Gene: SIRPB1

10326
CD172b|SIRP-BETA-1
signal regulatory protein beta 1
protein-coding
20p13
Ensembl:ENSG00000101307 MIM:603889 Vega:OTTHUMG00000031676 UniprotKB:O00241
NC_000020.11
PubMed
0   ANCO-SNPs
AD
1   
9.357e-1 (AD)  6.994e-1 (ND)   (Frontal_Cortex)
8.682e-1 (AD)  7.143e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25799433chr20:1600623SIRPB1Promoter3.210e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC34A30.387
GK50.384
TTF20.383
UVSSA0.383
GAL3ST20.382
PIGL0.381
MSH50.381
PDPR0.381
GOLGA8T0.378
MRI10.378

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APOA4-0.227
OIT3-0.222
H2AFB1-0.205
TMSB15A-0.203
DAND5-0.2
OR52N5-0.189
APOA1-0.185
FOXD4L1-0.185
FOXA2-0.181
OTX2-0.176

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SIRPB1 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SIRPB1 mRNA24449571
D001374AzacitidineAzacitidine results in decreased expression of SIRPB1 mRNA20823114
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SIRPB1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SIRPB1 mRNA20823114
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SIRPB1 mRNA20938992
D019327Copper SulfateCopper Sulfate results in increased expression of SIRPB1 mRNA19549813
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SIRPB1 mRNA20823114
D004041Dietary FatsDietary Fats results in increased expression of SIRPB1 mRNA22609946
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SIRPB1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of SIRPB1 mRNA23649840
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SIRPB1 mRNA20823114
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SIRPB1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of SIRPB1 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SIRPB1 mRNA23649840
C523799MRK 003SIRPB1 results in increased susceptibility to MRK 00319903844
D009532NickelNickel results in increased expression of SIRPB1 mRNA25583101
C558013NSC 689534NSC 689534 results in increased expression of SIRPB1 mRNA20971185
C006253pirinixic acidpirinixic acid results in decreased expression of SIRPB1 mRNA20813756
C089730rosiglitazonerosiglitazone results in increased expression of SIRPB1 mRNA16982809
D053260SootSoot results in increased expression of SIRPB1 mRNA22461453
D014028Tobacco Smoke PollutionNFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution affects the expression of SIRPB1 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SIRPB1 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SIRPB1 mRNA19042947
D014750VincristineVincristine results in decreased expression of SIRPB1 mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of SIRPB1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10940905  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9062191  
GO:0007166cell surface receptor signaling pathway-TAS9062191  
GO:0022409positive regulation of cell-cell adhesion-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0045087innate immune response-TAS-  
GO:0050766positive regulation of phagocytosis-IBA21873635  
GO:0050870positive regulation of T cell activation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9062191  
GO:0030667secretory granule membrane-TAS-  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-391160Signal regulatory protein family interactionsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25039969SIRPB1 copy-number polymorphism as candidate quantitative trait locus for impulsive-disinhibited personality. (2014 Sep)Laplana MGenes Brain Behav