Gene: MRVI1

10335
IRAG|JAW1L
murine retrovirus integration site 1 homolog
protein-coding
11p15.4
Ensembl:ENSG00000072952 MIM:604673 Vega:OTTHUMG00000165773 UniprotKB:Q9Y6F6
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.729e-1 (AD)  3.677e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00510149chr11:10674966MRVI18.140e-9Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RFX40.914
ALDH1L10.911
ITPKB0.905
RHOBTB30.903
STON20.895
LRP100.895
PLCD10.885
PLSCR40.884
FERMT20.882
YAP10.882

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.577
AGMAT-0.57
PPEF1-0.548
ADRA1D-0.545
CALHM1-0.543
MYOZ3-0.538
ZNF860-0.537
TYRP1-0.536
MCHR1-0.536
KCNS3-0.529

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MRVI1 mRNA"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
D000082AcetaminophenAcetaminophen results in decreased expression of MRVI1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MRVI1 gene27153756
D001151ArsenicArsenic affects the methylation of MRVI1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MRVI1 mRNA"19446018
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MRVI1 mRNA22228805
D004958EstradiolEstradiol affects the expression of MRVI1 mRNA22574217
C006780bisphenol Abisphenol A results in decreased expression of MRVI1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of MRVI1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MRVI1 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MRVI1 mRNA17484886
D003300CopperCopper deficiency results in increased expression of MRVI1 mRNA26033743
D000069439DasatinibDasatinib results in increased expression of MRVI1 mRNA20579391
D003907DexamethasoneDexamethasone results in increased expression of MRVI1 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MRVI1 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MRVI1 mRNA22023808
C058705diethyl malatediethyl malate affects the expression of MRVI1 mRNA24814887
D002117CalcitriolCalcitriol results in decreased expression of MRVI1 mRNA26485663
D004237DiuronDiuron results in increased expression of MRVI1 mRNA21551480
C039281furanfuran results in increased expression of MRVI1 mRNA27387713
C039281furanfuran results in increased methylation of MRVI1 gene22079235
D017313FenretinideFenretinide results in increased expression of MRVI1 mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MRVI1 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MRVI1 mRNA26644586
D008727MethotrexateMethotrexate results in decreased expression of MRVI1 mRNA17400583
D009151Mustard GasMustard Gas results in decreased expression of MRVI1 mRNA15674844
D009532NickelNickel results in decreased expression of MRVI1 mRNA25583101
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MRVI1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MRVI1 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MRVI1 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MRVI1 mRNA28511854
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MRVI1 mRNA27935865
D011374ProgesteroneProgesterone results in increased expression of MRVI1 mRNA19690047
C005556propionaldehydepropionaldehyde results in increased expression of MRVI1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of MRVI1 mRNA24780913
D012834SilverSilver results in increased expression of MRVI1 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of MRVI1 mRNA21795629
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MRVI1 mRNA21570461
D013849ThimerosalThimerosal results in decreased expression of MRVI1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of MRVI1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MRVI1 mRNA25729387
C025643vinclozolinvinclozolin results in decreased expression of MRVI1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16990611  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-TAS10321731  
GO:0016021integral component of membrane-IEA-  
GO:0016529sarcoplasmic reticulum-IEA-  
GO:0031095platelet dense tubular network membrane-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418457cGMP effectsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28209224Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)Webb TRJ Am Coll Cardiol