Gene info: ID 1033

Gene: CDKN3

GENE ID: 1033

Synonyms: CDI1|CIP2|KAP|KAP1

Description: cyclin dependent kinase inhibitor 3

Gene type: protein-coding

Location: 14q22.2

dbXrefs: Ensembl:ENSG00000100526 MIM:123832 Vega:OTTHUMG00000140302 UniprotKB:Q16667

RefSeq: NG_023235.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.793e-1 (AD) 2.835e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
BZW2	0.848
EBNA1BP2	0.835
EID2	0.831
CMSS1	0.829
PSMG1	0.826
PSMA5	0.826
EIF2B3	0.826
SEPHS2	0.821
CISD1	0.82
NME1	0.817

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
P2RY14	-0.444
MTRNR2L6	-0.421
HVCN1	-0.42
RAI14	-0.406
STON2	-0.405
MAGEA12	-0.403
DISC1	-0.403
DOCK1	-0.401
PARD3B	-0.401
REST	-0.4

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of CDKN3 mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CDKN3 mRNA"	22698814\|2890350
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of CDKN3 mRNA"	27291303
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDKN3 mRNA"	19167446
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CDKN3 mRNA"	17547211
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of CDKN3 mRNA"	21346803
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CDKN3 mRNA]	28655636
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CDKN3 mRNA]	28655636
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of CDKN3 mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CDKN3 mRNA"	25380136
D000082	Acetaminophen	Acetaminophen affects the expression of CDKN3 mRNA	25458485
D000082	Acetaminophen	Acetaminophen results in increased expression of CDKN3 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of CDKN3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CDKN3 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of CDKN3 mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of CDKN3 mRNA	23630614
D000965	Antimony	Antimony results in increased expression of CDKN3 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of CDKN3 mRNA	17547211
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CDKN3 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CDKN3 mRNA	17547211
D001280	Atrazine	Atrazine results in increased expression of CDKN3 mRNA	22378314
D001379	Azathioprine	Azathioprine results in decreased expression of CDKN3 mRNA	22623647
C547126	AZM551248	AZM551248 results in increased expression of CDKN3 mRNA	22323515
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of CDKN3 mRNA	26377693
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of CDKN3 mRNA	23117580
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDKN3 mRNA	16120219
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CDKN3 mRNA	21839799
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDKN3 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of CDKN3 mRNA	20061341
D004958	Estradiol	Estradiol results in decreased expression of CDKN3 mRNA	16474171
D004958	Estradiol	Estradiol results in increased expression of CDKN3 mRNA	19167446
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in decreased expression of CDKN3 mRNA	18192240
C044887	beta-methylcholine	beta-methylcholine affects the expression of CDKN3 mRNA	21179406
C006780	bisphenol A	bisphenol A results in decreased expression of CDKN3 mRNA	16474171\|2927551
C006780	bisphenol A	bisphenol A affects the expression of CDKN3 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of CDKN3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of CDKN3 gene	28505145
D002065	Buspirone	Buspirone results in decreased expression of CDKN3 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CDKN3 mRNA	27509014
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CDKN3 mRNA	15003993
C584509	C646 compound	C646 compound results in decreased expression of CDKN3 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of CDKN3 mRNA	21120746
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDKN3 mRNA	20061341
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDKN3 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CDKN3 mRNA	25993096
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CDKN3 mRNA	17484886\|2733941
D002330	Carmustine	Carmustine results in decreased expression of CDKN3 mRNA	16005536
D002706	Chlordan	Chlordan results in increased expression of CDKN3 mRNA	20403969
C035377	chlorendic acid	chlorendic acid results in increased expression of CDKN3 mRNA	22584684
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of CDKN3 mRNA	21356183
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN3 mRNA	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of CDKN3 mRNA	22008536
D003033	Coal Tar	Coal Tar results in increased expression of CDKN3 mRNA	27858113
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDKN3 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of CDKN3 mRNA	24386269
D003078	Colchicine	Colchicine results in decreased expression of CDKN3 mRNA	20624997
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of CDKN3 mRNA	21356183
D003300	Copper	Copper results in decreased expression of CDKN3 mRNA	21356183
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of CDKN3 mRNA	19549813
C030123	coumarin	coumarin results in decreased expression of CDKN3 mRNA	18480146
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CDKN3 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN3 mRNA	18310284
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of CDKN3 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of CDKN3 mRNA	19167446
D003375	Coumestrol	ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN3 mRNA]	18310284
C024015	cryptolepine	cryptolepine results in decreased expression of CDKN3 mRNA	16120219
C029892	cupric chloride	cupric chloride results in decreased expression of CDKN3 mRNA	19174923
D016572	Cyclosporine	Cyclosporine affects the expression of CDKN3 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of CDKN3 mRNA	21632981\|2556210
D000069439	Dasatinib	Dasatinib results in decreased expression of CDKN3 mRNA	20579391
C014347	decitabine	decitabine affects the expression of CDKN3 mRNA	23300844
D003907	Dexamethasone	Dexamethasone results in decreased expression of CDKN3 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CDKN3 mRNA]	20032058
D003976	Diazinon	Diazinon affects the expression of CDKN3 mRNA	22546817
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of CDKN3 mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of CDKN3 mRNA	23300844
D002945	Cisplatin	[Piroxicam co-treated with Cisplatin] results in decreased expression of CDKN3 mRNA	21858171
D002945	Cisplatin	Cisplatin results in increased expression of CDKN3 protein modified form	26739623
D002945	Cisplatin	Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form]	26739623
C000944	dicrotophos	dicrotophos results in decreased expression of CDKN3 mRNA	28302478
D004026	Dieldrin	Dieldrin results in increased expression of CDKN3 mRNA	20438755
D004026	Dieldrin	Dieldrin affects the expression of CDKN3 mRNA	22546817
D004026	Dieldrin	Dieldrin results in increased expression of CDKN3 mRNA	23153324
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDKN3 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CDKN3 mRNA	24535843
D002117	Calcitriol	Calcitriol results in decreased expression of CDKN3 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of CDKN3 mRNA	21592394
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CDKN3 mRNA	25380136
D004147	Dioxins	Dioxins affects the expression of CDKN3 mRNA	20463971
C521792	DMU-212	DMU-212 affects the expression of CDKN3 mRNA	26428916
C118739	entinostat	entinostat results in increased expression of CDKN3 mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CDKN3 mRNA	16872691
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDKN3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CDKN3 mRNA	17351261
D005047	Etoposide	Etoposide results in decreased expression of CDKN3 mRNA	16120219
C082360	fipronil	fipronil results in increased expression of CDKN3 mRNA	23962444
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of CDKN3 mRNA	22213190\|2258468
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CDKN3 mRNA]	15016801
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDKN3 mRNA	24657277
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN3 mRNA	20938992
C039281	furan	furan results in increased methylation of CDKN3 gene	22079235
D019833	Genistein	Genistein results in decreased expression of CDKN3 mRNA	16474171
D005897	Glafenine	Glafenine results in decreased expression of CDKN3 mRNA	24136188
D005944	Glucosamine	Glucosamine results in decreased expression of CDKN3 mRNA	17109745
C004312	glycidol	glycidol results in increased expression of CDKN3 mRNA	24915197
D006533	Heptachlor	Heptachlor results in increased expression of CDKN3 mRNA	23153324
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDKN3 mRNA	25613284
C051890	irinotecan	irinotecan metabolite results in decreased expression of CDKN3 mRNA	15956246
C051890	irinotecan	irinotecan results in decreased expression of CDKN3 mRNA	15956246
C051890	irinotecan	irinotecan results in decreased expression of CDKN3 mRNA	20097248
C544151	jinfukang	jinfukang results in increased expression of CDKN3 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of CDKN3 mRNA	24086573
C008261	lead acetate	lead acetate results in increased expression of CDKN3 mRNA	22641619
D064704	Levofloxacin	Levofloxacin results in decreased expression of CDKN3 mRNA	24136188
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CDKN3 mRNA	25613284
D008148	Lovastatin	Lovastatin inhibits the reaction [Cisplatin results in increased expression of CDKN3 protein modified form]	26739623
D008154	Lucanthone	Lucanthone results in decreased expression of CDKN3 mRNA	21148553
D008345	Manganese	Manganese results in decreased expression of CDKN3 mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of CDKN3 mRNA	17175027
D008628	Mercury	Mercury results in increased expression of CDKN3 mRNA	17547211
D008701	Methapyrilene	Methapyrilene results in increased expression of CDKN3 mRNA	22584684
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDKN3 mRNA	20938992
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of CDKN3 mRNA	24657277
D008727	Methotrexate	Methotrexate results in decreased expression of CDKN3 mRNA	24657277
D008727	Methotrexate	Methotrexate results in decreased expression of CDKN3 mRNA	16005536
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CDKN3 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of CDKN3 mRNA	20061341
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CDKN3 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CDKN3 mRNA	23649840
D008917	Mirex	Mirex results in increased expression of CDKN3 mRNA	23153324
D009151	Mustard Gas	Mustard Gas results in decreased expression of CDKN3 mRNA	25102026
C554954	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride	N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of CDKN3 mRNA	28174063
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of CDKN3 mRNA"	15585362
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CDKN3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CDKN3 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of CDKN3 mRNA	25380136
D009532	Nickel	Nickel results in increased expression of CDKN3 mRNA	25583101
C022838	nickel chloride	nickel chloride affects the expression of CDKN3 mRNA	22546817
C028007	nickel monoxide	nickel monoxide results in increased expression of CDKN3 mRNA	19167457
C012655	nimesulide	nimesulide results in decreased expression of CDKN3 mRNA	24136188
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKN3 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of CDKN3 mRNA	25729387
D010126	Ozone	[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of CDKN3 mRNA	25658374
D010126	Ozone	Ozone results in increased expression of CDKN3 mRNA	25658374
C500026	palbociclib	palbociclib results in decreased expression of CDKN3 mRNA	22869556
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of CDKN3 mRNA]	28655636
D052638	Particulate Matter	Particulate Matter results in decreased expression of CDKN3 mRNA	28655636
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of CDKN3 mRNA	18467677
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of CDKN3 mRNA]	18467677
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of CDKN3 mRNA	26678675
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDKN3 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDKN3 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of CDKN3 mRNA	19482888\|2040396
D010634	Phenobarbital	Phenobarbital results in decreased expression of CDKN3 mRNA	22008536
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of CDKN3 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in increased expression of CDKN3 mRNA	18467677\|2381119
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of CDKN3 mRNA]	18467677
D010894	Piroxicam	[Piroxicam co-treated with Cisplatin] results in decreased expression of CDKN3 mRNA	21858171
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of CDKN3 mRNA	16474171
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of CDKN3 mRNA	22698814
D011374	Progesterone	Progesterone results in decreased expression of CDKN3 mRNA	21795739
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CDKN3 mRNA	24780913
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDKN3 mRNA"	21152443
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of CDKN3 mRNA"	21152443
D011794	Quercetin	Quercetin results in decreased expression of CDKN3 mRNA	21632981
C012526	quercitrin	quercitrin results in decreased expression of CDKN3 mRNA	25193878
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of CDKN3 mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of CDKN3 mRNA	19167446
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CDKN3 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CDKN3 mRNA	25351596
D012834	Silver	Silver results in decreased expression of CDKN3 mRNA	27131904
C009277	sodium arsenate	sodium arsenate results in increased expression of CDKN3 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in increased expression of CDKN3 mRNA	12016162
C017947	sodium arsenite	sodium arsenite results in decreased expression of CDKN3 mRNA	17998272
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of CDKN3 mRNA	18175754
D012999	Soman	Soman results in increased expression of CDKN3 mRNA	19281266
D053260	Soot	Soot results in increased expression of CDKN3 mRNA	22461453\|2655175
C561322	sparstolonin B	sparstolonin B results in decreased expression of CDKN3 mRNA	23940584
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of CDKN3 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of CDKN3 mRNA	21592394
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CDKN3 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDKN3 mRNA	17942748
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CDKN3 mRNA	25613284
D013866	Thioguanine	Thioguanine results in decreased expression of CDKN3 mRNA	16005536
C009495	titanium dioxide	titanium dioxide results in increased expression of CDKN3 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKN3 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of CDKN3 mRNA	25729387
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of CDKN3 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in decreased expression of CDKN3 mRNA	21934132
D014241	Trichloroethylene	Trichloroethylene results in increased expression of CDKN3 mRNA	25549359
C012589	trichostatin A	trichostatin A results in increased expression of CDKN3 mRNA	27188386
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of CDKN3 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDKN3 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of CDKN3 mRNA	19140230
C080163	trovafloxacin	trovafloxacin results in decreased expression of CDKN3 mRNA	24136188
C406224	valdecoxib	valdecoxib results in decreased expression of CDKN3 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of CDKN3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CDKN3 mRNA	23179753\|2718838
D001335	Vehicle Emissions	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of CDKN3 mRNA]	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CDKN3 mRNA	28655636
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CDKN3 gene	25560391
D014747	Vinblastine	Vinblastine results in decreased expression of CDKN3 mRNA	20624997
C025643	vinclozolin	vinclozolin results in increased expression of CDKN3 mRNA	21126777
C029297	vinylidene chloride	vinylidene chloride results in increased expression of CDKN3 mRNA	26682919
C111237	vorinostat	vorinostat results in increased expression of CDKN3 mRNA	27188386
D015032	Zinc	Zinc deficiency results in increased expression of CDKN3 mRNA	16140947
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of CDKN3 mRNA]	16140947
C088658	zoledronic acid	zoledronic acid results in decreased expression of CDKN3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004722	protein serine/threonine phosphatase activity	-	IBA	21873635
GO:0004722	protein serine/threonine phosphatase activity	-	IDA	12745075
GO:0004725	protein tyrosine phosphatase activity	-	IBA	21873635
GO:0004725	protein tyrosine phosphatase activity	-	IDA	8242750
GO:0005515	protein binding	-	IPI	8242750 9840943 11463386 15530371 15671017 24218572 25852190
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	-	TAS	8242750

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	-	TAS	8242750
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	8127873
GO:0007050	cell cycle arrest	-	IBA	21873635
GO:0007050	cell cycle arrest	-	IDA	8242750
GO:0008285	negative regulation of cell proliferation	-	TAS	8242750
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005829	cytosol	-	IDA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	10669749

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
14501029	Matrix-degrading and pro-inflammatory changes in human vascular endothelial cells exposed to cigarette smoke condensate. (2003)	Nordskog BK	Cardiovasc Toxicol