GO:0030098lymphocyte differentiation-IMP17934067  
GO:0030218erythrocyte differentiation-IMP17934067  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0051291protein heterooligomerization-IMP15491138  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21548011  22106042  
GO:0005654nucleoplasm-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IEA-  
GO:0031618nuclear pericentric heterochromatin-IDA21548011  
GO:0032991protein-containing complex-IDA23071339  
GO:0032991protein-containing complex-IMP15491138  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-162582Signal TransductionIEA
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9013508NOTCH3 Intracellular Domain Regulates TranscriptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26045716Genetic susceptibility in childhood acute leukaemias: a systematic review. (2015)Brisson GDEcancermedicalscience
26445409Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia. (2015 Oct 6)Pedersen SKBMC Cancer
25806972ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study. (2015)Rudant JPLoS One
24786325Disease risk factors identified through shared genetic architecture and electronic medical records. (2014 Apr 30)Li LSci Transl Med
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One