Gene: TFG

10342
HMSNP|SPG57|TF6|TRKT3
TRK-fused gene
protein-coding
3q12.2
Ensembl:ENSG00000114354 MIM:602498 Vega:OTTHUMG00000159085 UniprotKB:Q92734
NG_027821.1
PubMed
0   ANCO-SNPs
ND
2   
8.172e-1 (AD)  2.868e-1 (ND)   (Frontal_Cortex)
6.727e-1 (AD)  3.245e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMD60.953
POLR2C0.947
TAF70.947
DPM10.946
GORASP20.945
ILF20.944
H2AFY0.941
ARF40.939
XRCC60.938
PSMC40.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.744
OR4F29-0.689
MTRNR2L9-0.246
KLRB1-0.232
MTRNR2L6-0.224
TRPV5-0.222
CTNNA3-0.216
MTRNR2L10-0.212
TCL1A-0.212
OR6C74-0.209

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TFG mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of TFG mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of TFG mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of TFG mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of TFG mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of TFG mRNA19774075
C015001arsenitearsenite affects the expression of TFG mRNA22959463
D001241AspirinAspirin results in increased expression of TFG mRNA15928584
C547126AZM551248AZM551248 results in increased expression of TFG mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TFG mRNA"20018196
C006780bisphenol Abisphenol A affects the expression of TFG mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TFG mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TFG mRNA25181051
D002065BuspironeBuspirone results in decreased expression of TFG mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of TFG mRNA23741332
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TFG mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of TFG mRNA19320972
D016572CyclosporineCyclosporine results in increased expression of TFG mRNA20106945|2556210
C000944dicrotophosdicrotophos results in increased expression of TFG mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TFG protein23301498
D005485FlutamideFlutamide results in increased expression of TFG mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TFG mRNA"18930950
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of TFG protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TFG protein26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TFG mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TFG mRNA"25554681
C045950propiconazolepropiconazole results in increased expression of TFG mRNA21278054
C017947sodium arsenitesodium arsenite affects the methylation of TFG gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TFG mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in increased methylation of TFG gene27618143
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of TFG mRNA"18930950
C080163trovafloxacintrovafloxacin results in decreased expression of TFG mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TFG mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of TFG gene29154799
D014635Valproic AcidValproic Acid affects the expression of TFG mRNA17292431
C025643vinclozolinvinclozolin affects the expression of TFG mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14743216  15557341  16189514  25416956  25910212  26871637  
27107014  27813252  
GO:0042802identical protein binding-IPI16169070  25416956  27107012  
GO ID GO Term Qualifier Evidence PubMed
GO:0006888ER to Golgi vesicle-mediated transport-IMP27813252  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-HMP12761501  
GO:0048208COPII vesicle coating-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005737cytoplasm-NAS7565764  
GO:0005829cytosol-TAS-  
GO:0070971endoplasmic reticulum exit site-IDA27813252  
KEGG ID KEGG Term
hsa05200Pathways in cancer
hsa05216Thyroid cancer
Reactome ID Reactome Term Evidence
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18242762EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. (2008 Aug)Shinmura KLung Cancer
22623064Is the expression of Transforming Growth Factor-Beta1 after fracture of long bones solely influenced by the healing process? (2012 Oct)Kaiser GInt Orthop