Gene: SMYD5

10322
NN8-4AG|RAI15|RRG1|ZMYND23
SMYD family member 5
protein-coding
2p13.2
Ensembl:ENSG00000135632 Vega:OTTHUMG00000150482 UniprotKB:Q6GMV2
NC_000002.12
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.856e-1 (AD)  9.110e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3188114chr2:73227128 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs2303904chr2:73220647 (GRCh38.p7)A>C / A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCAR20.944
RXRB0.944
ERAL10.942
IP6K10.939
ZFYVE270.937
MICU10.936
USP200.936
TMUB20.935
GNPDA10.934
TM9SF40.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.682
OR4F29-0.626
TFPI2-0.384
C9orf153-0.361
MTRNR2L9-0.343
MTRNR2L6-0.338
KLRB1-0.337
RAI14-0.328
SH2D1A-0.324
PABPC4L-0.316

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SMYD5 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SMYD5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SMYD5 mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of SMYD5 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of SMYD5 mRNA17562736
D001151ArsenicArsenic affects the methylation of SMYD5 gene25304211
D001280AtrazineAtrazine results in increased expression of SMYD5 mRNA22378314
D001280AtrazineAtrazine results in increased expression of SMYD5 mRNA22982499
C547126AZM551248AZM551248 results in increased expression of SMYD5 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of SMYD5 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SMYD5 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of SMYD5 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of SMYD5 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of SMYD5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SMYD5 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SMYD5 mRNA19770486
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SMYD5 mRNA]27941970
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMYD5 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SMYD5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMYD5 mRNA17942748
D005485FlutamideFlutamide results in increased expression of SMYD5 mRNA24136188
C016517indole-3-carbinolindole-3-carbinol affects the expression of SMYD5 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMYD5 mRNA25613284
C544151jinfukangjinfukang results in increased expression of SMYD5 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SMYD5 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SMYD5 mRNA25982114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SMYD5 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SMYD5 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SMYD5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SMYD5 mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of SMYD5 mRNA24612858
D010416PentachlorophenolPentachlorophenol results in increased expression of SMYD5 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SMYD5 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of SMYD5 mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of SMYD5 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of SMYD5 mRNA23557933
C016104sodium bichromatesodium bichromate results in increased expression of SMYD5 mRNA24612858
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SMYD5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMYD5 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SMYD5 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of SMYD5 mRNA23411599
C012589trichostatin Atrichostatin A affects the expression of SMYD5 mRNA28542535
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SMYD5 mRNA19042947
D014520UrethaneUrethane results in decreased expression of SMYD5 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of SMYD5 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SMYD5 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0008168methyltransferase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0032259methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal