Gene: TLR6

10333
CD286
toll like receptor 6
protein-coding
4p14
Ensembl:ENSG00000174130 MIM:605403 Vega:OTTHUMG00000128579 UniprotKB:Q9Y2C9
NG_028087.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.665e-1 (AD)  8.900e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR70.931
DOCK20.93
SYK0.926
ADAM280.923
SIRPB20.921
CD840.917
TBXAS10.917
CD330.917
PTPRC0.912
BTK0.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.396
C9orf24-0.383
ASPDH-0.382
KCNIP3-0.373
ZSCAN1-0.364
WFDC1-0.364
KCNK4-0.362
HAGHL-0.361
GSG1-0.359
MAGIX-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TLR6 mRNA"23146750
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR6 mRNA23405061
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of TLR6 mRNA"23146750
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of TLR6 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR6 mRNA23405061
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TLR6 mRNA"21346803
C0038982-anisidine2-anisidine results in decreased expression of TLR6 mRNA28089782
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of TLR6 mRNA"23146750
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TLR6 mRNA]"26546572
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TLR6 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of TLR6 mRNA28522335
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA"23405061
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
D0150752-Aminopurine"2-Aminopurine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TLR6 mRNA24449571
D001151ArsenicArsenic results in increased expression of TLR6 mRNA27838757
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TLR6 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TLR6 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of TLR6 mRNA23146750
D020148Butyric AcidButyric Acid results in increased expression of TLR6 mRNA15196572
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR6 mRNA22342292
C030583ceric oxideceric oxide analog results in decreased expression of TLR6 mRNA24821434
D002738Chloroquine[Chloroquine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA20938992
C060728cobalt oxidecobalt oxide analog results in decreased expression of TLR6 mRNA24821434
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TLR6 mRNA23405061
D003471CuprizoneCuprizone results in increased expression of TLR6 mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of TLR6 mRNA20106945
D002945Cisplatin"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [Cisplatin results in increased expression of TLR6 mRNA]"26546572
D002945CisplatinCisplatin results in increased expression of TLR6 mRNA26546572
D004041Dietary FatsDietary Fats results in increased expression of TLR6 mRNA23409006
D004317DoxorubicinDoxorubicin results in increased expression of TLR6 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR6 mRNA]27181935
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TLR6 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of TLR6 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA20938992
C460864FSL-1 lipoprotein, synthetic"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
C460864FSL-1 lipoprotein, synthetic"2-Aminopurine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
C460864FSL-1 lipoprotein, synthetic"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
C460864FSL-1 lipoprotein, synthetic"[FSL-1 lipoprotein, synthetic co-treated with tripterine] results in increased expression of TLR6 mRNA"23405061
C460864FSL-1 lipoprotein, synthetic"FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA"23405061
C460864FSL-1 lipoprotein, synthetic"U 0126 inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
C460864FSL-1 lipoprotein, synthetic"FSL-1 lipoprotein, synthetic binds to and results in increased activity of TLR6 protein"23266719
D037741FullerenesFullerenes analog results in increased expression of TLR6 mRNA22342292
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR6 mRNA]27181935
C082585iberiniberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]25294874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR6 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TLR6 mRNA26752646
C008261lead acetatelead acetate results in decreased expression of TLR6 mRNA22641619
D008043Linseed OilLinseed Oil results in increased expression of TLR6 mRNA23409006
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in decreased expression of TLR6 mRNA"23090859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR6 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR6 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR6 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR6 mRNA23405061
D008070Lipopolysaccharidesiberin inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR6 protein binds to TLR2 protein]]25294874
C018091maduramicinmaduramicin results in decreased expression of TLR6 mRNA29128925
C013592mangiferinmangiferin results in decreased expression of TLR6 mRNA15135318
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR6 mRNA20938992
C500085muraglitazarmuraglitazar results in decreased expression of TLR6 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of TLR6 mRNA"29244179
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TLR6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TLR6 mRNA"25554681
D009532NickelNickel results in decreased expression of TLR6 mRNA23195993
C508075Pam(3)CSK(4) peptide[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Pam(3)CSK(4) peptide] results in decreased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptide"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA"23405061
C508075Pam(3)CSK(4) peptide[Chloroquine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptide[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in decreased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptide[pyrazolanthrone co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptide[tripterine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C508075Pam(3)CSK(4) peptide[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C002669parthenolideparthenolide results in decreased expression of TLR6 mRNA16921510
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of TLR6 mRNA23146750
D011070Poly I-CPoly I-C results in increased expression of TLR6 mRNA23405061
C432165pyrazolanthrone[pyrazolanthrone co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C089730rosiglitazonerosiglitazone results in decreased expression of TLR6 mRNA21515302
C093642SB 203580[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR6 mRNA23405061
D012834SilverSilver results in increased expression of TLR6 mRNA22342292
C017947sodium arsenitesodium arsenite results in increased expression of TLR6 protein21925251
C016766sulforafansulforafan results in increased expression of TLR6 mRNA26833863
C501413tesaglitazartesaglitazar results in decreased expression of TLR6 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TLR6 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR6 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TLR6 mRNA22342292
D014118Toxins, Biological"Toxins, Biological affects the expression of TLR6 mRNA"19682533
C050414tripterine"[FSL-1 lipoprotein, synthetic co-treated with tripterine] results in increased expression of TLR6 mRNA"23405061
C050414tripterine[tripterine co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
C113580U 0126[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR6 mRNA23405061
C113580U 0126"U 0126 inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of TLR6 mRNA]"23405061
D014520UrethaneUrethane results in increased expression of TLR6 mRNA28818685
D014638VanadatesVanadates results in increased expression of TLR6 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TLR6 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TLR6 mRNA18629315
C009687wortmannin[wortmannin co-treated with Pam(3)CSK(4) peptide] results in increased expression of TLR6 mRNA23405061
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TLR6 mRNA16979875
D015034Zinc Oxide[Zinc Oxide analog co-treated with OVAL protein] results in increased expression of TLR6 protein25127755
D015034Zinc OxideZinc Oxide analog promotes the reaction [OVAL protein results in increased expression of TLR6 mRNA]25127755
D015034Zinc OxideZinc Oxide analog results in increased expression of TLR6 mRNA25127755
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] results in increased expression of TLR6 mRNA22342292
D015054ZymosanPTX3 protein promotes the reaction [Zymosan results in increased expression of TLR6 mRNA]14726497

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI20037584  
GO:0005515protein binding-IPI16880211  20037584  23155421  
GO:0035663Toll-like receptor 2 binding-IBA21873635  
GO:0035663Toll-like receptor 2 binding-IPI16880211  
GO:0038023signaling receptor activity-TAS10426995  
GO:0042802identical protein binding-IDA25088687  
GO:0042802identical protein binding-IPI23155421  
GO:0046982protein heterodimerization activity-IPI20037584  
GO:0071723lipopeptide binding-IBA21873635  
GO:0071723lipopeptide binding-ISS11431423  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-IEA-  
GO:0001775cell activation-IDA15294986  
GO:0002224toll-like receptor signaling pathway-IBA21873635  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-ISS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-TAS-  
GO:0006954inflammatory response-IBA21873635  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-TAS10426995  
GO:0007165signal transduction-TAS10231569  
GO:0007250activation of NF-kappaB-inducing kinase activity-NAS10231569  
GO:0010628positive regulation of gene expression-ISS-  
GO:0034136negative regulation of toll-like receptor 2 signaling pathway-IGI22198949  
GO:0034150toll-like receptor 6 signaling pathway-IEA-  
GO:0035666TRIF-dependent toll-like receptor signaling pathway-ISS-  
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway-TAS-  
GO:0042496detection of diacyl bacterial lipopeptide-IDA19931471  
GO:0042742defense response to bacterium-TAS10426995  
GO:0043032positive regulation of macrophage activation-ISS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IDA10231569  
GO:0043507positive regulation of JUN kinase activity-IDA10231569  
GO:0045087innate immune response-IEA-  
GO:0045410positive regulation of interleukin-6 biosynthetic process-ISS12077222  
GO:0045429positive regulation of nitric oxide biosynthetic process-ISS-  
GO:0046209nitric oxide metabolic process-IEA-  
GO:0050702interleukin-1 beta secretion-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IGI20037584  
GO:0071221cellular response to bacterial lipopeptide-IBA21873635  
GO:0071726cellular response to diacyl bacterial lipopeptide-IBA21873635  
GO:0071726cellular response to diacyl bacterial lipopeptide-IDA16880211  19931471  
GO:0140052cellular response to oxidised low-density lipoprotein particle stimulus-ISS-  
GO:1900017positive regulation of cytokine production involved in inflammatory response-ISS-  
GO:1900227positive regulation of NLRP3 inflammasome complex assembly-ISS-  
GO:1903223positive regulation of oxidative stress-induced neuron death-ISS-  
GO:1903428positive regulation of reactive oxygen species biosynthetic process-ISS-  
GO:1904646cellular response to amyloid-beta-IGI20037584  
GO:2000483negative regulation of interleukin-8 secretion-IGI22198949  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IPI20037584  
GO:0005794Golgi apparatus-IDA16880211  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10231569  
GO:0030670phagocytic vesicle membrane-IEA-  
GO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complex-IBA21873635  
GO:0043235receptor complex-IPI20037584  
GO:0045121membrane raft-IDA16880211  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1643685DiseaseTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-5260271Diseases of Immune SystemTAS
R-HSA-5602358Diseases associated with the TLR signaling cascadeTAS
R-HSA-5602498MyD88 deficiency (TLR2/4)TAS
R-HSA-5603041IRAK4 deficiency (TLR2/4)TAS
R-HSA-5686938Regulation of TLR by endogenous ligandTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26061394Expression of Toll-like receptors in nasal epithelium in allergic rhinitis. (2015 Aug)Renkonen JAPMIS
23823019A TLR6 polymorphism is associated with increased risk of Legionnaires' disease. (2013 Oct)Misch EAGenes Immun
27920557Effect of smoking on the genetic makeup of toll-like receptors 2 and 6. (2016)Kohailan MOnco Targets Ther