Gene: ABCA8

10351
-
ATP binding cassette subfamily A member 8
protein-coding
17q24.2
Ensembl:ENSG00000141338 MIM:612505 Vega:OTTHUMG00000180192 UniprotKB:O94911
NC_000017.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.132e-1 (AD)  4.802e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP20.9
FRMD4B0.892
C21orf910.891
UGT80.891
C10orf900.887
ANLN0.886
HHIP0.882
MYRF0.882
ST180.881
CLDN110.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.423
NEUROD1-0.414
CHRNA2-0.391
PCDH8-0.389
LTK-0.381
CALB2-0.38
PRTN3-0.372
GRIN2D-0.367
SHISA8-0.365
PAX2-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of ABCA8 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ABCA8 mRNA26690555
D000255Adenosine TriphosphateAdenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABCA8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABCA8 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ABCA8 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ABCA8 mRNA21298039
D010130p-Aminohippuric AcidABCA8 protein affects the transport of p-Aminohippuric Acid12379217
C547126AZM551248AZM551248 results in increased expression of ABCA8 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ABCA8 gene25435355
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ABCA8 mRNA"20382639
D004958EstradiolEstradiol results in decreased expression of ABCA8 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of ABCA8 mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of ABCA8 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ABCA8 mRNA26079696
D002994ClofibrateClofibrate results in decreased expression of ABCA8 mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of ABCA8 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of ABCA8 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased methylation of ABCA8 promoter27989131
D004077DigoxinDigoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C024629dimethyl phthalatedimethyl phthalate affects the expression of ABCA8 mRNA26924002
C067311docetaxel[docetaxel results in decreased susceptibility to docetaxel] which results in increased expression of ABCA8 mRNA19944135
C087719dofequidardofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide12379217
C025483estradiol-17 beta-glucuronideAdenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideDigoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronidedofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideProbenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideVerapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C025483estradiol-17 beta-glucuronideverlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C017296estrone sulfateABCA8 protein affects the transport of estrone sulfate12379217
D005485FlutamideFlutamide results in decreased expression of ABCA8 mRNA24136188|2479361
D005557FormaldehydeFormaldehyde results in increased expression of ABCA8 mRNA28937961
C045463leflunomideleflunomide results in increased expression of ABCA8 mRNA24136188
D017997Leukotriene C4ABCA8 protein affects the transport of Leukotriene C412379217
C018091maduramicinmaduramicin results in decreased expression of ABCA8 mRNA29128925
D009532NickelNickel results in decreased expression of ABCA8 mRNA25583101
C025589ochratoxin AABCA8 protein affects the transport of ochratoxin A12379217
C025589ochratoxin Aochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
D010098OxycodoneOxycodone results in increased expression of ABCA8 mRNA23439660
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ABCA8 mRNA26705709
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABCA8 mRNA27153767
D011339ProbenecidProbenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of ABCA8 mRNA17404688
D012293RifampinRifampin results in decreased expression of ABCA8 mRNA27199754
C089730rosiglitazonerosiglitazone results in decreased expression of ABCA8 mRNA25572481
D012906SmokeSmoke results in decreased expression of ABCA8 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of ABCA8 gene28589171
C017947sodium arsenitesodium arsenite results in increased expression of ABCA8 mRNA22714537
C016104sodium bichromatesodium bichromate affects the expression of ABCA8 mRNA22110744
D018038Sodium SeleniteSodium Selenite results in decreased expression of ABCA8 mRNA24383545
D013656Taurocholic AcidABCA8 protein affects the transport of Taurocholic Acid12379217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABCA8 mRNA21215274
D014635Valproic AcidValproic Acid affects the expression of ABCA8 mRNA25979313
D014700VerapamilVerapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
C059141verlukastverlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]12379217
D014750Vincristine[Vincristine results in decreased susceptibility to Vincristine] which affects the expression of ABCA8 mRNA19944135
C111237vorinostatvorinostat results in decreased expression of ABCA8 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0008559xenobiotic transmembrane transporting ATPase activity-TAS-  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IBA21873635  
GO:0042626ATPase activity, coupled to transmembrane movement of substances-IDA12379217  
GO ID GO Term Qualifier Evidence PubMed
GO:0006855drug transmembrane transport-IEA-  
GO:0006869lipid transport-IBA21873635  
GO:0042908xenobiotic transport-IEA-  
GO:0055085transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa02010ABC transporters
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-382556ABC-family proteins mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res