Gene: ABCA7

10347
ABCA-SSN|ABCX|AD9
ATP binding cassette subfamily A member 7
protein-coding
19p13.3
Ensembl:ENSG00000064687 MIM:605414 Vega:OTTHUMG00000167547 UniprotKB:Q8IZY2
NG_046909.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.992e-1 (AD)  4.318e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HOOK20.889
SEMA6C0.871
SFI10.858
KLHL170.854
IFFO10.847
NEIL10.843
CUL90.841
MICAL10.84
PKD10.839
STK360.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRAT-0.46
ZFHX4-AS1-0.405
MYOZ1-0.379
OR4F5-0.376
NXT2-0.373
YES1-0.37
ASB4-0.363
MTRNR2L6-0.363
REST-0.362
ANGPTL1-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ABCA7 mRNA"27291303
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ABCA7 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ABCA7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ABCA7 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ABCA7 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABCA7 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ABCA7 mRNA26377693
C006780bisphenol Abisphenol A affects the expression of ABCA7 mRNA22574217
C006780bisphenol Abisphenol A results in increased expression of ABCA7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride affects the methylation of ABCA7 promoter22457795
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ABCA7 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABCA7 mRNA24386269
D019327Copper SulfateCopper Sulfate results in increased expression of ABCA7 mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of ABCA7 mRNA18579281
D013759DronabinolDronabinol results in decreased expression of ABCA7 mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ABCA7 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ABCA7 mRNA27392435
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which results in decreased expression of ABCA7 mRNA19944135
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ABCA7 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ABCA7 mRNA23649840
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of ABCA7 mRNA24680724
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ABCA7 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ABCA7 mRNA26752646
C030272maleic acidmaleic acid results in increased expression of ABCA7 mRNA28392987
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ABCA7 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABCA7 mRNA"25620056
D017239PaclitaxelPaclitaxel results in increased expression of ABCA7 mRNA20737486
C006253pirinixic acidpirinixic acid results in decreased expression of ABCA7 mRNA17426115
D011441PropylthiouracilPropylthiouracil results in decreased expression of ABCA7 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ABCA7 mRNA21632981
D012643SeleniumSelenium results in increased expression of ABCA7 mRNA19244175
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA"18579281
C004648testosterone enanthatetestosterone enanthate affects the expression of ABCA7 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABCA7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCA7 mRNA24680724
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ABCA7 mRNA28973375
C009495titanium dioxidetitanium dioxide results in increased expression of ABCA7 mRNA23557971
D014212TretinoinTretinoin results in increased expression of ABCA7 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of ABCA7 mRNA28542535
D014635Valproic AcidValproic Acid results in increased methylation of ABCA7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ABCA7 mRNA20546886
C025643vinclozolinvinclozolin results in decreased expression of ABCA7 mRNA23034163
D015215ZidovudineZidovudine results in decreased expression of ABCA7 mRNA24292225
D015215ZidovudineZidovudine results in increased expression of ABCA7 mRNA24292225

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-TAS10873640  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IDA24097981  
GO:0034188apolipoprotein A-I receptor activity-IDA14570867  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0090554phosphatidylcholine-translocating ATPase activity-IDA24097981  
GO:0090556phosphatidylserine-translocating ATPase activity-IDA24097981  
GO ID GO Term Qualifier Evidence PubMed
GO:0006869lipid transport-IBA21873635  
GO:0006909phagocytosis-IEA-  
GO:0007613memory-ISS-  
GO:0010875positive regulation of cholesterol efflux-ISS-  
GO:0018149peptide cross-linking-ISS-  
GO:0033344cholesterol efflux-IDA14570867  
GO:0033700phospholipid efflux-IDA14570867  
GO:0034380high-density lipoprotein particle assembly-IDA14570867  
GO:0034504protein localization to nucleus-ISS-  
GO:0038027apolipoprotein A-I-mediated signaling pathway-IDA14570867  
GO:0042985negative regulation of amyloid precursor protein biosynthetic process-ISS-  
GO:0045332phospholipid translocation-IDA24097981  
GO:0050766positive regulation of phagocytosis-ISS-  
GO:0055085transmembrane transport-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO:1900223positive regulation of amyloid-beta clearance-ISS-  
GO:1901076positive regulation of engulfment of apoptotic cell-ISS-  
GO:1902430negative regulation of amyloid-beta formation-ISS-  
GO:1902995positive regulation of phospholipid efflux-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0001891phagocytic cup-ISS-  
GO:0005794Golgi apparatus-IDA-  
GO:0005886plasma membrane-IDA14570867  
GO:0005886plasma membrane-TAS-  
GO:0009986cell surface-ISS-  
GO:0016021integral component of membrane-TAS10873640  
GO:0030054cell junction-IDA-  
GO:0031901early endosome membrane-IEA-  
GO:0032587ruffle membrane-ISS-  
GO:0043190ATP-binding cassette (ABC) transporter complex-TAS10873640  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-1369062ABC transporters in lipid homeostasisTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
27770636Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. (2017 Feb)Mez JAlzheimers Dement